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[해외논문] Endothelial-specific Crif1 deletion induces BBB maturation and disruption via the alteration of actin dynamics by impaired mitochondrial respiration 원문보기

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, v.40 no.7, 2020년, pp.1546 - 1561  

Lee, Min Joung (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Jang, Yunseon (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Han, Jeongsu (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Kim, Soo J (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Ju, Xianshu (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Lee, Yu Lim (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Cui, Jianchen (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Zhu, Jiebo (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Ryu, Min Jeong (Department of Biochemistry, Chungnam National University, Daejeon, Republic of Korea) ,  Choi, Song-Yi (Department of Pathology, Chungnam National University, Daejeon, Republic of Korea) ,  Chung, Woosuk (Department of Medical Science, Chungnam National University, Daejeon, Republic of Korea) ,  Heo, Chaejeong (Center for Integrat) ,  Yi, Hyon-Seung ,  Kim, Hyun Jin ,  Huh, Yang H ,  Chung, Sookja K ,  Shong, Minho ,  Kweon, Gi-Ryang ,  Heo, Jun Young

Abstract AI-Helper 아이콘AI-Helper

Cerebral endothelial cells (ECs) require junctional proteins to maintain blood-brain barrier (BBB) integrity, restricting toxic substances and controlling peripheral immune cells with a higher concentration of mitochondria than ECs of peripheral capillaries. The mechanism underlying BBB disruption ...

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