[논문]Acyclic Triterpenoid Isolated from Alpinia katsumadai Alleviates Formalin-Induced Chronic Mouse Paw Inflammation by Inhibiting the Phosphorylation of ERK and NF-κB

Lim, Hyung Jin; Bak, Seon Gyeong; Lim, Hee Ju; Lee, Seung Woong; Lee, Soyoung; Ku, Sae-Kwang; Park, Sang-Ik; Lee, Seung-Jae; Rho, Mun-Chual

doi:10.3390/molecules25153345

[해외논문] Acyclic Triterpenoid Isolated from Alpinia katsumadai Alleviates Formalin-Induced Chronic Mouse Paw Inflammation by Inhibiting the Phosphorylation of ERK and NF-κB 원문보기

Molecules a journal of synthetic chemistry and natural product chemistry, v.25 no.15, 2020년, pp.3345 -

Lim, Hyung Jin (Immunoregulatory Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeonbuk 56212, Korea) , Bak, Seon Gyeong (lhjin@kribb.re.kr (H.J.L.)) , Lim, Hee Ju (tsk9096@kribb.re.kr (S.G.B.)) , Lee, Seung Woong (limhj09@kribb.re.kr (H.J.L.)) , Lee, Soyoung (lswdoc@kribb.re.kr (S.W.L.)) , Ku, Sae-Kwang (sylee@kribb.re.kr (S.L.)) , Park, Sang-Ik (Immunoregulatory Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, Jeonbuk 56212, Korea) , Lee, Seung-Jae (lhjin@kribb.re.kr (H.J.L.)) , Rho, Mun-Chual (tsk9096@kribb.re.kr (S.G.B.))

Abstract ▼ AI-Helper

Chronic and excessive inflammation can destroy host organs and cause inflammatory diseases such as inflammatory bowel disease, asthma, and rheumatoid arthritis. In this study, we investigated the anti-inflammatory effects of Alpinia katsumadai seed-derived 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (PHT) using lipopolysaccharide (LPS)-stimulated J774 cells and a formalin-induced chronic paw inflammation mouse model. The in vitro results showed that PHT exhibited no cytotoxicity and decreased LPS-induced NO secretion. Additionally, PHT inhibited LPS-induced inducible NO synthase (iNOS) and cyclooxygenase 2 (COX2) protein expression. The quantitative real-time PCR results showed that PHT downregulated the gene expression of the proinflammatory cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) but not tumor necrosis factor α (TNF-α). PHT inhibited the LPS-induced phosphorylation of extracellular signal-regulated kinase (ERK) and nuclear factor kappa light chain enhancer of activated B cells (NF-κB). In a mouse model, oral administration of 50 mg/kg PHT significantly alleviated both mouse paw thickness and volume. These results indicate that PHT has potential anti-inflammatory effects and should be considered a possible functional material.

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