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[해외논문] SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitro 원문보기

Stem cell research & therapy, v.11 no.1, 2020년, pp.209 -   

Ju, Younghee (Department of Biological Sciences, KAIST, Daejeon, 34141 Republic of Korea) ,  Park, Jun Sung (Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141 Republic of Korea) ,  Kim, Daejeong (Department of Bio and Brain Engineering, KAIST, Daejeon, 34141 Republic of Korea) ,  Kim, Bumsoo (Department of Biological Sciences, KAIST, Daejeon, 34141 Republic of Korea) ,  Lee, Jeong Ho (Graduate School of Medical Science and Engineering, KAIST, Daejeon, 34141 Republic of Korea) ,  Nam, Yoonkey (Department of Bio and Brain Engineering, KAIST, Daejeon, 34141 Republic of Korea) ,  Yoo, Han-Wook (Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, 05505 Republic of Korea) ,  Lee, Beom Hee (Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, 05505 Republic of Korea) ,  Han, Yong-Mahn (Department of Biological Sciences, KAIST, Daejeon, 34141 Republic of Korea)

Abstract AI-Helper 아이콘AI-Helper

BackgroundNoonan syndrome (NS) is a developmental disorder caused by mutations of Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2). Although NS patients have diverse neurological manifestations, the mechanisms underlying the involvement of SHP2 mutations in neurological dysfunc...

Keyword

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