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[해외논문] Detection and Assessment of α-Synuclein Oligomers in the Urine of Parkinson’s Disease Patients

Journal of Parkinson's Disease, v.10 no.3, 2020년, pp.981 - 991  

Nam, Daleum (InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunposi, Gyeonggido, Republic of Korea) ,  Lee, Jee-Young (Department of Neurology, Seoul National University Boramae Medical Center, Seoul, Republic of Korea) ,  Lee, Minhyung (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) ,  Kim, Janghwan (Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea) ,  Seol, Wongi (InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunposi, Gyeonggido, Republic of Korea) ,  Son, Ilhong (InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunposi, Gyeonggido, Republic of Korea) ,  Ho, Dong Hwan (InAm Neuroscience Research Center, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunposi, Gyeonggido, Republic of Korea)

초록이 없습니다.

참고문헌 (34)

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  2. Biomolecules 5 282 Seeking a mechanism for the toxicity of oligomeric α-synuclein Roberts 2015 10.3390/biom5020282 

  3. Parkinsonism Relat Disord 10 319 The neuromythology of Parkinson’s disease Calne 2004 10.1016/j.parkreldis.2004.03.006 

  4. J Neuropathol Exp Neurol 68 816 Lewy body pathology in normal elderly subjects Markesbery 2009 10.1097/NEN.0b013e3181ac10a7 

  5. Cell Tissue Res 373 149 Is Lewy pathology in the human nervous system chiefly an indicator of neuronal protection or of toxicity? Chartier 2018 10.1007/s00441-018-2854-6 

  6. Nat Commun 4 2575 Structural and functional characterization of two alpha-synuclein strains Bousset 2013 10.1038/ncomms3575 

  7. Brain Pathol 26 410 Alpha-synuclein as a biomarker for Parkinson’s disease Atik 2016 10.1111/bpa.12370 

  8. Mol Neurodegener 11 7 Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease Majbour 2016 10.1186/s13024-016-0072-9 

  9. Mov Disord 33 1724 alpha-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies van Steenoven 2018 10.1002/mds.111 

  10. Parkinsons Dis 2016 14 Blood plasma of patients with Parkinson’s disease increases alpha-synuclein aggregation and neurotoxicity Wang 2016 

  11. PLoS One 11 e0151156 Abnormal salivary total and oligomeric alpha-synuclein in Parkinson’s disease Vivacqua 2016 10.1371/journal.pone.0151156 

  12. Discov Med 25 57 Urine biomarkers in the early stages of diseases: current status and perspective Jing 2018 

  13. Biomed Res Int 2014 8 Increased DJ-1 in urine exosome of Korean males with Parkinson’s disease Ho 2014 10.1155/2014/704678 

  14. Parkinsons Dis 2018 9 Oxidized DJ-1 levels in urine samples as a putative biomarker for Parkinson’sdisease Jang 2018 

  15. Oncotarget 7 43432 Urine gamma-synuclein as a biomarker for the diagnosis of bladder cancer Liu 2016 10.18632/oncotarget.9468 

  16. Neurology 84 S7.002 Phosphorylated pS1292 LRRK2 to total LRRK2 concentration ratio in urine exosomes distinguishes LRRK2-PD and idiopathic PD (S7.002) Alcalay 2015 10.1212/WNL.84.14_supplement.S7.002 

  17. Int J Stem Cells 12 474 Direct reprogramming to human induced neuronal progenitors from fibroblasts of familial and sporadic Parkinson’s disease patients Lee 2019 10.15283/ijsc19075 

  18. PLoS One 13 e0196056 ELISA method to detect alpha-synuclein oligomers in cell and animal models Lassen 2018 10.1371/journal.pone.0196056 

  19. Toxicol Lett 233 163 The molecular mechanism of rotenone-induced alpha-synuclein aggregation: emphasizing the role of the calcium/GSK3beta pathway Yuan 2015 10.1016/j.toxlet.2014.11.029 

  20. Sci Rep 2 898 Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice Pan-Montojo 2012 10.1038/srep00898 

  21. PLoS One 9 e90857 A generic method for design of oligomer-specific antibodies Brännström 2014 10.1371/journal.pone.0090857 

  22. Front Oncol 8 362 Urinary markers in bladder cancer: an update Santoni 2018 10.3389/fonc.2018.00362 

  23. Mol Psychiatry 18 67 Potential metabolite markers of schizophrenia Yang 2013 10.1038/mp.2011.131 

  24. Front CellNeurosci 13 150 Urine organic acids as potential biomarkers for autism-spectrum disorder in Chinese children Chen 2019 

  25. Psychol Med 6 649 Urinary dimethyltryptamine and psychiatric symptomatology and classification Rodnight 1976 10.1017/S0033291700018304 

  26. Ann Rheum Dis 63 1159 Presence of systemic autoimmune disorders in patients with autoimmune thyroid diseases Tektonidou 2004 10.1136/ard.2004.022624 

  27. J Alzheimers Dis 65 421 Urine-based biomarkers for Alzheimer’s disease identified through coupling computational and experimental methods Yao 2018 10.3233/JAD-180261 

  28. Acta Neuropathol 134 819 Alpha-synuclein oligomers: a new hope Bengoa-Vergniory 2017 10.1007/s00401-017-1755-1 

  29. J Biol Chem 279 26846 The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils Zhu 2004 10.1074/jbc.M403129200 

  30. Neurochem Res 41 2788 Epigallocatechin Gallate (EGCG) Inhibits alpha-synuclein aggregation: a potential agent for Parkinson’s disease Xu 2016 10.1007/s11064-016-1995-9 

  31. Nature 477 107 alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation Bartels 2011 10.1038/nature10324 

  32. Exp Mol Med 49 e314 Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification Jung 2017 10.1038/emm.2017.1 

  33. FASEB J 20 419 Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson’s disease El-Agnaf 2006 10.1096/fj.03-1449com 

  34. Neuroepidemiology 42 204 Increased risk of Parkinson’s disease in patients with end-stage renal disease: a retrospective cohort study Wang 2014 10.1159/000358921 

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