[논문]Toxicity Assessment of SiO 2 and TiO 2 in Normal Colon Cells, In Vivo and in Human Colon Organoids

Park, Sung Bum; Jung, Won Hoon; Kim, Ki Young; Koh, Byumseok

doi:10.3390/molecules25163594

[해외논문] Toxicity Assessment of SiO 2 and TiO 2 in Normal Colon Cells, In Vivo and in Human Colon Organoids 원문보기

Molecules a journal of synthetic chemistry and natural product chemistry, v.25 no.16, 2020년, pp.3594 -

Park, Sung Bum , Jung, Won Hoon , Kim, Ki Young , Koh, Byumseok

Abstract ▼ AI-Helper

We conducted systemic assessments on the toxicity of silicon dioxide (SiO2) and titanium dioxide (TiO2) nanoparticles using different forms of normal colon cells (CCD-18Co), in vivo and in human colon organoids. The in vivo acute oral toxicity data showed that the LD50 values are greater than 2000 mg/kg for both the SiO2 and TiO2 nanoparticles; however, the SiO2 and TiO2 nanoparticles induced cytotoxicity in two-dimensional CCD-18Co cells and three-dimensional CCD-18Co spheroids and human colon organoids, with IC50 values of 0.6, 0.8 and 0.3 mM for SiO2 and 2.5, 1.1 and 12.5 mM for TiO2 nanoparticles, respectively. The data suggest that, when SiO2 and TiO2 are in nanoparticle form, cytotoxicity is induced; thus, care should be taken with these materials.

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[해외논문] Toxicity Assessment of SiO 2 and TiO 2 in Normal Colon Cells, In Vivo and in Human Colon Organoids 원문보기

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[해외논문] Toxicity Assessment of SiO 2 and TiO 2 in Normal Colon Cells, In Vivo and in Human Colon Organoids 원문보기

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