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[해외논문] Recent advances in development of hetero-bivalent kinase inhibitors

European journal of medicinal chemistry, v.216, 2021년, pp.113318 -   

Lee, Seungbeom (College of Pharmacy, CHA University, Pocheon-si) ,  Kim, Jisu (College of Pharmacy, Pusan National University) ,  Jo, Jeyun (College of Pharmacy, Pusan National University) ,  Chang, Jae Won (Department of Pharmacology & Chemical Biology, School of Medicine, Emory University) ,  Sim, Jaehoon (College of Pharmacy, Chungnam National University) ,  Yun, Hwayoung (College of Pharmacy, Pusan National University)

Abstract AI-Helper 아이콘AI-Helper

Abstract Identifying a pharmacological agent that targets only one of more than 500 kinases present in humans is an important challenge. One potential solution to this problem is the development of bivalent kinase inhibitors, which consist of two connected fragments, each bind to a dissimilar bindi...

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