$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] Forskolin Increases cAMP Levels and Enhances Recombinant Antibody Production in CHO Cell Cultures

Biotechnology journal, v.15 no.10, 2020년, pp.2000264 -   

Yoon, Chansik (Department of Biological Sciences KAIST Daejeon 34141 Republic of Korea) ,  Kim, Dongil (Department of Biological Sciences KAIST Daejeon 34141 Republic of Korea) ,  Lim, Ju Hyeon (New Drug Development Center Cheongju 28160 Republic of Korea) ,  Lee, Gyun Min (Department of Biological Sciences KAIST Daejeon 34141 Republic of Korea)

Abstract AI-Helper 아이콘AI-Helper

AbstractCyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger essential to many biological processes. Forskolin, a labdane diterpene, is widely used to increase cAMP levels in various cell types. When 5 µm of forskolin is added to recombinant Chinese hamster ovary (rCHO) cell ...

참고문헌 (66)

  1. Noh, S.M., Sathyamurthy, M., Lee, G.M.. Development of recombinant Chinese hamster ovary cell lines for therapeutic protein production. Current opinion in chemical engineering, vol.2, no.4, 391-397.

  2. Walsh, Gary. Biopharmaceutical benchmarks 2018. Nature biotechnology, vol.36, no.12, 1136-1145.

  3. Palermo, D.P., DeGraaf, M.E., Marotti, K.R., Rehberg, E., Post, L.E.. Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression. Journal of biotechnology, vol.19, no.1, 35-47.

  4. Sung, Yun Hee, Song, Yeon Jung, Lim, Seung Wook, Chung, Joo Young, Lee, Gyun Min. Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells. Journal of biotechnology, vol.112, no.3, 323-335.

  5. Wang, Wenying, Yi, Xiaoping, Zhang, Yuanxing. Gene transcription acceleration: main cause of hepatitis B surface antigen production improvement by dimethyl sulfoxide in the culture of Chinese hamster ovary cells. Biotechnology and bioengineering, vol.97, no.3, 526-535.

  6. Park, Jin Hyoung, Noh, Soo Min, Woo, Ju Rang, Kim, Jong Won, Lee, Gyun Min. Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity. Biotechnology journal, vol.11, no.4, 487-496.

  7. Chang, Kern Hee, Kim, Kyung Soo, Kim, Jung Hoe. N-acetylcysteine increases the biosynthesis of recombinant EPO in apoptotic Chinese hamster ovary cells. Free radical research, vol.30, no.2, 85-91.

  8. Yang, William C., Lu, Jiuyi, Nguyen, Ngan B., Zhang, An, Healy, Nicholas V., Kshirsagar, Rashmi, Ryll, Thomas, Huang, Yao-Ming. Addition of Valproic Acid to CHO Cell Fed-Batch Cultures Improves Monoclonal Antibody Titers. Molecular biotechnology, vol.56, no.5, 421-428.

  9. Sutherland, Earl W.. Studies on the Mechanism of Hormone Action. Science, vol.177, no.4047, 401-408.

  10. Xiaodong, Cheng, Zhenyu, Ji, Tamara, Tsalkova, Fang, Mei. Epac and PKA: a tale of two intracellular cAMP receptors. Acta biochimica et biophysica Sinica, vol.40, no.7, 651-662.

  11. Perianayagam, M. C., Madias, N. E., Pereira, B. J. G., Jaber, B. L.. CREB transcription factor modulates Bcl2 transcription in response to C5a in HL-60-derived neutrophils. European journal of clinical investigation, vol.36, no.5, 353-361.

  12. Wilson, Byron E., Mochon, Evonne, Boxer, Linda M.. Induction of bcl-2 Expression by Phosphorylated CREB Proteins during B-Cell Activation and Rescue from Apoptosis. Molecular and cellular biology, vol.16, no.10, 5546-5556.

  13. Lugnier, Claire. Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacology & therapeutics, vol.109, no.3, 366-398.

  14. Fu, Dong, Wakabayashi, Yoshiyuki, Lippincott-Schwartz, Jennifer, Arias, Irwin M.. Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway. Proceedings of the National Academy of Sciences of the United States of America, vol.108, no.4, 1403-1408.

  15. Hindupur, Sravanth K., González, Asier, Hall, Michael N.. The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control. Cold Spring Harbor perspectives in biology, vol.7, no.8, a019141-a019141.

  16. LIANG, XIAOYAN, WANG, PILONG, GAO, QING, TAO, XIAOHONG. Exogenous activation of LKB1/AMPK signaling induces G1 arrest in cells with endogenous LKB1 expression. Molecular medicine reports, vol.9, no.3, 1019-1024.

  17. Lin, H.H., Lee, T.Y., Liu, T.W., Tseng, C.P.. High glucose enhances cAMP level and extracellular signal-regulated kinase phosphorylation in Chinese hamster ovary cell: Usage of Br-cAMP in foreign protein β-galactosidase expression. Journal of bioscience and bioengineering, vol.124, no.1, 108-114.

  18. Seamon, K B, Padgett, W, Daly, J W. Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.. Proceedings of the National Academy of Sciences of the United States of America, vol.78, no.6, 3363-3367.

  19. Pharmazie Alasbahi R. H. 5 67 2012 

  20. Insel, Paul A., Ostrom, Rennolds S.. Forskolin as a Tool for Examining Adenylyl Cyclase Expression, Regulation, and G Protein Signaling. Cellular and molecular neurobiology, vol.23, no.3, 305-314.

  21. Han, Sangyeul, Lee, Seung-Jun, Kim, Kyung Eun, Lee, Hyo Seon, Oh, Nuri, Park, Inwon, Ko, Eun, Oh, Seung Ja, Lee, Yoon-Sook, Kim, David, Lee, Seungjoo, Lee, Dae Hyun, Lee, Kwang-Hoon, Chae, Su Young, Lee, Jung-Hoon, Kim, Su-Jin, Kim, Hyung-Chan, Kim, Seokkyun, Kim, Sung Hyun, Kim, Chungho, Nakaoka, Yoshikazu, He, Yulong, Augustin, Hellmut G., Hu, Junhao, Song, Paul H., Kim, Yong-In, Kim, Pilhan, Kim, Injune, Koh, Gou Young. Amelioration of sepsis by TIE2 activation–induced vascular protection. Science translational medicine, vol.8, no.335, 335ra55-335ra55.

  22. 10.1002/(SICI)1097-0290(19980405)58:1<73::AID-BIT8>3.0.CO;2-R 

  23. Renard, J. M., Spagnoli, R., Mazier, C., Salles, M. F., Mandine, E.. Evidence that monoclonal antibody production kinetics is related to the integral of the viable cells curve in batch systems. Biotechnology letters. : a monthly journal for the rapid communication of results and developments in all aspects of biotechnology, vol.10, no.2, 91-96.

  24. Hwang, Sun Ok, Lee, Gyun Min. Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture. Biotechnology and bioengineering, vol.99, no.3, 678-685.

  25. Kim, Kang Ho, Sederstrom, Joel M.. Assaying Cell Cycle Status Using Flow Cytometry. Current protocols in molecular biology, vol.111, no.1,

  26. Hyoung Park, Jin, Sin Lim, Myung, Rang Woo, Ju, Won Kim, Jong, Min Lee, Gyun. The molecular weight and concentration of dextran sulfate affect cell growth and antibody production in CHO cell cultures. Biotechnology progress, vol.32, no.5, 1113-1122.

  27. Nikodemova, Maria, Kasckow, John, Liu, Hanguan, Manganiello, Vincent, Aguilera, Greti. Cyclic Adenosine 3′,5′-Monophosphate Regulation of Corticotropin-Releasing Hormone Promoter Activity in AtT-20 Cells and in a Transformed Hypothalamic Cell Line. Endocrinology, vol.144, no.4, 1292-1300.

  28. Dahle, Maria K., Myhre, Anders E., Aasen, Ansgar O., Wang, Jacob E.. Effects of Forskolin on Kupffer Cell Production of Interleukin-10 and Tumor Necrosis Factor Alpha Differ from Those of Endogenous Adenylyl Cyclase Activators: Possible Role for Adenylyl Cyclase 9. Infection and immunity, vol.73, no.11, 7290-7296.

  29. Lee, Jae Seong, Lee, Gyun Min. Rapamycin treatment inhibits CHO cell death in a serum‐free suspension culture by autophagy induction. Biotechnology and bioengineering, vol.109, no.12, 3093-3102.

  30. Hou, Pingping, Li, Yanqin, Zhang, Xu, Liu, Chun, Guan, Jingyang, Li, Honggang, Zhao, Ting, Ye, Junqing, Yang, Weifeng, Liu, Kang, Ge, Jian, Xu, Jun, Zhang, Qiang, Zhao, Yang, Deng, Hongkui. Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds. Science, vol.341, no.6146, 651-654.

  31. Hanna, Jacob, Cheng, Albert W., Saha, Krishanu, Kim, Jongpil, Lengner, Christopher J., Soldner, Frank, Cassady, John P., Muffat, Julien, Carey, Bryce W., Jaenisch, Rudolf. Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proceedings of the National Academy of Sciences of the United States of America, vol.107, no.20, 9222-9227.

  32. Hsieh, Jenny, Nakashima, Kinichi, Kuwabara, Tomoko, Mejia, Eunice, Gage, Fred H.. Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proceedings of the National Academy of Sciences of the United States of America, vol.101, no.47, 16659-16664.

  33. Palmer, Theo D., Takahashi, Jun, Gage, Fred H.. The Adult Rat Hippocampus Contains Primordial Neural Stem Cells. Molecular and cellular neurosciences, vol.8, no.6, 389-404.

  34. McDonough, Kathleen A., Rodriguez, Ana. The myriad roles of cyclic AMP in microbial pathogens: from signal to sword. Nature reviews. Microbiology, vol.10, no.1, 27-38.

  35. Chambard, J.C., Lefloch, R., Pouyssegur, J., Lenormand, P.. ERK implication in cell cycle regulation. Biochimica et biophysica acta, Molecular cell research, vol.1773, no.8, 1299-1310.

  36. Osaki, Luciana H., Gama, Patricia. MAPK Signaling Pathway Regulates p27 Phosphorylation at Threonin 187 as Part of the Mechanism Triggered by Early-Weaning to Induce Cell Proliferation in Rat Gastric Mucosa. PloS one, vol.8, no.6, e66651-.

  37. Gysin, Stephan, Lee, Sang-Hyun, Dean, Nicholas M., McMahon, Martin. Pharmacologic Inhibition of RAF→MEK→ERK Signaling Elicits Pancreatic Cancer Cell Cycle Arrest Through Induced Expression of p27Kip1. Cancer research : the official organ of the American Association for Cancer Research, Inc, vol.65, no.11, 4870-4880.

  38. Wolf, G., Reinking, R., Zahner, G., Stahl, R. A. K., Shankland, S. J.. Erk 1,2 phosphorylates p27 Kip1 : Functional evidence for a role in high glucose-induced hypertrophy of mesangial cells. Diabetologia, vol.46, no.8, 1090-1099.

  39. Li, Nan, Wang, Chunmei, Wu, Yanan, Liu, Xingguang, Cao, Xuetao. Ca2+/Calmodulin-dependent Protein Kinase II Promotes Cell Cycle Progression by Directly Activating MEK1 and Subsequently Modulating p27 Phosphorylation. The Journal of biological chemistry, vol.284, no.5, 3021-3027.

  40. 10.1101/gad.13.9.1181 

  41. Woods, Angela, Johnstone, Stephen R., Dickerson, Kristina, Leiper, Fiona C., Fryer, Lee G.D., Neumann, Dietbert, Schlattner, Uwe, Wallimann, Theo, Carlson, Marian, Carling, David. LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade. Current biology : CB, vol.13, no.22, 2004-2008.

  42. Hardie, D. Grahame, Ross, Fiona A., Hawley, Simon A.. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nature reviews. Molecular cell biology, vol.13, no.4, 251-262.

  43. Mihaylova, Maria M., Shaw, Reuben J.. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nature cell biology, vol.13, no.9, 1016-1023.

  44. Kyriakis, John M. At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation. Journal of biology, vol.2, no.4, 26-26.

  45. Kopsiaftis, Stavros, Sullivan, Katie L., Garg, Isha, Taylor III, John A., Claffey, Kevin P.. AMPKα2 Regulates Bladder Cancer Growth through SKP2-Mediated Degradation of p27. Molecular cancer research, vol.14, no.12, 1182-1194.

  46. Liang, Jiyong, Shao, Shan H., Xu, Zhi-Xiang, Hennessy, Bryan, Ding, Zhiyong, Larrea, Michelle, Kondo, Seiji, Dumont, Dan J., Gutterman, Jordan U., Walker, Cheryl L., Slingerland, Joyce M., Mills, Gordon B.. The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis. Nature cell biology, vol.9, no.2, 218-224.

  47. Lipner, Matthew B., Marayati, Raoud, Deng, Yangmei, Wang, Xianxi, Raftery, Laura, O’Neil, Bert H., Yeh, Jen Jen. Metformin Treatment Does Not Inhibit Growth of Pancreatic Cancer Patient-Derived Xenografts. PloS one, vol.11, no.1, e0147113-.

  48. Kim, Joungmok, Kundu, Mondira, Viollet, Benoit, Guan, Kun-Liang. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature cell biology, vol.13, no.2, 132-141.

  49. Cherra III, Salvatore J., Kulich, Scott M., Uechi, Guy, Balasubramani, Manimalha, Mountzouris, John, Day, Billy W., Chu, Charleen T.. Regulation of the autophagy protein LC3 by phosphorylation. The Journal of cell biology, vol.190, no.4, 533-539.

  50. Ragazzon, Bruno, Cazabat, Laure, Rizk-Rabin, Marthe, Assie, Guillaume, Groussin, Lionel, Fierrard, Hélène, Perlemoine, Karine, Martinez, Antoine, Bertherat, Jérôme. Inactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGFβ-Stimulated Apoptosis in Adrenocortical Cells. Cancer research : the official organ of the American Association for Cancer Research, Inc, vol.69, no.18, 7278-7284.

  51. Yang, Der-Chih, Tsay, Huey-Jen, Lin, Shan-Yang, Chiou, Shih-Hwa, Li, Mei-Jane, Chang, Tai-Jay, Hung, Shih-Chieh. cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin. PloS one, vol.3, no.2, e1540-.

  52. Altarejos, Judith Y., Montminy, Marc. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nature reviews. Molecular cell biology, vol.12, no.3, 141-151.

  53. Wang, Haitao, Xu, Jiangping, Lazarovici, Philip, Quirion, Remi, Zheng, Wenhua. cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia. Frontiers in molecular neuroscience, vol.11, 255-.

  54. Meller, Robert, Minami, Manabu, Cameron, Jennifer A, Impey, Soren, Chen, Dexi, Lan, Jing-Quan, Henshall, David C, Simon, Roger P. CREB-Mediated Bcl-2 Protein Expression after Ischemic Preconditioning. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, vol.25, no.2, 234-246.

  55. Wang, P., Yan, H., Li, J.C.. CREB-mediated Bcl-2 expression in trichosanthin-induced Hela cell apoptosis. Biochemical and biophysical research communications, vol.363, no.1, 101-105.

  56. Xiang, Hong, Wang, Jinghong, Boxer, Linda M.. Role of the Cyclic AMP Response Element in the bcl-2 Promoter in the Regulation of Endogenous Bcl-2 Expression and Apoptosis in Murine B Cells. Molecular and cellular biology, vol.26, no.22, 8599-8606.

  57. Pugazhenthi, Subbiah, Nesterova, Albina, Sable, Carol, Heidenreich, Kim A., Boxer, Linda M., Heasley, Lynn E., Reusch, Jane E.-B.. Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein. The Journal of biological chemistry, vol.275, no.15, 10761-10766.

  58. Yang, Jie, Liu, Xuesong, Bhalla, Kapil, Kim, Caryn Naekyung, Ibrado, Ana Maria, Cai, Jiyang, Peng, Tsung-I, Jones, Dean P., Wang, Xiaodong. Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked. Science, vol.275, no.5303, 1129-1132.

  59. Jeon, Min Kyoung, Yu, Da Young, Lee, Gyun Min. Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells. Applied microbiology and biotechnology, vol.92, no.4, 779-790.

  60. Rosenberg, Amy S.. Effects of protein aggregates: An immunologic perspective. The AAPS journal, vol.8, no.3, E501-E507.

  61. Kaschak, Timothy, Boyd, Daniel, Lu, Franklin, Derfus, Gayle, Kluck, Brian, Nogal, Bartek, Emery, Craig, Summers, Christie, Zheng, Kai, Bayer, Robert, Amanullah, Ashraf, Yan, Boxu. Characterization of the basic charge variants of a human IgG1 : Effect of copper concentration in cell culture media. mAbs, vol.3, no.6, 577-583.

  62. Reusch, Dietmar, Tejada, Max L. Fc glycans of therapeutic antibodies as critical quality attributes. Glycobiology, vol.25, no.12, 1325-1334.

  63. Hodoniczky, J., Zheng, Y. Z., James, D. C.. Control of Recombinant Monoclonal Antibody Effector Functions by Fc N-Glycan Remodeling in Vitro. Biotechnology progress, vol.21, no.6, 1644-1652.

  64. Jiang, Xu-Rong, Song, An, Bergelson, Svetlana, Arroll, Thomas, Parekh, Bhavin, May, Kimberly, Chung, Shan, Strouse, Robert, Mire-Sluis, Anthony, Schenerman, Mark. Advances in the assessment and control of the effector functions of therapeutic antibodies. Nature reviews. Drug discovery, vol.10, no.2, 101-111.

  65. Aghamohseni, H., Ohadi, K., Spearman, M., Krahn, N., Moo-Young, M., Scharer, J.M., Butler, M., Budman, H.M.. Effects of nutrient levels and average culture pH on the glycosylation pattern of camelid-humanized monoclonal antibody. Journal of biotechnology, vol.186, 98-109.

  66. Du, Zhimei, Treiber, David, McCarter, John D, Fomina-Yadlin, Dina, Saleem, Ramsey A, McCoy, Rebecca E, Zhang, Yuling, Tharmalingam, Tharmala, Leith, Matthew, Follstad, Brian D, Dell, Brad, Grisim, Brent, Zupke, Craig, Heath, Carole, Morris, Arvia E, Reddy, Pranhitha. Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures. Biotechnology and bioengineering, vol.112, no.1, 141-155.

LOADING...

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

유발과제정보 저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로