[논문]Progesterone increases blood glucose via hepatic progesterone receptor membrane component 1 under limited or impaired action of insulin

Lee, Sang R.; Choi, Woo-Young; Heo, Jun H.; Huh, Jiyoung; Kim, Globinna; Lee, Kyu-Pil; Kwun, Hyo-Jung; Shin, Hyun-Jin; Baek, In-Jeoung; Hong, Eui-Ju

doi:10.1038/s41598-020-73330-7

[해외논문] Progesterone increases blood glucose via hepatic progesterone receptor membrane component 1 under limited or impaired action of insulin 원문보기

Scientific reports, v.10 no.1, 2020년, pp.16316 -

Lee, Sang R. (College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Suite 401Veterinary medicine Bldg., Yuseong, Daejeon, 34134 Republic of Korea) , Choi, Woo-Young (College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Suite 401Veterinary medicine Bldg., Yuseong, Daejeon, 34134 Republic of Korea) , Heo, Jun H. (College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Suite 401Veterinary medicine Bldg., Yuseong, Daejeon, 34134 Republic of Korea) , Huh, Jiyoung (College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Suite 401Veterinary medicine Bldg., Yuseong, Daejeon, 34134 Republic of Korea) , Kim, Globinna (Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505 Republic of Korea) , Lee, Kyu-Pil (College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Suite 401Veterinary medicine Bldg., Yuseong, Daejeon, 34134 Republic of Korea) , Kwun, Hyo-Jung (College of Veterinary Medicine, Chungnam National University, 99 Daehak-ro, Suite 401Vete) , Shin, Hyun-Jin , Baek, In-Jeoung , Hong, Eui-Ju

Abstract ▼ AI-Helper

Hepatic gluconeogenesis is the main pathway for blood glucose maintenance activated during fasting. Retardation of insulin action, such as in diabetes mellitus, activates gluconeogenesis during the fed state. While the role of progesterone (P4) in diabetes is controversial, the P4 receptor, progesterone receptor membrane component 1 (PGRMC1), is known to stimulate pancreatic insulin secretion. We investigated the role of P4, via hepatic PGRMC1, during gluconeogenesis. The PGRMC1 binding chemical, AG-205, induced PGRMC1 monomer (25 kDa) abundance, and increased PEPCK expression and glucose production in parallel with cyclic AMP (cAMP) induction in Hep3B cells. PGRMC1-mediated cyclic AMP was inhibited by an adenylate cyclase inhibitor (MDL-12,330A). PEPCK suppression in Pgrmc1 KO hepatocyte was not observed after treatment of MDL-12,330A. PGRMC1 knockdown or overexpression systems in Hep3B cells confirmed that PGRMC1 mediates PEPCK expression via phosphorylation of cAMP-response element binding protein (CREB). CREB phosphorylation and PEPCK expression in primary hepatocytes were greater than that in PGRMC1 knock-out hepatocytes. Progesterone increased PGRMC1 expression, which induced cAMP and PEPCK induction and glucose production. In vivo, P4 suppressed gluconeogenesis following plasma insulin induction under normal conditions in a mouse model. However, P4 increased blood glucose via gluconeogenesis in parallel with increases in PGRMC1 and PEPCK expression in mice in both insulin-deficient and insulin-resistant conditions. We conclude that P4 increases hepatic glucose production via PGRMC1, which may exacerbate hyperglycaemia in diabetes where insulin action is limited.

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