[논문]Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm

Jeong, Se-Jin; Cho, Min Ji; Ko, Na Young; Kim, Sinai; Jung, In-Hyuk; Min, Jeong-Ki; Lee, Sang Hak; Park, Jong-Gil; Oh, Goo Taeg

doi:10.1038/s12276-020-00498-3

[국내논문] Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm 원문보기

Experimental & molecular medicine : EMM, v.52 no.9, 2020년, pp.1587 - 1601

Jeong, Se-Jin (Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO USA) , Cho, Min Ji (Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon, Republic of Korea) , Ko, Na Young (Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea) , Kim, Sinai (Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences, Ewha Womans University, Seoul, Republic of Korea) , Jung, In-Hyuk (Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO USA) , Min, Jeong-Ki (Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon, Republic of Korea) , Lee, Sang Hak (Division of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea) , Park, Jong-Gil (Biotherapeutics Translational Research Center, Korea Research) , Oh, Goo Taeg

Abstract ▼ AI-Helper

Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease characterized by structural deterioration of the aorta caused by inflammation and oxidative stress, leading to aortic dilatation and rupture. Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, has been reported as a potential negative regulator of inflammatory vascular diseases, and it has been identified as a protein that is increased in patients with ruptured AAA compared to patients with nonruptured AAA. In this study, we demonstrated that PRDX2 was a pivotal factor involved in the inhibition of AAA progression. PRDX2 levels were increased in AAA compared with those in normal aortas in both humans and mice. Ultrasound imaging revealed that the loss of PRDX2 accelerated the development of AAA in the early stages and increased AAA incidence in mice infused with angiotensin II (Ang II). Prdx2−/− mice infused with Ang II exhibited increased aortic dilatation and maximal aortic diameter without a change in blood pressure. Structural deterioration of the aortas from Prdx2−/− mice infused with Ang II was associated with increases in the degradation of elastin, oxidative stress, and intramural thrombi caused by microhemorrhages, immature neovessels, and the activation of matrix metalloproteinases compared to that observed in controls. Moreover, an increase in inflammatory responses, including the production of cell adhesion molecules and the accumulation of inflammatory cells and proinflammatory cytokines due to PRDX2 deficiency, accelerated Ang II-induced AAA progression. Our data confirm that PRDX2 plays a role as a negative regulator of the pathological process of AAA and suggest that increasing PRDX2 activity may be a novel strategy for the prevention and treatment of AAA.Abdominal aortic aneurysm: Potential enzyme biomarker identifiedAn enzyme with antioxidant properties may provide a biomarker and therapeutic agent to help treat abdominal aortic aneurysm (AAA). AAA involves the structural deterioration of the aorta through chronic inflammation and oxidative stress, and can trigger life-threatening artery rupture. An antioxidant enzyme called peroxiredoxin 2 (PRDX2) is increased in patients with ruptures, but whether its role in AAA is beneficial or detrimental is unclear. Goo Taeg Oh at the Ewha Womans University in Seoul, Jong-Gil Park at the Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea, and co-workers examined the effect of PRDX2 on AAA progression. PRDX2 suppressed structural damage in mice, limiting artery dilation and protein degradation. Loss of PRDX2 accelerated AAA development. Measuring levels of PRDX2 may indicate AAA severity in patients, while boosting the enzyme could repair aortic damage.

참고문헌 (50)

1. Kent KC Clinical practice. Abdominal aortic aneurysms New Engl. J. Med. 2014 371 2101 2108 25427112
2. Benjamin EJ Heart Disease and Stroke Statistics-2018 update: a report from the American Heart Association Circulation 2018 137 e67 e492 29386200

상세보기
3. Sakalihasan N Limet R Defawe OD Abdominal aortic aneurysm Lancet 2005 365 1577 1589 15866312
4. Freestone T Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm Arterioscler. Thromb. Vasc. Biol. 1995 15 1145 1151 7627708

상세보기
5. Zhang J Inducible nitric oxide synthase is present in human abdominal aortic aneurysm and promotes oxidative vascular injury J. Vasc. Surg. 2003 38 360 367 12891121
6. Paik D Tilson MD Neovascularization in the abdominal aortic aneurysm. Endothelial nitric oxide synthase, nitric oxide, and elastolysis Ann. N. Y. Acad. Sci. 1996 800 277 8959013
7. Miller FJ Jr. Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling Arterioscler. Thromb. Vasc. Biol. 2002 22 560 565 11950691

상세보기
8. Thomas M Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice Circulation 2006 114 404 413 16864727

상세보기
9. Gavazzi G NOX1 deficiency protects from aortic dissection in response to angiotensin II Hypertension 2007 50 189 196 17502491

상세보기
10. Moxon JV Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects Curr. Probl. Cardiol. 2010 35 512 548 20932435

상세보기
11. Wilmink AB Are antihypertensive drugs associated with abdominal aortic aneurysms? J. Vasc. Surg. 2002 36 751 757 12368736
12. Propanolol Aneurysm Trial Investigators. Propranolol for small abdominal aortic aneurysms: results of a randomized trial J. Vasc. Surg. 2002 35 72 79 11802135
13. Sweeting MJ Thompson SG Brown LC Greenhalgh RM Powell JT Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms J. Vasc. Surg. 2010 52 1 4 20494541
14. Mastoraki ST Treatment with simvastatin inhibits the formation of abdominal aortic aneurysms in rabbits Ann. Vasc. Surg. 2012 26 250 258 22222170

상세보기
15. Periard D Reduction of small infrarenal abdominal aortic aneurysm expansion rate by statins Vasa. Z. fur Gefasskrankheiten 2012 41 35 42
16. Takagi H Effects of statin therapy on abdominal aortic aneurysm growth: a meta-analysis and meta-regression of observational comparative studies Eur. J. Vasc. Endovasc. Surg. 2012 44 287 292 22824348

상세보기
17. Baxter BT Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study J. Vasc. Surg. 2002 36 1 12 12096249
18. Curci JA Petrinec D Liao S Golub LM Thompson RW Pharmacologic suppression of experimental abdominal aortic aneurysms: acomparison of doxycycline and four chemically modified tetracyclines J. Vasc. Surg. 1998 28 1082 1093 9845660
19. Rhee SG Chae HZ Kim K Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling Free Radic. Biol. Med. 2005 38 1543 1552 15917183

상세보기
20. Rhee SG Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins Curr. Opin. Cell Biol. 2005 17 183 189 15780595

상세보기
21. Rhee SG Overview on peroxiredoxin Mol. Cells 2016 39 1 5 26831451

원문보기 상세보기
22. Wood ZA Schroder E Robin Harris J Poole LB Structure, mechanism and regulation of peroxiredoxins Trends Biochem. Sci. 2003 28 32 40 12517450

상세보기
23. Chae HZ Kim HJ Kang SW Rhee SG Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin Diabetes Res. Clin. Pract. 1999 45 101 112 10588361

상세보기
24. Jeong SJ Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux Autophagy 2018 14 120 133 28605287

상세보기
25. Park JG Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice Circulation Res. 2011 109 739 749 21835911
26. Choi MH Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II Nature 2005 435 347 353 15902258

상세보기
27. Urbonavicius S Proteomic identification of differentially expressed proteins in aortic wall of patients with ruptured and nonruptured abdominal aortic aneurysms J. Vasc. Surg. 2009 49 455 463 19038529
28. Daugherty A Manning MW Cassis LA Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis Br. J. Pharmacol. 2001 134 865 870 11606327
29. Ray JL Leach R Herbert JM Benson M Isolation of vascular smooth muscle cells from a single murine aorta Methods Cell Sci. 2001 23 185 188 12486328

상세보기
30. Valentin F Bueb JL Kieffer P Tschirhart E Atkinson J Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells Fundam. Clin. Pharm. 2005 19 661 667
31. Clempus RE Griendling KK Reactive oxygen species signaling in vascular smooth muscle cells Cardiovascular Res. 2006 71 216 225
32. McCormick ML Gavrila D Weintraub NL Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms Arterioscler. Thromb. Vasc. Biol. 2007 27 461 469 17218601

상세보기
33. Csala M On the role of 4-hydroxynonenal in health and disease Biochimica et. biophysica acta 2015 1852 826 838 25643868
34. Millett CE Phillips BE Saunders EFH The Sex-specific Effects of LPS on Depressive-like Behavior and Oxidative Stress in the Hippocampus of the Mouse Neuroscience 2019 399 77 88 30553795

상세보기
35. Tretter L Patocs A Chinopoulos C Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis Biochimica et. biophysica acta 2016 1857 1086 1101 26971832
36. Lee TH Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice Blood 2003 101 5033 5038 12586629

상세보기
37. Mullen L Hanschmann EM Lillig CH Herzenberg LA Ghezzi P Cysteine Oxidation Targets Peroxiredoxins 1 and 2 for Exosomal Release through a Novel Mechanism of Redox-Dependent Secretion Mol. Med 2015 21 98 108 25715249

상세보기
38. Martinez-Pinna R Identification of peroxiredoxin-1 as a novel biomarker of abdominal aortic aneurysm Arterioscler. Thromb. Vasc. Biol. 2011 31 935 943 21273562

상세보기
39. Ejiri J Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin II type 1 receptor blocker Cardiovasc. Res. 2003 59 988 996 14553839

상세보기
40. Li PF Dietz R von Harsdorf R Reactive oxygen species induce apoptosis of vascular smooth muscle cell FEBS Lett. 1997 404 249 252 9119073

상세보기
41. Tan S Sagara Y Liu Y Maher P Schubert D The regulation of reactive oxygen species production during programmed cell death J. Cell Biol. 1998 141 1423 1432 9628898

상세보기
42. Meli DN Christen S Leib SL Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway J. Infect. Dis. 2003 187 1411 1415 12717622

상세보기
43. Rajagopalan S Meng XP Ramasamy S Harrison DG Galis ZS Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability J. Clin. Investig. 1996 98 2572 2579 8958220
44. Longo GM Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms J. Clin. Investig. 2002 110 625 632 12208863
45. Newman KM Jean-Claude J Li H Ramey WG Tilson MD Cytokines that activate proteolysis are increased in abdominal aortic aneurysms Circulation 1994 90 II224 II227 7955258
46. Henderson EL Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms Circulation 1999 99 96 104 9884385

상세보기
47. Sundaresan M Yu ZX Ferrans VJ Irani K Finkel T Requirement for generation of H2O2 for platelet-derived growth factor signal transduction Science 1995 270 296 299 7569979

상세보기
48. Patel MI Ghosh P Melrose J Appleberg M Smooth muscle cell migration and proliferation is enhanced in abdominal aortic aneurysms Aust. N. Z. J. Surg. 1996 66 305 308 8634049

상세보기
49. Kang DH Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells Mol. Cell 2011 44 545 558 22099303
50. Escobar E Rodriguez-Reyna TS Arrieta O Sotelo J Angiotensin II, cell proliferation and angiogenesis regulator: biologic and therapeutic implications in cancer Curr. Vasc. Pharmacol. 2004 2 385 399 15320819

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