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TF-343 Alleviates Diesel Exhaust Particulate-Induced Lung Inflammation via Modulation of Nuclear Factor-κB Signaling 원문보기

Journal of immunology research, v.2019, 2019년, pp.1 - 12  

Kim, Dong Im (National Center for Efficacy Evaluation of Respiratory Disease Products, Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, 30 Baehak1-gil, Jeongeup, Jeollabuk-do 56212, Republic of Korea) ,  Song, Mi-Kyung (National Center for Efficacy Evaluation of Respiratory Disease Products, Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, 30 Baehak1-gil, Jeongeup, Jeollabuk-do 56212, Republic of Korea) ,  Kim, Seon-Hee (Sungkyun Biotech Co. Ltd., Suwon, Gyeonggi-do 164, Republic of Korea) ,  Park, Chan Young (Sungkyun Biotech Co. Ltd., Suwon, Gyeonggi-do 164, Republic of Korea) ,  Lee, Kyuhong (National Center for Efficacy Evaluation of Respiratory Disease Products, Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, 30 Baehak1-gil, Jeongeup, Jeollabuk-do 56212, Republic of Korea)

Abstract AI-Helper 아이콘AI-Helper

Inhalation of diesel exhaust particulate (DEP) causes oxidative stress-induced lung inflammation. This study investigated the protective effects of TF-343, an antioxidant and anti-inflammatory agent, in mouse and cellular models of DEP-induced lung inflammation as well as the underlying molecular me...

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