[논문]Cough Inhibition Activity of Schisandra chinensis in Guinea Pigs

Zhong, Shan; Bai, Li-Ping; Liu, Xiao-Dong; Cai, Die-Yi; Yau, Lee-Fong; Huang, Chu-Qin; Zhang, Jia-Qi; Lai, Ke-Fang; Zhong, Nan-Shan

doi:10.1089/jmf.2020.4824

[국내논문] Cough Inhibition Activity of Schisandra chinensis in Guinea Pigs

Journal of medicinal food, v.24 no.4, 2021년, pp.348 - 357

Zhong, Shan (State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.) , Bai, Li-Ping (State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, China.) , Liu, Xiao-Dong (State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.) , Cai, Die-Yi (State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.) , Yau, Lee-Fong (State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and H) , Huang, Chu-Qin , Zhang, Jia-Qi , Lai, Ke-Fang , Zhong, Nan-Shan

Abstract ▼ AI-Helper

Chronic cough is very common in respiratory clinics, and no effective drugs are available. Schisandra chinensis (Turcz.) Baill. (S. chinensis), an important traditional Chinese medicine, has been extensively prescribed for patients with a persistent cough. Preliminary research indicated that 95% ethanol extracts (EE) of S. chinensis showed remarkable antitussive activity in guinea pigs exposed to cigarette smoke (CS). To find out the antitussive ingredients of S. chinensis, EE was divided into four fractions according to the polarity: petroleum ether extract (PEE), ethyl acetate extract (ECE), n-butyl alcohol extract, and residue extract. The antitussive, antioxidant, and anti-inflammatory effects of the four fractions were evaluated in a guinea pig model of cough hypersensitivity induced by CS exposure. Eighteen main constituents of the two effective fractions, PEE and ECE, were identified using ultra-high-pressure liquid chromatography electronic spray ion time-of-flight mass spectrometry. The cough inhibition activities of compound 1, 3, 9, 10, 17 were evaluated on citric acid induced acute cough guinea pigs. The results showed that the antitussive activity of EE was almost all contained in PEE and ECE. The 16 major peaks in PEE were identified as 15 lignans (1-12 and 14-16) and 1 triterpene (compound 13), and 3 major peaks (1, 17, and 18) in ECE were also identified as lignans. Three doses of five compounds brought about a significant decrease in number of cough efforts (P < .01), and the cough inhibition rates were between 40.9% and 85.1%. Therefore, lignans are the antitussive ingredients of S. chinensis.

Keyword

참고문헌 (21)

Pavord, I.D., Chung, K.F.. Management of chronic cough. The Lancet, vol.371, no.9621, 1375-1384.

상세보기
Chronic Cough Lai KF 2015 2
Chin J Tuberc Respir Dis Asthma Group of Respiratory Medicine Branch of Chinese Medical Association 323 39 2016
Chung, K.F., Pavord, I.D.. Prevalence, pathogenesis, and causes of chronic cough. The Lancet, vol.371, no.9621, 1364-1374.

상세보기
Morice, Alyn H.. The Cough Hypersensitivity Syndrome: A Novel Paradigm for Understanding Cough. Lung, vol.188, no.1, 87-90.

상세보기
Morjaria, J.B., Dickinson, R.S., Morice, A.H.. Novel antitussive strategies. Drug discovery today, vol.18, no.7, 380-388.

상세보기
Moreaux, Benoit, Nemmar, Abderrahim, Vincke, Grégoire, Halloy, David, Beerens, Dominique, Advenier, Charles, Gustin, Pascal. Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs. European journal of pharmacology, vol.408, no.3, 305-312.

상세보기
Khalid, S., Murdoch, R., Newlands, A., Smart, K., Kelsall, A., Holt, K., Dockry, R., Woodcock, A., Smith, J.A.. Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial. The Journal of allergy and clinical immunology : official organ of American Academy of Allergy, vol.134, no.1, 56-62.e4.

상세보기
Wang, B.L., Hu, J.P., Tan, W., Sheng, L., Chen, H., Li, Y.. Simultaneous quantification of four active schisandra lignans from a traditional Chinese medicine Schisandra chinensis(Wuweizi) in rat plasma using liquid chromatography/mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, vol.865, no.1, 114-120.

상세보기
Kim, Hyungwoo, Ahn, Yong-Tae, Kim, Youn Sook, Cho, Su In, An, Won Gun. Antiasthmatic effects of schizandrae fructus extract in mice with asthma. Pharmacognosy magazine, vol.10, no.37, S80-S85.

상세보기
Zhong, S., Nie, Y.c., Gan, Z.y., Liu, X.d., Fang, Z.f., Zhong, B.n., Tian, J., Huang, C.q., Lai, K.f., Zhong, N.s.. Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure. Journal of ethnopharmacology, vol.165, 73-82.

상세보기
Zhong, S., Liu, X.d., Nie, Y.c., Gan, Z.y., Yang, L.q., Huang, C.q., Lai, K.f., Zhong, N.s.. Antitussive activity of the Schisandra chinensis fruit polysaccharide (SCFP-1) in guinea pigs models. Journal of ethnopharmacology, vol.194, 378-385.

상세보기
Sutovska, M., Capek, P., Franova, S., Pawlaczyk, I., Gancarz, R.. Antitussive and bronchodilatory effects of Lythrum salicaria polysaccharide-polyphenolic conjugate. International journal of biological macromolecules, vol.51, no.5, 794-799.

상세보기
Zhang, H., Yang, H., Zhang, M., Wang, Y., Wang, J., Yau, L., Jiang, Z., Hu, P.. Identification of flavonol and triterpene glycosides in Luo-Han-Guo extract using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems, vol.25, no.2, 142-148.

상세보기
Iwata, Hiroshi, Tezuka, Yasuhiro, Kadota, Shigetoshi, Hiratsuka, Akira, Watabe, Tadashi. IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP3A4 INHIBITORS IN SCHISANDRA FRUIT EXTRACT. Drug metabolism and disposition: the biological fate of chemicals, vol.32, no.12, 1351-1358.

상세보기
Xie, Jiaxing, Zhang, Qingling, Zhong, Nanshan, Lai, Kefang. BAL Fluid 8-Isoprostane Concentrations in Eosinophilic Bronchitis and Asthma. The Journal of asthma, vol.46, no.7, 712-715.

상세보기
Yoshida, Takashi, Inoue, Ryuji, Morii, Takashi, Takahashi, Nobuaki, Yamamoto, Shinichiro, Hara, Yuji, Tominaga, Makoto, Shimizu, Shunichi, Sato, Yoji, Mori, Yasuo. Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nature chemical biology, vol.2, no.11, 596-607.

상세보기
Rahman, I, MacNee, W. Oxidative stress and regulation of glutathione in lung inflammation.. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol.16, no.3, 534-554.

상세보기
Guo, Lian Yu, Hung, Tran Manh, Bae, Ki Hwan, Shin, Eun Myoung, Zhou, Hong Yu, Hong, Yoo Na, Kang, Sam Sik, Kim, Hyun Pyo, Kim, Yeong Shik. Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. European journal of pharmacology, vol.591, no.1, 293-299.

상세보기
Hu, D., Yang, Z., Yao, X., Wang, H., Han, N., Liu, Z., Wang, Y., Yang, J., Yin, J.. Dibenzocyclooctadiene lignans from Schisandra chinensis and their inhibitory activity on NO production in lipopolysaccharide-activated microglia cells. Phytochemistry, vol.104, 72-78.

상세보기
Zhu, M., Lin, K.F., Yeung, R.Y., Li, R.C.. Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl₄ intoxication model. Journal of ethnopharmacology, vol.67, no.1, 61-68.

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[국내논문] Cough Inhibition Activity of Schisandra chinensis in Guinea Pigs

Abstract ▼ AI-Helper

Keyword

참고문헌 (21)

이 논문을 인용한 문헌

관련 콘텐츠

원문 URL 링크

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트