[논문]Fiber-Based Electrochemical Biosensors for Monitoring pH and Transient Neurometabolic Lactate

Booth, Marsilea A.; Gowers, Sally A. N.; Hersey, Melinda; Samper, Isabelle C.; Park, Seongjun; Anikeeva, Polina; Hashemi, Parastoo; Stevens, Molly M.; Boutelle, Martyn G.

doi:10.1021/acs.analchem.0c05108

[해외논문] Fiber-Based Electrochemical Biosensors for Monitoring pH and Transient Neurometabolic Lactate 원문보기

Analytical chemistry, v.93 no.17, 2021년, pp.6646 - 6655

Booth, Marsilea A. (Department of Bioengineering , Imperial College London , London SW7 2AZ , U.K.) , Gowers, Sally A. N. (Department of Bioengineering , Imperial College London , London SW7 2AZ , U.K.) , Hersey, Melinda (Department of Chemistry , University of South Carolina , Columbia , South Carolina 29208 , United States) , Samper, Isabelle C. (Department of Bioengineering , Imperial College London , London SW7 2AZ , U.K.) , Park, Seongjun (Department of Electrical Engineering and Computer Science , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States) , Anikeeva, Polina (Department of Materials Science and Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States) , Hashemi, Parastoo (Department of Materials , Imperial College London , London SW7 2AZ , U.K.) , Stevens, Molly M. , Boutelle, Martyn G.

Abstract ▼ AI-Helper

Developing tools that are able to monitor transient neurochemical dynamics is important to decipher brain chemistry and function. Multifunctional polymer-based fibers have been recently applied to monitor and modulate neural activity. Here, we explore the potential of polymer fibers comprising six graphite-doped electrodes and two microfluidic channels within a flexible polycarbonate body as a platform for sensing pH and neurometabolic lactate. Electrodes were made into potentiometric sensors (responsive to pH) or amperometric sensors (lactate biosensors). The growth of an iridium oxide layer made the fiber electrodes responsive to pH in a physiologically relevant range. Lactate biosensors were fabricated via platinum black growth on the fiber electrode, followed by an enzyme layer, making them responsive to lactate concentration. Lactate fiber biosensors detected transient neurometabolic lactate changes in an in vivo mouse model. Lactate concentration changes were associated with spreading depolarizations, known to be detrimental to the injured brain. Induced waves were identified by a signature lactate concentration change profile and measured as having a speed of ∼2.7 mm/min (n = 4 waves). Our work highlights the potential applications of fiber-based biosensors for direct monitoring of brain metabolites in the context of injury.[FIG OMISSION]

참고문헌 (44)

Xu C. ; Wu F. ; Yu P. ; Mao L. In Vivo Electrochemical Sensors for Neurochemicals: Recent Update . ACS Sens. 2019 , 4 , 3102 – 3118 . 10.1021/acssensors.9b01713 . 31718157

상세보기
Booth M. A. ; Gowers S. A. N. ; Leong C. L. ; Rogers M. L. ; Samper I. C. ; Wickham A. P. ; Boutelle M. G. Chemical Monitoring in Clinical Settings: Recent Developments toward Real-Time Chemical Monitoring of Patients . Anal. Chem. 2018 , 90 , 2 – 18 . 10.1021/acs.analchem.7b04224 . 29083872

상세보기
Yu P. ; Wei H. ; Zhong P. ; Xue Y. ; Wu F. ; Liu Y. ; Fei J. ; Mao L. Single Carbon Fiber-Powered Microsensor for In Vivo Neurochemical Sensing with High Neuronal Compatibility . Angew. Chem., Int. Ed. 2020 , 59 , 22652 10.1002/anie.202010195 .

상세보기
Benveniste H. ; Hüttemeier P. C. Microdialysis-Theory and Application . Prog. Neurobiol. 1990 , 35 , 195 – 215 . 10.1016/0301-0082(90)90027-E . 2236577

상세보기
Gowers S. A. N. ; Rogers M. L. ; Booth M. A. ; Leong C. L. ; Samper I. C. ; Phairatana T. ; Jewell S. L. ; Pahl C. ; Strong A. J. ; Boutelle M. G. Clinical Translation of Microfluidic Sensor Devices: Focus on Calibration and Analytical Robustness . Lab Chip 2019 , 19 , 2537 – 2548 . 10.1039/c9lc00400a . 31290529

상세보기
Rogers M. L. ; Leong C. L. ; Gowers S. A. ; Samper I. C. ; Jewell S. L. ; Khan A. ; McCarthy L. ; Pahl C. ; Tolias C. M. ; Walsh D. C. ; et al. Simultaneous Monitoring of Potassium, Glucose and Lactate during Spreading Depolarization in the Injured Human Brain - Proof of Principle of a Novel Real-Time Neurochemical Analysis System, Continuous Online Microdialysis . J. Cereb. Blood Flow Metab. 2017 , 37 , 1883 – 1895 . 10.1177/0271678X16674486 . 27798268

상세보기
Kozai T. D. Y. ; Jaquins-Gerstl A. S. ; Vazquez A. L. ; Michael A. C. ; Cui X. T. Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies . ACS Chem. Neurosci. 2015 , 6 , 48 – 67 . 10.1021/cn500256e . 25546652

상세보기
Varner E. L. ; Leong C. L. ; Jaquins-Gerstl A. ; Nesbitt K. M. ; Boutelle M. G. ; Michael A. C. Enhancing Continuous Online Microdialysis Using Dexamethasone: Measurement of Dynamic Neurometabolic Changes during Spreading Depolarization . ACS Chem. Neurosci. 2017 , 8 , 1779 – 1788 . 10.1021/acschemneuro.7b00148 . 28482157

상세보기
Ngernsutivorakul T. ; Steyer D. J. ; Valenta A. C. ; Kennedy R. T. In Vivo Chemical Monitoring at High Spatiotemporal Resolution Using Microfabricated Sampling Probes and Droplet-Based Microfluidics Coupled to Mass Spectrometry . Anal. Chem. 2018 , 90 , 10943 – 10950 . 10.1021/acs.analchem.8b02468 . 30107117

상세보기
Lee W. H. ; Ngernsutivorakul T. ; Mabrouk O. S. ; Wong J.-M. T. ; Dugan C. E. ; Pappas S. S. ; Yoon H. J. ; Kennedy R. T. Microfabrication and in Vivo Performance of a Microdialysis Probe with Embedded Membrane . Anal. Chem. 2016 , 88 , 1230 – 1237 . 10.1021/acs.analchem.5b03541 . 26727611

상세보기
Schultz K. N. ; Kennedy R. T. Time-Resolved Microdialysis for In Vivo Neurochemical Measurements and Other Applications . Annu. Rev. Anal. Chem. 2008 , 1 , 627 – 661 . 10.1146/annurev.anchem.1.031207.113047 .

상세보기
Jaquins-Gerstl A. ; Michael A. C. The Advantage of Microelectrode Technologies for Measurement in Delicate Biological Environments Such as Brain Tissue . Neuromethods 2013 , 80 , 55 – 68 . 10.1007/978-1-62703-370-1_3 .

상세보기
Chatard C. ; Sabac A. ; Moreno-Velasquez L. ; Meiller A. ; Marinesco S. Minimally Invasive Microelectrode Biosensors Based on Platinized Carbon Fibers for in Vivo Brain Monitoring . ACS Cent. Sci. 2018 , 4 , 1751 – 1760 . 10.1021/acscentsci.8b00797 . 30648158

상세보기
Park J. ; Sempionatto J. R. ; Kim J. ; Jeong Y. ; Gu J. ; Wang J. ; Park I. Microscale Biosensor Array Based on Flexible Polymeric Platform toward Lab-on-a-Needle: Real-Time Multiparameter Biomedical Assays on Curved Needle Surfaces . ACS Sens. 2020 , 5 , 1363 10.1021/acssensors.0c00078 . 32105060

상세보기
Quiroz C. ; Orrú M. ; Rea W. ; Ciudad-Roberts A. ; Yepes G. ; Britt J. P. ; Ferré S. Local Control of Extracellular Dopamine Levels in the Medial Nucleus Accumbens by a Glutamatergic Projection from the Infralimbic Cortex . J. Neurosci. 2016 , 36 , 851 – 859 . 10.1523/JNEUROSCI.2850-15.2016 . 26791215

상세보기
Altuna A. ; Berganzo J. ; Fernández L. J. Polymer SU-8-Based Microprobes for Neural Recording and Drug Delivery . Front. Mater. 2015 , 2 , 1 – 5 . 10.3389/fmats.2015.00047 .
Wang B. ; Wen X. ; Cao Y. ; Huang S. ; Lam H. A. ; Liu T. L. ; Chung P.-S. ; Monbouquette H. G. ; Chiou P.-Y. ; Maidment N. T. An Implantable Multifunctional Neural Microprobe for Simultaneous Multi-Analyte Sensing and Chemical Delivery . Lab Chip 2020 , 20 , 1390 – 1397 . 10.1039/d0lc00021c . 32211718

상세보기
Abouraddy A. F. ; Bayindir M. ; Benoit G. ; Hart S. D. ; Kuriki K. ; Orf N. ; Shapira O. ; Sorin F. ; Temelkuran B. ; Fink Y. Towards Multimaterial Multifunctional Fibres That See, Hear, Sense and Communicate . Nat. Mater. 2007 , 6 , 336 10.1038/nmat1889 . 17471274

상세보기
Park S. ; Guo Y. ; Jia X. ; Choe H. K. ; Grena B. ; Kang J. ; Park J. ; Lu C. ; Canales A. ; Chen R. ; et al. One-Step Optogenetics with Multifunctional Flexible Polymer Fibers . Nat. Neurosci. 2017 , 20 , 612 – 619 . 10.1038/nn.4510 . 28218915

상세보기
Koppes R. A. ; Park S. ; Hood T. ; Jia X. ; Abdolrahim Poorheravi N. ; Achyuta A. H. ; Fink Y. ; Anikeeva P. Thermally Drawn Fibers as Nerve Guidance Scaffolds . Biomaterials 2016 , 81 , 27 – 35 . 10.1016/j.biomaterials.2015.11.063 . 26717246

상세보기
Park S. ; Loke G. ; Fink Y. ; Anikeeva P. Flexible Fiber-Based Optoelectronics for Neural Interfaces . Chem. Soc. Rev. 2019 , 48 , 1826 – 1852 . 10.1039/c8cs00710a . 30815657

상세보기
Rogers M. L. ; Feuerstein D. ; Leong C. L. ; Takagaki M. ; Niu X. ; Graf R. ; Boutelle M. G. Continuous Online Microdialysis Using Microfluidic Sensors: Dynamic Neurometabolic Changes during Spreading Depolarization . ACS Chem. Neurosci. 2013 , 4 , 799 – 807 . 10.1021/cn400047x . 23574576

상세보기
West A. ; Best J. ; Abdalla A. ; Nijhout H. F. ; Reed M. ; Hashemi P. Voltammetric Evidence for Discrete Serotonin Circuits, Linked to Specific Reuptake Domains, in the Mouse Medial Prefrontal Cortex . Neurochem. Int. 2019 , 123 , 50 – 58 . 10.1016/j.neuint.2018.07.004 . 30031052

상세보기
Hashemi P. ; Dankoski E. C. ; Lama R. ; Wood K. M. ; Takmakov P. ; Wightman R. M. Brain Dopamine and Serotonin Differ in Regulation and Its Consequences . Proc. Natl. Acad. Sci. U.S.A. 2012 , 109 , 11510 – 11515 . 10.1073/pnas.1201547109 . 22778401

상세보기
Abdalla A. ; Atcherley C. W. ; Pathirathna P. ; Samaranayake S. ; Qiang B. ; Peña E. ; Morgan S. L. ; Heien M. L. ; Hashemi P. In Vivo Ambient Serotonin Measurements at Carbon-Fiber Microelectrodes . Anal. Chem. 2017 , 89 , 9703 – 9711 . 10.1021/acs.analchem.7b01257 . 28795565

상세보기
Yamanaka K. Anodically Electrodeposited Iridium Oxide Films (AEIROF) from Alkaline Solutions for Electrochromic Display Devices . Jpn. J. Appl. Phys. 1989 , 28 , 632 – 637 . 10.1143/JJAP.28.632 .

상세보기
Gowers S. A. N. ; Freeman D. M. E. ; Rawson T. M. ; Rogers M. L. ; Wilson R. C. ; Holmes A. H. ; Cass A. E. ; O’Hare D. Development of a Minimally Invasive Microneedle-Based Sensor for Continuous Monitoring of β-Lactam Antibiotic Concentrations in Vivo . ACS Sens. 2019 , 4 , 1072 – 1080 . 10.1021/acssensors.9b00288 . 30950598

상세보기
Vasylieva N. ; Barnych B. ; Meiller A. ; Maucler C. ; Pollegioni L. ; Lin J.-S. ; Barbier D. ; Marinesco S. Covalent Enzyme Immobilization by Poly(Ethylene Glycol) Diglycidyl Ether (PEGDE) for Microelectrode Biosensor Preparation . Biosens. Bioelectron. 2011 , 26 , 3993 – 4000 . 10.1016/j.bios.2011.03.012 . 21546239

상세보기
Richter F. ; Rupprecht S. ; Lehmenkühler A. ; Schaible H.-G. Spreading Depression Can Be Elicited in Brain Stem of Immature but Not Adult Rats . J. Neurophysiol. 2003 , 90 , 2163 – 2170 . 10.1152/jn.00388.2003 . 12789015

상세보기
Vasylieva N. ; Marinesco S. ; Barbier D. ; Sabac A. Silicon/SU8 Multi-Electrode Micro-Needle for in Vivo Neurochemical Monitoring . Biosens. Bioelectron. 2015 , 72 , 148 – 155 . 10.1016/j.bios.2015.05.004 . 25978443

상세보기
Samper I. C. ; Gowers S. A. N. ; Booth M. A. ; Wang C. ; Watts T. ; Phairatana T. ; Vallant N. ; Sandhu B. ; Papalois V. ; Boutelle M. G. Portable Micro Fluidic Biosensing System for Real-Time Analysis of Microdialysate in Transplant Kidneys . Anal. Chem. 2019 , 91 , 14631 10.1021/acs.analchem.9b03774 . 31647870

상세보기
Pásztor K. ; Sekiguchi A. ; Shimo N. ; Kitamura N. ; Masuhara H. Iridium Oxide-Based Microelectrochemical Transistors for PH Sensing . Sens. Actuators, B 1993 , 12 , 225 – 230 . 10.1016/0925-4005(93)80023-5 .

상세보기
Olthuis W. ; Robben M. A. M. ; Bergveld P. ; Bos M. ; van der Linden W. E. PH Sensor Properties of Electrochemically Grown Iridium Oxide . Sens. Actuators, B 1990 , 2 , 247 – 256 . 10.1016/0925-4005(90)80150-X .

상세보기
Lourenço C. F. ; Ledo A. ; Gerhardt G. A. ; Laranjinha J. ; Barbosa R. M. Neurometabolic and Electrophysiological Changes during Cortical Spreading Depolarization: Multimodal Approach Based on a Lactate-Glucose Dual Microbiosensor Arrays . Sci. Rep. 2017 , 7 , 6764 10.1038/s41598-017-07119-6 . 28754993

상세보기
Pernot P. ; Mothet J. P. ; Schuvailo O. ; Soldatkin A. ; Pollegioni L. ; Pilone M. ; Cespugijo R. ; Marinesco S. Characterization of a D-Amino Acid Oxidase Microbiosensor for D- Serine Detection in the Central Nervous System . TRANSDUCERS and EUROSENSORS ’07—4th International Conference on Solid-State Sensors, Actuators and Microsystems , 2007 ; pp 99 – 101 .
Malitesta C. ; Palmisano F. ; Torsi L. ; Zambonin P. G. Glucose Fast-Response Amperometric Sensor Based on Glucose Oxidase Immobilized in an Electropolymerized Poly(o-Phenylenediamine) Film . Anal. Chem. 1990 , 62 , 2735 – 2740 . 10.1021/ac00223a016 . 2096737

상세보기
Hartings J. A. ; Bullock M. R. ; Okonkwo D. O. ; Murray L. S. ; Murray G. D. ; Fabricius M. ; Maas A. I. ; Woitzik J. ; Sakowitz O. ; Mathern B. ; et al. Spreading Depolarisations and Outcome after Traumatic Brain Injury: A Prospective Observational Study . Lancet Neurol. 2011 , 10 , 1058 – 1064 . 10.1016/S1474-4422(11)70243-5 . 22056157

상세보기
Hartings J. A. ; Shuttleworth C. W. ; Kirov S. A. ; Ayata C. ; Hinzman J. M. ; Foreman B. ; Andrew R. D. ; Boutelle M. G. ; Brennan K. ; Carlson A. P. ; et al. The Continuum of Spreading Depolarizations in Acute Cortical Lesion Development: Examining Leão’s Legacy . J. Cereb. Blood Flow Metab. 2017 , 37 , 1571 – 1594 . 10.1177/0271678X16654495 . 27328690

상세보기
Xiao T. ; Wang Y. ; Wei H. ; Yu P. ; Jiang Y. ; Mao L. Electrochemical Monitoring of Propagative Fluctuation of Ascorbate in the Live Rat Brain during Spreading Depolarization . Angew. Chem., Int. Ed. 2019 , 58 , 6616 – 6619 . 10.1002/anie.201901035 .

상세보기
Kudo C. ; Nozari A. ; Moskowitz M. A. ; Ayata C. The Impact of Anesthetics and Hyperoxia on Cortical Spreading Depression . Exp. Neurol. 2008 , 212 , 201 – 206 . 10.1016/j.expneurol.2008.03.026 . 18501348

상세보기
Wyss M. T. ; Jolivet R. ; Buck A. ; Magistretti P. J. ; Weber B. In Vivo Evidence for Lactate as a Neuronal Energy Source . J. Neurosci. 2011 , 31 , 7477 – 7485 . 10.1523/JNEUROSCI.0415-11.2011 . 21593331

상세보기
Feuerstein D. ; Backes H. ; Gramer M. ; Takagaki M. ; Gabel P. ; Kumagai T. ; Graf R. Regulation of Cerebral Metabolism during Cortical Spreading Depression . J. Cereb. Blood Flow Metab. 2016 , 36 , 1965 – 1977 . 10.1177/0271678X15612779 . 26661217

상세보기
Nakamura H. ; Strong A. J. ; Dohmen C. ; Sakowitz O. W. ; Vollmar S. ; Sué M. ; Kracht L. ; Hashemi P. ; Bhatia R. ; Yoshimine T. ; et al. Spreading Depolarizations Cycle around and Enlarge Focal Ischaemic Brain Lesions . Brain 2010 , 133 , 1994 – 2006 . 10.1093/brain/awq117 . 20504874

상세보기
Dreier J. P. ; Fabricius M. ; Ayata C. ; Sakowitz O. W. ; William Shuttleworth C. ; Dohmen C. ; Graf R. ; Vajkoczy P. ; Helbok R. ; Suzuki M. ; et al. Recording, Analysis, and Interpretation of Spreading Depolarizations in Neurointensive Care: Review and Recommendations of the COSBID Research Group . J. Cereb. Blood Flow Metab. 2017 , 37 , 1595 – 1625 . 10.1177/0271678X16654496 . 27317657

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