[논문]Silk Fibroin Enhances Cytocompatibilty and Dimensional Stability of Alginate Hydrogels for Light-Based Three-Dimensional Bioprinting

Kim, Eunu; Seok, Ji Min; Bae, Su Bin; Park, Su A; Park, Won Ho

doi:10.1021/acs.biomac.1c00034

[해외논문] Silk Fibroin Enhances Cytocompatibilty and Dimensional Stability of Alginate Hydrogels for Light-Based Three-Dimensional Bioprinting

Biomacromolecules, v.22 no.5, 2021년, pp.1921 - 1931

Kim, Eunu (Department of Organic Materials Engineering , Chungnam National University , Daejeon 34134 , South Korea) , Seok, Ji Min (Department of Nature-Inspired Nanoconvergence Systems , Korea Institute of Machinery and Materials , Daejeon 34103 , South Korea) , Bae, Su Bin (Department of Organic Materials Engineering , Chungnam National University , Daejeon 34134 , South Korea) , Park, Su A , Park, Won Ho

Abstract ▼ AI-Helper

Three-dimensional (3D) bioprinting is a technology under active study for use in tissue engineering and regenerative medicine. Bioink comprises cells and polymers and is the essential material for 3D bioprinting. The characteristics of the bioink affect its printability, gelation behavior, and cell compatibility. In this study, alginate derivatives were synthesized to induce rapid gelation, and a bioink was prepared by mixing these alginate derivatives with silk fibroin to enhance cell compatibility. A low-concentration (3 wt %) alginate/silk fibroin (Alg/SF) bioink was pregelated by the ionic cross-linking of Alg to increase the viscosity for 3D printing. The rheological and mechanical properties were analyzed using a rheometer and a texture meter, respectively. Analysis of cell viability and proliferation using fibroblasts (NIH-3T3) in the bioinks showed that the Alg/SF bioink has improved cytocompatibility compared to that of conventional Alg bioinks, making it a promising material for tissue engineering.[FIG OMISSION]

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