[논문]Evaluation of the Effects of Particle Sizes of Silver Nanoparticles on Various Biological Systems

Kong, In Chul; Ko, Kyung-Seok; Koh, Dong-Chan

doi:10.3390/ijms21228465

[해외논문] Evaluation of the Effects of Particle Sizes of Silver Nanoparticles on Various Biological Systems 원문보기

International journal of molecular sciences, v.21 no.22, 2020년, pp.8465 -

Kong, In Chul (Department of Environmental Engineering, Yeungnam University, Gyungsan 38541, Korea) , Ko, Kyung-Seok (ickong@ynu.ac.kr) , Koh, Dong-Chan (Geologic Environment Division, Korea Institute of Geoscience & Mineral Resources (KIGAM), Daejeon 34132, Korea)

Abstract ▼ AI-Helper

Seven biological methods were adopted (three bacterial activities of bioluminescence, enzyme, enzyme biosynthetic, algal growth, seed germination, and root and shoot growth) to compare the toxic effects of two different sizes of silver nanoparticles (AgNPs). AgNPs showed a different sensitivity in each bioassay. Overall, the order of inhibitory effects was roughly observed as follows; bacterial bioluminescence activity ≈ root growth > biosynthetic activity of enzymes ≈ algal growth > seed germination ≈ enzymatic activity > shoot growth. For all bacterial activities (bioluminescence, enzyme, and enzyme biosynthesis), the small AgNPs showed statistically significantly higher toxicity than the large ones (p < 0.0036), while no significant differences were observed among other biological activities. The overall effects on the biological activities (except shoot growth) of the small AgNPs were shown to have about 4.3 times lower EC50 (high toxicity) value than the large AgNPs. These results also indicated that the bacterial bioluminescence activity appeared to be an appropriate method among the tested ones in terms of both sensitivity and the discernment of particle sizes of AgNPs.

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