[논문]Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage

Bae, Su Bin; Jeong, Jae Eun; Park, Su A.; Park, Won Ho

doi:10.1016/j.polymer.2021.123739

[해외논문] Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage

Polymer, v.224, 2021년, pp.123739 -

Bae, Su Bin (Department of Organic Materials Engineering, Chungnam National University) , Jeong, Jae Eun (Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials) , Park, Su A. (Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials) , Park, Won Ho (Department of Organic Materials Engineering, Chungnam National University)

Abstract ▼ AI-Helper

Abstract Water-soluble conjugates of silk fibroin (SF) and butyl glycidyl ether (BGE) were synthesized via the ring-opening reaction of BGE of the epoxide group of BGE with the side chains of SF (-COOH, –OH, and –NH2 groups). The degree of substitution of the SF-BGE conjugates was calculated by 1H NMR spectroscopy and amino acid analysis. The color of the SF-BGE solution gradually changed from transparent to pale yellow with the increase in the amount of BGE, and its pH also changed from acidic to a weakly basic one. The photocrosslinking efficiency of the SF-BGE solution according to the polymer concentration, photoinitiator content, and irradiation time were investigated to achieve optimal chemical crosslinking. In addition, the mechanical strength of the photocrosslinked SF-BGE hydrogels was increased by treating with an aqueous ethanol solution to generate a dual-crosslinked structure. The crystalline structure, mechanical strength, crosslinking density, swelling, and biodegradation behavior of the SF-BGE hydrogels were analyzed. Finally, the in vitro cytocompatibility of the SF-BGE hydrogels was evaluated as a preliminary study toward its application in articular cartilage. Highlights Water-soluble conjugates of silk fibroin (SF) was synthesized via butyl glycidyl ether modification. SF conjugate hydrogel showed excellent mechanical strength, elasticity, and recovery properties. SF conjugate hydrogel is promising as a soft tissue scaffold, especially for articular cartilage. Graphical abstract [DISPLAY OMISSION]

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[해외논문] Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage

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[해외논문] Dual-crosslinked silk fibroin hydrogels with elasticity and cytocompatibility for the regeneration of articular cartilage

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