[논문]Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation

Kang, Min Soo; Han, Jin-Hee

doi:10.1186/s13041-020-00719-w

[해외논문] Optogenetic inhibition of medial entorhinal cortex inputs to the hippocampus during a short period of time right after learning disrupts contextual fear memory formation 원문보기

Molecular brain, v.14 no.1, 2021년, pp.2 -

Kang, Min Soo (Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, 34141 Korea) , Han, Jin-Hee (Department of Biological Sciences, KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, 34141 Korea)

Abstract ▼ AI-Helper

Formation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs are also involved in memory formation during a post-learning period has not been directly tested yet. To examine this possibility, we optogenetically inhibited axons and terminals originating from bilateral dorsal MEC excitatory neurons in the dorsal hippocampus for 5 min right after contextual fear conditioning (CFC). Mice expressing eNpHR3.0 exhibited significantly less freezing compared to control mice expressing EGFP alone during retrieval test in the conditioned context 1 day after learning. In contrast, the same optogenetic inhibition of MEC inputs performed 30 min before retrieval test did not affect freezing during retrieval test, excluding the possibility of non-specific deleterious effect of optical inhibition on retrieval process. These results support that contextual fear memory formation requires MEC inputs to the hippocampus during a post-learning period.

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