[논문]Enhanced Hemodynamic and Clinical Response to αCGRP in Migraine Patients—A TCD Study

Visoč; nik, Darja; Zaletel, Marjan; Ž; van, Bojana; Zupan, Matija

doi:10.3389/fneur.2021.638903

Enhanced Hemodynamic and Clinical Response to αCGRP in Migraine Patients—A TCD Study 원문보기

Frontiers in neurology, v.12, 2021년, pp.638903 -

Visočnik, Darja , Zaletel, Marjan , Žvan, Bojana , Zupan, Matija

Abstract ▼ AI-Helper

Introduction: Sensitisation of the nervous system in a patient with migraine is supposed to be associated with calcitonin gene-related peptide (CGRP) activity. Therefore, the vascular response to human αCGRP (hαCGRP) could be a surrogate marker for the sensitization. We hypothesize that vascular response to hαCGRP is augmented in a patient with migraine.Methods: Twenty healthy subjects and 20 patients with migraine participated in our study. TCD was used to monitor mean arterial velocity in the middle cerebral artery (vm MCA). Simultaneously, end-tidal CO2 (Et-CO2), mean arterial pressure (MAP), and heart rate (HR) were measured. The reconstruction of the signals was made for basal conditions, during and after CGRP infusion which were compared using statistics.Results: In both groups, we found significant decrease between measurement points of vm MCA and Et-CO2 during and after hαCGRP infusion. MAP did not show significant trends during the infusion, but it was significantly increased after the infusion in migraine patients only. Responses to hαCGRP, defined as differences between two measurement points, were significantly higher for vm MCA and Et-CO2 in patients with migraine. A significant difference between groups was found in MAP response. Significant relationships were found between migraine and vm MCA, Et-CO2, and MAP.Conclusion: In patients with migraine, vm MCA responses to hαCGRP are significantly higher and are associated with CGRP-induced headache which indicates that patients with migraine are more prone to sensitization.

주제어

참고문헌 (22)

1. Andreou AP Edvinsson L . Mechanisms of migraine as a chronic evolutive condition . J Headache Pain. ( 2019 ) 20 : 117 . 10.1186/s10194-019-1066-0 31870279

상세보기
2. Iyengar S Ossipov MH Johnson KW . The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine . Pain. ( 2017 ) 158 : 543 – 59 . 10.1097/j.pain.0000000000000831 28301400

상세보기
3. Petersen KA Lassen LH Birk S Lesko L Olesen J . BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation . Clin Pharmacol Ther. ( 2005 ) 77 : 202 – 13 . 10.1016/j.clpt.2004.10.001 15735614

상세보기
4. Asghar MS Hansen AE Kapijimpanga T van der Geest RJ van der Koning P Larsson HBW . Dilation by CGRP of middle meningeal artery and reversal by sumatriptan in normal volunteers . Neurology. ( 2010 ) 75 : 1520 – 6 . 10.1212/WNL.0b013e3181f9626a 20975053

상세보기
5. Lassen LH Jacobsen VB Haderslev PA Sperling B Iversen HK Olesen J . Involvement of calcitonin gene-related peptide in migraine: regional cerebral blood flow and blood flow velocity in migraine patients . J Headache Pain. ( 2008 ) 9 : 151 – 7 . 10.1007/s10194-008-0036-8 18437288

상세보기
6. Lassen LH Haderslev PA Jacobsen VB Iversen HK Sperling B Olesen J . CGRP may play a causative role in migraine . Cephalalgia. ( 2002 ) 22 : 54 – 61 . 10.1046/j.1468-2982.2002.00310.x 11993614

상세보기
7. Ornello R Frattale I Caponnetto V Pistoia F Sacco S . Cerebral vascular reactivity and the migraine-stroke relationship: a narrative review . J Neurol Sci. ( 2020 ) 414 : 116887 . 10.1016/j.jns.2020.116887 32407982

상세보기
8. Sedighi B Ali Ebrahimi H Jabbarpour S Shafiee K . Transcranial doppler sonography diagnostic value for the cerebral flow velocity changes in the interictal phase of classic migraine . Caspian J Intern Med. ( 2011 ) 2 : 178 – 82 . 24024011
9. Zaletel M Strucl M Bajrović FF Pogacnik T Coupling between visual evoked cerebral blood flow velocity responses and visual evoked potentials in migraineurs . Cephalalgia. ( 2005 ) 25 : 567 – 74 . 10.1111/j.1468-2982.2005.00918.x 16033381

상세보기
10. Carmine Belin A Ran C Edvinsson L . Calcitonin Gene-Related Peptide (CGRP) and cluster headache . Brain Sci. ( 2020 ) 10 : 30 . 10.3390/brainsci10010030 31935868

상세보기
11. Raddant AC Russo AF . Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation . Expert Rev Mol Med. ( 2011 ) 13 : e36 . 10.1017/S1462399411002067 22123247

상세보기
12. Woolf CJ . Central sensitization: implications for the diagnosis and treatment of pain . Pain. ( 2011 ) 152 ( 3Suppl. ): S2 – 15 . 10.1016/j.pain.2010.09.030 20961685

상세보기
13. Hoiland RL Fisher JA Ainslie PN . Regulation of the cerebral circulation by arterial carbon dioxide . Compr Physiol. ( 2019 ) 9 : 1101 – 54 . 10.1002/cphy.c180021 31187899
14. Altamura C Viticchi G Fallacara A Costa CM Brunelli N Fiori C . Erenumab does not alter cerebral hemodynamics and endothelial function in migraine without aura . Cephalalgia. ( 2020 ) 31 : 333102420956692 . 10.1177/0333102420956692 32867533

상세보기
15. Wolf ME Functional TCD: regulation of cerebral hemodynamic–cerebral autoregulation, vasomotor reactivity, and neurovascular coupling . Front Neurol Neurosci. ( 2015 ) 36 : 40 – 56 . 10.1159/000366236 25531662

상세보기
16. Goadsby PJ Edvinsson L . The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats . Ann Neurol. ( 1993 ) 33 : 48 – 56 . 10.1002/ana.410330109 8388188

상세보기
17. Gennari C Fischer JA . Cardiovascular action of calcitonin gene-related peptide in humans . Calcif Tissue Int. ( 1985 ) 37 : 581 – 4 . 10.1007/BF02554909 3937576

상세보기
18. Petersen KA Birk S Lassen LH Kruuse C Jonassen O Lesko L The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers . Cephalalgia. ( 2005 ) 25 : 139 – 47 . 10.1111/j.1468-2982.2004.00830.x 15658951

상세보기
19. Sacco S Ripa P Grassi D Pistoia F Ornello R Carolei A . Peripheral vascular dysfunction in migraine: a review . J Headache Pain. ( 2013 ) 14 : 80 . 10.1186/1129-2377-14-80 24083826

상세보기
20. Kee Z Kodji X Brain SD . The Role of Calcitonin Gene Related Peptide (CGRP) in neurogenic vasodilation and its cardioprotective effects . Front Physiol. ( 2018 ) 9 : 1249 . 10.3389/fphys.2018.01249 30283343

상세보기
21. Dzator JS Howe PR Wong RH . Profiling cerebrovascular function in migraine: a systematic review and meta-analysis . J Cereb Blood Flow Metab . ( 2020 ) 22 : 271678X20964344 . 10.1177/0271678X20964344 33086920

상세보기
22. Altamura C Paolucci M Brunelli N Cascio Rizzo A Cecchi G Assenza F . Right-to-left shunts and hormonal therapy influence cerebral vasomotor reactivity in patients with migraine with aura . PLoS ONE . ( 2019 ) 1 : 14 . 10.1371/journal.pone.0220637 31369637

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Enhanced Hemodynamic and Clinical Response to αCGRP in Migraine Patients—A TCD Study 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (22)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트