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NTIS 바로가기Pharmaceutics, v.13 no.3, 2021년, pp.344 -
Lee, Jong-Hwa (Bioanalysis and Pharmacokinetic Research Group, Korea Institute of Toxicology, Daejeon 35365, Korea) , Jeong, Hyeong Sik (jhl@kitox.re.kr (J.-H.L.)) , Jeong, Jong-Woo (egaria1105@naver.com (J.-W.J.)) , Koo, Tae-Sung (Department of Pharmaceutics & Biotechnology, Konyang University, Daejeon 35365, Korea) , Kim, Do-Kyun (goodmanu@naver.com) , Cho, Young Ho (Bioanalysis and Pharmacokinetic Research Group, Korea Institute of Toxicology, Daejeon 35365, Korea) , Lee, Gye Won (jhl@kitox.re.kr (J.-H.L.))
Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer...
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