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[해외논문] The Development and Optimization of Hot-Melt Extruded Amorphous Solid Dispersions Containing Rivaroxaban in Combination with Polymers 원문보기

Pharmaceutics, v.13 no.3, 2021년, pp.344 -   

Lee, Jong-Hwa (Bioanalysis and Pharmacokinetic Research Group, Korea Institute of Toxicology, Daejeon 35365, Korea) ,  Jeong, Hyeong Sik (jhl@kitox.re.kr (J.-H.L.)) ,  Jeong, Jong-Woo (egaria1105@naver.com (J.-W.J.)) ,  Koo, Tae-Sung (Department of Pharmaceutics & Biotechnology, Konyang University, Daejeon 35365, Korea) ,  Kim, Do-Kyun (goodmanu@naver.com) ,  Cho, Young Ho (Bioanalysis and Pharmacokinetic Research Group, Korea Institute of Toxicology, Daejeon 35365, Korea) ,  Lee, Gye Won (jhl@kitox.re.kr (J.-H.L.))

Abstract AI-Helper 아이콘AI-Helper

Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) containing RXB is prepared by changing the drug:polymer...

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