[논문]Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity

Park, Seongjun; Yuk, Hyunwoo; Zhao, Ruike; Yim, Yeong Shin; Woldeghebriel, Eyob W.; Kang, Jeewoo; Canales, Andres; Fink, Yoel; Choi, Gloria B.; Zhao, Xuanhe; Anikeeva, Polina

doi:10.1038/s41467-021-23802-9

[해외논문] Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity 원문보기

Nature communications, v.12 no.1, 2021년, pp.3435 -

Park, Seongjun (Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA USA) , Yuk, Hyunwoo (Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA USA) , Zhao, Ruike (Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA USA) , Yim, Yeong Shin (McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA USA) , Woldeghebriel, Eyob W. (Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA USA) , Kang, Jeewoo (Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA USA) , Canales, Andres (Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA USA) , Fink, Yoel (Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA USA) , Choi, Gloria B. (Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA USA) , Zhao, Xuanhe (Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambrid) , Anikeeva, Polina

Abstract ▼ AI-Helper

To understand the underlying mechanisms of progressive neurophysiological phenomena, neural interfaces should interact bi-directionally with brain circuits over extended periods of time. However, such interfaces remain limited by the foreign body response that stems from the chemo-mechanical mismatch between the probes and the neural tissues. To address this challenge, we developed a multifunctional sensing and actuation platform consisting of multimaterial fibers intimately integrated within a soft hydrogel matrix mimicking the brain tissue. These hybrid devices possess adaptive bending stiffness determined by the hydration states of the hydrogel matrix. This enables their direct insertion into the deep brain regions, while minimizing tissue damage associated with the brain micromotion after implantation. The hydrogel hybrid devices permit electrophysiological, optogenetic, and behavioral studies of neural circuits with minimal foreign body responses and tracking of stable isolated single neuron potentials in freely moving mice over 6 months following implantation.Neural probes for experimental studies can cause tissue damage. Here the authors describe a probe incorporated with a hydrogel structure for adaptive bending stiffness to enable insertion to the rodent brain while minimising tissue damage.

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DOI : 10.1038/s41467-021-23802-9
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