[논문]Molecular laterality encodes stress susceptibility in the medial prefrontal cortex

Chae, Sujin; Hong, Jiso; Kang, Keunsoo; Shin, Anna; Kim, Dae-Gun; Lee, Sinjeong; Kim, Moo-young; Jung, Inkyung; Kim, Daesoo

doi:10.1186/s13041-021-00802-w

[해외논문] Molecular laterality encodes stress susceptibility in the medial prefrontal cortex 원문보기

Molecular brain, v.14 no.1, 2021년, pp.92 -

Chae, Sujin (Behavioral Genetics Lab., Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 Korea) , Hong, Jiso (Behavioral Genetics Lab., Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 Korea) , Kang, Keunsoo (Department of Microbiology, College of Natural Sciences, Dankook University, Chungnam, 31116 Korea) , Shin, Anna (Behavioral Genetics Lab., Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 Korea) , Kim, Dae-Gun (KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701 Korea) , Lee, Sinjeong (Behavioral Genetics Lab., Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701 Korea) , Kim, Moo-young (Behavioral Genetics Lab., Department of Biological Sciences, Korea Advanced Institute) , Jung, Inkyung , Kim, Daesoo

Abstract ▼ AI-Helper

Functional lateralization of the prefrontal cortex has been implicated in stress and emotional disorders, yet underlying gene expression changes remains unknown. Here, we report molecular signatures lateralized by chronic social defeats between the two medial prefrontal cortices (mPFCs). Stressed mice show 526 asymmetrically expressed genes between the mPFCs. This cortical asymmetry selectively occurs in stressed mice with depressed social activity, but not in resilient mice with normal behavior. We have isolated highly asymmetric genes including connective tissue growth factor (CTGF), a molecule that modulates wound healing at the periphery. Knockdown of CTGF gene in the right mPFC by shRNA led to a stress-resistant behavioral phenotype. Overexpression of CTGF in the right mPFC using viral transduction induces social avoidance while the left mPFC thereof prevent stress-induced social avoidance. Our study provides a molecular window into the mechanism of stress-induced socioemotional disorders, which can pave the way for new interventions by targeting cortical asymmetry.Supplementary InformationThe online version contains supplementary material available at 10.1186/s13041-021-00802-w.

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