[논문]Self-crosslinkable hyaluronate-based hydrogels as a soft tissue filler

Hong, Bo Min; Hong, Geum Lan; Gwak, Min A.; Kim, Kyung Hyun; Jeong, Jae Eun; Jung, Ju Young; Park, Su A.; Park, Won Ho

doi:10.1016/j.ijbiomac.2021.06.047

[해외논문] Self-crosslinkable hyaluronate-based hydrogels as a soft tissue filler

International journal of biological macromolecules, v.185, 2021년, pp.98 - 110

Hong, Bo Min (Department of Organic Materials Engineering, Chungnam National University) , Hong, Geum Lan (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) , Gwak, Min A. (Department of Organic Materials Engineering, Chungnam National University) , Kim, Kyung Hyun (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) , Jeong, Jae Eun (Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials) , Jung, Ju Young (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) , Park, Su A. (Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials) , Park, Won Ho (Department of Organic Materials Engineering, Chungnam National University)

Abstract ▼ AI-Helper

Abstract With increasing interest in aging and skin care, the use of fillers to increase the volume of soft tissue volume is increasing globally. However, the side effects caused by the residual chemical crosslinking agents present in these fillers limit the effective application of commercialized filler products. Therefore, the development of a novel crosslinking system with a non-toxic chemical crosslinking agent is required to overcome the limitations of commercial hyaluronate (HA)-based fillers. In this paper, a new injectable hydrogel with enhanced mechanical properties, tissue adhesion, injectability, and biocompatibility is reported. The HA derivatives modified with catechol groups (HA-DA) were crosslinked by self-oxidation under in vivo physiological conditions (pH 7.4) without chemical crosslinkers to form hydrogels, which can be further accelerated by the dissolved oxygen in the body. The fabricated HA-DA filler showed excellent mechanical properties and could be easily injected with a low injection force. Further, the HA-DA filler stably attached to the injection site due to the tissue adhesion properties of the catechol groups, thus leading to an improved displacement stability. In addition, the HA-DA filler showed excellent cell viability, cell proliferation, and biocompatibility. Therefore, the HA-DA hydrogel is a novel soft tissue filler with great potential to overcome the limitations of commercial soft tissue fillers. Highlights HA-based self-crosslinkable hydrogel was developed for application as a soft tissue filler. This hydrogel filler showed excellent mechanical and elastic properties as well as superior injectability. HA-based filler also showed excellent cell viability, cell proliferation, and biocompatibility. HA-based hydrogel has great potential to overcome the limitations of commercial soft tissue fillers.

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참고문헌 (51)

Clin. Interv. Aging Brandt 3 1 153 2008 Hyaluronic acid gel fillers in the management of facial aging
Int. J. Nanomedicine Ganesan 11 1987 2016 10.2147/IJN.S104701 Current application of phytocompound-based nanocosmeticals for beauty and skin therapy

상세보기
Phytotherapy Dini 33 12 3054 2019 10.1002/ptr.6494 Nutricosmetics: a brief overview

상세보기
Carbohydr. Polym. Collins 92 2 1262 2013 10.1016/j.carbpol.2012.10.028 Hyaluronic acid based scaffolds for tissue engineering-a review

상세보기
Biomater. Res. Chun 20 1 24 2016 10.1186/s40824-016-0073-3 Effect of molecular weight of hyaluronic acid (HA) on viscoelasticity and particle texturing feel of HA dermal biphasic fillers

상세보기
Acta Biomater. Fakhari 9 7 7081 2013 10.1016/j.actbio.2013.03.005 Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment

상세보기
Exp. Physiol. Brown 76 1 125 1991 10.1113/expphysiol.1991.sp003474 Turnover of hyaluronan in synovial joints: elimination of labelled hyaluronan from the knee joint of the rabbit

상세보기
Biomater. Res. Choi 18 1 1 2014 10.1186/2055-7124-18-6 Purification and biocompatibility of fermented hyaluronic acid for its applications to biomaterials

상세보기
J. Biomed. Mater. Shimojo 103 2 730 2015 10.1002/jbm.a.35225 The crosslinking degree controls the mechanical, rheological, and swelling properties of hyaluronic acid microparticles

상세보기
Bioconjug. Chem. Yeom 21 2 240 2010 10.1021/bc9002647 Effect of cross-linking reagents for hyaluronic acid hydrogel dermal fillers on tissue augmentation and regeneration

상세보기
J. Mater. Chem. B Guo 6 39 6234 2018 10.1039/C8TB01776J The multifaceted nature of catechol chemistry: bioinspired pH initiated hyaluronic acid hydrogels with tunable cohesive and adhesive properties

상세보기
Adv. Funct. Mater. Hong 23 14 1774 2013 10.1002/adfm.201202365 Hyaluronic acid catechol: a biopolymer exhibiting a pH-dependent adhesive or cohesive property for human neural stem cell engineering

상세보기
Acta Biomater. Ryu 27 101 2015 10.1016/j.actbio.2015.08.043 Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: a mini review

상세보기
Adv. Funct. Mater. Shin 25 25 3814 2015 10.1002/adfm.201500006 Tissue adhesive catechol-modified hyaluronic acid hydrogel for effective, minimally invasive cell therapy

상세보기
Adv. Healthc. Mater. Hong 5 1 75 2016 10.1002/adhm.201400833 STAPLE: stable alginate gel prepared by linkage exchange from ionic to covalent bonds

상세보기
Soft Matter Lee 6 5 977 2010 10.1039/b919944f Thermo-sensitive, injectable, and tissue adhesive sol-gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction

상세보기
Biomacromolecules Burke 17 1 237 2015 10.1021/acs.biomac.5b01330 Silk fibroin aqueous-based adhesives inspired by mussel adhesive proteins

상세보기
J. Polym. Sci. B Polym. Phys. Stewart 49 11 757 2011 10.1002/polb.22256 Natural underwater adhesives

상세보기
J. Tissue Eng. Lih 7 2016 10.1177/2041731416683745 Optimal conjugation of catechol group onto hyaluronic acid in coronary stent substrate coating for the prevention of restenosis

상세보기
Small Neto 10 12 2459 2014 10.1002/smll.201303568 Nanostructured polymeric coatings based on chitosan and dopamine-modified hyaluronic acid for biomedical applications

상세보기
Biomimetics Sousa 2 4 19 2017 10.3390/biomimetics2040019 Cell-adhesive bioinspired and catechol-based multilayer freestanding membranes for bone tissue engineering

상세보기
Chem. Mater. Lee 31 23 9614 2019 10.1021/acs.chemmater.9b02802 In situ self-cross-linkable, long-term stable hyaluronic acid filler by gallol autoxidation for tissue augmentation and wrinkle correction

상세보기
ACS Appl. Mater. Interfaces Han 10 33 28015 2018 10.1021/acsami.8b05314 Mussel-inspired tissue-adhesive hydrogel based on the polydopamine-chondroitin sulfate complex for growth-factor-free cartilage regeneration

상세보기
Aquat. Sci. Miler 74 1 31 2012 10.1007/s00027-011-0188-5 Biomechanical properties of aquatic plants and their effects on plant-flow interactions in streams and rivers

상세보기
Macromol. Biosci. Poveda-Reyes 16 9 1311 2016 10.1002/mabi.201500469 Gelatin-hyaluronic acid hydrogels with tuned stiffness to counterbalance cellular forces and promote cell differentiation

상세보기
Carbohydr. Polym. Loebel 115 325 2015 10.1016/j.carbpol.2014.08.097 Precise tailoring of tyramine-based hyaluronan hydrogel properties using DMTMM conjugation

상세보기
Orwoll 2007 Polymer-solvent interaction parameter?
Acta Biomater. Park 9 1 4779 2013 10.1016/j.actbio.2012.08.033 Injectable chitosan hyaluronic acid hydrogels for cartilage tissue engineering

상세보기
Acta Biomater. Hu 8 5 1730 2012 10.1016/j.actbio.2012.01.029 Visible light crosslinkable chitosan hydrogels for tissue engineering

상세보기
Biomater. Sci. Cai 7 8 3143 2019 10.1039/C9BM00298G Shear-thinning hyaluronan-based fluid hydrogels to modulate viscoelastic properties of osteoarthritis synovial fluids

상세보기
Carbohydr. Polym. Kim 196 414 2018 10.1016/j.carbpol.2018.05.042 Effect of vitamin derivatives on gelation rate and gel strength of methylcellulose

상세보기
Int. J. Biol. Macromol. Kim 109 57 2018 10.1016/j.ijbiomac.2017.12.068 Injectable methylcellulose hydrogel containing calcium phosphate nanoparticles for bone regeneration

상세보기
J. Agric. Food Chem. Dudonne 57 5 1768 2009 10.1021/jf803011r Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays

상세보기
J. Agric. Food Chem. Hu 64 29 5893 2016 10.1021/acs.jafc.6b02255 In vitro antioxidant-activity evaluation of gallic-acid-grafted chitosan conjugate synthesized by free-radical-induced grafting method

상세보기
Polymer Cheon 125 126 2017 10.1016/j.polymer.2017.08.005 Enhanced thermal stabilization of polymer nanofibrous web using self-polymerized 3, 4-dihydroxy-L-phenylalanine

상세보기
Adv. Funct. Mater. Hong 30 26 1908497 2019 10.1002/adfm.201908497 Alginate-boronic acid: pH-triggered bioinspired glue for hydrogel assembly

상세보기
Adv. Funct. Mater. Wang 30 1 1904156 2020 10.1002/adfm.201904156 A novel double-crosslinking-double-network design for injectable hydrogels with enhanced tissue adhesion and antibacterial capability for wound treatment

상세보기
Adv. Funct. Mater. Shin 29 49 1903863 2019 10.1002/adfm.201903863 Tissue tapes-phenolic hyaluronic acid hydrogel patches for off-the-shelf therapy

상세보기
Carbohydr. Polym. Shin 238 2020 10.1016/j.carbpol.2020.116192 Dual-crosslinked methylcellulose hydrogels for 3D bioprinting applications

상세보기
Soft Matter Lee 4 4 880 2008 10.1039/b719557e An injectable enzymatically crosslinked hyaluronic acid-tyramine hydrogel system with independent tuning of mechanical strength and gelation rate

상세보기
Chem. Rev. Liu 114 9 5057 2014 10.1021/cr400407a Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields

상세보기
Proc. Natl. Acad. Sci. Lee 103 35 12999 2006 10.1073/pnas.0605552103 Single-molecule mechanics of mussel adhesion

상세보기
Biomacromolecules Park 17 6 1939 2016 10.1021/acs.biomac.5b01670 Catechol-functionalized hyaluronic acid hydrogels enhance angiogenesis and osteogenesis of human adipose-derived stem cells in critical tissue defects

상세보기
Macromol. Mater. Eng. Guo 304 4 1800715 2019 10.1002/mame.201800715 A Facile Strategy for Preparing Tough, Self-healing double-network hyaluronic acid hydrogels inspired by mussel cuticles

상세보기
ACS Appl. Mater. Interfaces Lü 7 23 13029 2015 10.1021/acsami.5b03143 Injectable and self-healing carbohydrate-based hydrogel for cell encapsulation

상세보기
Biomater Sci. Choi 6 10 2627 2018 10.1039/C8BM00524A An injectable and physical levan-based hydrogel as a dermal filler for soft tissue augmentation

상세보기
J. Mater. Chem. B Li 3 23 4742 2015 10.1039/C5TB00408J Novel multifunctional PB and PBH hydrogels as soft filler for tissue engineering

상세보기
Mater. Sci. Eng. C Li 57 189 2015 10.1016/j.msec.2015.07.059 Novel hydrogels based on carboxyl pullulan and collagen crosslinking with 1, 4-butanediol diglycidylether for use as a dermal filler: initial in vitro and in vivo investigations

상세보기
J. Mater. Chem. B Ma 2 18 2749 2014 10.1039/C3TB21842B A novel chitosan-collagen-based hydrogel for use as a dermal filler: initial in vitro and in vivo investigations

상세보기
Anal. Methods Vanhee 9 28 4175 2017 10.1039/C7AY01130J Characterization of suspected dermal fillers containing hyaluronic acid

상세보기
J. Mater. Chem. B Xiao 3 27 5635 2015 10.1039/C5TB00270B Adipose stem cell-laden injectable thermosensitive hydrogel reconstructing depressed defects in rats: filler and scaffold

상세보기

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