[논문]Hyaluronan Hydrogels for Injection in Superficial Dermal Layers: An In Vitro Characterization to Compare Performance and Unravel the Scientific Basis of Their Indication

La Gatta, Annalisa; Aschettino, Maria; Stellavato, Antonietta; D’Agostino, Antonella; Vassallo, Valentina; Bedini, Emiliano; Bellia, Gilberto; Schiraldi, Chiara

doi:10.3390/ijms22116005

Hyaluronan Hydrogels for Injection in Superficial Dermal Layers: An In Vitro Characterization to Compare Performance and Unravel the Scientific Basis of Their Indication 원문보기

International journal of molecular sciences, v.22 no.11, 2021년, pp.6005 -

La Gatta, Annalisa (Department of Experimental Medicine, School of Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy) , Aschettino, Maria (maryaschettino75@gmail.com (M.A.)) , Stellavato, Antonietta (antonietta.stellavato@unicampania.it (A.S.)) , D’Agostino, Antonella (antonella.dagostino@unicampania.it (A.D.)) , Vassallo, Valentina (valentina.vassallo@unicampania.it (V.V.)) , Bedini, Emiliano (Department of Experimental Medicine, School of Medicine, University of Campania Luigi Vanvitelli, Via L. De Crecchio 7, 80138 Naples, Italy) , Bellia, Gilberto (maryaschettino75@gmail.com (M.A.)) , Schiraldi, Chiara (antonietta.stellavato@unicampania.it (A.S.))

Abstract ▼ AI-Helper

Background: Skinboosters represent the latest category of hyaluronan (HA) hydrogels released for aesthetic purposes. Different from originally developed gels, they are intended for more superficial injections, claiming a skin rejuvenation effect through hydration and possibly prompting biochemical effects in place of the conventional volumetric action. Here, three commercial skinboosters were characterized to unravel the scientific basis for such indication and to compare their performances. Methods: Gels were evaluated for water-soluble/insoluble-HA composition, rheology, hydration, cohesivity, stability and effect, in vitro, on human dermal fibroblasts towards the production of extracellular matrix components. Results: Marked differences in the insoluble-hydrogel amount and in the hydrodynamic parameters for water-soluble-HA chains were evidenced among the gels. Hydration, rigidity and cohesivity also varied over a wide range. Sensitivity to hyaluronidases and Reactive Oxygen Species was demonstrated allowing a stability ranking. Slight differences were found in gels’ ability to prompt elastin expression and in ColIV/ColI ratio. Conclusions. A wide panel of biophysical and biochemical parameters for skinboosters was provided, supporting clinicians in the conscious tuning of their use. Data revealed great variability in gels’ behavior notwithstanding the same clinical indication and unexpected similarities to the volumetric formulations. Data may be useful to improve customization of gel design toward specific uses.

주제어

참고문헌 (48)

1. Ave M.N. de Almeida Issa M.C. Hyaluronic Acid Dermal Filler: Physical Properties and Its Indications Botulinum Toxins, Fillers and Related Substances. Clinical Approaches and Procedures in Cosmetic Dermatology Issa M. Tamura B. Springer Cham, Switzerland 2018 Volume 4 187 197
2. Fallacara A. Manfredini S. Durini E. Vertuani S. Hyaluronic acid fillers in soft tissue regeneration Facial. Plast. Surg. 2017 33 87 96 10.1055/s-0036-1597685 28226376

상세보기
3. Cui Y. Wang F. Voorhees J.J. Fisher G.J. Rejuvenation of Aged Human Skin by Injection of Cross-linked Hyaluronic Acid Plast. Reconstr. Surg. 2021 147 43S 49S 10.1097/PRS.0000000000007620 33347074

상세보기
4. Basta S.L. Cosmetic fillers perspective on the industry Facial. Plast. Surg. Clin. N. Am. 2015 23 417 421 10.1016/j.fsc.2015.07.001

상세보기
5. Heitmiller K. Ring C. Saedi N. Rheologic properties of soft tissue fillers and implications for clinical use J. Cosmet. Dermatol. 2021 20 28 34 10.1111/jocd.13487

상세보기
6. Moillard S.G. Betemps J.B. Hadjab B. Topchian D. Micheels P. Salomon D. Key rheological properties of hyaluronic acid fillers: From tissue integration to product degradation Plast. Aesthet. Res. 2018 5 17 24 10.20517/2347-9264.2018.10

상세보기
7. La Gatta A. Salzillo R. Catalano C. D’Agostino A. Pirozzi A.V.A. De Rosa M. Schiraldi C. Hyaluronan-based hydrogels as dermal fillers: The biophysical properties that translate into a “volumetric” effect PLoS ONE 2019 14 e0218287 31185059

상세보기
8. La Gatta A. De Rosa M. Frezza M.A. Catalano C. Meloni M. Schiraldi C. Biophysical and biological characterization of a new line of hyaluronan-based dermal fillers: A scientific rationale to specific clinical indications Mater. Sci. Eng. C Mater. Biol. Appl. 2016 68 565 572 10.1016/j.msec.2016.06.008 27524055

상세보기
9. Allemann I.B. Baumann L. Hyaluronic acid gel (Juvederm) preparations in the treatment of facial wrinkles and folds J. Clin. Interv. Aging 2008 3 629 634
10. Muhn C. Rosen N. Solish N. Bertucci V. Lupin M. Dansereau A. Weksberg F. Remington B.K. Swift A. The evolving role of hyaluronic acid fillers for facial volume restoration and contouring: A Canadian overview Clin. Cosmet. Investig. Dermatol. 2012 5 147 158 10.2147/CCID.S30794

상세보기
11. Borrell M. Leslie D.B. Tezel A. Lift capabilities of hyaluronic acid fillers J. Cosmet. Laser Ther. 2011 13 21 27 10.3109/14764172.2011.552609 21254807

상세보기
12. Raspaldo H. Volumizing effect of a new hyaluronic acid sub-dermal facial filler: A retrospective analysis based on 102 cases Cosmet. Laser Ther. 2008 10 134 142 10.1080/14764170802154607 18788032

상세보기
13. Jones D. Volumizing the Face with Soft Tissue Fillers Clin. Plastic. Surg. 2011 38 379 390 10.1016/j.cps.2011.03.011 21824536

상세보기
14. Sundaram H. Cassuto D. Biophysical characteristics of hyaluronic acid soft-tissue fillers and their relevance to aesthetic applications Plast. Reconstr. Surg. 2013 132 5S 21S 10.1097/PRS.0b013e31829d1d40 24077013

상세보기
15. La Gatta A. Schiraldi C. Papa A. De Rosa M. Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation Polym. Degrad. Stab. 2011 96 630 636 10.1016/j.polymdegradstab.2010.12.025

상세보기
16. Falcone S.J. Berg R.A. Crosslinked hyaluronic acid dermal fillers: A comparison of rheological properties J. Biomed. Mater. Res. Part A 2008 87 264 271 10.1002/jbm.a.31675

상세보기
17. Edsman K. Nord L.I. Ohrlund A. Larkner H. Kenne A.H. Gel properties of hyaluronic acid dermal fillers Dermatol. Surg. 2012 38 1170 1179 10.1111/j.1524-4725.2012.02472.x 22759254

상세보기
18. Edsman K.L.M. Ohrlund A. Cohesion of hyaluronic acid fillers: Correlation between cohesion and other physicochemical properties Dermatol. Surg. 2018 44 557 562 10.1097/DSS.0000000000001370 29059137

상세보기
19. Sundaram H. Going with the flow: An overview of soft tissue filler rheology and its potential clinical applications (2of 3) Cosmet. Chall. 2011 23 28
20. Sundaram H. Rohrich R.J. Liew S. Sattler G. Talarico S. Trevidic P. Molliard S.G. Cohesivity of Hyaluronic Acid Fillers: Development and Clinical Implications of a Novel Assay, Pilot Validation with a Five-Point Grading Scale, and Evaluation of Six U.S. Food and Drug Administration-Approved Fillers Plast. Reconstr Surg. 2015 136 678 686 10.1097/PRS.0000000000001638 26397245

상세보기
21. La Gatta A. Schiraldi C. Zaccaria G. Cassuto D. Hyaluronan Dermal Fillers: Efforts Towards a Wider Biophysical Characterization and the Correlation of the Biophysical Parameters to the Clinical Outcome Clin. Cosmet. Investig. Dermatol. 2020 13 87 97 10.2147/CCID.S220227

상세보기
22. Sparavigna A. La Gatta A. Bellia G. La Penna L. Giori A.M. Vecchi G. Tenconi B. Schiraldi C. Evaluation of the Volumizing Performance of a New Volumizer Filler in Volunteers with Age-Related Midfacial Volume Defects Clin. Cosmet. Investig. Dermatol. 2020 13 683 690 10.2147/CCID.S262839 32982362

상세보기
23. Kablik J. Monheit G.D. Yu L.P. Chang G. Gershkovich J. Comparative physical properties of hyaluronic acid dermal fillers Dermatol. Surg. 2009 35 302 312 10.1111/j.1524-4725.2008.01046.x 19207319

상세보기
24. Stocks D. Sundaram H. Michaels J. Durrani M.J. Wortzman M.S. Nelson D.B. Rheological evaluation of the physical properties of hyaluronic acid dermal fillers J. Drugs Dermatol. 2011 10 974 980 22052265
25. La Gatta A. Salzillo R. Catalano C. Pirozzi A.V.A. D’Agostino A. Bedini E. Cammarota M. De Rosa M. Schiraldi C. Hyaluronan-based hydrogels via ether-crosslinking: Is HA molecular weight an effective means to tune gel performance? Int. J. Biol. Macromol. 2020 144 94 101 10.1016/j.ijbiomac.2019.11.227 31794831

상세보기
26. Sito G. Hydrolift Action: A New Approach in Facial Reshaping. IBSA Hyaluronic Acid Experts Available online: prime-journal.com (accessed on 25 March 2013)
27. Arsiwala S.Z. Current trends in facial rejuvenation with fillers J. Cutan. Aesthet. Surg. 2015 8 125 126 10.4103/0974-2077.167261 26644733

상세보기
28. Kerscher M. Buntrock H. Hund M. Mokosch A. Ogilvie A. Samimi-Fard S. Waibel M. Restylane ® Skinboosters™ for the improvement of the skin quality―Results of a consensus meeting Cosmet. Med. 2017 17 28 34
29. Niforos F. Ogilvie P. Cavallini M. Leys C. Chantrey J. Safa M. Abrams S. Hopfinger R. Marx A. VYC-12 Injectable Gel Is Safe and Effective for Improvement of Facial Skin Topography: A Prospective Study Clin. Cosmet. Investig. Dermatol. 2019 12 791 798 10.2147/CCID.S216222
30. Beatini A. Piersini P. Russo R. “REAL LIFE” efficacy evaluation of a new hyaluronic acid gel suitable for deep hydration and fine wrinkles correction Aesthetic Med. J. 2019 5 19 24
31. Viscoderm Hydrobooster ® [Package Insert] RosePharma S.A. Lugano, Switzerland 2019
32. Juvederm Volite ® [Package Insert] Allergan Pringy, France 2019
33. Restylane ® Skinboosters TM Vital Q-Med AB Uppsala, Sweden 2019
34. D’Agostino A. Stellavato A. Corsuto L. Diana P. Filosa R. La Gatta A. De Rosa M. Schiraldi C. Is molecular size a discriminating factor in hyaluronan interaction with human cells? Carbohyd. Polym. 2017 157 21 30 10.1016/j.carbpol.2016.07.125 27987920

상세보기
35. Urdiales-Galvez F. Delgado N.E. Figueiredo V. Lajo-Plaza J.V. Mira M. Moreno A. Ortiz-Marti F. Del Rio-Reyes R. Romero-Alvarez N. Del Cueto S.R. Treatment of Soft Tissue Filler Complications: Expert Consensus Recommendations Aesthetic Plast. Surg. 2018 42 498 510 10.1007/s00266-017-1063-0 29305643

상세보기
36. Beasley K.L. Weiss M.A. Weiss R.A. Hyaluronic acid fillers: A comprehensive review Facial. Plast. Surg. 2009 25 86 94 10.1055/s-0029-1220647 19415575

상세보기
37. Sundaram H. Fagien S. Cohesive Polydensified Matrix Hyaluronic Acid for Fine Lines Plast. Reconstr. Surg. 2015 136 Suppl. 5 149 163 10.1097/PRS.0000000000001835

상세보기
38. Stern R. Jedrzejas M. Hyaluronidases: Their genomics, structures, and mechanism of action Chem. Rev. 2006 106 818 838 10.1021/cr050247k 16522010

상세보기
39. Sall I. Ferard G. Comparison of the sensitivity of 11 crosslinked hyaluronic acid gels to bovine testis hyaluronidase Polym. Degrad. Stabil. 2007 92 915 919 10.1016/j.polymdegradstab.2006.11.020

상세보기
40. La Gatta A. De Rosa M. Marzaioli I. Busico T. Schiraldi C. A complete hyaluronan hydrodynamic characterization using a size exclusion chromatography-triple detector array system during in vitro enzymatic degradation Anal Biochem. 2010 404 21 29 10.1016/j.ab.2010.04.014 20399193

상세보기
41. Perez-Sanchez A. Barrajon-Catalan E. Herranz-Lopez M. Micol V. Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies Nutrients 2018 10 403 10.3390/nu10040403 29587342

상세보기
42. Shin J.W. Kwon S.H. Choi J.Y. Na J.I. Huh C.H. Choi H.R. Park K.C. Molecular Mechanisms of Dermal Aging and Antiaging Approaches Int. J. Mol. Sci. 2019 20 2126 10.3390/ijms20092126 31036793

상세보기
43. El-Domyati M. Attia S. Saleh F. Brown D. Birk D.E. Gasparro F. Ahmad H. Uitto J. Intrinsic aging vs. photoaging: A comparative histopathological, immunohistochemical, and ultrastructural study of skin Exp. Dermatol. 2002 11 398 405 10.1034/j.1600-0625.2002.110502.x 12366692

상세보기
44. de Filippis A. D’Agostino A. Pirozzi A.V.A. Tufano M.A. Schiraldi C. Baroni A. Q-switched Nd-YAG laser alone and in combination with innovative hyaluronic acid gels improve keratinocytes wound healing in vitro Lasers Med. Sci. 2020 10.1007/s10103-020-03145-5

상세보기
45. Manou D. Caon I. Bouris P. Triantaphyllidou I.E. Giaroni C. Passi A. Karamanos N.K. Vigetti D. Theocharis A.D. The Complex Interplay Between Extracellular Matrix and Cells in Tissues Methods Mol. Biol. 2019 1952 1 20 30825161
46. Moulin V. Plamondon M. Differential expression of collagen integrin receptor on fetal vs. adult skin fibroblasts: Implication in wound contraction during healing Br. J. Dermatol. 2002 147 886 892 10.1046/j.1365-2133.2002.04975.x 12410697

상세보기
47. Donejko M. Rysiak E. Galicka E. Terlikowski R. Głaewska E.K. Przylipiak A. Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol Drug Des. Devel. Ther. 2017 11 669 676 10.2147/DDDT.S125843 28293103

상세보기
48. Stellavato A. Corsuto L. D’Agostino A. La Gatta A. Diana P. Bernini P. De Rosa M. Schiraldi C. Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation PLoS ONE 2016 11 e0163510 10.1371/journal.pone.0163510 27723763

상세보기

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Hyaluronan Hydrogels for Injection in Superficial Dermal Layers: An In Vitro Characterization to Compare Performance and Unravel the Scientific Basis of Their Indication 원문보기

Abstract ▼ AI-Helper

주제어

참고문헌 (48)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

이 논문과 함께 이용한 콘텐츠

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트