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[해외논문] 8-Geranylumbelliferone isolated from Paramignya trimera triggers RIPK1/RIPK3-dependent programmed cell death upon TNFR1 ligation

Biochemical pharmacology, v.192, 2021년, pp.114733 -   

Piao, Xuezhe (Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University) ,  Byun, Hee Sun (Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University) ,  Lee, So-Ra (Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University) ,  Ju, Eunjin (Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University) ,  Park, Kyeong Ah (Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University) ,  Sohn, Kyung-Cheol (Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University) ,  Quan, Khong Trong (College of Pharmacy, Chungnam National University) ,  Lee, Jinbae (Colle) ,  Na, MinKyun ,  Hur, Gang Min

Abstract AI-Helper 아이콘AI-Helper

Abstract In tumor necrosis factor (TNF) signaling, IκB kinase (IKK) complex-mediated activation of NF-κB is a well-known protective mechanism against cell death via transcriptional induction of pro-survival genes occurring as a late checkpoint. However, recent belief holds that IKK func...

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