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Journal of biochemical and molecular toxicology, v.15 no.5, 2001년, pp.256 - 262
Gunasekar, Palur G. (Neurotoxicology Laboratory, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA) , Mickova, Vera (Department of Pharmacology and Toxicology, Faculty of Medicine, Charles University, Karlovarska 48, CZ 301 66 Pilsen, Czech Republic) , Kotyzova, Dana (Department of Pharmacology and Toxicology, Faculty of Medicine, Charles University, Karlovarska 48, CZ 301 66 Pilsen, Czech Republic) , Li, Li (Neurotoxicology Laboratory, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA) , Borowitz, Joseph L. (Neurotoxicology Laboratory, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA) , Eybl, Vladislav (Department of Pharmacology and Toxicology, Faculty of Medicine, Charles University, Karlovarska 48, CZ 301 66 Pilsen, Czech Republic) , Isom, Gary E. (Neurotoxicology Laboratory, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA)
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Although the neurotoxicity of trimethyltin (TMT) is well known, mechanisms are still not clear. Glia have been proposed to mediate the toxic action of TMT on nerve cells. Accordingly, the effects of TMT were tested in primary neuronal cultures from rat cerebellum and compared to effects in astrocyte...
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