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[국내논문] Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells

Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, v.44 no.7, 2021년, pp.702 - 712  

Jeon, Hyesu ,  Jin, Yujin ,  Myung, Chang-Seon ,  Heo, Kyung-Sun

초록이 없습니다.

참고문헌 (40)

  1. Arch Pharm Res J Ahn 43 735 2020 10.1007/s12272-020-01254-x Ahn J, Kim H, Yang KM (2020) Omega-hydroxyundec-9-enoic acid induction of breast cancer cells apoptosis through generation of mitochondrial ROS and phosphorylation of AMPK. Arch Pharm Res 43:735-743. https://doi.org/10.1007/s12272-020-01254-x 

  2. Asian Pac J Cancer Prev N Azamjah 20 2015 2019 10.31557/APJCP.2019.20.7.2015 Azamjah N, Soltan-Zadeh Y, Zayeri F (2019) Global Trend of Breast Cancer Mortality Rate: A 25-Year Study. Asian Pac J Cancer Prev 20:2015-2020. https://doi.org/10.31557/APJCP.2019.20.7.2015 

  3. Int J Mol Med MJ Bak 34 1516 2014 10.3892/ijmm.2014.1972 Bak MJ, Jeong WS, Kim KB (2014) Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells. Int J Mol Med 34:1516-1522. https://doi.org/10.3892/ijmm.2014.1972 

  4. Am J Cancer Res F Bost 9 198 2019 Bost F, Kaminski L (2019) The metabolic modulator PGC-1alpha in cancer. Am J Cancer Res 9:198-211 

  5. Biochem J: N Brandie 465 1 49 2015 10.1042/BJ20131608 Brandie N, Radde MM, Ivanova HX, Mai, Joshua K, Salabei BG, Hill, Carolyn M, Klinge (2015) Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by oestradiol and tamoxifen. Biochem J: 465(1):49-61. https://doi.org/10.1042/BJ20131608 

  6. Cell Death Discov B Chaube 1 15063 2015 10.1038/cddiscovery.2015.63 Chaube B, Malvi P, Singh SV, Mohammad N, Viollet B, Bhat MK (2015) AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1alpha-mediated mitochondrial biogenesis. Cell Death Discov 1:15063. https://doi.org/10.1038/cddiscovery.2015.63 

  7. Chem Biol Interact J Cui 275 152 2017 10.1016/j.cbi.2017.07.021 Cui J, Wang J, Zheng M, Gou D, Liu C, Zhou Y (2017) Ginsenoside Rg2 protects PC12 cells against beta-amyloid25-35-induced apoptosis via the phosphoinositide 3-kinase/Akt pathway. Chem Biol Interact 275:152-161. https://doi.org/10.1016/j.cbi.2017.07.021 

  8. Arch Pharm Res L Cui 41 299 2018 10.1007/s12272-017-0990-2 Cui L, Bu W, Song J, Feng L, Xu T, Liu D, Ding W, Wang J, Li C, Ma B, Luo Y, Jiang Z, Wang C, Chen J, Hou J, Yan H, Yang L, Jia X (2018) Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway. Arch Pharm Res 41:299-313. https://doi.org/10.1007/s12272-017-0990-2 

  9. J Cancer X Dai 8 3131 2017 10.7150/jca.18457 Dai X, Cheng H, Bai Z, Li J (2017) Breast cancer cell line classification and its relevance with breast tumor subtyping. J Cancer 8:3131-3141. https://doi.org/10.7150/jca.18457 

  10. Curr Med Chem FV Duarte 22 2468 2015 10.2174/0929867322666150514095910 Duarte FV, Amorim JA, Palmeira CM, Rolo AP (2015) Regulation of mitochondrial function and its impact in metabolic stress. Curr Med Chem 22:2468-2479. https://doi.org/10.2174/0929867322666150514095910 

  11. J Ginseng Res D Gou 44 717 2020 10.1016/j.jgr.2019.06.005 Gou D, Pei X, Wang J, Wang Y, Hu C, Song C, Cui S, Zhou Y (2020) Antiarrhythmic effects of ginsenoside Rg2 on calcium chloride-induced arrhythmias without oral toxicity. J Ginseng Res 44:717-724. https://doi.org/10.1016/j.jgr.2019.06.005 

  12. Science DR Green 281 1309 1998 10.1126/science.281.5381.1309 Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281:1309-1312. https://doi.org/10.1126/science.281.5381.1309 

  13. Oncogene DN Gross 27 2320 2008 10.1038/onc.2008.25 Gross DN, van den Heuvel AP, Birnbaum MJ (2008) The role of FoxO in the regulation of metabolism. Oncogene 27:2320-2336. https://doi.org/10.1038/onc.2008.25 

  14. Neural Regen Res C Guo 8 2003 2013 10.3969/j.issn.1673-5374.2013.21.009 Guo C, Sun L, Chen X, Zhang D (2013) Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res 8:2003-2014. https://doi.org/10.3969/j.issn.1673-5374.2013.21.009 

  15. Int J Mol Sci DTN Huynh 2020 10.3390/ijms21186656 Huynh DTN, Baek N, Sim S, Myung CS, Heo KS (2020) Minor ginsenoside Rg2 and Rh1 attenuates LPS-induced acute liver and kidney damages via downregulating activation of TLR4-STAT1 and inflammatory cytokine production in macrophages. Int J Mol Sci. https://doi.org/10.3390/ijms21186656 

  16. Cancers DTN Huynh 13 1892 2021 10.3390/cancers13081892 Huynh DTN, Jin Y, Myung C-S, Heo K-S (2021) Ginsenoside Rh1 induces MCF-7 cell apoptosis and autophagic cell death through ROS-mediated Akt signal. Cancers 13:1892 

  17. Phytomedicine H Jeon 85 153549 2021 10.1016/j.phymed.2021.153549 Jeon H, Huynh DTN, Baek N, Nguyen TLL, Heo KS (2021) Ginsenoside-Rg2 affects cell growth via regulating ROS-mediated AMPK activation and cell cycle in MCF-7 cells. Phytomedicine 85:153549. doi:https://doi.org/10.1016/j.phymed.2021.153549 

  18. J cell Mol Med S Jiang 23 6 3951 2019 10.1111/jcmm.14279 Jiang S, Wang Y, Luo L, Shi F, Zou J, Lin H, Ying Y, Luo Y, Zhan Z, Liu P, Zhu B, Huang D, Luo Z (2019) AMP-activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events. J cell Mol Med 23(6):3951-3961. doi:https://doi.org/10.1111/jcmm.14279 

  19. BMB Rep Y Jin 52 706 2019 10.5483/BMBRep.2019.52.12.234 Jin Y, Huynh DTN, Kang KW, Myung CS, Heo KS (2019) Inhibition of p90RSK activation sensitizes triple-negative breast cancer cells to cisplatin by inhibiting proliferation, migration and EMT. BMB Rep 52:706-711 

  20. Arch Pharm Res Y Jin 43 773 2020 10.1007/s12272-020-01265-8 Jin Y, Huynh DTN, Nguyen LLT, Jeon HS, Heo KS (2020) Therapeutic effects of ginsenosides on breast cancer growth and metastasis. Arch Pharm Res 43:773-787. https://doi.org/10.1007/s12272-020-01265-8 

  21. Arch Pharm Res SW Kang 38 338 2015 10.1007/s12272-015-0550-6 Kang SW, Lee S, Lee EK (2015) ROS and energy metabolism in cancer cells: alliance for fast growth. Arch Pharm Res 38:338-345. https://doi.org/10.1007/s12272-015-0550-6 

  22. Biol Pharm Bull MY Kim 41 713 2018 10.1248/bpb.b17-00898 Kim MY, Bo HH, Choi EO, Kwon DH, Kim HJ, Ahn KI, Ji SY, Jeong JW, Park SH, Hong SH, Kim GY, Park C, Kim HS, Moon SK, Yun SJ, Kim WJ, Choi YH (2018) Induction of apoptosis by citrus unshiu peel in human breast cancer MCF-7 cells: involvement of ROS-dependent activation of AMPK. Biol Pharm Bull 41:713-721. https://doi.org/10.1248/bpb.b17-00898 

  23. Cell Death Dis MJ Kong 9 488 2018 10.1038/s41419-018-0537-6 Kong MJ, Han SJ, Kim JI, Park JW, Park KM (2018) Mitochondrial NADP(+)-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells. Cell Death Dis 9:488. https://doi.org/10.1038/s41419-018-0537-6 

  24. Arch Pharm Res YJ Lee 42 890 2019 10.1007/s12272-019-01181-6 Lee YJ, Park KS, Heo SH, Nam HS, Cho MK, Lee SH (2019) Pifithrin-µ induces necroptosis through oxidative mitochondrial damage but accompanies epithelial-mesenchymal transition-like phenomenon in malignant mesothelioma cells under lactic acidosis. Arch Pharm Res 42:890-901. https://doi.org/10.1007/s12272-019-01181-6 

  25. Phytomedicine X Li 53 124 2019 10.1016/j.phymed.2018.09.033 Li X, Qu Z, Jing S, Li X, Zhao C, Man S, Wang Y, Gao W (2019) Dioscin-6’-O-acetate inhibits lung cancer cell proliferation via inducing cell cycle arrest and caspase-dependent apoptosis. Phytomedicine 53:124-133. https://doi.org/10.1016/j.phymed.2018.09.033 

  26. Food Funct H Liu 10 3603 2019 10.1039/c9fo00027e Liu H, Liu M, Jin Z, Yaqoob S, Zheng M, Cai D, Liu J, Guo S (2019) Ginsenoside Rg2 inhibits adipogenesis in 3T3-L1 preadipocytes and suppresses obesity in high-fat-diet-induced obese mice through the AMPK pathway. Food Funct 10:3603-3614. https://doi.org/10.1039/c9fo00027e 

  27. Arch Pharm Res TLL Nguyen 44 241 2021 10.1007/s12272-020-01304-4 Nguyen TLL, Huynh DTN, Jin Y, Jeon H, Heo KS (2021) Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway. Arch Pharm Res 44:241-252. https://doi.org/10.1007/s12272-020-01304-4 

  28. FEBS J A Pena-Blanco 285 416 2018 10.1111/febs.14186 Pena-Blanco A, Garcia-Saez AJ (2018) Bax, Bak and beyond - mitochondrial performance in apoptosis. FEBS J 285:416-431. https://doi.org/10.1111/febs.14186 

  29. Cancer Lett LA Pluchino 381 124 2016 10.1016/j.canlet.2016.07.036 Pluchino LA, Choudhary S, Wang HC (2016) Reactive oxygen species-mediated synergistic and preferential induction of cell death and reduction of clonogenic resistance in breast cancer cells by combined cisplatin and FK228. Cancer Lett 381:124-132. https://doi.org/10.1016/j.canlet.2016.07.036 

  30. Breast Cancer M Pordeli 24 299 2017 10.1007/s12282-016-0704-5 Pordeli M, Nakhjiri M, Safavi M, Ardestani SK, Foroumadi A (2017) Anticancer effects of synthetic hexahydrobenzo [g]chromen-4-one derivatives on human breast cancer cell lines. Breast Cancer 24:299-311. https://doi.org/10.1007/s12282-016-0704-5 

  31. Redox Biol C Shao 36 101685 2020 10.1016/j.redox.2020.101685 Shao C, Lu W, Du Y, Yan W, Bao Q, Tian Y, Wang G, Ye H, Hao H (2020) Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis. Redox Biol 36:101685. https://doi.org/10.1016/j.redox.2020.101685 

  32. Arch Pharm Res MK Shin 42 113 2019 10.1007/s12272-019-01127-y Shin MK, Cheong JH (2019) Mitochondria-centric bioenergetic characteristics in cancer stem-like cells. Arch Pharm Res 42:113-127. https://doi.org/10.1007/s12272-019-01127-y 

  33. Oxid Med Cell Longev M Skonieczna 2017 9420539 2017 10.1155/2017/9420539 Skonieczna M, Hejmo T, Poterala-Hejmo A, Cieslar-Pobuda A, Buldak RJ (2017) NADPH oxidases: insights into selected functions and mechanisms of action in cancer and stem cells. Oxid Med Cell Longev 2017:9420539. https://doi.org/10.1155/2017/9420539 

  34. Mol Cancer Ther Z Tan 15 774 2016 10.1158/1535-7163.MCT-15-0621 Tan Z, Luo X, Xiao L, Tang M, Bode AM, Dong Z, Cao Y (2016) The role of PGC1alpha in cancer metabolism and its therapeutic implications. Mol Cancer Ther 15:774-782. https://doi.org/10.1158/1535-7163.MCT-15-0621 

  35. Nat Rev Cancer DC Wallace 12 685 2012 10.1038/nrc3365 Wallace DC (2012) Mitochondria and cancer. Nat Rev Cancer 12:685-698. https://doi.org/10.1038/nrc3365 

  36. Oncol Lett B Yi 6 583 2013 10.3892/ol.2013.1403 Yi B, Liu D, He M, Li Q, Liu T, Shao J (2013) Role of the ROS/AMPK signaling pathway in tetramethylpyrazine-induced apoptosis in gastric cancer cells. Oncol Lett 6:583-589. https://doi.org/10.3892/ol.2013.1403 

  37. Cell Res Y Zhang 17 363 2007 10.1038/cr.2007.11 Zhang Y, Ba Y, Liu C, Sun G, Ding L, Gao S, Hao J, Yu Z, Zhang J, Zen K, Tong Z, Xiang Y (2007) PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathway. Cell Res 17:363-373 

  38. ijBCB HS Zhang 95 85 2018 10.1016/j.biocel Zhang HS, Du GY, Zhang ZG, Zhou Z, Sun HL, Yu XY, Shi YT, Xiong DN, Li H, Huang YH (2018) NRF2 facilitates breast cancer cell growth via HIF1ɑ-mediated metabolic reprogramming. ijBCB 95:85-92. https://doi.org/10.1016/j.biocel 

  39. J Cell Mol Med HS Zhang 23 5 3451 2019 10.1111/jcmm.14241 Zhang HS, Zhang ZG, Du GY, Sun HL, Liu HY, Zhou Z, Gou XM, Wu XH, Yu XY, Huang YH (2019) Nrf2 promotes breast cancer cell migration via up-regulation of G6PD/HIF-1α/Notch1 axis. J Cell Mol Med 23(5):3451-3463. https://doi.org/10.1111/jcmm.14241 

  40. Mol Cancer Y Zhao 16 79 2017 10.1186/s12943-017-0648-1 Zhao Y, Hu X, Liu Y, Dong S, Wen Z, He W, Zhang S, Huang Q, Shi M (2017) ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway. Mol Cancer 16:79. https://doi.org/10.1186/s12943-017-0648-1 

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