[논문]Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2 -mutant mice

Lee, Eunee; Lee, Seungjoon; Shin, Jae Jin; Choi, Woochul; Chung, Changuk; Lee, Suho; Kim, Jihye; Ha, Seungmin; Kim, Ryunhee; Yoo, Taesun; Yoo, Ye-Eun; Kim, Jisoo; Noh, Young Woo; Rhim, Issac; Lee, Soo Yeon; Kim, Woohyun; Lee, Taekyung; Shin, Hyogeun; Cho, Il-Joo; Deisseroth, Karl; Kim, Sang Jeong; Park, Joo Min; Jung, Min Whan; Paik, Se-Bum; Kim, Eunjoon

doi:10.1038/s41467-021-25356-2

[해외논문] Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2 -mutant mice 원문보기

Nature communications, v.12 no.1, 2021년, pp.5116 -

Lee, Eunee (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea) , Lee, Seungjoon (Department of Biological Sciences, KAIST, Daejeon, Korea) , Shin, Jae Jin (Department of Brain and Cognitive Science, College of Natural Science, Seoul National University, Seoul, Korea) , Choi, Woochul (Program of Brain and Cognitive Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea) , Chung, Changuk (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea) , Lee, Suho (Department of Biological Sciences, KAIST, Daejeon, Korea) , Kim, Jihye (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea) , Ha, Seungmin (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea) , Kim, Ryunhee (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea) , Yoo, Taesun (Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea) , Yoo, Ye-Eun (Department of Biological Sciences, KAIST, Daejeon, Kor) , Kim, Jisoo , Noh, Young Woo , Rhim, Issac , Lee, Soo Yeon , Kim, Woohyun , Lee, Taekyung , Shin, Hyogeun , Cho, Il-Joo , Deisseroth, Karl , Kim, Sang Jeong , Park, Joo Min , Jung, Min Whan , Paik, Se-Bum , Kim, Eunjoon

Abstract ▼ AI-Helper

NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these dysfunctions impair social cognition and behavior remains unclear. We report here that NMDARs in cortical parvalbumin (Pv)-positive interneurons cooperate with gap junctions to promote high-frequency (>80 Hz) Pv neuronal burst firing and social cognition. Shank2–/– mice, displaying improved sociability upon NMDAR activation, show impaired cortical social representation and inhibitory neuronal burst firing. Cortical Shank2–/– Pv neurons show decreased NMDAR activity, which suppresses the cooperation between NMDARs and gap junctions (GJs) for normal burst firing. Shank2–/– Pv neurons show compensatory increases in GJ activity that are not sufficient for social rescue. However, optogenetic boosting of Pv neuronal bursts, requiring GJs, rescues cortical social cognition in Shank2–/– mice, similar to the NMDAR-dependent social rescue. Therefore, NMDARs and gap junctions cooperate to promote cortical Pv neuronal bursts and social cognition.How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.

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