[논문]Chrysanthemum indicum Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells

Jeong, Yun Hee; Kim, Tae In; Oh, You-Chang; Ma, Jin Yeul

doi:10.3390/nu13113690

[해외논문] Chrysanthemum indicum Prevents Hydrogen Peroxide-Induced Neurotoxicity by Activating the TrkB/Akt Signaling Pathway in Hippocampal Neuronal Cells 원문보기

Nutrients, v.13 no.11, 2021년, pp.3690 -

Jeong, Yun Hee , Kim, Tae In , Oh, You-Chang , Ma, Jin Yeul

Abstract ▼ AI-Helper

Oxidative stress-mediated neuronal damage is associated with the pathogenesis and development of neurodegenerative diseases. Chrysanthemum indicum has antioxidant properties. However, the neuroprotective effects and the cellular mechanism of C. indicum ethanol extract (CIE) against oxidative damage in hippocampal neuronal cells have not been clearly elucidated. Therefore, this study investigated whether CIE has protective effects against hydrogen peroxide (H2O2)-induced oxidative toxicity in HT22 cells. CIE pretreatment significantly improved neuronal cell viability. Moreover, the formation of intracellular reactive oxygen species and apoptotic bodies, and mitochondrial depolarization were significantly reduced in HT22 cells with H2O2-induced oxidative toxicity. Furthermore, CIE increased the phosphorylation of tropomyosin-related kinase receptor B (TrkB), protein kinase B (Akt), cAMP response element-binding protein, the expression of brain-derived neurotrophic factor, antioxidant enzymes, and the nuclear translocation of nuclear factor erythroid 2-related factor 2 by activating the TrkB/Akt signaling pathway. In contrast, the addition of K252a, a TrkB inhibitor, or MK-2206, an Akt-selective inhibitor, reduced the neuroprotective and antioxidant effects of CIE. Taken together; CIE exhibits neuroprotective and antioxidant effects against oxidative damage. Therefore, it can be a potential agent for treating oxidative stress-related neurodegenerative diseases.

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참고문헌 (41)

1. Pollari E. Goldsteins G. Bart G. Koistinaho J. Giniatullin R. The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis Front. Cell Neurosci. 2014 8 131 10.3389/fncel.2014.00131 24860432

상세보기
2. Jiang T. Sun Q. Chen S. Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease Prog. Neurobiol. 2016 147 1 19 10.1016/j.pneurobio.2016.07.005 27769868

상세보기
3. Amaro S. Llull L. Renu A. Laredo C. Perez B. Vila E. Torres F. Planas A.M. Chamorro A. Uric acid improves glucose-driven oxidative stress in human ischemic stroke Ann. Neurol. 2015 77 775 783 10.1002/ana.24378 25627874

상세보기
4. Fatokun A.A. Stone T.W. Smith R.A. Oxidative stress in neurodegeneration and available means of protection Front. Biosci. 2008 13 3288 3311 10.2741/2926 18508433

상세보기
5. Trushina E. McMurray C.T. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases Neuroscience 2007 145 1233 1248 10.1016/j.neuroscience.2006.10.056 17303344

상세보기
6. Baillet A. Chanteperdrix V. Trocme C. Casez P. Garrel C. Besson G. The role of oxidative stress in amyotrophic lateral sclerosis and Parkinson’s disease Neurochem. Res. 2010 35 1530 1537 10.1007/s11064-010-0212-5 20535556

상세보기
7. Ma Z.A. The role of peroxidation of mitochondrial membrane phospholipids in pancreatic beta -cell failure Curr. Diabetes Rev. 2012 8 69 75 10.2174/157339912798829232 22414059
8. Zuccato C. Liber D. Ramos C. Tarditi A. Rigamonti D. Tartari M. Valenza M. Cattaneo E. Progressive loss of BDNF in a mouse model of Huntington’s disease and rescue by BDNF delivery Pharmacol. Res. 2005 52 133 139 10.1016/j.phrs.2005.01.001 15967378

상세보기
9. Park H. Poo M.M. Neurotrophin regulation of neural circuit development and function Nat. Rev. Neurosci. 2013 14 7 23 10.1038/nrn3379 23254191

상세보기
10. Xu Q. Ji X.F. Chi T.Y. Liu P. Jin G. Gu S.L. Zou L.B. Sigma 1 receptor activation regulates brain-derived neurotrophic factor through NR2A-CaMKIV-TORC1 pathway to rescue the impairment of learning and memory induced by brain ischaemia/reperfusion Psychopharmacology 2015 232 1779 1791 10.1007/s00213-014-3809-6 25420607

상세보기
11. Rossler O.G. Giehl K.M. Thiel G. Neuroprotection of immortalized hippocampal neurones by brain-derived neurotrophic factor and Raf-1 protein kinase: Role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase J. Neurochem. 2004 88 1240 1252 10.1046/j.1471-4159.2003.02255.x 15009680

상세보기
12. Zhang F. Kang Z. Li W. Xiao Z. Zhou X. Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer’s disease J. Clin. Neurosci. 2012 19 946 949 10.1016/j.jocn.2011.12.022 22613489

상세보기
13. Ji J.F. Ji S.J. Sun R. Li K. Zhang Y. Zhang L.Y. Tian Y. Forced running exercise attenuates hippocampal neurogenesis impairment and the neurocognitive deficits induced by whole-brain irradiation via the BDNF-mediated pathway Biochem. Biophys. Res. Commun. 2014 443 646 651 10.1016/j.bbrc.2013.12.031 24333433

상세보기
14. Baek S.Y. Kim M.R. Neuroprotective Effect of Carotenoid-Rich Enteromorpha prolifera Extract via TrkB/Akt Pathway against Oxidative Stress in Hippocampal Neuronal Cells Mar. Drugs 2020 18 372 10.3390/md18070372 32707633

상세보기
15. Wei Y. Gong J. Yoshida T. Eberhart C.G. Xu Z. Kombairaju P. Sporn M.B. Handa J.T. Duh E.J. Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury Free Radic. Biol. Med. 2011 51 216 224 10.1016/j.freeradbiomed.2011.04.026 21545836

상세보기
16. Cheng Z.G. Zhang G.D. Shi P.Q. Du B.S. Expression and antioxidation of Nrf2/ARE pathway in traumatic brain injury Asian Pac. J. Trop. Med. 2013 6 305 310 10.1016/S1995-7645(13)60061-9 23608333

상세보기
17. Trinh K. Andrews L. Krause J. Hanak T. Lee D. Gelb M. Pallanck L. Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson’s disease through an NRF2-dependent mechanism J. Neurosci. 2010 30 5525 5532 10.1523/JNEUROSCI.4777-09.2010 20410106

상세보기
18. Schipper H.M. Bennett D.A. Liberman A. Bienias J.L. Schneider J.A. Kelly J. Arvanitakis Z. Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment Neurobiol. Aging 2006 27 252 261 10.1016/j.neurobiolaging.2005.01.016 16399210

상세보기
19. Wang Y. Santa-Cruz K. DeCarli C. Johnson J.A. NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Aalzheimer’s disease Neurobiol. Aging 2000 21 525 531 10.1016/S0197-4580(00)00114-7 10924765

상세보기
20. Cheng W. Li J. You T. Hu C. Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linne J. Ethnopharmacol. 2005 101 334 337 10.1016/j.jep.2005.04.035 16029939

상세보기
21. Shunying Z. Yang Y. Huaidong Y. Yue Y. Guolin Z. Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum J. Ethnopharmacol. 2005 96 151 158 10.1016/j.jep.2004.08.031 15588664

상세보기
22. Lee D.Y. Choi G. Yoon T. Cheon M.S. Choo B.K. Kim H.K. Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation J. Ethnopharmacol. 2009 123 149 154 10.1016/j.jep.2009.02.009 19429354

상세보기
23. Lee S.H. Hwang I.G. Nho J.W. Chang Y.D. Lee C.H. Woo K.S. Jeong H.S. Quality characteristics and antioxidant activity of Chrysanthemum indicum L., Chrysanthemum boreale M. and Chrysanthemum zawadskii K. powdered teas J. Korean Soc. Food Sci. Nutr. 2009 38 824 831 10.3746/jkfn.2009.38.7.824

원문보기 상세보기
24. Li Z.F. Wang Z.D. Ji Y.Y. Zhang S. Huang C. Li J. Xia X.M. Induction of apoptosis and cell cycle arrest in human HCC MHCC97H cells with Chrysanthemum indicum extract World J. Gastroenterol. 2009 15 4538 4546 10.3748/wjg.15.4538 19777612

상세보기
25. Zhang Q. Li J. Wang C. Sun W. Zhang Z. Cheng W. A gradient HPLC method for the quality control of chlorogenic acid, linarin and luteolin in Flos Chrysanthemi Indici suppository J. Pharm. Biomed. Anal. 2007 43 753 757 10.1016/j.jpba.2006.07.037 16930915

상세보기
26. Kamat P.K. Tota S. Shukla R. Ali S. Najmi A.K. Nath C. Mitochondrial dysfunction: A crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain Pharmacol. Biochem. Behav. 2011 100 311 319 10.1016/j.pbb.2011.08.019 21893081

상세보기
27. Numakawa T. Suzuki S. Kumamaru E. Adachi N. Richards M. Kunugi H. BDNF function and intracellular signaling in neurons Histol. Histopathol. 2010 25 237 258 20017110
28. Guo W. Ji Y. Wang S. Sun Y. Lu B. Neuronal activity alters BDNF-TrkB signaling kinetics and downstream functions J. Cell Sci. 2014 127 2249 2260 10.1242/jcs.139964 24634513

상세보기
29. Cunha C. Brambilla R. Thomas K.L. A simple role for BDNF in learning and memory? Front. Mol. Neurosci. 2010 3 1 10.3389/neuro.02.001.2010 20162032

상세보기
30. Yoo J.M. Lee B.D. Sok D.E. Ma J.Y. Kim M.R. Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells Redox Biol. 2017 11 592 599 10.1016/j.redox.2016.12.034 28110215

상세보기
31. Tosovic J. Markovic S. Dimitric Markovic J.M. Mojovic M. Milenkovic D. Antioxidative mechanisms in chlorogenic acid Food Chem. 2017 237 390 398 10.1016/j.foodchem.2017.05.080 28764012

상세보기
32. Zhang L. Fan Y. Su H. Wu L. Huang Y. Zhao L. Han B. Shu G. Xiang M. Yang J.M. Chlorogenic acid methyl ester exerts strong anti-inflammatory effects via inhibiting the COX-2/NLRP3/NF-kappaB pathway Food Funct. 2018 9 6155 6164 10.1039/C8FO01281D 30379164

상세보기
33. Wang H. Chu W. Ye C. Gaeta B. Tao H. Wang M. Qiu Z. Chlorogenic acid attenuates virulence factors and pathogenicity of Pseudomonas aeruginosa by regulating quorum sensing Appl. Microbiol. Biotechnol. 2019 103 903 915 10.1007/s00253-018-9482-7 30421108

상세보기
34. Kim H. Pan J.H. Kim S.H. Lee J.H. Park J.W. Chlorogenic acid ameliorates alcohol-induced liver injuries through scavenging reactive oxygen species Biochimie 2018 150 131 138 10.1016/j.biochi.2018.05.008 29787793

상세보기
35. Kang T.Y. Yang H.R. Zhang J. Li D. Lin J. Wang L. Xu X. The studies of chlorogenic Acid antitumor mechanism by gene chip detection: The immune pathway gene expression J. Anal. Methods Chem. 2013 2013 617243 10.1155/2013/617243 23762780

상세보기
36. Sun X. Sun G.B. Wang M. Xiao J. Sun X.B. Protective effects of cynaroside against H 2 O 2 -induced apoptosis in H9c2 cardiomyoblasts J. Cell Biochem. 2011 112 2019 2029 10.1002/jcb.23121 21445859

상세보기
37. Xiong J. Li S. Wang W. Hong Y. Tang K. Luo Q. Screening and identification of the antibacterial bioactive compounds from Lonicera japonica Thunb. leaves Food Chem. 2013 138 327 333 10.1016/j.foodchem.2012.10.127 23265495

상세보기
38. Baskar A.A. Ignacimuthu S. Michael G.P. Al Numair K.S. Cancer chemopreventive potential of luteolin-7-O-glucoside isolated from Ophiorrhiza mungos Linn Nutr. Cancer 2011 63 130 138 10.1080/01635581.2010.516869 21161823

상세보기
39. Jay F.T. Coultas C. Jones D.S. The use of a dipolar ion-exchanger for the fractionation of transfer ribonucleic acid Nucleic Acids Res. 1976 3 177 190 10.1093/nar/3.1.177 1250696

상세보기
40. Iwai K. Kishimoto N. Kakino Y. Mochida K. Fujita T. In vitro antioxidative effects and tyrosinase inhibitory activities of seven hydroxycinnamoyl derivatives in green coffee beans J. Agric. Food Chem. 2004 52 4893 4898 10.1021/jf040048m 15264931

상세보기
41. Chen X.M. Ma Z. Kitts D.D. Effects of processing method and age of leaves on phytochemical profiles and bioactivity of coffee leaves Food Chem. 2018 249 143 153 10.1016/j.foodchem.2017.12.073 29407917

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