최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기The journals of gerontology. Series A, Biological sciences and medical sciences, v.76 no.10, 2021년, pp.1714 - 1725
Liao, Chen-Yu (Buck Institute for Research on Aging, Novato, California, USA) , Kummert, Oona M P (Buck Institute for Research on Aging, Novato, California, USA) , Bair, Amanda M (Buck Institute for Research on Aging, Novato, California, USA) , Alavi, Nora (Buck Institute for Research on Aging, Novato, California, USA) , Alavi, Josef (Buck Institute for Research on Aging, Novato, California, USA) , Miller, Delana M (Buck Institute for Research on Aging, Novato, California, USA) , Bagga, Isha (Buck Institute for Research on Aging, Novato, California, USA) , Schempf, Anja M (Buck Institute for Research on Aging, Novato, California, USA) , Hsu, Yueh-Mei (Buck Institute for Research on Aging, Novato, California, USA) , Woods II, Bruce D (Buck Institute for Research on Aging, Novato, California, USA) , Brown Mayfield, Stephen M (Buck Institute for Research on Aging, Novato, California, USA) , Mitchell, Angelina N (Buck Institute for Research on Aging, Novato, California, USA) , Tannady, Gabriella (Buck Institute for Research on Aging, Novato, California, USA) , Talbot, Aislinn R (Buck Institute for Research on Aging, Novato, California, USA) , Dueck, Aaron M (Buck Institute for Research on Aging, Novato, California, USA) , Barrera Ovando, Ricardo (Buck Institute for Research on Aging, No) , Parker, Heather D , Wang, Junying , Schoeneweis, Jane K , Kennedy, Brian K , Anderson, Rozalyn M
AbstractAutophagy, a process catabolizing intracellular components to maintain energy homeostasis, impacts aging and metabolism. Spermidine, a natural polyamine and autophagy activator, extends life span across a variety of species, including mice. In addition to protecting cardiac and liver tissue,...
Cell Kennedy 159 4 709 2014 10.1016/j.cell.2014.10.039 Geroscience: linking aging to chronic disease
Cell López-Otín 153 6 1194 2013 10.1016/j.cell.2013.05.039 The hallmarks of aging
Nat Rev Mol Cell Biol Hansen 19 9 579 2018 10.1038/s41580-018-0033-y Autophagy as a promoter of longevity: insights from model organisms
Cell Rubinsztein 146 5 682 2011 10.1016/j.cell.2011.07.030 Autophagy and aging
Nature Johnson 493 7432 338 2013 10.1038/nature11861 mTOR is a key modulator of ageing and age-related disease
J Gerontol A Biol Sci Med Sci Fok 68 2 108 2013 10.1093/gerona/gls127 Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice
Nat Rev Mol Cell Biol Liu 21 4 183 2020 10.1038/s41580-019-0199-y mTOR at the nexus of nutrition, growth, ageing and disease
Nat Commun Pyo 4 2300 2013 10.1038/ncomms3300 Overexpression of Atg5 in mice activates autophagy and extends lifespan
Autophagy Taneike 6 5 600 2010 10.4161/auto.6.5.11947 Inhibition of autophagy in the heart induces age-related cardiomyopathy
Nature Fernandez 558 7708 136 2018 10.1038/s41586-018-0162-7 Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice
Cell Galluzzi 159 6 1263 2014 10.1016/j.cell.2014.11.006 Metabolic control of autophagy
Cell López-Otín 166 4 802 2016 10.1016/j.cell.2016.07.031 Metabolic control of longevity
Science Madeo 359 6374 2018 10.1126/science.aan2788 Spermidine in health and disease
Nat Cell Biol Eisenberg 11 11 1305 2009 10.1038/ncb1975 Induction of autophagy by spermidine promotes longevity
Nat Med Eisenberg 22 12 1428 2016 10.1038/nm.4222 Cardioprotection and lifespan extension by the natural polyamine spermidine
Cancer Res Yue 77 11 2938 2017 10.1158/0008-5472.CAN-16-3462 Spermidine prolongs lifespan and prevents liver fibrosis and hepatocellular carcinoma by activating MAP1S-mediated autophagy
Endocrinology Badman 150 11 4931 2009 10.1210/en.2009-0532 Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis
Proc Natl Acad Sci USA He 100 26 15712 2003 10.1073/pnas.2536828100 Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
J Cell Biol Morselli 192 4 615 2011 10.1083/jcb.201008167 Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
J Biol Chem Myeku 286 25 22426 2011 10.1074/jbc.M110.149252 Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62
Eur J Pharmacol Sadasivan 729 8 94 2014 10.1016/j.ejphar.2014.01.073 Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice
Cell Death Dis Fernandez 8 8 e2970 2017 10.1038/cddis.2017.373 Autophagy counteracts weight gain, lipotoxicity and pancreatic beta-cell death upon hypercaloric pro-diabetic regimens
Circ Res Bravo-San Pedro 120 11 1812 2017 10.1161/CIRCRESAHA.117.311082 Autophagy and mitophagy in cardiovascular disease
Obes Facts Maixner 5 5 710 2012 10.1159/000343983 Autophagy in adipose tissue
Aging Cell Sheng 16 1155 2017 10.1111/acel.12652 Opposing effects on cardiac function by calorie restriction in different-aged mice
Front Cell Dev Biol Schmeisser 7 192 2019 10.3389/fcell.2019.00192 Pleiotropic effects of mTOR and autophagy during development and aging
Biochem Soc Trans Sarkar 41 5 1103 2013 10.1042/BST20130134 Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
Diabetes Barzilai 61 6 1315 2012 10.2337/db11-1300 The critical role of metabolic pathways in aging
Proc Natl Acad Sci USA Hoehn 106 42 17787 2009 10.1073/pnas.0902380106 Insulin resistance is a cellular antioxidant defense mechanism
J Gerontol A Biol Sci Med Sci Barzilai 67 12 1329 2012 10.1093/gerona/gls145 Insulin resistance and aging: a cause or a protective response?
Diabetologia Tramunt 63 3 453 2020 10.1007/s00125-019-05040-3 Sex differences in metabolic regulation and diabetes susceptibility
Endocr Rev Wajchenberg 21 6 697 2000 10.1210/edrv.21.6.0415 Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
J Gerontol A Biol Sci Med Sci Barzilai 53 2 B141 1998 10.1093/gerona/53A.2.B141 The effect of age-dependent increase in fat mass on peripheral insulin action is saturable
Diabetes Gabriely 51 10 2951 2002 10.2337/diabetes.51.10.2951 Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?
Aging Cell Muzumdar 7 3 438 2008 10.1111/j.1474-9726.2008.00391.x Visceral adipose tissue modulates mammalian longevity
Cell Metab Tran 7 5 410 2008 10.1016/j.cmet.2008.04.004 Beneficial effects of subcutaneous fat transplantation on metabolism
J Clin Endocrinol Metab McLaughlin 96 11 E1756 2011 10.1210/jc.2011-0615 Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity
J Biol Chem Schweiger 281 52 40236 2006 10.1074/jbc.M608048200 Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
Ageing Res Rev Salminen 37 79 2017 10.1016/j.arr.2017.05.004 Regulation of longevity by FGF21: interaction between energy metabolism and stress responses
Endocrinology Whittle 157 5 1722 2016 10.1210/en.2016-1193 FGF21 conducts a metabolic orchestra and fat is a key player
Trends Endocrinol Metab Lewis 30 8 491 2019 10.1016/j.tem.2019.05.007 Going back to the biology of FGF21: new insights
Cell Metab Inagaki 5 6 415 2007 10.1016/j.cmet.2007.05.003 Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
Endocrinology Hotta 150 10 4625 2009 10.1210/en.2009-0119 Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
Mol Metab Adams 2 3 205 2013 10.1016/j.molmet.2013.05.005 Fibroblast growth factor 21 is not required for the antidiabetic actions of the thiazoladinediones
Nat Commun Li 9 1 272 2018 10.1038/s41467-017-02677-9 Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat
Cell Metab BonDurant 25 4 935 2017 10.1016/j.cmet.2017.03.005 FGF21 regulates metabolism through adipose-dependent and -independent mechanisms
Rejuvenation Res Pucciarelli 15 6 590 2012 10.1089/rej.2012.1349 Spermidine and spermine are enriched in whole blood of nona/centenarians
Cortex Wirth 109 181 2018 10.1016/j.cortex.2018.09.014 The effect of spermidine on memory performance in older adults at risk for dementia: a randomized controlled trial
Am J Clin Nutr Kiechl 108 2 371 2018 10.1093/ajcn/nqy102 Higher spermidine intake is linked to lower mortality: a prospective population-based study
Rejuvenation Res Emanuele 17 6 518 2014 10.1089/rej.2014.1607 Can enhanced autophagy be associated with human longevity? Serum levels of the autophagy biomarker beclin-1 are increased in healthy centenarians
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
저자가 공개 리포지터리에 출판본, post-print, 또는 pre-print를 셀프 아카이빙 하여 자유로운 이용이 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.