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[해외논문] Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives

Journal of medicinal chemistry, v.64 no.20, 2021년, pp.14913 - 14929  

Shrestha, Aarajana (New Drug Development Center , Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) , Daegu 41061 , Republic of Korea) ,  Kim, Nayeon (New Drug Development Center , Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) , Daegu 41061 , Republic of Korea) ,  Lee, Su-Jeong (New Drug Development Center , Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) , Daegu 41061 , Republic of Korea) ,  Jeon, Yong Hyun (Laboratory Animal Center , Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) , Daegu 41061 , Republic of Korea) ,  Song, Ji-Joon (Department of Biological Sciences , Korea Advanced Institute of Science and Technology (KAIST) , Daejeon 34141 , Republic of Korea) ,  An, Hongchan ,  Cho, Sung Jin ,  Kadayat, Tara Man ,  Chin, Jungwook

Abstract AI-Helper 아이콘AI-Helper

Nuclear receptor-binding SET domain (NSD) proteins are a class of histone lysine methyltransferases (HKMTases) that are amplified, mutated, translocated, or overexpressed in various types of cancers. Several campaigns to develop NSD inhibitors for cancer treatment have begun following recent advance...

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