[논문]Silver Nanoparticles Induce Apoptosis Via Nox4 -Derived Mitochondrial Reactive Oxygen Species and Endoplasmic Reticulum Stress in Colorectal Cancer Cells

Quan, Juan-Hua; Gao, Fei Fei; Chu, Jia-Qi; Cha, Guang-Ho; Yuk, Jae-Min; Wu, Weiyun; Lee, Young-Ha

doi:10.2217/nnm-2021-0098

[해외논문] Silver Nanoparticles Induce Apoptosis Via Nox4 -Derived Mitochondrial Reactive Oxygen Species and Endoplasmic Reticulum Stress in Colorectal Cancer Cells

Nanomedicine, v.16 no.16, 2021년, pp.1357 - 1375

Quan, Juan-Hua (Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524-001, People’s Republic of China) , Gao, Fei Fei (Brain Korea 21 Four Project for Medical Science, Chungnam National University, Daejeon 35015, Korea) , Chu, Jia-Qi (Stem Cell Research & Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524-001, People’s Republic of China) , Cha, Guang-Ho (Departments of Medical Science and Department of Infection Biology, Chungnam National University College of Medicine, Daejeon 35015, Korea) , Yuk, Jae-Min (Brain Korea 21 Four Project for Medical Science, Chungnam National University, Daejeon 35015, Korea) , Wu, Weiyun (Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524-001, People’s Republic of China) , Lee, Young-Ha (Brain Korea 21 Four Project for Medical Science, Chungnam National University, Daejeon 35015, Korea)

Abstract ▼ AI-Helper

Aim: To investigate the anticancer mechanisms of silver nanoparticles (AgNPs) in colorectal cancer. Methods: Anticancer effects of AgNPs were determined in colorectal cancer HCT116 cells and xenograft mice using cellular and molecular methods. Results: AgNPs induced mitochondrial reactive oxygen species production, mitochondrial dysfunction and endoplasmic reticulum (ER) stress responses through NOX4 and led to HCT116 cell apoptosis. Pretreatment with DPI or 4-PBA significantly inhibited mitochondrial reactive oxygen species production, apoptosis, ER stress response, NOX4 expression and mitochondrial dysfunction in AgNP-treated HCT116 cells. AgNPs also significantly suppressed HCT116 cell-based xenograft tumor growth in nude mice by inducing apoptosis and ER stress responses. Conclusion: AgNPs exert anticancer effects against colorectal cancer via ROS- and ER stress-related mitochondrial apoptosis pathways.

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