[논문]G-749 Promotes Receptor Tyrosine Kinase TYRO3 Degradation and Induces Apoptosis in Both Colon Cancer Cell Lines and Xenograft Mouse Models

Kim, Hae Dong; Park, Eun Jung; Choi, Eun Kyoung; Song, Seuk Young; Hoe, Kwang-Lae; Kim, Dong-Uk

doi:10.3389/fphar.2021.730241

[해외논문] G-749 Promotes Receptor Tyrosine Kinase TYRO3 Degradation and Induces Apoptosis in Both Colon Cancer Cell Lines and Xenograft Mouse Models 원문보기

Frontiers in pharmacology, v.12, 2021년, pp.730241 -

Kim, Hae Dong (Rare Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon , South Korea) , Park, Eun Jung (Rare Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon , South Korea) , Choi, Eun Kyoung (Rare Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon , South Korea) , Song, Seuk Young (Rare Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon , South Korea) , Hoe, Kwang-Lae (Department of New Drug Development, Chungnam National University, Daejeon , South Korea) , Kim, Dong-Uk (Rare Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon , South Korea)

Abstract ▼ AI-Helper

G-749 is an FLT3 kinase inhibitor that was originally developed as a treatment for acute myeloid leukemia. Some FLT3 kinase inhibitors are dual kinase inhibitors that inhibit the TAM (Tyro3, Axl, Mer) receptor tyrosine kinase family and are used to treat solid cancers such as non-small cell lung cancer (NSCLC) and triple-negative breast cancer (TNBC). AXL promotes metastasis, suppression of immune response, and drug resistance in NSCLC and TNBC. G-749, a potential TAM receptor tyrosine kinase inhibitor, and its derivative SKI-G-801, effectively inhibits the phosphorylation of AXL at nanomolar concentration (IC50 = 20 nM). This study aimed to investigate the anticancer effects of G-749 targeting the TAM receptor tyrosine kinase in colon cancer. Here, we demonstrate the potential of G-749 to effectively inhibit tumorigenesis by degrading TYRO3 via regulated intramembrane proteolysis both in vitro and in vivo. In addition, we demonstrated that G-749 inhibits the signaling pathway associated with cell proliferation in colon cancer cell lines HCT15 and SW620, as well as tumor xenograft mouse models. We propose G-749 as a new therapeutic agent for the treatment of colon cancer caused by abnormal TYRO3 expression or activity.

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저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
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안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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