$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Müller glia 원문보기

eLife, v.10, 2021년, pp.e70079 -   

Lim, Soyeon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology Daejeon Republic of Korea) ,  Kim, You-Joung (Department of Biological Sciences, Korea Advanced Institute of Science and Technology Daejeon Republic of Korea) ,  Park, Sooyeon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology Daejeon Republic of Korea) ,  Choi, Ji-heon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology Daejeon Republic of Korea) ,  Sung, Young Hoon (Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University Yonsei Republic of Korea) ,  Nishimori, Katsuhiko (Department of Obesity and Internal Inflammation) ,  Kozmik, Zbynek (Bioregulation and Pharmacological Medicine, Fukushima Medical University Fukushima Japan) ,  Lee, Han-Woong (Institute of Molecular Genetics of the Czech Academy of Sciences Prague) ,  Kim, Jin Woo

Abstract AI-Helper 아이콘AI-Helper

Retinal progenitor cells (RPCs) divide in limited numbers to generate the cells comprising vertebrate retina. The molecular mechanism that leads RPC to the division limit, however, remains elusive. Here, we find that the hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) in an RPC...

참고문헌 (59)

  1. Agathocleous M Love NK Randlett O Harris JJ Liu J Murray AJ Harris WA 2012 Metabolic differentiation in the embryonic retina Nature Cell Biology 14 859 864 10.1038/ncb2531 22750943 

  2. Alexiades MR Cepko C 1996 Quantitative analysis of proliferation and cell cycle length during development of the rat retina Developmental Dynamics 205 293 307 10.1002/(SICI)1097-0177(199603)205:3<293::AID-AJA9>3.0.CO;2-D 8850565 

  3. Aydin IT Beermann F 2011 A mart-1::Cre transgenic line induces recombination in melanocytes and retinal pigment epithelium Genesis 49 403 409 10.1002/dvg.20725 21309074 

  4. Belanger MC Robert B Cayouette M 2017 Msx1-Positive Progenitors in the Retinal Ciliary Margin Give Rise to Both Neural and Non-neural Progenies in Mammals Developmental Cell 40 137 150 10.1016/j.devcel.2016.11.020 28011038 

  5. Ben-Sahra I Manning BD 2017 mTORC1 signaling and the metabolic control of cell growth Current Opinion in Cell Biology 45 72 82 10.1016/j.ceb.2017.02.012 28411448 

  6. Bernardi R Guernah I Jin D Grisendi S Alimonti A Teruya-Feldstein J Cordon-Cardo C Simon MC Rafii S Pandolfi PP 2006 PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR Nature 442 779 785 10.1038/nature05029 16915281 

  7. Calado RT Dumitriu B 2013 Telomere dynamics in mice and humans Seminars in Hematology 50 165 174 10.1053/j.seminhematol.2013.03.030 23956466 

  8. Cepko C 2014 Intrinsically different retinal progenitor cells produce specific types of progeny Nature Reviews. Neuroscience 15 615 627 10.1038/nrn3767 25096185 

  9. Cerychova R Pavlinkova G 2018 HIF-1, Metabolism, and Diabetes in the Embryonic and Adult Heart Frontiers in Endocrinology 9 460 10.3389/fendo.2018.00460 30158902 

  10. Choi J-H Jo HS Lim S Kim H-T Lee KW Moon KH Ha T Kwak SS Kim Y Lee EJ Joe CO Kim JW 2018 mTORC1 accelerates retinal development via the immunoproteasome Nature Communications 9 2502 10.1038/s41467-018-04774-9 29950673 

  11. Clark BS Stein-O’Brien GL Shiau F Cannon GH Davis-Marcisak E Sherman T Santiago CP Hoang TV Rajaii F James-Esposito RE Gronostajski RM Fertig EJ Goff LA Blackshaw S 2019 Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification Neuron 102 1111 1126 10.1016/j.neuron.2019.04.010 31128945 

  12. Cleal K Baird DM 2020 Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability Trends in Genetics 36 347 359 10.1016/j.tig.2020.02.001 32294415 

  13. Das G Clark AM Levine EM 2012 Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina Developmental Dynamics 241 941 952 10.1002/dvdy.23782 22434780 

  14. de Melo J Miki K Rattner A Smallwood P Zibetti C Hirokawa K Monuki ES Campochiaro PA Blackshaw S 2012 Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2 PNAS 109 4657 4662 10.1073/pnas.1107488109 22393024 

  15. Duvel K Yecies JL Menon S Raman P Lipovsky AI Souza AL Triantafellow E Ma Q Gorski R Cleaver S Vander Heiden MG MacKeigan JP Finan PM Clish CB Murphy LO Manning BD 2010 Activation of a metabolic gene regulatory network downstream of mTOR complex 1 Molecular Cell 39 171 183 10.1016/j.molcel.2010.06.022 20670887 

  16. Eagle RC Shields JA Shields CL Wood MG 2000 Hamartomas of the iris and ciliary epithelium in tuberous sclerosis complex Archives of Ophthalmology 118 711 715 10.1001/archopht.118.5.711 10815166 

  17. Fischer AJ Bosse JL El-Hodiri HM 2013 The ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye Experimental Eye Research 116 199 204 10.1016/j.exer.2013.08.018 24025744 

  18. Fuchs Y Steller H 2011 Programmed cell death in animal development and disease Cell 147 742 758 10.1016/j.cell.2011.10.033 22078876 

  19. Gao X Zhang Y Arrazola P Hino O Kobayashi T Yeung RS Ru B Pan D 2002 Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling Nature Cell Biology 4 699 704 10.1038/ncb847 12172555 

  20. Ha T Moon KH Dai L Hatakeyama J Yoon K Park HS Kong YY Shimamura K Kim JW 2017 The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina Cell Reports 19 351 363 10.1016/j.celrep.2017.03.040 28402857 

  21. Hagglund A-C Jones I Carlsson L 2017 A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development Disease Models & Mechanisms 10 245 257 10.1242/dmm.028605 28250050 

  22. Harris WA Perron M 1998 Molecular recapitulation: the growth of the vertebrate retina Tl J Dev Biol 42 299 304 

  23. He D Wu H Xiang J Ruan X Peng P Ruan Y Chen Y-G Wang Y Yu Q Zhang H Habib SL De Pinho RA Liu H Li B 2020 Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway Nature Communications 11 37 10.1038/s41467-019-13911-x 31896747 

  24. Hidema S Fukuda T Date S Tokitake Y Matsui Y Sasaki H Nishimori K 2016 Transgenic expression of Telomerase reverse transcriptase (Tert) improves cell proliferation of primary cells and enhances reprogramming efficiency into the induced pluripotent stem cell Bioscience, Biotechnology, and Biochemistry 80 1925 1933 10.1080/09168451.2016.1191330 27297181 

  25. Hoang T Wang J Boyd P Wang F Santiago C Jiang L Yoo S Lahne M Todd LJ Jia M Saez C Keuthan C Palazzo I Squires N Campbell WA Rajaii F Parayil T Trinh V Kim DW Wang G Campbell LJ Ash J Fischer AJ Hyde DR Qian J Blackshaw S 2020 Gene regulatory networks controlling vertebrate retinal regeneration Science 370 eabb8598 10.1126/science.abb8598 33004674 

  26. Homem CCF Repic M Knoblich JA 2015 Proliferation control in neural stem and progenitor cells Nature Reviews. Neuroscience 16 647 659 10.1038/nrn4021 26420377 

  27. Inoki K Li Y Zhu T Wu J Guan KL 2002 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nature Cell Biology 4 648 657 10.1038/ncb839 12172553 

  28. Ivan M Kondo K Yang H Kim W Valiando J Ohh M Salic A Asara JM Lane WS Kaelin WG Jr 2001 HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing Science 292 464 468 10.1126/science.1059817 11292862 

  29. Jaakkola P Mole DR Tian YM Wilson MI Gielbert J Gaskell SJ von Kriegsheim A Hebestreit HF Mukherji M Schofield CJ Maxwell PH Pugh CW Ratcliffe PJ 2001 Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Science 292 468 472 10.1126/science.1059796 11292861 

  30. Jorstad NL Wilken MS Grimes WN Wohl SG VandenBosch LS Yoshimatsu T Wong RO Rieke F Reh TA 2017 Stimulation of functional neuronal regeneration from Muller glia in adult mice Nature 548 103 107 10.1038/nature23283 28746305 

  31. Keith B Johnson RS Simon MC 2011 HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression Nature Reviews. Cancer 12 9 22 10.1038/nrc3183 22169972 

  32. Kim DH Sarbassov DD Ali SM King JE Latek RR Erdjument-Bromage H Tempst P Sabatini DM 2002 mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery Cell 110 163 175 10.1016/s0092-8674(02)00808-5 12150925 

  33. Kim Y Lim S Ha T Song Y-H Sohn Y-I Park D-J Paik S-S Kim-Kaneyama J-R Song M-R Leung A Levine EM Kim I-B Goo YS Lee S-H Kang KH Kim JW 2017 The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity eLife 6 e21303 10.7554/eLife.21303 28139974 

  34. Klimova L Lachova J Machon O Sedlacek R Kozmik Z 2013 Generation of mRx-Cre transgenic mouse line for efficient conditional gene deletion in early retinal progenitors PLOS ONE 8 e63029 10.1371/journal.pone.0063029 23667567 

  35. Kuilman T Michaloglou C Mooi WJ Peeper DS 2010 The essence of senescence Genes & Development 24 2463 2479 10.1101/gad.1971610 21078816 

  36. Lahne M Nagashima M Hyde DR Hitchcock PF 2020 Reprogramming Muller Glia to Regenerate Retinal Neurons Annual Review of Vision Science 6 171 193 10.1146/annurev-vision-121219-081808 32343929 

  37. Levine EM Close J Fero M Ostrovsky A Reh TA 2000 p27(Kip1) regulates cell cycle withdrawal of late multipotent progenitor cells in the mammalian retina Developmental Biology 219 299 314 10.1006/dbio.2000.9622 10694424 

  38. Lutty GA McLeod DS 2018 Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye Progress in Retinal and Eye Research 62 58 76 10.1016/j.preteyeres.2017.10.001 29081352 

  39. Madiraju AK Erion DM Rahimi Y Zhang X-M Braddock DT Albright RA Prigaro BJ Wood JL Bhanot S MacDonald MJ Jurczak MJ Camporez J-P Lee H-Y Cline GW Samuel VT Kibbey RG Shulman GI 2014 Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase Nature 510 542 546 10.1038/nature13270 24847880 

  40. Marcucci F Murcia-Belmonte V Wang Q Coca Y Ferreiro-Galve S Kuwajima T Khalid S Ross ME Mason C Herrera E 2016 The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells Cell Reports 17 3135 3164 10.1016/j.celrep.2016.11.016 

  41. Marquardt T Ashery-Padan R Andrejewski N Scardigli R Guillemot F Gruss P 2001 Pax6 is required for the multipotent state of retinal progenitor cells Cell 105 43 55 10.1016/S0092-8674(01)00295-1 11301001 

  42. Milea D Burillon C 1997 Aniridia in a patient with tuberous sclerosis British Journal of Ophthalmology 81 802c 10.1136/bjo.81.9.802c 

  43. Moon KH Kim HT Lee D Rao MB Levine EM Lim DS Kim JW 2018 Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development Developmental Cell 44 13 28 10.1016/j.devcel.2017.11.011 29249622 

  44. Mori M Metzger D Garnier JM Chambon P Mark M 2002 Site-specific somatic mutagenesis in the retinal pigment epithelium Vestigative Ophthalmology & Visual Science 43 1384 1388 11980850 

  45. Obernier K Alvarez-Buylla A 2019 Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain Development 146 dev156059 10.1242/dev.156059 30777863 

  46. Ohnuma S Harris WA 2003 Neurogenesis and the cell cycle Neuron 40 199 208 10.1016/S0896-6273(03)00632-9 14556704 

  47. Owen MR Doran E Halestrap AP 2000 Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain Biochemical Journal 348 607 614 10.1042/bj3480607 

  48. Rowan S Cepko CL 2004 Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter Developmental Biology 271 388 402 10.1016/j.ydbio.2004.03.039 15223342 

  49. Saint-Geniez M D’amore PA 2004 Development and pathology of the hyaloid, choroidal and retinal vasculature The International Journal of Developmental Biology 48 1045 1058 10.1387/ijdb.041895ms 15558494 

  50. Saxton RA Sabatini DM 2017 mTOR Signaling in Growth, Metabolism, and Disease Cell 169 361 371 10.1016/j.cell.2017.03.035 28388417 

  51. Shay JW 2016 Role of Telomeres and Telomerase in Aging and Cancer Cancer Discovery 6 584 593 10.1158/2159-8290.CD-16-0062 27029895 

  52. Srinivasan Y Lovicu FJ Overbeek PA 1998 Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts The Journal of Clinical Investigation 101 625 634 10.1172/JCI1360 9449696 

  53. Thien A Prentzell MT Holzwarth B Klasener K Kuper I Boehlke C Sonntag AG Ruf S Maerz L Nitschke R Grellscheid S-N Reth M Walz G Baumeister R Neumann-Haefelin E Thedieck K 2015 TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition Developmental Cell 32 617 630 10.1016/j.devcel.2015.01.026 25727005 

  54. Vander Heiden MG Cantley LC Thompson CB 2009 Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 1029 1033 10.1126/science.1160809 19460998 

  55. Varghese AJ Gulyas S Mohindra JK 1976 Hypoxia-dependent reduction of 1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol by Chinese hamster ovary cells and KHT tumor cells in vitro and in vivo Cancer Research 36 3761 3765 986241 

  56. Vaux DL Korsmeyer SJ 1999 Cell death in development Cell 96 245 254 10.1016/s0092-8674(00)80564-4 9988219 

  57. Wick AN Drury DR Nakada HI Wolfe JB 1957 Localization of the primary metabolic block produced by 2-deoxyglucose The Journal of Biological Chemistry 224 963 969 13405925 

  58. Willbold E Rothermel A Tomlinson S Layer PG 2000 Muller glia cells reorganize reaggregating chicken retinal cells into correctly laminated in vitro retinae Glia 29 45 57 10594922 

  59. Xie Y Zhao Y Shi L Li W Chen K Li M Chen X Zhang H Li T Matsuzawa-Ishimoto Y Yao X Shao D Ke Z Li J Chen Y Zhang X Cui J Cui S Leng Q Cadwell K Li X Wei H Zhang H Li H Xiao H 2020 Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer The Journal of Clinical Investigation 130 2111 2128 10.1172/JCI133264 31961824 

LOADING...

활용도 분석정보

상세보기
다운로드
내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

관련 콘텐츠

오픈액세스(OA) 유형

GOLD

오픈액세스 학술지에 출판된 논문

유발과제정보 저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로