[논문]Anti-Obesity Effects of Combined Cornus officinalis and Ribes fasciculatum Extract in High-Fat Diet-Induced Obese Male Mice

Park, Eunkuk; Lee, Chang-Gun; Jeon, Hyoju; Jeong, Hyesoo; Yeo, Subin; Yong, Yoonjoong; Jeong, Seon-Yong

doi:10.3390/ani11113187

[해외논문] Anti-Obesity Effects of Combined Cornus officinalis and Ribes fasciculatum Extract in High-Fat Diet-Induced Obese Male Mice 원문보기

Animals an open access journal from MDPI, v.11 no.11, 2021년, pp.3187 -

Park, Eunkuk (Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, Korea) , Lee, Chang-Gun (jude0815@hotmail.com (E.P.)) , Jeon, Hyoju (dangsunsang@naver.com (C.-G.L.)) , Jeong, Hyesoo (wjsgywn0315@ajou.ac.kr (H.J.)) , Yeo, Subin (Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, Korea) , Yong, Yoonjoong (jude0815@hotmail.com (E.P.)) , Jeong, Seon-Yong (dangsunsang@naver.com (C.-G.L.))

Abstract ▼ AI-Helper

Simple SummaryObesity is a general health problem representing a high risk factor for a low-quality lifestyle. Various Food and Drug Administration-approved pharmacological medications have been established for the treatment and prevention of obesity. However, some pharmacotherapies present adverse effects and limited long-term use. Natural herbal medicines as alternative cures have shown low side-effects and suitability for long-term treatment. Cornus officinalis and Ribes fasciculatum (CR) are well-known oriental plants used for health dietary supplements and herbal medicine. This study examined the anti-obesity effect of CR in high-fat diet (HFD)-induced obese male mice. Treatment of CR extract prevented body weight gain through the downregulation of adipogenic inducible genes and recovered the dysregulated energy metabolism in HFD-induced obese male mice. Therefore, CR reduced elevated biochemical obesity parameters in plasma, as well as inhibited hepatic steatosis in the liver and adipocyte size increase in fat tissue. These findings of the study reveal the potential anti-obesity effects of CR as an herbal medicine.AbstractMedicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of Cornus officinalis and Ribes fasciculatum (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.

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참고문헌 (48)

1. Thaker V.V. Genetic and Epigenetic Causes of Obesity Adolesc. Med. State Art Rev. 2017 28 379 405 30416642
2. Aleksandar K. Social causes of obesity Med. Pregl. 1986 39 591 592 3614116
3. Kotsis V. Stabouli S. Papakatsika S. Rizos Z. Parati G. Mechanisms of obesity-induced hypertension Hypertens. Res. 2010 33 386 393 10.1038/hr.2010.9 20442753

상세보기
4. Ezquerra E.A. Vazquez J.M.C. Barrero A.A. Obesity, metabolic syndrome and diabetes: Cardiovascular implications and therapy Rev. Esp. Cardiol. 2008 61 752 764 10.1157/13123996 18590648

상세보기
5. Hall K.D. Kahan S. Maintenance of Lost Weight and Long-Term Management of Obesity Med. Clin. N. Am. 2018 102 183 197 10.1016/j.mcna.2017.08.012 29156185

상세보기
6. Yanovski S.Z. Yanovski J.A. Long-term drug treatment for obesity: A systematic and clinical review JAMA 2014 311 74 86 10.1001/jama.2013.281361 24231879

상세보기
7. Yuan H. Ma Q. Ye L. Piao G. The Traditional Medicine and Modern Medicine from Natural Products Molecules 2016 21 559 10.3390/molecules21050559 27136524

상세보기
8. Barnes J. McLachlan A.J. Sherwin C.M. Enioutina E.Y. Herbal medicines: Challenges in the modern world. Part 1. Australia and New Zealand Expert Rev. Clin. Pharmacol. 2016 9 905 915 10.1586/17512433.2016.1171712 27070431

상세보기
9. Sammons H.M. Gubarev M.I. Krepkova L.V. Bortnikova V.V. Corrick F. Job K.M. Sherwin C.M. Enioutina E.Y. Herbal medicines: Challenges in the modern world. Part 2. European Union and Russia Expert Rev. Clin. Pharmacol. 2016 9 1117 1127 10.1080/17512433.2016.1189326 27171366

상세보기
10. Lee Y.H. Jin B. Lee S. Oh J.-Y. Song J. Lee D. Kim Y.-S. Kim H. A herbal formula HT051, a combination of Pueraria lobata and Rehmannia glutinosa, Prevents postmenopausal obesity in ovariectomized rats Evid. Based Complement. Altern. Med. 2017 2017 8641535 10.1155/2017/8641535

상세보기
11. Yinghong L. Ming K.J. Sai C.L. Khang G.N. Synergistic Effect of Traditional Chinese Medicine Asian J. Chem. 2007 19 867

상세보기
12. Park E. Ryu M.J. Kim N.K. Bae M.H. Seo Y. Kim J. Yeo S. Kanwal M. Choi C.W. Heo J.Y. Synergistic Neuroprotective Effect of Schisandra chinensis and Ribes fasciculatum on Neuronal Cell Death and Scopolamine-Induced Cognitive Impairment in Rats Int. J. Mol. Sci. 2019 20 4517 10.3390/ijms20184517 31547274

상세보기
13. Mechesso A.F. Lee S.J. Park N.H. Kim J.Y. Im Z.E. Suh J.W. Park S.C. Preventive effects of a novel herbal mixture on atopic dermatitis-like skin lesions in BALB/C mice BMC Complement. Altern. Med. 2019 19 25 10.1186/s12906-018-2426-z 30658631

상세보기
14. Quah Y. Lee S.J. Lee E.B. Birhanu B.T. Ali M.S. Abbas M.A. Boby N. Im Z.E. Park S.C. Cornus officinalis Ethanolic Extract with Potential Anti-Allergic, Anti-Inflammatory, and Antioxidant Activities Nutrients 2020 12 3317 10.3390/nu12113317

상세보기
15. Sangsefidi Z.S. Yarhosseini F. Hosseinzadeh M. Ranjbar A. Akhondi-Meybodi M. Fallahzadeh H. Mozaffari-Khosravi H. The effect of ( Cornus mas L.) fruit extract on liver function among patients with nonalcoholic fatty liver: A double-blind randomized clinical trial Phytother. Res. PTR 2021 35 5259 5268 10.1002/ptr.7199 34254372

상세보기
16. Jeon H. Cha D.S. Anti-aging properties of Ribes fasciculatum in Caenorhabditis elegans Chin. J. Nat. Med. 2016 14 335 342 10.3724/SP.J.1009.2016.00335 27478096

상세보기
17. Jung J.W. Kim S.J. Ahn E.M. Oh S.R. Lee H.J. Jeong J.A. Lee J.Y. Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro Biomol. Ther. 2014 22 547 552 10.4062/biomolther.2014.015

원문보기 상세보기
18. Park E. Lim E. Yeo S. Yong Y. Yang J. Jeong S.Y. Anti-Menopausal Effects of Cornus officinalis and Ribes fasciculatum Extract In Vitro and In Vivo Nutrients 2020 12 369 10.3390/nu12020369

상세보기
19. Park E. Lee C.G. Jeong H. Yeo S. Kim J.A. Jeong S.Y. Antiadipogenic Effects of Mixtures of Cornus officinalis and Ribes fasciculatum Extracts on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Mice Molecules 2020 25 2350 10.3390/molecules25102350

상세보기
20. Park E. Lee C.G. Kim J. Kang J.H. Cho Y.G. Jeong S.Y. Efficacy and Safety of Combined Extracts of Cornus officinalis and Ribes fasciculatum for Body Fat Reduction in Overweight Women J. Clin. Med. 2020 9 3629 10.3390/jcm9113629

상세보기
21. Lin I.T. Lee M.Y. Wang C.W. Wu D.W. Chen S.C. Gender Differences in the Relationships among Metabolic Syndrome and Various Obesity-Related Indices with Nonalcoholic Fatty Liver Disease in a Taiwanese Population Int. J. Environ. Res. Public Health 2021 18 857 10.3390/ijerph18030857 33498329

상세보기
22. Kroll D.S. Feldman D.E. Biesecker C.L. McPherson K.L. Manza P. Joseph P.V. Volkow N.D. Wang G.J. Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission Nutrients 2020 12 1942 10.3390/nu12071942 32629783

상세보기
23. Golay A. Bobbioni E. The role of dietary fat in obesity Int. J. Obes. Relat. Metab. Disord. 1997 21 (Suppl. S3) S2 S11
24. Hariri N. Thibault L. High-fat diet-induced obesity in animal models Nutr. Res. Rev. 2010 23 270 299 10.1017/S0954422410000168 20977819

상세보기
25. Blaak E. Gender differences in fat metabolism Curr. Opin. Clin. Nutr. Metab. Care 2001 4 499 502 10.1097/00075197-200111000-00006 11706283

상세보기
26. Andrikopoulos S. Blair A.R. Deluca N. Fam B.C. Proietto J. Evaluating the glucose tolerance test in mice Am. J. Physiol. Endocrinol. Metab. 2008 295 E1323 E1332 10.1152/ajpendo.90617.2008 18812462

상세보기
27. Nagy C. Einwallner E. Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT) J. Vis. Exp. 2018 131 e56672 10.3791/56672

상세보기
28. Wilcox G. Insulin and insulin resistance Clin. Biochem. Rev. 2005 26 19 39 16278749

상세보기
29. Rutter G.A. Insulin secretion: Fatty acid signalling via serpentine receptors Curr. Biol. 2003 13 R403 R405 10.1016/S0960-9822(03)00322-1 12747853

상세보기
30. Pedro P.F. Tsakmaki A. Bewick G.A. The Glucose Tolerance Test in Mice Methods Mol. Biol. 2020 2128 207 216 10.1007/978-1-0716-0385-7_14 32180195
31. Cozar-Castellano I. Perdomo G. Assessment of Insulin Tolerance In Vivo in Mice Methods Mol. Biol. 2020 2128 217 224 10.1007/978-1-0716-0385-7_15 32180196
32. Winzell M.S. Ahren B. The high-fat diet-fed mouse: A model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes Diabetes 2004 53 (Suppl. S3) S215 S219 10.2337/diabetes.53.suppl_3.S215 15561913

상세보기
33. Gerber L. Otgonsuren M. Mishra A. Escheik C. Birerdinc A. Stepanova M. Younossi Z.M. Non-alcoholic fatty liver disease (NAFLD) is associated with low level of physical activity: A population-based study Aliment. Pharmacol. Ther. 2012 36 772 781 10.1111/apt.12038 22958053

상세보기
34. Salmela P.I. Sotaniemi E.A. Niemi M. Maentausta O. Liver function tests in diabetic patients Diabetes Care 1984 7 248 254 10.2337/diacare.7.3.248 6734394

상세보기
35. Saligram S. Williams E.J. Masding M.G. Raised liver enzymes in newly diagnosed Type 2 diabetes are associated with weight and lipids, but not glycaemic control Indian J. Endocrinol. Metab. 2012 16 1012 1014 10.4103/2230-8210.103027 23226654

상세보기
36. Czech M.P. Insulin action and resistance in obesity and type 2 diabetes Nat. Med. 2017 23 804 814 10.1038/nm.4350 28697184

상세보기
37. Al-Jameil N. Khan F.A. Arjumand S. Khan M.F. Tabassum H. Associated liver enzymes with hyperlipidemic profile in type 2 diabetes patients Int. J. Clin. Exp. Pathol. 2014 7 4345 4349 25120819

상세보기
38. Berndt J. Kovacs P. Ruschke K. Kloting N. Fasshauer M. Schon M.R. Korner A. Stumvoll M. Bluher M. Fatty acid synthase gene expression in human adipose tissue: Association with obesity and type 2 diabetes Diabetologia 2007 50 1472 1480 10.1007/s00125-007-0689-x 17492427

상세보기
39. McManaman J.L. Bales E.S. Orlicky D.J. Jackman M. MacLean P.S. Cain S. Crunk A.E. Mansur A. Graham C.E. Bowman T.A. Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease J. Lipid Res. 2013 54 1346 1359 10.1194/jlr.M035063 23402988

상세보기
40. Heyde I. Begemann K. Oster H. Contributions of white and brown adipose tissues to the circadian regulation of energy metabolism Endocrinology 2021 162 bqab009 10.1210/endocr/bqab009 33453099

상세보기
41. Moreno-Fernandez S. Garces-Rimon M. Vera G. Astier J. Landrier J.F. Miguel M. High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model Nutrients 2018 10 1502 10.3390/nu10101502

상세보기
42. Lancaster G.I. Henstridge D.C. Body Composition and Metabolic Caging Analysis in High Fat Fed Mice J. Vis. Exp. 2018 135 57280 10.3791/57280 29889190

상세보기
43. Singer P. Simple equations for complex physiology: Can we use VCO2 for calculating energy expenditure? Crit. Care 2016 20 72 10.1186/s13054-016-1251-3 26997171

상세보기
44. Marvyn P.M. Bradley R.M. Mardian E.B. Marks K.A. Duncan R.E. Data on oxygen consumption rate, respiratory exchange ratio, and movement in C57BL/6J female mice on the third day of consuming a high-fat diet Data Brief 2016 7 472 475 10.1016/j.dib.2016.02.066 27014733

상세보기
45. Panzhinskiy E. Hua Y. Lapchak P.A. Topchiy E. Lehmann T.E. Ren J. Nair S. Novel curcumin derivative CNB-001 mitigates obesity-associated insulin resistance J. Pharmacol. Exp. Ther. 2014 349 248 257 10.1124/jpet.113.208728 24549372

상세보기
46. Kendig S. Implications for policy to support healthy weight for women J. Obstet. Gynecol. Neonatal Nurs. 2015 44 793 801 10.1111/1552-6909.12752 26402435

상세보기
47. Power M.L. Schulkin J. Sex differences in fat storage, fat metabolism, and the health risks from obesity: Possible evolutionary origins Br. J. Nut. 2008 99 931 940 10.1017/S0007114507853347

상세보기
48. White M.C. Miller A.J. Loloi J. Bingaman S.S. Shen B. Wang M. Silberman Y. Lindsey S.H. Arnold A.C. Sex differences in metabolic effects of angiotensin-(1–7) treatment in obese mice Biol. Sex Differ. 2019 10 36 10.1186/s13293-019-0251-9 31315689

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