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Journal of the American Chemical Society, v.144 no.46, 2022년, pp.21096 - 21102
Meyer, Samantha M. (Department of Chemistry , UF Scripps Biomedical Research and The Scripps Research Institute , Jupiter , Florida 33458 , United States) , Tanaka, Toru (Department of Chemistry , UF Scripps Biomedical Research and The Scripps Research Institute , Jupiter , Florida 33458 , United States) , Zanon, Patrick R. A. (Department of Chemistry , UF Scripps Biomedical Research and The Scripps Research Institute , Jupiter , Florida 33458 , United States) , Baisden, Jared T. (Department of Chemistry , UF Scripps Biomedical Research and The Scripps Research Institute , Jupiter , Florida 33458 , United States) , Abegg, Daniel (Department of Chemistry , UF Scripps Biomedical Research and The Scripps Research Institute , Jupiter , Florida 33458 , United States) , Yang, Xueyi (Department of Chemistry , UF Scripps Biomedical Research and The Scripps Research Institute , Jupiter , Florida 33458 , United States United) , Akahori, Yoshihiro , Alshakarchi, Zainab , Cameron, Michael D. , Adibekian, Alexander , Disney, Matthew D.
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Ribonuclease targeting chimeras (RiboTACs) induce degradation of an RNA target by facilitating an interaction between an RNA and a ribonuclease (RNase). We describe the screening of a DNA-encoded library (DEL) to identify binders of monomeric RNase L to provide a compound that induced dimerization o...
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