참고문헌 (45)

1. Gems D Is “cellular senescence” a misnomer? Geroscience 2022 44 5 2461 Gems D, Kern CC. Is “cellular senescence” a misnomer? Geroscience 2022; 44(5): 2461-2469. https://doi.org/10.1007/s11357-022-00652-x. 

2. Tchkonia T Cellular senescence and the senescent secretory phenotype: therapeutic opportunities J Clin Invest 2013 123 3 966 Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest 2013; 123(3): 966-972. https://doi.org/10.1172/JCI64098. 

3. Lopez-Otin C The hallmarks of aging Cell 2013 153 6 1194 Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell 2013; 153(6): 1194-1217. https://doi.org/10.1016/j.cell.2013.05.039. 

4. Gorgoulis V Cellular senescence: defining a path forward Cell 2019 179 4 813 Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular senescence: defining a path forward. Cell 2019; 179(4): 813-827. https://doi.org/10.1016/j.cell.2019.10.005. 

5. Mylonas A Cellular senescence and ageing: mechanisms and interventions Front Aging 2022 3 Mylonas A, O'Loghlen A. Cellular senescence and ageing: mechanisms and interventions. Front Aging 2022; 3: 866718. https://doi.org/10.3389/fragi.2022.866718. 

6. Xu M Senolytics improve physical function and increase lifespan in old age Nat Med 2018 24 8 1246 Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, et al. Senolytics improve physical function and increase lifespan in old age. Nat Med 2018; 24(8): 1246-1256. https://doi.org/10.1038/s41591-018-0092-9. 

7. Zhu Y The Achilles' heel of senescent cells: from transcriptome to senolytic drugs Aging Cell 2015 14 4 644 Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 2015; 14(4): 644-658. https://doi.org/10.1111/acel.12344. 

8. Justice JN Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study EBioMedicine 2019 40 554 Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, et al. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study. EBioMedicine 2019; 40: 554-563. https://doi.org/10.1016/j.ebiom.2018.12.052. 

9. Hense JD Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary Geroscience 2022 44 3 1747 Hense JD, Garcia DN, Isola JV, Alvarado-Rincon JA, Zanini BM, Prosczek JB, et al. Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary. Geroscience 2022; 44(3): 1747-1759. https://doi.org/10.1007/s11357-022-00573-9. 

10. Harris ID Fertility and the aging male Rev Urol 2011 13 4 e184 Harris ID, Fronczak C, Roth L, Meacham RB. Fertility and the aging male. Rev Urol 2011; 13(4): e184-e190. 

11. Oliveira JBA The effects of age on sperm quality: an evaluation of 1,500 semen samples JBRA Assist Reprod 2014 18 2 34 Oliveira JBA, Petersen CG, Mauri AL, Vagnini LD, Baruffi RLR, Franco JG Jr. The effects of age on sperm quality: an evaluation of 1,500 semen samples. JBRA Assist Reprod 2014; 18(2): 34-41. https://doi.org/10.5935/1518-0557.20140002. 

12. Smith LB The regulation of spermatogenesis by androgens Semin Cell Dev Biol 2014 30 2 Smith LB, Walker WH. The regulation of spermatogenesis by androgens. Semin Cell Dev Biol 2014; 30: 2-13. https://doi.org/10.1016/j.semcdb.2014.02.012. 

13. Kenyon CJ The genetics of ageing Nature 2010 464 7288 504 Kenyon CJ. The genetics of ageing. Nature 2010; 464(7288): 504-512. https://doi.org/10.1038/nature08980. 

14. Garcia DN Effect of caloric restriction and rapamycin on ovarian aging in mice Geroscience 2019 41 4 395 Garcia DN, Saccon TD, Pradiee J, Rincon JAA, Andrade KRS, Rovani MT, et al. Effect of caloric restriction and rapamycin on ovarian aging in mice. Geroscience 2019; 41(4): 395-408. https://doi.org/10.1007/s11357-019-00087-x. 

15. Chen H Aging and caloric restriction: effects on Leydig cell steroidogenesis Exp Gerontol 2005 40 6 498 Chen H, Luo L, Liu J, Brown T, Zirkin BR. Aging and caloric restriction: effects on Leydig cell steroidogenesis. Exp Gerontol 2005; 40(6): 498-505. https://doi.org/10.1016/j.exger.2005.03.011. 

16. Sitzmann BD Effects of moderate calorie restriction on testosterone production and semen characteristics in young rhesus macaques (Macaca mulatta) Biol Reprod 2010 83 4 635 Sitzmann BD, Leone EH, Mattison JA, Ingram DK, Roth GS, Urbanski HF, et al. Effects of moderate calorie restriction on testosterone production and semen characteristics in young rhesus macaques (Macaca mulatta). Biol Reprod 2010; 83(4): 635-640. https://doi.org/10.1095/biolreprod.110.084186. 

17. Martins AD Caloric restriction alters the hormonal profile and testicular metabolome, resulting in alterations of sperm head morphology Am J Physiol Endocrinol Metab 2020 318 1 E33 Martins AD, Jarak I, Morais T, Carvalho RA, Oliveira PF, Monteiro MP, et al. Caloric restriction alters the hormonal profile and testicular metabolome, resulting in alterations of sperm head morphology. Am J Physiol Endocrinol Metab 2020; 318(1): E33-E43. https://doi.org/10.1152/ajpendo.00355.2019. 

18. Bitto A Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice Elife 2016 5 Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, et al. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife 2016; 5: e16351. https://doi.org/10.7554/eLife.16351. 

19. Jesus TT Mammalian target of rapamycin (mTOR): a central regulator of male fertility? Crit Rev Biochem Mol Biol 2017 52 3 235 Jesus TT, Oliveira PF, Sousa M, Cheng CY, Alves MG. Mammalian target of rapamycin (mTOR): a central regulator of male fertility? Crit Rev Biochem Mol Biol 2017; 52(3): 235-253. https://doi.org/10.1080/10409238.2017.1279120. 

20. Khaki A Beneficial effects of quercetin on sperm parameters in streptozotocin-induced diabetic male rats Phytother Res 2010 24 9 1285 Khaki A, Fathiazad F, Nouri M, Khaki A, Maleki NA, Khamnei HJ, et al. Beneficial effects of quercetin on sperm parameters in streptozotocin-induced diabetic male rats. Phytother Res 2010; 24(9): 1285-1291. https://doi.org/10.1002/ptr.3100. 

21. Ramu S The hypo-osmotic swelling test for evaluation of sperm membrane integrity Methods Mol Biol 2013 10.1007/978-1-62703-038-0_3 927 21 Ramu S, Jeyendran RS. The hypo-osmotic swelling test for evaluation of sperm membrane integrity. Methods Mol Biol 2013; 927: 21-25. https://doi.org/10.1007/978-1-62703-038-0_3. 

    

22. Agarwal A Hypoosmotic swelling test (HOS) Andrological evaluation of male infertility 2016 93 Agarwal A, Gupta S, Sharma R. Hypoosmotic swelling test (HOS). In: Andrological evaluation of male infertility. Springer International Publishing 2016; 93-96. https://doi.org/10.1007/978-3-319-26797-5_12. 

23. Wu Y Expression of flotilin-2 and acrosome biogenesis are regulated by MiR-124 during spermatogenesis PLoS One 2015 10 8 Wu Y, Zhong A, Zheng H, Jiang M, Xia Z, Yu J, et al. Expression of flotilin-2 and acrosome biogenesis are regulated by MiR-124 during spermatogenesis. PLoS One 2015; 10(8): e0136671. https://doi.org/10.1371/journal.pone.0136671. 

24. Isola JVV 17α-estradiol does not adversely affect sperm parameters or fertility in male mice: implications for reproduction-longevity trade-offs Geroscience 2022 Isola JVV, Veiga GB, de Brito CRC, Alvarado-Rincon JA, Garcia DN, Zanini BM, et al. 17α-estradiol does not adversely affect sperm parameters or fertility in male mice: implications for reproduction-longevity trade-offs. Geroscience 2022. https://doi.org/10.1007/s11357-022-00601-8. 

25. Snyder AN Histology, lipofuscin 2019 Snyder AN, Crane JS. Histology, lipofuscin. [Internet]. Treasure Island, FL: StatPearls Publishing; 2019. [updated 2022 May 8; cited 2023 Jan 25]. Available at: https://www.ncbi.nlm.nih.gov/books/NBK537358/. 

26. Evangelou K Sudan Black B, the specific histochemical stain for lipofuscin: a novel method to detect senescent cells Methods Mol Biol 2017 10.1007/978-1-4939-6670-7_10 1534 111 Evangelou K, Gorgoulis VG. Sudan Black B, the specific histochemical stain for lipofuscin: a novel method to detect senescent cells. Methods Mol Biol 2017; 1534: 111-119. https://doi.org/10.1007/978-1-4939-6670-7_10. 

    

27. Vandesompele J Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biol 2002 3 7 Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3(7): research0034. https://doi.org/10.1186/gb-2002-3-7-research0034. 

28. Fuhrmann-Stroissnigg H SA-β-galactosidase-based screening assay for the identification of senotherapeutic drugs J Vis Exp 2019 148 Fuhrmann-Stroissnigg H, Santiago FE, Grassi D, Ling YY, Niedernhofer LJ, Robbins PD. SA-β-galactosidase-based screening assay for the identification of senotherapeutic drugs. J Vis Exp 2019; 148: e58133. https://doi.org/10.3791/58133. 

29. Cai Y Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice Cell Res 2020 30 7 574 Cai Y, Zhou H, Zhu Y, Sun Q, Ji Y, Xue A, et al. Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice. Cell Res 2020; 30(7): 574-589. https://doi.org/10.1038/s41422-020-0314-9. 

30. Dungan CM Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice Aging Cell 2022 21 1 Dungan CM, Murach KA, Zdunek CJ, Tang ZJ, VonLehmden GL, Brightwell CR, et al. Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice. Aging Cell 2022; 21(1): e13528. https://doi.org/10.1111/acel.13528. 

31. Cheng CY The blood-testis barrier and its implications for male contraception Pharmacol Rev 2012 64 1 16 Cheng CY, Mruk DD. The blood-testis barrier and its implications for male contraception. Pharmacol Rev 2012; 64(1): 16-64. https://doi.org/10.1124/pr.110.002790. 

32. Yule TD Role of testicular autoantigens and influence of lymphokines in testicular autoimmune disease J Reprod Immunol 1990 18 1 89 Yule TD, Mahi-Brown CA, Tung KS. Role of testicular autoantigens and influence of lymphokines in testicular autoimmune disease. J Reprod Immunol 1990; 18(1): 89-103. https://doi.org/10.1016/0165-0378(90)90026-3. 

33. Georgakopoulou EA Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues Aging (Albany NY) 2013 5 1 37 Georgakopoulou EA, Tsimaratou K, Evangelou K, Fernandez Marcos PJ, Zoumpourlis V, Trougakos IP, et al. Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Albany NY) 2013; 5(1): 37-50. https://doi.org/10.18632/aging.100527. 

34. Nistal M Testicular changes in Elderly men Clues in the diagnosis of non-tumoral testicular pathology 2017 349 Nistal M, González-Peramato P, Serrano Á. Testicular changes in Elderly men. In: Clues in the diagnosis of non-tumoral testicular pathology. Cham: Springer International Publishing 2017; 349-361. https://doi.org/10.1007/978-3-319-49364-0_39. 

35. Ansere VA Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion Mech Ageing Dev 2021 194 Ansere VA, Ali-Mondal S, Sathiaseelan R, Garcia DN, Isola JVV, Henseb JD, et al. Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion. Mech Ageing Dev 2021; 194: 111425. https://doi.org/10.1016/j.mad.2020.111425. 

36. Hudgins AD Age- and tissue-specific expression of senescence biomarkers in mice Front Genet 2018 9 59 Hudgins AD, Tazearslan C, Tare A, Zhu Y, Huffman D, Suh Y. Age- and tissue-specific expression of senescence biomarkers in mice. Front Genet 2018; 9: 59. https://doi.org/10.3389/fgene.2018.00059. 

37. Martin LJ Improvement of testicular steroidogenesis using flavonoids and isoflavonoids for prevention of late-onset male hypogonadism Antioxidants (Basel) 2020 9 3 237 Martin LJ, Touaibia M. Improvement of testicular steroidogenesis using flavonoids and isoflavonoids for prevention of late-onset male hypogonadism. Antioxidants (Basel) 2020; 9(3): 237. https://doi.org/10.3390/antiox9030237. 

38. Holdcraft RW Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids Development 2004 131 2 459 Holdcraft RW, Braun RE. Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development 2004; 131(2): 459-467. https://doi.org/10.1242/dev.00957. 

39. Katragadda V Testosterone recuperates deteriorated male fertility in cypermethrin intoxicated rats Toxicol Res 2021 37 1 125 Katragadda V, Adem M, Mohammad RA, Sri Bhasyam S, Battini K. Testosterone recuperates deteriorated male fertility in cypermethrin intoxicated rats. Toxicol Res 2021; 37(1): 125-134. https://doi.org/10.1007/s43188-020-00046-1. 

40. Gilbert SF Developmental biology 2000 Gilbert SF. Developmental biology, 6th ed. Sunderland, Mass., Bethesda, MD, USA: Sinauer Associates; 2000. Available at: https://www.ncbi.nlm.nih.gov/books/NBK9983/. 

41. Ozkosem B Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice Redox Biol 2015 5 15 Ozkosem B, Feinstein SI, Fisher AB, O'Flaherty C. Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice. Redox Biol 2015; 5: 15-23. https://doi.org/10.1016/j.redox.2015.02.004. 

42. Anand David AV Overviews of biological importance of quercetin: a bioactive flavonoid Pharmacogn Rev 2016 10 20 84 Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacogn Rev 2016; 10(20): 84-89. https://doi.org/10.4103/0973-7847.194044. 

43. Desai N Free radical theory of aging: implications in male infertility Urology 2010 75 1 14 Desai N, Sabanegh E Jr., Kim T, Agarwal A. Free radical theory of aging: implications in male infertility. Urology 2010; 75(1): 14-19. https://doi.org/10.1016/j.urology.2009.05.025. 

44. Ranawat P Quercetin impairs the reproductive potential of male mice Andrologia 2013 45 1 56 Ranawat P, Kaushik G, Saikia UN, Pathak CM, Khanduja KL. Quercetin impairs the reproductive potential of male mice. Andrologia 2013; 45(1): 56-65. https://doi.org/10.1111/j.1439-0272.2012.01311.x. 

45. Caocci G Gynecomastia in a male after dasatinib treatment for chronic myeloid leukemia Leukemia 2008 22 11 2127 Caocci G, Atzeni S, Orru N, Azzena L, Martorana L, Littera R, et al. Gynecomastia in a male after dasatinib treatment for chronic myeloid leukemia. Leukemia 2008; 22(11): 2127-2128. https://doi.org/10.1038/leu.2008.106.