$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Impact of Preimmunization on Adenoviral Vector Expression and Toxicity in a Subcutaneous Mouse Cancer Model 원문보기

Molecular therapy : the journal of the American Society of Gene Therapy, v.6 no.3, 2002년, pp.342 - 348  

Vlachaki, Maria T (Department of Radiology, Baylor College of Medicine, Houston, Texas, 77030, USA) ,  Hernandez-Garcia, Andres (Department of Radiology, Baylor College of Medicine, Houston, Texas, 77030, USA) ,  Ittmann, Michael (Department of Pathology, Baylor College of Medicine, Houston, Texas, 77030, USA) ,  Chhikara, Madhu (Advantagene, Inc. San Diego, California, 92126, USA) ,  Aguilar, Laura K (Harvard Gene Therapy Initiative, Harvard Medical School, Boston, Massachussets, 02115, USA) ,  Zhu, Xiaohong (Department of Radiology, Baylor College of Medicine, Houston, Texas, 77030, USA) ,  The, Bin S (Department of Radiology, Baylor College of Medicine, Houston, Texas, 77030, USA) ,  Butler, E.Brian (Department of Radiology, Baylor College of Medicine, Houston, Texas, 77030, USA) ,  Woo, Shiao (Department of Radiology, Baylor College of Medicine, Houston, Texas, 77030, USA) ,  Thompson, Timothy C (Department of Radiology, Baylor College of Medicine, Houston, Texas, 77030, USA) ,  Barrera-Saldana, Hugo (Department of Biochemistry, Medical School, University of Nuevo Leon, Nuevo Leon, Mexico) ,  Aguilar-Cordova, Estuardo (Harvard Gene Therapy Initiative, Harvard Medical School, Boston, Massachussets, 02115, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractImmune responses against adenoviral vectors may influence the toxicity and therapeutic effectiveness of adenovirus-mediated gene transfer and may be a limiting factor in adenovirus-mediated gene therapy. The purpose of this study was to determine the effects of preimmunization on intratumora...

참고문헌 (24)

  1. Horwitz, M. S.1996. Adenoviruses. In Fields VirologyB. Fields, D. M. Knipe, and P. M. Howley, Eds., pp. 2149-2171. Lippincott, Philadelphia. 

  2. Adv. Drug Deliv. Rev. Trapnell 12 185 1993 10.1016/0169-409X(93)90059-D Adenoviral vectors for gene transfer 

  3. Gene Ther. Cichon 8 1794 2001 10.1038/sj.gt.3301611 Complement activation by recombinant adenoviruses 

  4. Hum. Gene Ther. Raper 13 163 2002 10.1089/10430340152712719 A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency 

  5. Hum. Gene Ther. Herman 10 1239 1999 10.1089/10430349950018229 In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial 

  6. Int. J. Radiat. Oncol. Biol. Phys. Vlachaki 51 1008 2001 10.1016/S0360-3016(01)01698-4 Enhanced therapeutic effect of multiple injections of HSV-TK+GCV gene therapy in combination with ionizing radiation in a mouse mammary tumor model 

  7. Int. J. Radiat. Oncol. Biol. Phys. Teh 51 605 2001 10.1016/S0360-3016(01)01692-3 Phase I-II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer-a preliminary report 

  8. Hum. Gene Ther. Miles 12 1955 2001 10.1089/104303401753204535 Prostate-specific antigen response and systemic T cell activation after in situ gene therapy in prostate cancer therapy failing radiotherapy 

  9. Hum. Gene Ther. Morral 8 1275 1997 10.1089/hum.1997.8.10-1275 Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: comparison of E2a wild type and E2a deleted vectors 

  10. Gene Ther. Bramson 4 1069 1997 10.1038/sj.gt.3300508 Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination 

  11. Hum. Gene Ther. Morral 13 143 2002 10.1089/10430340152712692 Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons 

  12. Hum. Gene Ther. Molnar-Kimber 9 2121 1998 10.1089/hum.1998.9.14-2121 Impact of preexisting and induced humoral and cellular immune responses in an adenovirus-based gene therapy phase I clinical trial for localized mesothelioma 

  13. Oncol. Res. Thompson 11 1 1999 In situ gene therapy for prostate cancer 

  14. J. Urol. Shalev 163 1747 2000 10.1016/S0022-5347(05)67534-9 Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer 

  15. Gene Ther. Yang 3 412 1996 Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver 

  16. Lab. Invest. Sun 63 467 1990 Two rat models of hepatic fibrosis. a morphologic and molecular comparison 

  17. J. Virol. Clabough 65 6242 1991 10.1128/JVI.65.11.6242-6251.1991 Immune-mediated thrombocytopenia in horses infected with equine infectious anemia virus 

  18. Clin. Exp. Immunol. Lurhuma 28 49 1977 The occurrence of circulating immune complexes and viral antigens in idiopathic thrombocytopenic purpura 

  19. Hum. Gene Ther. 13 3 2002 10.1089/10430340152712629 

  20. Proc. Natl. Acad. Sci. USA Morral 96 12816 1999 10.1073/pnas.96.22.12816 Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons 

  21. Hum. Gene Ther. Lanuti 10 463 1999 10.1089/10430349950018904 Evaluation of an E1E4-deleted adenovirus expressing the herpes simplex thymidine kinase suicide gene in cancer gene therapy 

  22. Hum. Gene Ther. Fang 6 1039 1995 10.1089/hum.1995.6.8-1039 Gene therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor IX expression 

  23. Eur. J. Immunol. Ludviksson 30 2011 2000 10.1002/1521-4141(200007)30:7<2101::AID-IMMU2101>3.0.CO;2-P The effect of TGF-β1 on immune responses of naive versus memory CD4+ Th1/Th2 T cells 

  24. Nat. Med. Nyberg-Hoffman 3 808 1997 10.1038/nm0797-808 Sensitivity and reproducibility in adenoviral infectious titer determination 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD(Hybrid)

저자가 APC(Article Processing Charge)를 지불한 논문에 한하여 자유로운 이용이 가능한, hybrid 저널에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로