[논문]Preparation of poly(<SMALL>DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method

doi:10.1016/S0378-5173(99)00187-8

Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method

International journal of pharmaceutics, v.187 no.2, 1999년, pp.143 - 152

Murakami, Hideki (Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd. 16-89 Kashima 3-chome, Yodogawa-ku, Osaka 532-8505, Japan) , Kobayashi, Masao (Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd. 16-89 Kashima 3-chome, Yodogawa-ku, Osaka 532-8505, Japan) , Takeuchi, Hirofumi (Department of Pharmaceutical Engineering, Gifu Pharmaceutical University, Mitahora-Higashi, Gifu 502-0003, Japan) , Kawashima, Yoshiaki (Department of Pharmaceutical Engineering, Gifu Pharmaceutical University, Mitahora-Higashi, Gifu 502-0003, Japan)

Abstract ▼ AI-Helper

AbstractPurpose: The objectives of this study were to establish a new preparation method for poly(DL-lactide-co-glycolide) (PLGA) nanoparticles by modifying the spontaneous emulsification solvent diffusion (SESD) method and to elucidate the mechanism of nanoparticle formation on the basis of the phase separation principle of PLGA and poly(vinyl alcohol) (PVA) in the preparation system. Methods: PLGA nanoparticles were prepared by the modified-SESD method using various solvent systems consisting of two water-miscible organic solvents, in which one solvent has more affinity to PLGA than to PVA and the other has more affinity to PVA than to PLGA. The yield, particle size, size distribution and PVA content of the PLGA nanoparticles were evaluated, and the phase separation behaviors of the polymers were elucidated. Results: The modified-SESD method provided a good yield of PLGA nanoparticles over a wide range of composition ratios in the binary mixture of organic solvents. Several process parameters, including the fed amount of PLGA, PLGA concentration and PVA concentration were examined to achieve the optimum preparation conditions. The discrete powder of PLGA nanoparticles was obtained by freeze-drying. No change in the PVA content of PLGA nanoparticles was observed even after several times of washing treatment by ultrafiltration, suggesting a strong surface adsorption. It was found that the appropriate selections of binary solvent mixtures and polymeric concentrations in both organic and aqueous phases could provide excellent yield and favorable physical properties of PLGA nanoparticles. Conclusion: The proposed modified-SESD method can be used to provide PLGA nanoparticles of satisfactory quality at an acceptable yield for industrial purposes.

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참고문헌 (20)

Int. J. Pharm. Allemann 87 247 1992 10.1016/0378-5173(92)90249-2 Preparation of aqueous polymeric nanodispersions by a reversible salting-out process, influence of process parameters on particle size

상세보기
Pharm. Res. Allemann 10 1732 1993 10.1023/A:1018970030327 In vitro extended-release properties of drug-loaded poly(dl-lactic acid) nanoparticles produced by a salting-out method

상세보기
J. Control. Rel. Bindschaedler 4 203 1986 10.1016/0168-3659(86)90004-0 Osmotically controlled drug delivery systems produced from organic solutions and aqueous dispersions of cellulose acetate

상세보기
J. Pharm. Sci. Bodmeier 78 10 819 1989 10.1002/jps.2600781008 Evaluation of biodegradable poly(lactide) pellets prepared by direct compression

상세보기
J. Control. Rel. Bodmeier 12 223 1990 10.1016/0168-3659(90)90103-Z Indomethacin polymeric nanosuspension prepared by microfluidization

상세보기
Pharm. Res. Cohen 5 10 54 1988 Biodegradable poly(lactide) pellets prepared by direct compression
Int. J. Pharm. Fessi 55 1 R1 1989 10.1016/0378-5173(89)90281-0 Nanocapsule formation by interfacial polymer deposition following solvent displacement

상세보기
Eur. J. Pharm. Biopharm. Frisbee 40 6 355 1994 Influence of nonionic surfactants on the physical and chemical properties of a biodegradable pseudolatex

상세보기
J. Pharm. Biomed. Anal. Haugsberger 13 747 1995 10.1016/0731-7085(95)01276-Q Characterization of biodegradable poly(d,l-lactide-co glycolide) polymers and microspheres

상세보기
10.1016/0021-9797(73)90386-X Iler, R.K., 1973. US Patent 3773776.

상세보기
J. Colloid Interface Sci. Iler 51 3 388 1975 10.1016/0021-9797(75)90134-4 Coacervates of polyvinylalcohol and colloidal silica

상세보기
Pharm. Res. Kawashima 15 11 1748 1998 10.1023/A:1011916930655 A new powder design method to improve inhalation efficiency of pranlukast hydrate dry powder aerosols by surface modification with hydroxy propyl methylcellulose phthalate nanospheres

상세보기
Lewis 1 1990 Biodegradable Polymers as Drug Delivery Systems Controlled release of bioactive agents from lactide/glycolide polymers
Int. J. Pharm. Murakami 149 43 1997 10.1016/S0378-5173(96)04854-5 Influence of the degrees of hydrolyzation and polyrnerization of poly(vinylalcohol) on the preparation and properties of poly(dl-lactide-co-glycolide) nanoparticle

상세보기
J. Control. Rel. Niwa 25 89 1993 10.1016/0168-3659(93)90097-O Preparation of biodegradable nanospheres of water-soluble and insoluble drugs with d,l-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior

상세보기
Pharm. Res. Omelczuk 9 1 26 1992 10.1023/A:1018967424392 The influence of polymer glass transition temperature and molecular weight on drug release from tablets containing poly(dl-lactic acid)

상세보기
Pharm Res. Omelczuk 10 4 542 1993 10.1023/A:1018993818206 The influence of thermal treatment on the physical-mechanical and dissolution properties of tablets containing poly(dl-lactic acid)

상세보기
STP-Pharm. Sci. Omelczuk 5 3 181 1995 A comparative investigation of the compaction and dissolution properties of tablets containing poly(dl-lactic acid) as a binder and retardant polymer
Int. J. Pharm. Schade 117 209 1995 10.1016/0378-5173(94)00333-Z Aqueous colloidal polymer dispersions of biodegradable dl-lactide/glycolide copolymer as basis for latex film: a new approach for the development of biodegradable depot systems

상세보기
A.I.Ch.E.J. Sternling 5 514 1959 10.1002/aic.690050421 Interfacial turbulence: hydrodynamic instability and the Marangoni effect

상세보기

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Preparation of poly(DL-lactide-co-glycolide) nanoparticles by modified spontaneous emulsification solvent diffusion method

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