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Proceedings of the National Academy of Sciences of the United States of America, v.101 no.47, 2004년, pp.16594 - 16599
Huang, Jing (Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, and Departments of Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138) , Zhu, Heng (Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520) , Haggarty, Stephen J. (and Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095) , Spring, David R. (Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, and Departments of Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138) , Hwang, Heejun (Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520) , Jin, Fulai (and Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095) , Snyder, Michael (Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, and Departments of Chemistry and Chemical Biology and Molecular and Cellular Biology, Harvar) , Schreiber, Stuart L.
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The TOR (target of rapamycin) proteins play important roles in nutrient signaling in eukaryotic cells. Rapamycin treatment induces a state reminiscent of the nutrient starvation response, often resulting in growth inhibition. Using a chemical genetic modifier screen, we identified two classes of sm...
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