• 검색어에 아래의 연산자를 사용하시면 더 정확한 검색결과를 얻을 수 있습니다.
  • 검색연산자
검색연산자 기능 검색시 예
() 우선순위가 가장 높은 연산자 예1) (나노 (기계 | machine))
공백 두 개의 검색어(식)을 모두 포함하고 있는 문서 검색 예1) (나노 기계)
예2) 나노 장영실
| 두 개의 검색어(식) 중 하나 이상 포함하고 있는 문서 검색 예1) (줄기세포 | 면역)
예2) 줄기세포 | 장영실
! NOT 이후에 있는 검색어가 포함된 문서는 제외 예1) (황금 !백금)
예2) !image
* 검색어의 *란에 0개 이상의 임의의 문자가 포함된 문서 검색 예) semi*
"" 따옴표 내의 구문과 완전히 일치하는 문서만 검색 예) "Transform and Quantization"
쳇봇 이모티콘
ScienceON 챗봇입니다.
궁금한 것은 저에게 물어봐주세요.

논문 상세정보

A Study of the Effect of Tacrolimus Ointment on the Staphylococcal Colonization in Atopic Dermatitis Patients


BACKGROUND: It is well known that topical tacrolimus is safe and effective on the treatment of atopic dermatitis (AD) patients. Tacrolimus is a primarily immunosuppressive agent without antistaphylococcal effect. Thus the colonization of staphylococcus aureus (S. aureus), on the skin of patients treated with this agent, might be increased. OBJECT: The purpose of this study is to know the effect of tacrolimus on S. aureus colonization of patients with AD and to compare the result with clinical severity and skin barrier function. METHOD: We enrolled 65 patients with moderate to severe AD. They were treated with 0.03% tacrolimus ointment twice daily for 4 weeks. Clinical severity was assessed by the eczema area and severity index (EASI). S. aureus colonization was measured by tape method. Skin barrier function was checked by measuring the transepidermal water loss (TEWL). Evaluations were performed at week 0 (baseline), 1st, 2nd and 4th. The results were compared and the statistical analysis was performed. RESULTS: S. aureus colonization was significantly decreased with tacrolimus treatment at week 1st as compared with baseline. But there were no differences among week 1st, 2nd and 4th. EASI and TEWL showed a decreasing tendency in a time dependent fashion. The correlations between each data were variable. CONCLUSION: Topical application of tacrolimus ointment reduce the colonization of S. aureus on the skin of patients with AD. Moreover, the severity of AD and skin barrier function were improved with treatment. However it is not sure the effect of tacrolimus as a long-term maintenance therapy based on this data, because this is a short term study. In future assessment of topical agents and S. aureus colonization, it will be important to make a study by the comparative method and for a long term period.

참고문헌 (0)

  1. 이 논문의 참고문헌 없음

이 논문을 인용한 문헌 (0)

  1. 이 논문을 인용한 문헌 없음


원문 PDF 다운로드

  • 원문 PDF 정보가 존재하지 않습니다.

원문 URL 링크

원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다. (원문복사서비스 안내 바로 가기)

상세조회 0건 원문조회 0건

DOI 인용 스타일