[논문]A Globin Gene of Ancient Evolutionary Origin in Lower Vertebrates: Evidence for Two Distinct Globin Families in Animals

Roesner, Anja; Fuchs, Christine; Hankeln, Thomas; Burmester, Thorsten

doi:10.1093/molbev/msh258

A Globin Gene of Ancient Evolutionary Origin in Lower Vertebrates: Evidence for Two Distinct Globin Families in Animals 원문보기

Molecular biology and evolution, v.22 no.1, 2005년, pp.12 - 20

Roesner, Anja , Fuchs, Christine , Hankeln, Thomas , Burmester, Thorsten

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Hemoglobin, myoglobin, neuroglobin, and cytoglobin are four types of vertebrate globins with distinct tissue distributions and functions. Here, we report the identification of a fifth and novel globin gene from fish and amphibians, which has apparently been lost in the evolution of higher vertebrates (Amniota). Because its function is presently unknown, we tentatively call it globin X (GbX). Globin X sequences were obtained from three fish species, the zebrafish Danio rerio, the goldfish Carassius auratus, and the pufferfish Tetraodon nigroviridis, and the clawed frog Silurana tropicalis. Globin X sequences are distinct from vertebrate hemoglobins, myoglobins, neuroglobins, and cytoglobins. Globin X displays the highest identity scores with neuroglobin (approximately 26% to 35%), although it is not a neuronal protein, as revealed by RT-PCR experiments on goldfish RNA from various tissues. The distal ligand-binding and the proximal heme-binding histidines (E7 and F8), as well as the conserved phenylalanine CD1 are present in the globin X sequences, but because of extensions at the N-terminal and C-terminal, the globin X proteins are longer than the typical eight alpha-helical globins and comprise about 200 amino acids. In addition to the conserved globin introns at helix positions B12.2 and G7.0, the globin X genes contain two introns in E10.2 and H10.0. The intron in E10.2 is shifted by 1 bp in respect to the vertebrate neuroglobin gene (E11.0), providing possible evidence for an intron sliding event. Phylogenetic analyses confirm an ancient evolutionary relationship of globin X with neuroglobin and suggest the existence of two distinct globin types in the last common ancestor of Protostomia and Deuterostomia.

참고문헌 (51)

10.1016/S0022-2836(05)80360-2 Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol.215:403-410.

상세보기
10.1126/science.1072104 Aparicio, S., J. Chapman, E. Stupka et al. (41 co-authors). 2002. Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science.297:1301-1310.

상세보기
Benton, M. J. 1990. Vertebrate paleontology. Unwin Hyman Ltd., London.
10.1152/nips.01513.2003 Burmester, T. and T. Hankeln. 2004. Neuroglobin: A respiratory protein of the nervous system. News Physiol. Sci.19:110-113.

상세보기
10.1093/oxfordjournals.molbev.a004096 Burmester, T., B. Ebner, B. Weich, and T. Hankeln. 2002. Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues. Mol. Biol. Evol.19:416-421.

상세보기
10.1038/35035093 Burmester, T., B. Weich, S. Reinhardt, and T. Hankeln. 2000. A vertebrate globin expressed in the brain. Nature407:520-523.

상세보기
10.1021/bi00591a005 Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry18:5294-5299.

상세보기
Dayhoff, M. O., R. M. Schwartz, and B. C. Orcutt. 1978. A model of evolutionary change in proteins. Pp. 345-352 in Dayhoff, M. O., ed. Atlas of protein sequence structure, Vol. 5, Supplement 3. National Biomedical Research Foundation, Washington, DC.
Dickerson, R. E., and I. Geis. 1983. Hemoglobin: structure, function, evolution, and pathology. Benjamin/Cummings Publishing Co., Menlo Park, Calif.
10.1016/0968-0004(92)90334-6 Dixon, B., and B. Pohajdak. 1992. Did the ancestral globin gene of plants and animals contain only two introns?. TIBS17:486-488.

상세보기
10.1093/molbev/msg164 Ebner, B., T. Burmester, and T. Hankeln. 2003. Globin genes are present in Ciona intestinalis. Mol. Biol. Evol.20:1521-1525.

상세보기
10.2307/2408678 Felsenstein, J. 1985. Confidence limits on phylogenies: an approach using the bootstrap. Evolution39:783-791.
---. 2004. PHYLIP (phylogeny inference package). Version 3.6b. Distributed by the author, Department of Genetics, University of Washington, Seattle.
10.1073/pnas.98.2.735 Flögel, U., M. W. Merx, A. Goedecke, U. Decking, and J. Schrader. 2001. Myoglobin: a scavenger of bioactive NO. Proc. Natl. Acad. Sci. USA98:735-740.

상세보기
10.1073/pnas.0308657101 Freitas, T. A., S. Hou, E. M. Dioum, J. A. Saito, J. Newhouse, G. Gonzalez, M. A. Gilles-Gonzalez, and M. Alam. 2004. Ancestral hemoglobins in Archaea. Proc. Natl. Acad. Sci. USA101:6675-6680.

상세보기
10.1074/jbc.M402011200 Fuchs, C., V. Heib, L. Kiger, M. Haberkamp, A. Roesner, M. Schmidt, D. Hamdane, M. C. Marden, T. Hankeln, and T. Burmester. 2004. Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern and ligand binding. J. Biol. Chem.279:24116-24122.

상세보기
10.1073/pnas.95.18.10378 Gardner, P. R., A. M. Gardner, L. A. Martin, and A. L. Salzman. 1998. Nitric oxide dioxygenase: an enzymic function for flavohemoglobin. Proc. Natl. Acad. Sci. USA95:10378-10383.

상세보기
Graur, D., and W.-H. Li. 2000. Fundamentals of molecular evolution, 2nd edition. Sinauer Associates, Sunderland, Mass.
10.1016/S0378-1119(97)00518-0 Hankeln, T., H. Friedl, I. Ebersberger, J. Martin, and E. R. Schmidt. 1997. A variable intron distribution in globin genes of Chironomus: evidence for recent intron gain. Gene205:151-160.

상세보기
10.1073/pnas.93.12.5675 Hardison, R. C. 1996. A brief history of hemoglobins: plant, animal, protist, and bacteria. Proc. Natl. Acad. Sci. USA93:5675-5679.

상세보기
10.1093/bioinformatics/17.8.754 Huelsenbeck, J. P., and F. Ronquist. 2001. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics17:754-755.

상세보기
10.1126/science.1065889 Huelsenbeck, J. P., F. Ronquist, R. Nielsen, and J. P. Bollback. 2001. Bayesian inference of phylogeny and its impact on evolutionary biology. Science294:2310-2314.

상세보기
10.1074/jbc.M102630200 Kawada, N., D. B. Kristensen, K. Asahina, K. Nakatani, Y. Minamiyama, S. Seki, and K. Yoshizato. 2001. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J. Biol. Chem.276:25318-25323.

상세보기
10.1016/S0167-4838(97)00181-7 Kleinschmidt, T., and R. E. Weber. 1998. Primary structures of Arenicola marina isomyoglobins: molecular basis for functional heterogeneity. Biochim. Biophys. Acta1383:55-62.

상세보기
10.1016/S0960-9822(07)00361-2 Logsdon, J. M., A. Stoltzfus, and W. F. Doolittle. 1998. Molecular evolution: recent cases of spliceosomal intron gain?. Curr. Biol.8:R560-563.

상세보기
10.1038/46822 Minning, D. M., A. J. Gow, J. Bonaventura, R. Braun, M. Dewhirst, D. E. Goldberg, and J. S. Stamler. 1999. Ascaris haemoglobin is a nitric oxide-activated ‘deoxygenase’. Nature401:497-502.

상세보기
10.1016/S0968-0004(98)01336-X Nakai, K., and P. Horton. 1999. PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem. Sci.24:34-36.

상세보기
10.1038/labinvest.3700013 Nakatani, K., H. Okuyama, Y. Shimahara, S. Saeki, D. H. Kim, Y. Nakajima, S. Seki, N. Kawada, and K. Yoshizato. 2004. Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis. Lab. Invest.84:91-101.

상세보기
Nei, M., and T. Gojobori. 1986. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol. Biol. Evol.3:418-426.
10.1093/nar/25.9.1665 Neuwald, A. F., J. S. Liu, D. J. Lipman, and C. E. Lawrence. 1997. Extracting protein alignment models from the sequence database. Nucleic Acids Res.25:1665-1677.

상세보기
Nicholas, K. B., and H. B. Nicholas Jr. 1997. GeneDoc: analysis and visualization of genetic variation. http://www.psc.edu/biomed/genedoc/.
Ota, T., and M. Nei. 1994. Variance and covariances of the numbers of synonymous and nonsynonymous substitutions per site. Mol. Biol. Evol.11:613-619.
10.1093/embo-reports/kvf248 Pesce, A., M. Bolognesi, P. Ascenzi, A. Bocedi, S. Dewilde, L. Moens, T. Hankeln, and T. Burmester. 2002. Neuroglobin and cytoglobin: fresh blood for the vertebrate globin family. EMBO Rep.3:1146-1151.

상세보기
10.1016/0168-9525(86)90237-4 Rogers, J. H. 1986. Introns between protein domains: selective insertion or frameshifting?. Trends Genet.2:223.

상세보기
10.1016/S0168-9525(00)02096-5 Rogozin, I. B., J. Lyons-Weiler, and E. V. Koonin. 2000. Intron sliding in conserved gene families. Trends Genet.16:430-432.

상세보기
10.1038/173848a0 Ruud, J. T. 1954. Vertebrates without erythrocytes and blood pigment. Nature173:848-850.

상세보기
10.1074/jbc.M209909200 Schmidt, M., A. Giessl, T. Laufs, T. Hankeln, U. Wolfrum, and T. Burmester. 2003. How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina. J. Biol. Chem.278:1932-1935.

상세보기
10.1074/jbc.M310540200 Schmidt, M., F. Gerlach, A. Avivi et al. (11 co-authors). 2004. Cytoglobin is a respiratory protein expressed in connective tissue and neurons that is up-regulated by hypoxia. J. Biol. Chem.279:8063-8069.

상세보기
10.1073/pnas.94.7.3420 Sidell, B. D., M. E. Vayda, D. J. Small, T. J. Moylan, R. L. Londraville, M. L. Yuan, K. J. Rodnick, Z. A. Eppley, and L. Costello. 1997. Variable expression of myoglobin among the hemoglobinless Antarctic icefishes. Proc. Natl. Acad. Sci. USA94:3420-3424.

상세보기
10.1073/pnas.95.17.10317 Sowa, A. W., S. M. G. Duff, P. A. Guy, and R. D. Hill. 1998. Altering hemoglobin levels changes energy status in maize cells under hypoxia. Proc. Natl. Acad. Sci. USA95:10317-10321.

상세보기
10.1073/pnas.94.20.10739 Stoltzfus, A., J. M. Logsdon Jr, J. D. Palmer, and W. F. Doolittle. 1997. Intron “sliding” and the diversity of intron positions. Proc. Natl. Acad. Sci. USA94:10739-10744.

상세보기
10.1093/oxfordjournals.molbev.a025664 Strimmer, K., and A. von Haeseler. 1996. Quartet puzzling: a quartet maximum likelihood method for reconstructing tree topologies. Mol. Biol. Evol.13:964-969.

상세보기
10.1073/pnas.251466698 Sun, Y., K. Jin, X. O. Mao, Y. Zhu, and D. A. Greenberg. 2001. Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc. Natl. Acad. Sci. USA98:15306-15311.

상세보기
10.1016/S0168-9525(02)02599-4 Thomas, J. W., and J. W. Touchman. 2002. Vertebrate genome sequencing: building a backbone for comparative genomics. Trends. Genet.18:104-108.

상세보기
10.1074/jbc.M201934200 Trent, J. T. 3rd, and M. S. Hargrove. 2002. A ubiquitously expressed human hexacoordinate hemoglobin. J. Biol. Chem.277:19538-19545.

상세보기
10.1152/physrev.2001.81.2.569 Weber, R. E., and S. N. Vinogradov. 2001. Nonvertebrate hemoglobins: functions and molecular adaptations. Physiol. Rev.81:569-628.

상세보기
10.1093/oxfordjournals.molbev.a003851 Whelan, S., and Goldman, N. 2001. A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. Mol. Biol. Evol.18:691-699.

상세보기
10.1038/nrg704 Wittbrodt, J., A. Shima, and M. Schartl. 2002. Medaka-a model organism from the far east. Nat. Rev. Genet.3:53-64.

상세보기
Wittenberg, J. B. 1992. Functions of cytoplasmatic hemoglobins and myohemerythrin. Adv. Comp. Environ. Physiol.13:60-85.
10.1242/jeb.00243 Wittenberg, J. B., and B. A. Wittenberg. 2003. Myoglobin function reassessed. J. Exp. Biol.206:2011-2020.

상세보기
10.1159/000078011 Wystub, S., B. Ebner, C. Fuchs, B. Weich, T. Burmester, and T. Hankeln. 2004. Interspecies comparison of neuroglobin, cytoglobin and myoglobin: sequence evolution and candidate regulatory elements. Cytogenet. Genome Res.105:65-78.

상세보기

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A Globin Gene of Ancient Evolutionary Origin in Lower Vertebrates: Evidence for Two Distinct Globin Families in Animals 원문보기

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