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[해외논문] A facile and improved synthesis of sildenafil (Viagra�) analogs through solid support microwave irradiation possessing tyrosinase inhibitory potential, their conformational analysis and molecular dynamics simulation studies

Molecular diversity, v.9 no.1/3, 2005년, pp.15 - 26  

Khan, Khalid M. ,  Maharvi, Ghulam M. ,  Khan, Mahmud T. H. ,  Perveen, Shahnaz ,  Choudhary, Muhammad I. ,  Rahman, Atta-ur-

Abstract AI-Helper 아이콘AI-Helper

Herein, the synthesis of some analogs of sildenafil (Viagra) (21) is described, employing MW irradiations in key steps such as, SNAr reaction on important precursor bromopyrazole (7). Compound 7 was synthesized by the bromination followed by the amidation of readily available 1-methyl-3-propyl-1H-py...

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