참고문헌 (125)

1. Arthritis Rheum ED Harris Jr. 44 1969 2004 10.1002/1529-0131(200109)44:9<1969::AID-ART342>3.0.CO;2-A Harris, E. D. Jr. The Bone and Joint decade: a catalyst for progress. Arthritis Rheum 44, 1969-1970 (2004). 

   상세보기

2. WHO Scientific group. The burden of musculoskeletal conditions at the start of the new millennium. World Health Organ Tech. Rep. Ser. 919, 1-218 (2003). The tremendous challenge of the disease is summarized in this report of the epidemiology of musculoskeletal diseases. 

3. Ann. Rheum. Dis. H Merx 62 222 2003 10.1136/ard.62.3.222 Merx, H. et al. International variation in hip replacement rates. Ann. Rheum. Dis. 62, 222-226 (2003). 

   상세보기

4. 10.2106/00004623-200406000-00030 NIH Consensus Statement on Total Knee Replacement December 8-10, 2003. J. Bone Joint Surg. Am. 86, 1328-1335 (2004). 

   상세보기

5. Inflammo-pharmacology WF Kean 12 3 2004 10.1163/156856004773121347 Kean, W. F., Kean, R. & Buchanan, W. W. Osteoarthritis: symptoms, signs and source of pain. Inflammo-pharmacology 12, 3-31 (2004). 

   상세보기

6. J. Rheumatol. EM Badley 25 138 1998 Badley, E. M. & Wang, P. P. Arthritis and the aging population: projections of arthritis prevalence in Canada 1991 to 2031. J. Rheumatol. 25, 138-144 (1998). 

   상세보기

7. Decision Resources, Inc. Osteoarthritis: Immune and Inflammatory Disorders Study (Decision Resources, Inc., Waltham, Massachusetts, 2004). 

8. J. Rheumatol. MT Hannan 27 1513 2000 Hannan, M. T., Felson, D. T. & Pincus, T. Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J. Rheumatol. 27, 1513-1517 (2000). 

   상세보기

9. Nature Rev. Drug. Discov. RJ Flower 2 179 2003 10.1038/nrd1034 Flower, R. J. The development of COX2 inhibitors. Nature Rev. Drug. Discov. 2, 179-191 (2003). A comprehensive review of COX2 inhibitor development. 

   상세보기

10. N. Engl. J. Med. EJ Topol 351 1707 2004 10.1056/NEJMp048286 Topol, E. J. Failing the public health - Rofecoxib, Merck, and the FDA. N. Engl. J. Med. 351, 1707-1711 (2004). 

    상세보기

11. Nature Rev. Drug. Discov. S Petit-Zeman 3 726 2004 10.1038/nrd1517 Petit-Zeman, S. Characteristics of COX 2 inhibitors questioned. Nature Rev. Drug. Discov. 3, 726-727 (2004). This paper and reference10 provide evidence that the safety of COX2 inhibitors will be re-evaluated. 

    상세보기

12. Radiol. Clin. N. Am. DT Felson 42 1 2004 10.1016/S0033-8389(03)00161-1 Felson, D. T. An update on the pathogenesis and epidemiology of osteoarthritis. Radiol. Clin. N. Am. 42, 1-9 (2004). 

    상세보기

13. Osteoarthr. Cartil. TD Spector 12 S39 2004 10.1016/j.joca.2003.09.005 Spector, T. D. & MacGregor, A. J. Risk factors for osteoarthritis: genetics. Osteoarthr. Cartil. 12, S39-S44 (2004). 

    상세보기

14. Joint Bone Spine P Richette 71 18 2004 10.1016/S1297-319X(03)00129-5 Richette, P. & Bardin, T. Structure-modifying agents for osteoarthritis: an update. Joint Bone Spine 71, 18-23 (2004). 

    상세보기

15. Ann. Rheum. Dis. KM Jordan 62 1145 2003 10.1136/ard.2003.011742 Jordan, K. M. et al. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann. Rheum. Dis. 62, 1145-1155 (2003). Recent clinical recommendations issued by an osteoarthritis task force. 

    상세보기

16. Ann. Rheum. Dis. W Zhang 63 901 2004 10.1136/ard.2003.018531 Zhang, W., Jones, A. & Doherty, M. Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. Ann. Rheum. Dis. 63, 901-907 (2004). 

    상세보기

17. Ann. Rheum. Dis. R Neame 63 897 2004 10.1136/ard.2004.020727 Neame, R., Zhang, W. & Doherty, M. A historic issue of the Annals: three papers examine paracetamol in osteoarthritis. Ann. Rheum. Dis. 63, 897-900 (2004). 

    상세보기

18. Arthritis Rheum. C Lee 51 746 2004 10.1002/art.20698 Lee, C., Straus, W. L., Balshaw, R., Barlas, S., Vogel, S. & Schnitzer, T. J. A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: a meta-analysis. Arthritis Rheum. 51, 746-754 (2004). 

    상세보기

19. Ann. Rev. Pharmacol. Toxicol. JR Vane 38 97 1998 10.1146/annurev.pharmtox.38.1.97 Vane, J. R., Bakhle, Y. S. & Botting, R. M. Cyclooxygenases 1 and 2. Ann. Rev. Pharmacol. Toxicol. 38, 97-120 (1998). 

    상세보기

20. Nature TA Samad 410 471 2001 10.1038/35068566 Samad, T. A. et al. Interleukin-1β-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410, 471-475 (2001). 

    상세보기

21. MC Watson 2003 The Cochrane Library Watson, M. C., Brookes, S. T., Kirwan, J. R. & Faulkner, A. in The Cochrane Library, Issue 1 10.1002/14651858.CD000142 (Update Software Ltd, Oxford, 2003). 

22. Proc. Natl Acad. Sci. USA TD Warner 96 7563 1999 10.1073/pnas.96.13.7563 Warner, T. D. et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc. Natl Acad. Sci. USA 96, 7563-7568 (1999). 

    상세보기

23. Mayo Clin. Proc. WG Bensen 74 1095 1999 10.4065/74.11.1095 Bensen, W. G. et al. Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial. Mayo Clin. Proc. 74, 1095-1105 (1999). 

    상세보기

24. Arch. Intern. Med. R Day 160 1781 2000 10.1001/archinte.160.12.1781 Day, R. et al. A randomized trial of the efficacy and tolerability of the COX-2 inhibitor rofecoxib vs ibuprofen in patients with osteoarthritis. Rofecoxib/Ibuprofen Comparator Study Group. Arch. Intern. Med. 160, 1781-1787 (2000). 

    상세보기

25. JAMA TE McAlindon 283 1469 2000 10.1001/jama.283.11.1469 McAlindon, T. E., LaValley, M. P., Gulin, J. P. & Felson, D. T. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 283, 1469-1475 (2000). 

    상세보기

26. Curr. Pain Headache Rep. D Zerkak 8 507 2004 10.1007/s11916-004-0074-0 Zerkak, D. & Dougados, M. The use of glucosamine therapy in osteoarthritis. Curr. Pain Headache Rep. 8, 507-511 (2004). 

    상세보기

27. BMJ J Chard 322 1439 2001 10.1136/bmj.322.7300.1439 Chard, J & Dieppe, P. Glucosamine for osteoarthritis: magic, hype, or confusion? It's probably safe - but there's no good evidence that it works. BMJ 322, 1439-1440 (2001). This paper questions the validity of glucosamine as a treatment for OA. 

    상세보기

28. Med. Health RI BA Biggee 87 176 2004 Biggee, B. A. & McAlindon, T. Glucosamine for osteoarthritis: part I, review of the clinical evidence. Med. Health RI 87, 176-179 (2004). 

    상세보기

29. BMJ J Lin 329 324 2004 10.1136/bmj.38159.639028.7C Lin, J., Zhang, W., Jones, A. & Doherty, M. Efficacy of topical non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis: meta-analysis of randomised controlled trials. BMJ 329, 324 (2004). 

    상세보기

30. BMC Musculoskelet. Disord. L Mason 5 28 2004 10.1186/1471-2474-5-28 Mason, L., Moore, R. A., Edwards, J. E., Derry, S. & McQuay, H. J. Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis. BMC Musculoskelet. Disord. 5, 28 (2004). 

    상세보기

31. Best Pract. Res. Clin. Rheumatol. X Ayral 15 609 2001 10.1053/berh.2001.0177 Ayral, X. Injections in the treatment of osteoarthritis. Best Pract. Res. Clin. Rheumatol. 15, 609-626 (2001). 

    상세보기

32. Ann. Rheum. Dis. L Gossec 63 478 2004 10.1136/ard.2003.013771 Gossec, L. & Dougados, M. Intra-articular treatments in osteoarthritis: from the symptomatic to the structure modifying. Ann. Rheum. Dis. 63, 478-482 (2004). 

    상세보기

33. Curr. Opin. Rheumatol. P Creamer 11 417 1999 10.1097/00002281-199909000-00016 Creamer, P. Intra-articular corticosteroid treatment in osteoarthritis. Curr. Opin. Rheumatol. 11, 417-421 (1999). 

    상세보기

34. Ann. Rheum. Dis. LS Lohmander 55 424 1996 10.1136/ard.55.7.424 Lohmander, L. S. et al. Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial. Hyaluronan Multicentre Trial Group. Ann. Rheum. Dis. 55, 424-431 (1996). 

    상세보기

35. Arthritis Rheum. KD Brandt 43 1192 2000 10.1002/1529-0131(200006)43:6<1192::AID-ANR2>3.0.CO;2-L Brandt, K. D., Smith, G. N. Jr & Simon, L. S. Intraarticular injection of hyaluronan as treatment for knee osteoarthritis: what is the evidence? Arthritis Rheum. 43, 1192-1203 (2000). 

    상세보기

36. JAMA. GH Lo 290 3115 2003 10.1001/jama.290.23.3115 Lo, G. H., LaValley, M., McAlindon, T. & Felson, D. T. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA. 290, 3115-3221 (2003). 

    상세보기

37. Curr. Opin. Rheumatol. F Berenbaum 16 616 2004 10.1097/01.bor.0000133663.37352.4a Berenbaum, F. Signaling transduction. Curr. Opin. Rheumatol. 16, 616-622 (2004). 

    상세보기

38. Ann. Rheum. Dis. JJ Haringman 63 1186 2004 10.1136/ard.2004.020529 Haringman, J. J., Ludikhuize, J. & Tak, P. P. Chemokines in joint disease: the key to inflammation? Ann. Rheum. Dis. 63, 1186-1194 (2004). 

    상세보기

39. Pharmacogenomics T Aigner 3 635 2002 10.1517/14622416.3.5.635 Aigner, T. et al. Functional genomics of osteoarthritis. Pharmacogenomics 3, 635-650 (2002). 

    상세보기

40. Clin. Exp. Rheumatol. Z Fan 22 103 2004 Fan, Z. et al. Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1. Clin. Exp. Rheumatol. 22, 103-106 (2004). 

    상세보기

41. Arthritis Res. LJ Sandell 3 107 2001 10.1186/ar148 Sandell, L. J. & Aigner, T. Articular cartilage and changes in osteoarthritis. An introduction: cell biology of osteoarthritis. Arthritis Res. 3, 107-113 (2001). 

    상세보기

42. J. Clin. Endocrinol. Metab. T Matsumoto 81 150 1996 Matsumoto, T., Gargosky, S. E., Iwasaki, K. & Rosenfeld, R. G. Identification and characterization of insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases in human synovial fluid. J. Clin. Endocrinol. Metab. 81, 150-155 (1996). 

    상세보기

43. Osteoarthr. Cartil. D Lajeunesse 12 S34 2004 10.1016/j.joca.2003.09.013 Lajeunesse, D. The role of bone in the treatment of osteoarthritis. Osteoarthr. Cartil. 12, S34-S38 (2004). 

    상세보기

44. Arthritis Rheum. H Dumond 48 3118 2003 10.1002/art.11303 Dumond, H. et al. Evidence for a key role of leptin in osteoarthritis. Arthritis Rheum. 48, 3118-3129 (2003). A recent perspective of leptin playing an important role in OA. 

    상세보기

45. Biochem. Biophys. Res. Commun. Y Figenschau 287 190 2001 10.1006/bbrc.2001.5543 Figenschau, Y. et al. Human articular chondrocytes express functional leptin receptors. Biochem. Biophys. Res. Commun. 287, 190-197 (2001). 

    상세보기

46. Arthritis Rheum. LS Lohmander 48 3130 2003 10.1002/art.11326 Lohmander, L. S., Atley, L. M., Pietka, T. A. & Eyre, D. R. The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum. 48, 3130-3139 (2003). 

    상세보기

47. Osteoarthr. Cartil. K Rudolphi 11 738 2003 10.1016/S1063-4584(03)00153-5 Rudolphi, K. et al. Pralnacasan, an inhibitor of interleukin-1β converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthr. Cartil. 11, 738-746 (2003). 

    상세보기

48. J. Orthop. Res. X Zhang 22 742 2004 10.1016/j.orthres.2003.12.007 Zhang, X., Mao, Z. & Yu, Ch. Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J. Orthop. Res. 22, 742-750 (2004). 

    상세보기

49. Osteoarthr. Cartil. S Fuchs 12 409 2004 10.1016/j.joca.2004.02.005 Fuchs, S. et al. Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and fluid synovial fibroblasts. Osteoarthr. Cartil. 12, 409-418 (2004). 

    상세보기

50. Arthritis Rheum. L Kevorkian 50 131 2004 10.1002/art.11433 Kevorkian, L. et al. Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis Rheum. 50, 131-141 (2004). 

    상세보기

51. J. Biol. Chem. M Francois 279 28411 2004 10.1074/jbc.M312708200 Francois, M. et al. Peroxisome proliferator-activated receptor-γ down regulates chondrocyte matrix meatlloproteinase-1 via a novel composite element. J. Biol. Chem. 279, 28411-28418 (2004). 

    상세보기

52. J. Biol. Chem. K Bordji 275 12243 2000 10.1074/jbc.275.16.12243 Bordji, K. et al. Evidence for the presence of peroxisome proliferator-activated receptor (PPAR)α and γ and retinoid Z receptor cartilage. J. Biol. Chem. 275, 12243-12250 (2000). 

    상세보기

53. Semin. Arthritis Rheum. M Martel-Pelletier 33 155 2003 10.1016/S0049-0172(03)00134-3 Martel-Pelletier, M., Pelletier, J. P. & Fahni, H. Cyclooxygenase-2 and prostaglandins in articular tissues. Semin. Arthritis Rheum. 33, 155-167 (2003). 

    상세보기

54. Osteoarthr. Cartil. H Fahmi 10 845 2002 10.1053/joca.2002.0835 Fahmi, H., Pelletier, J. P., Mineau, F. & Martel-Pelletier, J. 15d-PGJ2 is acting as “dual agent” on the regulation of COX-2 expression in human osteoarthritic chondrocytes. Osteoarthr. Cartil. 10, 845-848 (2002). 

    상세보기

55. J. Immunol. KR Aupperle 163 427 1999 10.4049/jimmunol.163.1.427 Aupperle, K. R. et al. NF-κB regulation by I kappa B kinase in primary fibroblast-like synoviocytes. J. Immunol. 163, 427-433 (1999). 

    상세보기

56. Cell. Immunol. KR Aupperle 214 54 2001 10.1006/cimm.2002.1885 Aupperle, K. R. et al. Expression and regulation of inducible IκB kinase (IKK-i) in human fibroblast-like synoviocytes. Cell. Immunol. 214, 54-59 (2001). 

    상세보기

57. J. Neurosci. I Tegeder 24 1673 2004 10.1523/JNEUROSCI.3118-03.2004 Tegeder, I. et al. Specific inhibition of IκB kinase reduces hyperalgesia in inflammatory and neuropathic pain models. J. Neurosci. 24, 1673-1645 (2004). 

    상세보기

58. Immunology C Jobin 95 537 1998 10.1046/j.1365-2567.1998.00646.x Jobin, C. et al. Specific NF-κB blockade selectively inhibits tumour necrosis factor α-induced COX2 but not constitutive Cox-1 gene expression in HT29 cells. Immunology 95, 537-543 (1998). 

    상세보기

59. Osteoarthr. Cartil. J-P Pelletier 12 Suppl. A 63 2003 Pelletier, J. -P. Rationale for the use of structure-modifying drugs and agents in the treatment of osteoarthritis. Osteoarthr. Cartil. 12 (Suppl. A), 63-68 (2003). 

60. Osteoarthr. Cartil. C Buckland-Wright 12 Suppl. A 10 2004 10.1016/j.joca.2003.09.007 Buckland-Wright, C. Subchondral bone changes in hand and knee osteoarthritis detected by radiography. Osteoarthr. Cartil. 12, (Suppl. A) 10-19 (2004). 

    상세보기

61. Arthritis Rheum. DT Felson 50 341 2004 10.1002/art.20051 Felson, D. T. & Neogi, T. Osteoarthritis: is it a disease of cartilage or bone? Arthritis Rheum. 50, 341-344 (2004). A recent paper discussing the contribution of both cartilage and bone to the progression of the disease. 

    상세보기

62. Calcif. Tissue Int. MD Grynpas 49 20 1991 10.1007/BF02555898 Grynpas, M. D., Alpert, B., Katz, I., Lieberman, I. & Pritzker, K. P. Subchondral bone in osteoarthritis. Calcif. Tissue Int. 49, 20-26 (1991). 

    상세보기

63. Arthritis Rheum. T Hayami 50 1193 2004 10.1002/art.20124 Hayami, T. et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum. 50, 1193-1206 (2004). 

    상세보기

64. J. Orthop. Res. MR Doschak 22 942 2004 10.1016/j.orthres.2003.12.018 Doschak, M. R., Wohl, G. R., Hanley, D. A., Bray, R. C. & Zernicke, R. F. Antiresorptive therapy conserves some periarticular bone and ligament mechanical properties after anterior cruciate ligament disruption in the rabbit knee. J. Orthop. Res. 22, 942-948 (2004). 

    상세보기

65. J. Rheumatol. SL Myers 26 2645 1999 Myers, S. L., Brandt, K. D., Burr, D. B., O'Connor, B. L. & Albrecht, M. Effects of a bisphosphonate on bone histomorphometry and dynamics in the canine cruciate deficiency model of osteoarthritis. J. Rheumatol. 26, 2645-2653 (1999). 

    상세보기

66. Osteoarthr. Cartil. C Bingham 12 S132 2004 Bingham, C. et al. Clinically significant placebo improvement occurs by 6 months and is maintained through 24 months in a study of knee OA pain and function. Osteoarthr. Cartil. 12, S132 Abs. P323 (2004). 

67. Osteoarthr. Cartil. CJ Menkes 12 S53 2004 10.1016/j.joca.2003.09.003 Menkes, C. J. & Lane, N. E. Are osteophytes good or bad? Osteoarthr. Cartil. 12, S53-S54 (2004). 

    상세보기

68. Clin. Orthop. M Uchino 377 119 2000 10.1097/00003086-200008000-00017 Uchino, M. et al. Growth factor expression in the osteophytes of the human femoral head in osteoarthritis. Clin. Orthop. 377, 119-125 (2000). 

    상세보기

69. Osteoarthr. Cartil. KD Brandt 7 334 1999 10.1053/joca.1998.0187 Brandt, K. D. Osteophytes in osteoarthritis. Clinical aspects. Osteoarthr. Cartil. 7, 334-335 (1999). 

    상세보기

70. Rheumatol. Int. GJ Van Osch 16 115 1996 10.1007/BF01409983 Van Osch, G. J., Van der Kraan, P. M., Van Valburg, A. A. & Van den Berg, W. B. The relation between cartilage damage and osteophyte size in a murine model for osteoarthritis in the knee. Rheumatol. Int. 16, 115-119 (1996). 

    상세보기

71. Ann. Rheum. Dis. P Lanyon 57 595 1998 10.1136/ard.57.10.595 Lanyon, P., O'Reilly, S., Jones, A. & Doherty, M. Radiographic assessment of symptomatic knee osteoarthritis in the community: definitions and normal joint space. Ann. Rheum. Dis. 57, 595-601 (1998). 

    상세보기

72. Best Practice Res. Clin. Rheumatol. P Ghosh 15 693 2001 10.1053/berh.2001.0188 Ghosh, P. Vascular mechanisms in osteoarthritis. Best Practice Res. Clin. Rheumatol. 15, 693-710 (2001). 

    상세보기

73. PA Simkin 179 2004 10.1002/0470867639.ch12 Osteoarthritic Joint Pain Simkin, P. A. in Osteoarthritic Joint Pain (Novartis Foundation Symposium) 179-190 (Wiley, Chichester, 2004). 

    

74. Cell S Takeda 111 305 2002 10.1016/S0092-8674(02)01049-8 Takeda, S. et al. Leptin regulates bone formation via the sympathetic nervous system. Cell 111, 305-317 (2002). 

    상세보기

75. Cell P Ducy 100 197 2000 10.1016/S0092-8674(00)81558-5 Ducy, P. et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 100, 197-207 (2000). 

    상세보기

76. Annu. Rev. Physiol. RS Ahima 62 413 2000 10.1146/annurev.physiol.62.1.413 Ahima, R. S. & Flier, J. S. Leptin. Annu. Rev. Physiol. 62, 413-437 (2000). 

    상세보기

77. Br. J. Rheumatol. G Dean 32 671 1993 10.1093/rheumatology/32.8.671 Dean, G., Hoyland, J. A., Denton, J., Donn, R. P. & Freemont, A. J. Mast cells in the synovium and synovial fluid in osteoarthritis. Br. J. Rheumatol. 32, 671-675 (1993). 

    

78. Arthritis Rheumatol. S Lindblad 30 1081 1987 10.1002/art.1780301001 Lindblad, S. & Hedfors, E. Arthroscopic and immunohistologic characterization of knee joint synovitis in osteoarthritis. Arthritis Rheumatol. 30, 1081-1088 (1987). 

    상세보기

79. Curr Opin. Rheumatol. PB Halverson 13 221 2001 10.1097/00002281-200105000-00013 Halverson, P. B. & Derfus, B. A. Calcium crystal-induced inflammation. Curr Opin. Rheumatol. 13, 221-224 (2001). 

    상세보기

80. Curr. Opin. Rheumatol. T Kato 16 604 2004 10.1097/01.bor.0000133661.52599.bf Kato, T., Xiang, Y., Nakamura, H. & Nishioka, K. Neoantigens in osteoarthritic cartilage. Curr. Opin. Rheumatol. 16, 604-608 (2004). 

    상세보기

81. J. Rheumatol. Suppl. SB Abramson 70 70 2004 Abramson, S. B. Inflammation in osteoarthritis. J. Rheumatol. Suppl. 70, 70-76 (2004). 

82. Rheum. Dis. Clin. North Am. AR Poole 29 803 2003 10.1016/S0889-857X(03)00056-5 Poole, A. R. Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis. Rheum. Dis. Clin. North Am. 29, 803-818 (2003). This paper provides a classic review on biomarkers in OA. 

    상세보기

83. Ann. Rheum. Dis. PI Mapp 54 398 1995 10.1136/ard.54.5.398 Mapp, P. I. Innervation of the synovium. Ann. Rheum. Dis. 54, 398-403 (1995). 

    상세보기

84. J. Neurosci. A Opree 20 6289 2000 10.1523/JNEUROSCI.20-16-06289.2000 Opree, A. & Kress, M. Involvement of the proinflammatory cytokines tumor necrosis factor-α, IL-1β, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin. J. Neurosci. 20, 6289-6293 (2000). 

    상세보기

85. Br. J. Pharmacol. B Safieh-Garabedian 115 1265 1995 10.1111/j.1476-5381.1995.tb15035.x Safieh-Garabedian, B., Poole, S., Allchorne, A., Winter, J. & Woolf, C. J. Contribution of interleukin-1β to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br. J. Pharmacol. 115, 1265-1275 (1995). 

    상세보기

86. Br. J. Pharmacol. CJ Woolf 121 417 1997 10.1038/sj.bjp.0701148 Woolf, C. J., Allchorne, A., Safieh-Garabedian, B. & Poole, S. Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α. Br. J. Pharmacol. 121, 417-424 (1997). 

    상세보기

87. Neurosci. Lett. X Chen 267 105 1999 10.1016/S0304-3940(99)00345-6 Chen, X., Tanner, K. & Levine, J. D. Mechanical sensitization of cutaneous C-fiber nociceptors by prostaglandin E2 in the rat. Neurosci. Lett. 267, 105-108 (1999). 

    상세보기

88. Clin. Pharmacol. Ther. DC Manning 50 721 1991 10.1038/clpt.1991.212 Manning, D. C., Raja, S. N., Meyer, R. A. & Campbell, J. N. Pain and hyperalgesia after intradermal injection of bradykinin in humans. Clin. Pharmacol. Ther. 50, 721-729 (1991). 

    상세보기

89. Pain Rev. K Mizumura 5 59 1998 10.1191/096813098678013353 Mizumura, K. Natural history of nociceptor sensitization - the search for peripheral mechanism of hyperalgesia. Pain Rev. 5, 59-82 (1998). 

    

90. Osteoarthr. Cartil. J Flechtenmacher 12 S137 2004 Flechtenmacher, J. et al. Bradykinin-receptor-inhibition - a therapeutic option in osteoarthritis? Osteoarthr. Cartil. 12, S137 Abs. P332 (2004). 

91. Clin. Orthop. T Saito 376 172 2000 10.1097/00003086-200007000-00024 Saito, T. & Koshino, T. Distribution of neuropeptides in synovium of the knee with osteoarthritis. Clin. Orthop. 376, 172-182 (2000). 

    상세보기

92. Curr. Opin. Rheumatol. JA Vilensky 10 251 1998 10.1097/00002281-199805000-00016 Vilensky, J. A. & Cook, J. A. Neurogenic acceleration of osteoarthritis. Curr. Opin. Rheumatol. 10, 251-255 (1998). 

    상세보기

93. Ann. Rheum. Dis. MV Hurley 56 641 1997 10.1136/ard.56.11.641 Hurley, M. V., Scott, D. L., Rees, J. & Newham, D. J. Sensorimotor changes and functional performance in patients with knee osteoarthritis. Ann. Rheum. Dis. 56, 641-648 (1997). 

    상세보기

94. Curr. Opin. Rheumatol. K Baker 12 456 2000 10.1097/00002281-200009000-00020 Baker, K. & McAlindon, T. Exercise for knee osteoarthritis. Curr. Opin. Rheumatol. 12, 456-463 (2000). 

    상세보기

95. Ann. Int. Med. C Slemenda 127 97 1997 10.7326/0003-4819-127-2-199707150-00001 Slemenda, C. et al. Quadriceps weakness and osteoarthritis of the knee. Ann. Int. Med. 127, 97-104 (1997). 

    상세보기

96. J. Orthop. Res. R Becker 22 768 2004 10.1016/j.orthres.2003.11.004 Becker, R., Berth, A., Nehring, M. & Awiszus, F. Neuromuscular quadriceps dysfunction prior to osteoarthritis of the knee. J. Orthop. Res. 22, 768-773 (2004). 

    상세보기

97. Am. J. Orthop. BL O'Connor 32 330 2003 O'Connor, B. L. & Vilensky, J. A. Peripheral and central nervous system mechanisms of joint protection. Am. J. Orthop. 32, 330-336 (2003). 

    상세보기

98. Ann. Intern. Med. L Sharma 138 613 2003 10.7326/0003-4819-138-8-200304150-00006 Sharma, L., Dunlop, D. D., Cahue, S., Song, J. & Hayes, K. W. Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Ann. Intern. Med. 138, 613-619 (2003). 

    상세보기

99. J. Rheumatol. P Creamer 23 1031 1996 Creamer, P., Hunt, M. & Dieppe, P. Pain mechanisms in osteoarthritis of the knee: effect of intraarticular anesthetic. J. Rheumatol. 23, 1031-1036 (1996). 

    상세보기

100. Ann. NY Acad. Sci. HG Schaible 966 343 2002 10.1111/j.1749-6632.2002.tb04234.x Schaible, H. G., Ebersberger, A., Von Banchet, G. S. Mechanisms of pain in arthritis. Ann. NY Acad. Sci. 966, 343-354 (2002). 

     상세보기

101. Br. J. Anaesth. BL Kidd 87 3 2001 10.1093/bja/87.1.3 Kidd, B. L. & Urban, L. A. Mechanisms of inflammatory pain. Br. J. Anaesth. 87, 3-11 (2001). 

     상세보기

102. US Department of Health and Human Services, Food and Drug Administration. Innovation and Stagnation: Challenge and Opportunity on the Critical Path to New Medical Products [online], < http://www.who.int/intellectualproperty/documents/en/FDAproposals.pdf > (2004). 

103. Nature Biotechnology EC Butcher 22 1253 2004 10.1038/nbt1017 Butcher, E. C., Berg, E. L. & Kunkel, E. J. Systems biology in drug discovery. Nature Biotechnology 22, 1253-1259 (2004). 

     상세보기

104. Rheumatology (Oxford) CS Bonnet 44 7 2005 10.1093/rheumatology/keh344 Bonnet, C. S. & Walsh, D. A. Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford) 44, 7-16 (2005). An interesting recent review illustrating the relevance of angiogenic processes to the pathophysiology of OA. 

     상세보기

105. Curr. Opin. Rheumatol. DA Walsh 16 609 2004 10.1097/01.bor.0000133662.60223.ee Walsh, D. A. Angiogenesis in osteoarthritis and spondylosis: successful repair with undesirable outcomes. Curr. Opin. Rheumatol. 16, 609-615 (2004). 

     상세보기

106. Baillieres Best. Pract. Res. Clin. Rheumatol. G Balint 14 219 2000 10.1053/berh.2000.0063 Balint, G. & Szebenyi, B. Hereditary disorders mimicking and/or causing premature osteoarthritis. Baillieres Best. Pract. Res. Clin. Rheumatol. 14, 219-250 (2000). 

     상세보기

107. Br. J. Rheumatol. J Dequeker 35 813 1996 10.1093/rheumatology/35.9.813 Dequeker, J., Boonen, N., Aerssens, J. & Westhovens, R. Inverse relationship osteoarthritis - osteoporosis: what is the evidence? What are the consequences? Br. J. Rheumatol. 35, 813-820 (1996). 

     

108. Curr. Opin. Pharmacol. MW Lark 4 273 2004 10.1016/j.coph.2004.04.002 Lark, M. W. & Blake, S. M. Development of novel therapeutics to treat joint diseases - what can be learned from other diseases? Curr. Opin. Pharmacol. 4, 273-275 (2004). 

     상세보기

109. Lancet RM Aspden 357 1118 2001 10.1016/S0140-6736(00)04264-1 Aspden, R. M., Scheven, B. A. A. & Hutchison, J. D. Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism. Lancet 357, 1118-1120 (2001). One of the first publications suggesting a direct relationship between OA and metabolic disorders. 

     상세보기

110. J. Rheumatol. Y Toda 25 2181 1998 Toda, Y. et al. Change in body fat, but not body weight or metabolic correlates of obesity, is related to symptomatic relief of obese patients with knee osteoarthritis after weight control program. J. Rheumatol. 25, 2181-2186 (1998). 

     상세보기

111. Endocrine JM Gimble 23 183 2004 10.1385/ENDO:23:2-3:183 Gimble, J. M. & Nuttall, M. E. Bone and fat. Endocrine 23, 183-188 (2004) 

     상세보기

112. Arthritis Rheum. RF Loeser 48 3009 2003 10.1002/art.11315 Loeser, R. F. Systemic and local regulation of articular cartilage metabolism: where does leptin fit in the puzzle? Arthritis Rheum. 48, 3009-3012 (2003) 

     상세보기

113. Bone K Yagami 34 648 2004 10.1016/j.bone.2003.12.016 Yagami, K. et al. A human chondrogenic cell line retains multi-potency that differentiates into osteoblasts and adipocytes. Bone 34, 648-655 (2004). 

     상세보기

114. Expert Opin. Ther. Patents Y Henroitin 12 29 2002 10.1517/13543776.12.1.29 Henroitin, Y., Sanchez, C. & Reginster, J. Y. The inhibition of metalloproteinases to treat osteoarthritis: reality and new perspectives. Expert Opin. Ther. Patents 12, 29-43 (2002). 

     상세보기

115. Curr. Med. Chem. JW Skiles 11 2911 2004 10.2174/0929867043364018 Skiles, J. W., Gonella, N. C. & Jeng, A. Y. The design, structure and clinical update of small metalloproteinase inhibitors. Curr. Med. Chem. 11, 2911-2977 (2004). 

     상세보기

116. Lancet. TJ Schnitzer 364 665 2004 10.1016/S0140-6736(04)16893-1 Schnitzer, T. J. et al. TARGET Study Group. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. Lancet. 364, 665-674 (2004). 

     상세보기

117. Rheumatology (Oxford). K Brune 43 S16 2004 10.1093/rheumatology/keh104 Brune, K. Safety of anti-inflammatory treatment - new ways of thinking. Rheumatology (Oxford). 43 S16-S20 (2004). 

     상세보기

118. IDrugs C Ding 6 802 2003 Ding, C & Cicuttini, F. Licofelone (Merckle). IDrugs 6, 802-808 (2003). 

     상세보기

119. Fundam. Clin. Pharmacol. JL Wallace 17 11 2003 10.1046/j.1472-8206.2003.00125.x Wallace, J. L. & Del Soldato, P. The therapeutic potential of NO-NSAIDs. Fundam. Clin. Pharmacol. 17, 11-20 (2003). 

     상세보기

120. Curr. Opin. Pharmacol. BJ Whittle 4 538 2004 10.1016/j.coph.2004.08.003 Whittle, B. J. Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs. Curr. Opin. Pharmacol. 4, 538-545 (2004). 

     상세보기

121. Schnitzer, T. J., Kivitz, A. J., Lipetz, S., Sanders, N. & Hee, A. A Phase II study of the efficacy and safety of AZD3582, a CINOD, in subjects with osteoarthritis of the knee. Eur. League Against Rheumatism 2004 Conference Abs OP0016 [online], < http://mcic3.textor.com/cgi-bin/mc/printabs.pl?APP=eular2004SCIE-abstract&TEMPLATE=&keyf=0094&showHide=show&client= > (2004) 

122. Arthritis Rheum. P Garnero 46 2613 2002 10.1002/art.10576 Garnero, P. et al. Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum. 46, 2613-2624 (2002). 

     상세보기

123. Arthritis Rheum. R Cerejo 46 S144 2002 10.1002/art.10530 Cerejo, R. et al. The association between cartilage activity measured in serum and progression of knee osteoarthritis in patients with and without evidence of generalized disease. Arthritis Rheum. 46, S144 (2002). 

     상세보기

124. Arthritis Rheum. M Sharif 50 2479 2004 10.1002/art.20365 Sharif, M. et al. Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years. Arthritis Rheum. 50, 2479-2488 (2004). 

     상세보기

125. Nature Rev. Drug Discovery I Kola 3 711 2004 10.1038/nrd1470 Kola, I. & Landis, J. Can the pharmaceutical industry reduce attrition rates? Nature Rev. Drug Discovery 3, 711-715 (2004). 

     상세보기