최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Journal of Korean medical science : JKMS, v.20 no.2 = no.102, 2005년, pp.291 - 296
Ji, Yong Cheol (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.) , Kim, Young Baeg (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.) , Park, Seung Won (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.) , Hwang, Sung Nam (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.) , Min, Byung Kook (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.) , Hong, Hyun Jong (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.) , Kwon, Jeong Taik (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.) , Suk, Jong Sik (Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.)
In the present study, we investigated whether ginseng total saponins (GTSs) protect hippocampal neurons after experimental traumatic brain injury (TBI) in rats. A moderate-grade TBI was made with the aid of a controlled cortical impact (CCI) device set at a velocity of 3.0 m/sec, a deformation of 3....
1 Attele AS Wu JA Yuan CS Ginseng pharmacology: multiple constituents and multiple actions Biochem Pharmacol 1999 58 1685 1693 10571242
2 Kim S Ahn K Oh TH Nah SY Rhim H Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons Biochem Biophys Res Commun 2002 296 247 254 12163009
3 Lee JH Kim SR Bae CS Kim DH Hong HN Nah SY Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus Neurosci Lett 2002 325 129 133 12044638
4 Kim HE Oh JH Lee SK Oh YJ Ginsenoside RH-2 induces apoptotic cell death in rat C6 glioma via a reactive oxygen- and caspase-dependent but Bcl-X(L)-independent pathway Life Sci 1999 65 PL33 PL40 10447219
5 Shibata S Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds J Korean Med Sci 2001 16 Suppl S28 S37 11748374
6 Faden AI Neuroprotection and traumatic brain injury: the search continues Arch Neurol 2001 58 1553 1555 11594912
7 Choi SM Suk JS Kwon JT Min BK Kim YB Hwang SN Choi DY Kim JH Lee SM Earmme YY Development of upgraded cortical impact model (Part I: Mechanics) J Korean Neurosurg Soc 2002 32 29 34
8 Choi SM Suk JS Min BK Hwang SN Kim YB Kim JH Development of upgraded cortical impact model (Part II: Functional outcome) J Korean Neurosurg Soc 2002 32 458 462
9 Wang LJ Lu YY Muramatsu S Ikeguchi K Fujimoto KI Okada T Mizukami H Matsushita T Hanazono Y Kume A Nagatsu T Ozawa K Nakano I Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis J Neurosci 2002 22 6920 6928 12177190
10 Wennersten A Holmin S Mathiesen T Characterization of Bax and Bcl-2 in apoptosis after experimental traumatic brain injury in the rat Acta Neuropathol (Berl) 2003 105 281 288 12557016
11 Stelmasiak Z Dudkowska-Konopa A Rejdak K Head trauma and neuroprotection Med Sci Monit 2000 6 426 432 11208350
12 Faden AI Neuroprotection and traumatic brain injury: theoretical option or realistic proposition Curr Opin Neurol 2002 15 707 712 12447109
13 Lighthall JW Controlled cortical impact: a new experimental brain injury model J Neurotrauma 1988 5 1 15 3193461
14 Lighthall JW Dixon CE Anderson TE Experimental models of brain injury J Neurotrauma 1989 6 83 97 2671392
15 Goodman JC Cherian L Bryan RM Jr Robertson CS Lateral cortical impact injury in rats: pathologic effects of varying cortical compression and impact velocity J Neurotrauma 1994 11 587 597 7861450
16 Baskaya MK Dogan A Temiz C Dempsey RJ Application of 2,3,5-triphenyltetrazolium chloride staining to evaluate injury volume after controlled cortical impact brain injury: role of brain edema in evolution of injury volume J Neurotrauma 2000 17 93 99 10674761
17 Hamm RJ Pike BR O'Dell DM Lyeth BG Jenkins LW The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury J Neurotrauma 1994 11 187 196 7932797
18 Liao B Newmark H Zhou R Neuroprotective effects of Ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro Exp Neurol 2002 173 224 234 11822886
19 Lim JH Wen TC Matsuda S Tanaka J Maeda N Peng H Aburaya J Ishihara K Sakanaka M Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root Neurosci Res 1997 28 191 200 9237267
20 Shen L Zhang J Ginsenoside Rg1 increases ischemia-induced cell proliferation and survival in the dentate gyrus of adult gerbils Neurosci Lett 2003 344 1 4 12781907
21 Lee YJ Chung E Lee KY Lee YH Hur B Lee SK Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor Mol Cell Endocrinol 1997 133 135 140 9406859
22 Chen XC Chen Y Zhu YG Fang F Chen LM Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons Acta Pharmacol Sin 2002 23 829 834 12230953
23 Chen XC Zhu YG Zhu LA Huang C Chen Y Chen LM Fang F Zhou YC Zhao CH Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress Eur J Pharmacol 2003 473 1 7 12877931
※ AI-Helper는 부적절한 답변을 할 수 있습니다.