Inverted papillomas are uncommon benign epithelial tumors which typically occur on the lateral wall of the nose or paranasal sinuses. Inverted papilloma of the nasal septum account for between 5.5% and 16.7% of inverted papilloma. Histopathologically, these tumors show inversion of the neoplastic epithelium into the underlying stroma, rather than proliferating outwards. The tumors also demonstrate local aggressiveness, a high recurrence rate and the possibility of malignant transformation. Malignant transformation rate varies from 2% to 53%. But there is no clinical prognostic indicator to show the malignant potency of tumors. Therefore, early diagnosis and careful follow-up is very important. Some cases of this condition have been reported in otolaryngologic literature, but there are no reports of it in dermatologic literature. Herein we report a case of squamous cell carcinoma arising from an inverted papilloma in the nasal septum of a 78-year-old man.
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