$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Serum IgE Reactivity to Malassezia furfur Extract and Recombinant M. furfur Allergens in Patients with Atopic Dermatitis

Acta dermato-venereologica, v.81 no.6, 2001년, pp.418 - 422  

Zargari, Arezou ,  Eshaghi, Hojjat ,  Bäck, Ove ,  Johansson, Sgo ,  Scheynius, Annika

Abstract

IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1, rMal f 5-9) from M. furfur . In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur -associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. Sixty-four percent had increased total serum IgE levels, 79% had specific IgE antibodies to common inhalant allergens and 47% had IgE antibodies to M. furfur extract. IgE antibodies to any of the rMal f allergens were detected among 86 (55%) of the patients, 14 (16%) of whom did not react to the M. furfur extract. Any individual rMal f allergen detected between 32% and 89% of the patients ImmunoCAP-positive to the M. furfur extract, with the highest sensitivity for rMal f 9. Therefore, a couple of individual rMal f allergens can improve the diagnosis of M. furfur associated IgE allergies in patients with AD.

주제어

참고문헌 (33)

  1. Eur J Biochem Schmidt, M. 246 181 1997 10.1111/j.1432-1033.1997.00181.x Schmidt M, Zargari A, Holt P, Lindbom L, Hellman U, Whitley P, et al. The complete cDNA sequence and expression of the first major allergenic protein of Malassezia furfur. Mal f 1. Eur J Biochem 1997; 246: 181-185. 

  2. Biochem Biophys Res Commun Yasueda, H. 248 240 1998 10.1006/bbrc.1998.8944 Yasueda H, Hashida-Okado T, Saito A, Uchida K, Kuroda M, Onishi Y, et al. Identification and cloning of two novel allergens from the lipophilic yeast, Malassezia furfur. Biochem Biophys Res Commun 1998; 248: 240-244. 

  3. Eur J Biochem Onishi, Y. 261 148 1999 10.1046/j.1432-1327.1999.00247.x Onishi Y, Kuroda M, Yasueda H, Saito A, Sono-Koyama E, Tunasawa S, et al. Two-dimensional electrophoresis of Malassezia allergens for atopic dermatitis and isolation of Mal f 4 homologs with mitochondria! malate dehydrogenase. Eur J Biochem 1999; 261: 148-154. 

  4. J Invest Dermatol Lindborg, M. 113 156 1999 10.1046/j.1523-1747.1999.00661.x Lindborg M, Magnusson CG, Zargari A, Schmidt M, Scheynius A, Crameri R, et al. Selective cloning of allergens from the skin colonizing yeast Malassezia furfur by phage surface display technology. J Invest Dermatol 1999; 113: 156-161. 

  5. Eur J Biochem Rasool, O. 267 4355 2000 10.1046/j.1432-1327.2000.01475.x Rasool O, Zargari A, Almqvist J, Eshaghi H, Whitley P, Scheynius A. Cloning, characterization and expression of complete coding sequences of three IgE binding Malassezia furfur allergens. Mal f 7, Mal f 8 and Mal f 9. Eur J Biochem 2000; 267: 4355-4361. 

  6. J Allergy Clin Immunol Zargari, A. 103 877 1999 10.1016/S0091-6749(99)70433-1 Zargari A, Schmidt M, Lundberg M, Scheynius A, Whitley P. Immunologie characterization of natural and recombinant Mal f 1 yeast allergen. J Allergy Clin Immunol 1999; 103: 877-884. 

  7. A eta Derm Venereol Hanifin, J. 92 44 1980 10.2340/00015555924447 Hanifin J, Rajka G. Diagnostic features of atopic dermatitis. A eta Derm Venereol 1980; 92: 4447. 

  8. Acta Derm Venereol Rajka, G. 144 13 1989 Rajka G, Langeland T. Grading of the severity of atopic dermatitis. Acta Derm Venereol 1989; 144(Suppl): 13-14. 

  9. Int Arch Allergy Immunol Johansson, E. 120 43 1999 10.1159/000024218 Johansson E, Eriksson TL, Olsson S, Kronqvist M, Whitley P, Johansson SGO, et al. Evaluation of specific IgE to the recombinant group 2 mite allergens Lep d 2 and Tyr p 2 in the Pharmacia CAP System. Int Arch Allergy Immunol 1999; 120: 43-49. 

  10. Clin Exp Allergy Crameri, R. 26 1411 1996 10.1111/j.1365-2222.1996.tb00543.x Crameri R, Lidholm J, Gronlund H, Stuber D, Blaser K, Menz G. Automated specific IgE assay with recombinant allergens: evaluation of the recombinant Aspergillus fumigatus allergen I in the Pharmacia Cap System. Clin Exp Allergy 1996; 26:1411-1419. 

  11. Borgå, Å 1990 Borgå Å. Allergens of Aspergillus fumigatus. Dissertation, Karolinska Institutet, Stockholm, 1990. 

  12. J Allergy Clin Immunol Niederberger, V. 102 579 1998 10.1016/S0091-6749(98)70273-8 Niederberger V, Paul! G, Gronlund H, Froschl R, Rumpold H, Kraft D, et al. Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations. J Allergy Clin Immunol 1998; 102:579-591. 

  13. Clin Exp Allergy Menz, G. 26 50 1996 10.1111/j.1365-2222.1996.tb00056.x Menz G, Dolecek C, Schönheit-Kenn U, Ferreira F, Moser M, Schneider T, et al. Serological and skin-test diagnosis of birch pollen allergy with recombinant Bet v I, the major birch pollen allergen. Clin Exp Allergy 1996; 26: 50-60. 

  14. Arch Dermatol Rokugo, M. 126 627 1990 10.1001/archderm.1990.01670290071011 Rokugo M, Tagami H, Usuba Y, Tomita Y. Contact sensitivity to Pityrosporum ovale in patients with atopic dermatitis. Arch Dermatol 1990; 126: 627-632. 

  15. Acta Derm Venereol U+014Ehman, S. 54 193 1974 10.2340/0001555554193202 U+014Ehman S, Johansson SGO. Immunoglobulins in atopic dermatitis with special reference to IgE. Acta Derm Venereol 1974; 54: 193-202. 

  16. Allergy Pepys, J. 49 397 1994 10.1111/j.1398-9995.1994.tb00830.x Pepys J. "Atopy": a study in definition. Allergy 1994; 49: 397-399. 

  17. Allergy Johansson, SGO 56 813 2001 10.1034/j.1398-9995.2001.t01-1-00001.x Johansson SGO, Hourihane JOB, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, et al. A revised nomenclature for allergy. Allergy 2001; 56: 813-824. 

  18. Clin Exp Dermatol Kim, TY 24 226 1999 10.1046/j.1365-2230.1999.00460.x Kim TY, Jang IG, Park YM, Kim HO, Kim CW. Head and neck dermatitis: the role of Malassezia furfur, topical steroid use and environmental factors in its causation. Clin Exp Dermatol 1999; 24:226-231. 

  19. Allergy Faergemann, J. 54 413 1999 10.1034/j.1398-9995.1999.00089.x Faergemann J. Pityrosporum species as a cause of allergy and infection. Allergy 1999; 54: 413-419. 

  20. Acta Derm Venereol Waersted, A. 114 146 1985 Waersted A, Hjorth N. Pityrosporum orbicular a a pathogenic factor in atopic dermatitis of the face, scalp and neck? Acta Derm Venereol 1985; 114(Suppl): 146-148. 

  21. J Am Acad Dermatol Kieffer, M. 22 739 1990 10.1016/0190-9622(90)70100-V Kieffer M, Bergbrant IM, Faergemann J, Jemec GB, Ottevanger V, Stahl Skov P, et al. Immune reactions to Pityrosporum ovale in adult patients with atopic and seborrhoeic dermatitis. J Am Acad Dermatol 1990; 22: 739-742. 

  22. Br J Dermatol Wessels, MW 125 227 1991 10.1111/j.1365-2133.1991.tb14745.x Wessels MW, Doekes G, van leperen-van Dijk AG, Koers WJ, Young E. IgE antibodies to Pityrosporum ovale in atopic dermatitis. Br J Dermatol 1991; 125: 227-232. 

  23. Scand J Immunol Tengvall Linder, M. 47 152 1998 10.1046/j.1365-3083.1998.00271.x Tengvall Linder M, Johansson C, Bengtsson A, Holm L, Härfast B, Scheynius A. Pityrosporum orbiculare-reactwe T-cell lines in atopic dermatitis patients and healthy individuals. Scand J Immunol 1998; 47: 152-158. 

  24. Tidsskr Nor Laegeforen Steinkjer, B. 112 2970 1992 Steinkjer B. Skin prick tests with Pityrosporum ovale extract in atopic dermatitis. Tidsskr Nor Laegeforen 1992; 112: 2970-2971. 

  25. Clin Exp Allergy Tengvall Linder, M. 30 122 2000 10.1046/j.1365-2222.2000.00702.x Tengvall Linder M, Johansson C, Scheynius A, Wahlgren C. Positive atopy patch test reactions to Pityrosporum orbiculare in atopic dermatitis patients. Clin Exp Allergy 2000; 30: 122-131. 

  26. Arch Dermatol Res Back, O. 287 448 1995 10.1007/BF00373427 Back O, Scheynius A, Johansson SGO. Ketoconazole in atopic dermatitis: therapeutic response is correlated with decrease in serum IgE. Arch Dermatol Res 1995; 287: 448-451. 

  27. J Eur Acad Dermatol Venereol Back, O. 15 34 2001 10.1046/j.1468-3083.2001.00207.x Back O, Bartosik J. Systemic ketoconazole for yeast allergic patients with atopic dermatitis. J Eur Acad Dermatol Venereol 2001; 15:34-38. 

  28. Acta Derm Venereol Johansson, S. 71 11 1991 10.2340/00015555711116 Johansson S, Karlström K. IgE-binding components in Pityrosporum orbiculare identified by an immunoblotting technique. Acta Derm Venereol 1991; 71: 11-16. 

  29. Allergy Zargari, A. 49 50 1994 10.1111/j.1398-9995.1994.tb00773.x Zargari A, Härfast B, Johansson S, Johansson SGO, Scheynius A. Identification of allergen components of the opportunistic yeast Pityrosporum orbiculare by monoclonal antibodies. Allergy 1994; 49: 50-56. 

  30. Allergy Huang, X. 50 648 1995 10.1111/j.1398-9995.1995.tb02581.x Huang X, Johansson SGO, Zargari A, Nordvall SL. Allergen cross-reactivity between Pityrosporum orbiculare and Candida albicans. Allergy 1995; 50: 648-656. 

  31. Clin Exp Allergy Lintu, P. 27 87 1997 10.1111/j.1365-2222.1997.tb00677.x Lintu P, Savolainen J, Kalimo K. IgE antibodies to protein and mannan antigens of Pityrosporum ovale in atopic dermatitis patients. Clin Exp Allergy 1997; 27: 87-95. 

  32. J Allergy Clin Immunol Jensen-Jarolim, E. 89 44 1992 10.1016/S0091-6749(05)80039-9 Jensen-Jarolim E, Poulsen LK, With H, Kieffer M, Ottevanger V, Stahl Skov P. A topic dermatitis of the face, scalp, and neck: type I reaction to the yeast Pityrosporum ovale? J Allergy Clin Immunol 1992; 89: 44-51. 

  33. Clin Exp Allergy Zargari, A. 25 1235 1995 10.1111/j.1365-2222.1995.tb03048.x Zargari A, Doekes G, van leperen-van Dijk AG, Landberg E, Härfast B, Scheynius A. Influence of culture period on the allergenic composition of Pityrosporum orbiculare extracts. Clin Exp Allergy 1995; 25: 1235-1245. 

관련 콘텐츠

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로