최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기Aging cell, v.5 no.5, 2006년, pp.423 - 436
Kang, Hyun Tae , Lee, Hyung Il , Hwang, Eun Seong
SummaryWe found that an ongoing application of nicotinamide to normal human fibroblasts not only attenuated expression of the aging phenotype but also increased their replicative lifespan, causing a greater than 1.6-fold increase in the number of population doublings. Although nicotinamide by itself...
Fagagna, Fabrizio d'Adda di, Reaper, Philip M., Clay-Farrace, Lorena, Fiegler, Heike, Carr, Philippa, von Zglinicki, Thomas, Saretzki, Gabriele, Carter, Nigel P., Jackson, Stephen P.. A DNA damage checkpoint response in telomere-initiated senescence. Nature, vol.426, no.6963, 194-198.
Allsopp, Richard C.. Models of initiation of replicative senescence by loss of telomeric DNA. Experimental gerontology, vol.31, no.1, 235-243.
Anderson, Rozalyn M., Bitterman, Kevin J., Wood, Jason G., Medvedik, Oliver, Sinclair, David A.. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature, vol.423, no.6936, 181-185.
Atamna, Hani, Paler-Martı́nez, Andrés, Ames, Bruce N.. N-t-Butyl Hydroxylamine, a Hydrolysis Product of α-Phenyl-N-t-butyl Nitrone, Is More Potent in Delaying Senescence in Human Lung Fibroblasts. The Journal of biological chemistry, vol.275, no.10, 6741-6748.
Beltrán, Belén, Mathur, Anthony, Duchen, Michael R., Erusalimsky, Jorge D., Moncada, Salvador. The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death. Proceedings of the National Academy of Sciences of the United States of America, vol.97, no.26, 14602-14607.
Bitterman, Kevin J., Anderson, Rozalyn M., Cohen, Haim Y., Latorre-Esteves, Magda, Sinclair, David A.. Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1. The Journal of biological chemistry, vol.277, no.47, 45099-45107.
Blazer, Shraga, Khankin, Eli, Segev, Yardena, Ofir, Rachel, Yalon-Hacohen, Michal, Kra-Oz, Zipora, Gottfried, Yossi, Larisch, Sarit, Skorecki, Karl L. High glucose-induced replicative senescence: point of no return and effect of telomerase. Biochemical and biophysical research communications, vol.296, no.1, 93-101.
Bodnar, Andrea G., Ouellette, Michel, Frolkis, Maria, Holt, Shawn E., Chiu, Choy-Pik, Morin, Gregg B., Harley, Calvin B., Shay, Jerry W., Lichtsteiner, Serge, Wright, Woodring E.. Extension of Life-Span by Introduction of Telomerase into Normal Human Cells. Science, vol.279, no.5349, 349-352.
Campisi, Judith. Cellular senescence as a tumor-suppressor mechanism. Trends in cell biology, vol.11, no.suppl1, S27-S31.
Campisi, Judith. Aging, tumor suppression and cancer: high wire-act!. Mechanisms of ageing and development, vol.126, no.1, 51-58.
Chen, Q, Fischer, A, Reagan, J D, Yan, L J, Ames, B N. Oxidative DNA damage and senescence of human diploid fibroblast cells.. Proceedings of the National Academy of Sciences of the United States of America, vol.92, no.10, 4337-4341.
Fisher, James, Hodges, T. K.. Monovalent Ion Stimulated Adenosine Triphosphatase From Oat Roots. Plant physiology, vol.44, no.3, 385-395.
GENOVA, MARIA LUISA, PICH, MILENA MERLO, BERNACCHIA, ANDREA, BIANCHI, CRISTINA, BIONDI, ANNALISA, BOVINA, CARLA, FALASCA, ANNA IDA, FORMIGGINI, GABRIELLA, CASTELLI, GIOVANNA PARENTI, LENAZ, GIORGIO. The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology. Annals of the New York Academy of Sciences, vol.1011, no.1, 86-100.
Grover, Gary J., Atwal, Karnail S., Sleph, Paul G., Wang, Feng-Li, Monshizadegan, Hossain, Monticello, Thomas, Green, David W.. Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity. American journal of physiology, Heart and circulatory physiology, vol.287, no.4, H1747-H1755.
Guarente, L. Diverse and dynamic functions of the Sir silencing complex. Nature genetics, vol.23, no.3, 281-285.
Guruprasad, K.P., Vasudev, V., Anilkumar, M.N., Chethan, S.A.. Inducible protective processes in animal systems. X. Influence of nicotinamide in methyl methanesulfonate-adapted mouse bone marrow cells. Mutagenesis, vol.17, no.1, 1-8.
Hatefi, Y. Flavoproteins of the electron transport system and the site of action of amytal, rotenone, and piericidin A.. Proceedings of the National Academy of Sciences of the United States of America, vol.60, no.2, 733-740.
Hatefi, Y, Stempel, K E, Hanstein, W G. Inhibitors and Activators of the Mitochondrial Reduced Diphosphopyridine Nucleotide Dehydrogenase. The Journal of biological chemistry, vol.244, no.9, 2358-2365.
Hayflick, L., Moorhead, P.S.. The serial cultivation of human diploid cell strains. Experimental cell research, vol.25, no.3, 585-621.
Hoshino, J., Schluter, U., Kroger, H.. Nicotinamide methylation and its relation to NAD synthesis in rat liver tissue culture - Biochemical basis fro the physiological activities of 1-methylnicotinamide. Biochimica et biophysica acta, General subjects, vol.801, no.2, 250-258.
Hütter, Eveline, Unterluggauer, Hermann, Überall, Florian, Schramek, Herbert, Jansen-Dürr, Pidder. Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress. Experimental gerontology, vol.37, no.10, 1165-1174.
Hwang, Eun Seong. Replicative senescence and senescence-like state induced in cancer-derived cells. Mechanisms of ageing and development, vol.123, no.12, 1681-1694.
Hynes, James, O'Riordan, Tomás C., Curtin, James, Cotter, Thomas G., Papkovsky, Dmitri B.. Fluorescence based oxygen uptake analysis in the study of metabolic responses to apoptosis induction. Journal of immunological methods, vol.306, no.1, 193-201.
J. Nutr. Jackson TM 1455 125 1995 Large supplements of nicotinic acid and nicotinamide increase tissue NAD+ and poly (ADP‐ribose) levels but do not affect diethylnitrosamine‐induced altered hepatic foci in Fischer‐344 rats
JAMES, Andrew M, WEI, Yau-Huei, PANG, Cheng-Yoong, MURPHY, Michael P.. Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations. The Biochemical journal, vol.318, no.2, 401-407.
Kaim, G, Dimroth, P. ATP synthesis by F-type ATP synthase is obligatorily dependent on the transmembrane voltage.. The EMBO journal, vol.18, no.15, 4118-4127.
Kallmann, B., Burkart, V., Kroncke, K.-D., Kolb-Bachofen, V., Kolb, H.. Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide. Life sciences, vol.51, no.9, 671-678.
Kamat, J.P., Devasagayam, T.P.A.. Nicotinamide (vitamin B3) as an effective antioxidant against oxidative damage in rat brain mitochondria. Redox report : communications in free radical research, vol.4, no.4, 179-184.
Karlseder, Jan, Smogorzewska, Agata, de Lange, Titia. Senescence Induced by Altered Telomere State, Not Telomere Loss. Science, vol.295, no.5564, 2446-2449.
Khaled, Annette R., Reynolds, Della A., Young, Howard A., Thompson, Craig B., Muegge, Kathrin, Durum, Scott K.. Interleukin-3 Withdrawal Induces an Early Increase in Mitochondrial Membrane Potential Unrelated to the Bcl-2 Family. The Journal of biological chemistry, vol.276, no.9, 6453-6462.
Kim, Moon-Moo, Yoon, Sang-Oh, Cho, Yee Sook, Chung, An-Sik. Histone deacetylases, HDAC1 and HSIR2, act as a negative regulator of ageing through p53 in human gingival fibroblast. Mechanisms of ageing and development, vol.125, no.5, 351-357.
Klaidman, Lori, Morales, Maria, Kem, Seyha, Yang, Jun, Chang, Mei-Ling, Adams, Jr., James D.. Nicotinamide Offers Multiple Protective Mechanisms in Stroke as a Precursor for NAD+, as a PARP Inhibitor and by Partial Restoration of Mitochondrial Function. Pharmacology, vol.69, no.3, 150-157.
Korshunov, Sergey S., Skulachev, Vladimir P., Starkov, Anatoly A.. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS letters, vol.416, no.1, 15-18.
Ingram, Donald K., Zhu, Min, Mamczarz, Jacek, Zou, Sige, Lane, Mark A., Roth, George S., DeCabo, Rafael. Calorie restriction mimetics: an emerging research field. Aging cell, vol.5, no.2, 97-108.
J. Bacteriol. Liu G 1111 152 1982 10.1128/jb.152.3.1111-1116.1982 Nucleoside salvage pathway for NAD biosynthesis in Salmonella typhimurium
López-Lluch, G., Hunt, N., Jones, B., Zhu, M., Jamieson, H., Hilmer, S., Cascajo, M. V., Allard, J., Ingram, D. K., Navas, P., de Cabo, R.. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proceedings of the National Academy of Sciences of the United States of America, vol.103, no.6, 1768-1773.
Recent Adv. Stud. Cardiac. Struct. Metab. Loschen G 3 7 1975 On the formation of hydrogen peroxide and oxygen radicals in heart mitochondria
Luo, Jianyuan, Nikolaev, Anatoly Y., Imai, Shin-ichiro, Chen, Delin, Su, Fei, Shiloh, Ariel, Guarente, Leonard, Gu, Wei. Negative Control of p53 by Sir2α Promotes Cell Survival under Stress. Cell, vol.107, no.2, 137-148.
Marcinek, David J., Schenkman, Kenneth A., Ciesielski, Wayne A., Lee, Donghoon, Conley, Kevin E.. Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle. The Journal of physiology, vol.569, no.2, 467-473.
Matuoka, K., Chen, K. Y., Takenawa, T.. Rapid reversion of aging phenotypes by nicotinamide through possible modulation of histone acetylation :. Cellular and molecular life sciences : CMLS, vol.58, no.14, 2108-2116.
McFarland, G.A., Holliday, R.. Retardation of the Senescence of Cultured Human Diploid Fibroblasts by Carnosine. Experimental cell research, vol.212, no.2, 167-175.
McLure, Kevin G., Takagi, Masatoshi, Kastan, Michael B.. NAD+ Modulates p53 DNA Binding Specificity and Function. Molecular and cellular biology, vol.24, no.22, 9958-9967.
Michishita, Eriko, Park, Jean Y., Burneskis, Jenna M., Barrett, J. Carl, Horikawa, Izumi. Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins. Molecular biology of the cell, vol.16, no.10, 4623-4635.
Mokudai, Toshihiko, Ayoub, Issam A., Sakakibara, Yohtaro, Lee, E-Jian, Ogilvy, Christopher S., Maynard, Kenneth I.. Delayed Treatment With Nicotinamide (Vitamin B 3 ) Improves Neurological Outcome and Reduces Infarct Volume After Transient Focal Cerebral Ischemia in Wistar Rats. Stroke, vol.31, no.7, 1679-1685.
Rattan, S.I.S., Clark, B.F.C.. Kinetin Delays the Onset of Aging Characteristics in Human Fibroblasts. Biochemical and biophysical research communications, vol.201, no.2, 665-672.
Reaper, Philip M., Fagagna, Fabrizio d'Adda di, Jackson, Stephen P.. Activation of the DNA Damage Response by Telomere Attrition: A Passage to Cellular Senescence. Cell cycle, vol.3, no.5, 541-544.
Cell Transplant. Sakai Y 435 1 2002 10.3727/000000002783985710 Enhanced in vitro maturation of fetal mouse liver cells with oncostatin M, nicotinamide, and dimethyl sulfoxide
Serra, Violeta, von Zglinicki, Thomas, Lorenz, Mario, Saretzki, Gabriele. Extracellular Superoxide Dismutase Is a Major Antioxidant in Human Fibroblasts and Slows Telomere Shortening. The Journal of biological chemistry, vol.278, no.9, 6824-6830.
Short, Kevin R., Bigelow, Maureen L., Kahl, Jane, Singh, Ravinder, Coenen-Schimke, Jill, Raghavakaimal, Sreekumar, Nair, K. Sreekumaran. Decline in skeletal muscle mitochondrial function with aging in humans. Proceedings of the National Academy of Sciences of the United States of America, vol.102, no.15, 5618-5623.
Sitte, N., Merker, K., Grune, T., von Zglinicki, T.. Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress. Experimental gerontology, vol.36, no.3, 475-486.
SKAPER, STEPHEN D.. Poly(ADP‐Ribose) Polymerase‐1 in Acute Neuronal Death and Inflammation : A Strategy for Neuroprotection. Annals of the New York Academy of Sciences, vol.993, no.1, 217-228.
Zhongguo Yao Li Xue Bao Sun AY 104 19 1998 Neuroprotective effects of poly (ADP‐ribose) polymerase inhibitors in transient focal cerebral ischemia of rats
Takeda, Yoshimasa, Pérez-Pinzón, Miguel A., Ginsberg, Myron D., Sick, Thomas J.. Mitochondria Consume Energy and Compromise Cellular Membrane Potential by Reversing ATP Synthetase Activity During Focal Ischemia in Rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, vol.24, no.9, 986-992.
Tanny, Jason C, Dowd, Gustave J, Huang, Julie, Hilz, Helmuth, Moazed, Danesh. An Enzymatic Activity in the Yeast Sir2 Protein that Is Essential for Gene Silencing. Cell, vol.99, no.7, 735-745.
Toussaint, O, Medrano, E.E, von Zglinicki, T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Experimental gerontology, vol.35, no.8, 927-945.
Vaca, P, Berná, G, Martín, F, Soria, B. Nicotinamide induces both proliferation and differentiation of embryonic stem cells into insulin-producing cells. Transplantation proceedings, vol.35, no.5, 2021-2023.
von Zglinicki, Thomas. Oxidative stress shortens telomeres. Trends in biochemical sciences, vol.27, no.7, 339-344.
von Zglinicki, T., Nilsson, E., Döcke, W.D., Brunk, U.T.. LIPOFUSCIN ACCUMULATION AND AGEING OF FIBROBLASTS. Gerontology, vol.41, no.suppl2, 95-108.
ZWERSCHKE, Werner, MAZUREK, Sybille, STÖCKL, Petra, HÜTTER, Eveline, EIGENBRODT, Erich, JANSEN-DÜRR, Pidder. Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence. The Biochemical journal, vol.376, no.2, 403-411.
해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.