다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Microbiology and molecular biology reviews : MMBR, v.70 no.4, 2006년, pp.1032 - 1060
García, M. A. (Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologí) , Gil, J. (a, Ciudad Universitaria Cantoblanco, 28049 Madrid, Spain) , Ventoso, I. (Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom) , Guerra, S. (Centro de Biologí) , Domingo, E. (a Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autó) , Rivas, C. (noma de Madrid, Cantoblanco, Madrid 28049, Spain) , Esteban, M. (Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologí)
AI-Helper
SUMMARYThe double-stranded RNA-dependent protein kinase PKR is a critical mediator of the antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector molecule on the cellular response to double-stranded RNA, but it also integrates signals in response to Toll-like rece...
Abraham, N., Jaramillo, M.L., Duncan, P.I., Methot, N., Icely, P.L., Stojdl, D.F., Barber, G.N., Bell, J.C.. The Murine PKR Tumor Suppressor Gene Is Rearranged in a Lymphocytic Leukemia. Experimental cell research, vol.244, no.2, 394-404.
Alcamí, A, Smith, G L. Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity. Journal of virology, vol.69, no.8, 4633-4639.
Alexopoulou, Lena, Holt, Agnieszka Czopik, Medzhitov, Ruslan, Flavell, Richard A.. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature, vol.413, no.6857, 732-738.
Arch, Robert H., Gedrich, Richard W., Thompson, Craig B.. Tumor necrosis factor receptor-associated factors (TRAFs)-a family of adapter proteins that regulates life and death. Genes & development, vol.12, no.18, 2821-2830.
Balachandran, Siddharth, Barber, Glen N.. Defective translational control facilitates vesicular stomatitis virus oncolysis. Cancer cell, vol.5, no.1, 51-65.
Balachandran, Siddharth, Kim, Caryn N., Yeh, Wen-Chen, Mak, Tak W., Bhalla, Kapil, Barber, Glen N.. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. The EMBO journal, vol.17, no.23, 6888-6902.
Balachandran, Siddharth, Roberts, Paul C, Brown, Laura E, Truong, Ha, Pattnaik, Asit K, Archer, David R, Barber, Glen N. Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection. Immunity, vol.13, no.1, 129-141.
Baltzis, Dionissios, Li, Suiyang, Koromilas, Antonis E.. Functional Characterization of pkr Gene Products Expressed in Cells from Mice with a Targeted Deletion of the N terminus or C terminus Domain of PKR. The Journal of biological chemistry, vol.277, no.41, 38364-38372.
Baltzis, Dionissios, Qu, Li-Ke, Papadopoulou, Stavroula, Blais, Jaime D., Bell, John C., Sonenberg, Nahum, Koromilas, Antonis E.. Resistance to Vesicular Stomatitis Virus Infection Requires a Functional Cross Talk between the Eukaryotic Translation Initiation Factor 2α Kinases PERK and PKR. Journal of virology, vol.78, no.23, 12747-12761.
10.2174/1570162052772924
Barber, G N. The dsRNA-dependent protein kinase, PKR and cell death. Cell death and differentiation, vol.12, no.6, 563-570.
Barber, G N. Host defense, viruses and apoptosis. Cell death and differentiation, vol.8, no.2, 113-126.
Barber, G.N., Edelhoff, S., Katze, M.G., Disteche, C.M.. Chromosomal Assignment of the Interferon-Inducible Double-Stranded RNA-Dependent Protein Kinase (PRKR) to Human Chromosome 2p21-p22 and Mouse Chromosome 17 E2. Genomics, vol.16, no.3, 765-767.
Barber, Glen N., Jagus, Rosemary, Meurs, Eliane F., Hovanessian, Ara G., Katze, Michael G.. Molecular Mechanisms Responsible for Malignant Transformation by Regulatory and Catalytic Domain Variants of the Interferon-induced Enzyme RNA-dependent Protein Kinase. The Journal of biological chemistry, vol.270, no.29, 17423-17428.
Barber, G N, Thompson, S, Lee, T G, Strom, T, Jagus, R, Darveau, A, Katze, M G. The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.. Proceedings of the National Academy of Sciences of the United States of America, vol.91, no.10, 4278-4282.
Distinct Patterns of IFN Sensitivity Observed in Cells Infected with Vaccinia K3L- and E3L- Mutant Viruses. Virology, vol.210, no.2, 254-263.
Beere, Helen M., Wolf, Beni B., Cain, Kelvin, Mosser, Dick D., Mahboubi, Artin, Kuwana, Tomomi, Tailor, Pankaj, Morimoto, Richard I., Cohen, Gerald M., Green, Douglas R.. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nature cell biology, vol.2, no.8, 469-475.
Behrmann, Iris, Walczak, Henning, Krammer, Peter H.. Structure of the human APO‐1 gene. European journal of immunology, vol.24, no.12, 3057-3062.
Ben-Asouli, Yitzhak, Banai, Yona, Pel-Or, Yehuda, Shir, Alexei, Kaempfer, Raymond. Human Interferon-γ mRNA Autoregulates Its Translation through a Pseudoknot that Activates the Interferon-Inducible Protein Kinase PKR. Cell, vol.108, no.2, 221-232.
Benkirane, M, Neuveut, C, Chun, R F, Smith, S M, Samuel, C E, Gatignol, A, Jeang, K T. Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.. The EMBO journal, vol.16, no.3, 611-624.
Bennett, Richard L., Blalock, William L., May, W. Stratford. Serine 18 Phosphorylation of RAX, the PKR Activator, Is Required for PKR Activation and Consequent Translation Inhibition. The Journal of biological chemistry, vol.279, no.41, 42687-42693.
Oncogene 1593 12 1996 Beretta, L., M. Gabbay, R. Berger, S. M. Hanash, and N. Sonenberg. 1996. Expression of the protein kinase PKR in modulated by IRF-1 and is reduced in 5q-associated leukemias. Oncogene12:1593-1596.
Characterization of the Thermosensitive ts453 Reovirus Mutant: Increased dsRNA Binding of σ3 Protein Correlates with Interferon Resistance. Virology, vol.246, no.2, 199-210.
Bergmann, Michael, Garcia-Sastre, Adolfo, Carnero, Elena, Pehamberger, Hubert, Wolff, Klaus, Palese, Peter, Muster, Thomas. Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication. Journal of virology, vol.74, no.13, 6203-6206.
Bertwistle, David, Sugimoto, Masataka, Sherr, Charles J.. Physical and Functional Interactions of the Arf Tumor Suppressor Protein with Nucleophosmin/B23. Molecular and cellular biology, vol.24, no.3, 985-996.
Beutler, Bruce. Inferences, questions and possibilities in Toll-like receptor signalling. Nature, vol.430, no.6996, 257-263.
Eur. J. Haematol. 150 45 1990 10.1111/j.1600-0609.1990.tb00442.x Billstrom, R., S. Heim, U. Kristoffersson, N. Mandahl, and F. Mitelman. 1990. Structural chromosomal abnormalities of 3q in myelodysplastic syndrome/acute myeloid leukaemia with Sweet's syndrome. Eur. J. Haematol.45:150-152.
Bonnet, Marion C., Weil, Robert, Dam, Elisabeth, Hovanessian, Ara G., Meurs, Eliane F.. PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex. Molecular and cellular biology, vol.20, no.13, 4532-4542.
Bottone Jr., Frank G., Moon, Yuseok, Kim, Jong Sik, Alston-Mills, Brenda, Ishibashi, Minako, Eling, Thomas E.. The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3). Molecular cancer therapeutics, vol.4, no.5, 693-703.
Brand, Stephen R., Kobayashi, Ryuji, Mathews, Michael B.. The Tat Protein of Human Immunodeficiency Virus Type 1 Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR. The Journal of biological chemistry, vol.272, no.13, 8388-8395.
Brandt, Teresa, Heck, Michael C., Vijaysri, Sangeetha, Jentarra, Garilyn M., Cameron, Jason M., Jacobs, Bertram L.. The N-terminal domain of the vaccinia virus E3L-protein is required for neurovirulence, but not induction of a protective immune response. Virology, vol.333, no.2, 263-270.
Brandt, Teresa A., Jacobs, Bertram L.. Both Carboxy- and Amino-Terminal Domains of the Vaccinia Virus Interferon Resistance Gene, E3L, Are Required for Pathogenesis in a Mouse Model. Journal of virology, vol.75, no.2, 850-856.
African Swine Fever Virus GeneA179L,a Viral Homologue ofbcl-2, Protects Cells from Programmed Cell Death. Virology, vol.225, no.1, 227-230.
Buchner, Johannes. Hsp90 & Co. – a holding for folding. Trends in biochemical sciences, vol.24, no.4, 136-141.
Burýšek, Ladislav, Pitha, Paula M.. Latently Expressed Human Herpesvirus 8-Encoded Interferon Regulatory Factor 2 Inhibits Double-Stranded RNA-Activated Protein Kinase. Journal of virology, vol.75, no.5, 2345-2352.
Cai, Ruorong, Carpick, Bruce, Chun, Rene F., Jeang, Kuan-Teh, Williams, Bryan R.G.. HIV-I TAT Inhibits PKR Activity by Both RNA-Dependent and RNA-Independent Mechanisms. Archives of biochemistry and biophysics, vol.373, no.2, 361-367.
Carpick, Bruce W., Graziano, Vito, Schneider, Dieter, Maitra, Ratan K., Lee, Xavier, Williams, Bryan R.G.. Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA. The Journal of biological chemistry, vol.272, no.14, 9510-9516.
Carroll, K., Elroy-Stein, O., Moss, B., Jagus, R.. Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase. The Journal of biological chemistry, vol.268, no.17, 12837-12842.
Casano, F.J., Rolando, A.M., Mudgett, J.S., Molineaux, S.M.. The Structure and Complete Nucleotide Sequence of the Murine Gene Encoding Interleukin-1β Converting Enzyme (ICE). Genomics, vol.20, no.3, 474-481.
Cassady, Kevin A., Gross, Martin. The Herpes Simplex Virus Type 1 U S 11 Protein Interacts with Protein Kinase R in Infected Cells and Requires a 30-Amino-Acid Sequence Adjacent to a Kinase Substrate Domain. Journal of virology, vol.76, no.5, 2029-2035.
Castelli, JoAnn C, Hassel, Bret A, Maran, Avudaiappan, Paranjape, Jayashree, Hewitt, Judith A, Li, Xiao-ling, Hsu, Yi-Te, Silverman, Robert H, Youle, Richard J. The role of 2′-5′ oligoadenylate-activated ribonuclease L in apoptosis. Cell death and differentiation, vol.5, no.4, 313-320.
Castet, Valérie, Fournier, Chantal, Soulier, Alexandre, Brillet, Rozenn, Coste, Joliette, Larrey, Dominique, Dhumeaux, Daniel, Maurel, Patrick, Pawlotsky, Jean-Michel. Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro. Journal of virology, vol.76, no.16, 8189-8199.
Caudell, Eva G., Mumm, John B., Poindexter, Nancy, Ekmekcioglu, Suhendan, Mhashilkar, Abner M., Yang, Xiaohong Helena, Retter, Mark W., Hill, Paul, Chada, Sunil, Grimm, Elizabeth A.. The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-24. The journal of immunology : official journal of the American Association of Immunologists, vol.168, no.12, 6041-6046.
Clemens, Michael J.. Epstein-Barr virus: Inhibition of apoptosis as a mechanism of cell transformation. The international journal of biochemistry & cell biology, vol.38, no.2, 164-169.
Clemens, Michael J.. PKR—A protein kinase regulated by double-stranded RNA. The international journal of biochemistry & cell biology, vol.29, no.7, 945-949.
Clemens, Michael J., Hershey, John W.B., Hovanessian, Ara C., Jacobs, Bertram C., Katze, Michael G., Kaufman, Randal J., Lengyel, Peter, Samuel, Charles E., Sen, Ganes C., Williams, Bryan R.G.. PKR: Proposed Nomenclature for the RNA-Dependent Protein Kinase Induced by Interferon. Journal of interferon research, vol.13, no.3, 241-241.
Colombo, Emanuela, Marine, Jean-Christophe, Danovi, Davide, Falini, Brunangelo, Pelicci, Pier Giuseppe. Nucleophosmin regulates the stability and transcriptional activity of p53. Nature cell biology, vol.4, no.7, 529-533.
Cosentino, G P, Venkatesan, S, Serluca, F C, Green, S R, Mathews, M B, Sonenberg, N. Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.. Proceedings of the National Academy of Sciences of the United States of America, vol.92, no.21, 9445-9449.
Craig, Andrew.W.B., Cosentino, Gregory P., Donzé, Olivier, Sonenberg, Nahum. The Kinase Insert Domain of Interferon-induced Protein Kinase PKR Is Required for Activity but Not for Interaction with the Pseudosubstrate K3L. The Journal of biological chemistry, vol.271, no.40, 24526-24533.
Cuddihy, Andrew R., Li, Suiyang, Tam, Nancy Wai Ning, Wong, Andrew Hoi-Tao, Taya, Yoichi, Abraham, Ninan, Bell, John C., Koromilas, Antonis E.. Double-Stranded-RNA-Activated Protein Kinase PKR Enhances Transcriptional Activation by Tumor Suppressor p53. Molecular and cellular biology, vol.19, no.4, 2475-2484.
Cuddihy, Andrew R, Hoi-Tao Wong, Andrew, Wai Ning Tam, Nancy, Li, Suiyang, Koromilas, Antonis E. The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro. Oncogene, vol.18, no.17, 2690-2702.
Cullen, B.R.. Does HIV-1 Tat induce a change in viral initiation rights?. Cell, vol.73, no.3, 417-420.
Chan, Wai Yee, Liu, Qing Rong, Borjigin, Jimo, Busch, Harris, Rennert, Owen M., Tease, Le Ann, Chan, Pui Kwong. Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth. Biochemistry, vol.28, no.3, 1033-1039.
Chang, H W, Watson, J C, Jacobs, B L. The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.. Proceedings of the National Academy of Sciences of the United States of America, vol.89, no.11, 4825-4829.
Chatterjee, Madhumita, Chatterjee, Nabendu, Datta, Rekha, Datta, Bansidhar, Gupta, Naba K.. Expression and Activity of p67 Are Induced during Heat Shock. Biochemical and biophysical research communications, vol.249, no.1, 113-117.
Reference deleted.
Cheshire, Jeanette L., Williams, Bryan R.G., Baldwin Jr., Albert S.. Involvement of Double-stranded RNA-activated Protein Kinase in the Synergistic Activation of Nuclear Factor-κB by Tumor Necrosis Factor-α and γ-Interferon in Preneuronal Cells. The Journal of biological chemistry, vol.274, no.8, 4801-4806.
Chong, K.L., Feng, L., Schappert, K., Meurs, E., Donahue, T.F., Friesen, J.D., Hovanessian, A.G., Williams, B.R.. Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.. The EMBO journal, vol.11, no.4, 1553-1562.
Chou, J, Kern, ER, Whitley, RJ, Roizman, B. Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture. Science, vol.250, no.4985, 1262-1266.
Chu, Wen-Ming, Ballard, Ruth, Carpick, Bruce W., Williams, Bryan R. G., Schmid, Carl W.. Potential Alu Function: Regulation of the Activity of Double-Stranded RNA-Activated Kinase PKR. Molecular and cellular biology, vol.18, no.1, 58-68.
Chu, Wen-Ming, Ostertag, Derek, Li, Zhi-Wei, Chang, Lufen, Chen, Yi, Hu, Yinling, Williams, Bryan, Perrault, Jacques, Karin, Michael. JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection. Immunity, vol.11, no.6, 721-731.
Chung, Jee Y., Park, Young Chul, Ye, Hong, Wu, Hao. All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. Journal of cell science, vol.115, no.4, 679-688.
Daher, Aı̈cha, Longuet, Michèle, Dorin, Dominique, Bois, Florence, Segeral, Emmanuel, Bannwarth, Sylvie, Battisti, Pier-Luigi, Purcell, Damian F., Benarous, Richard, Vaquero, Catherine, Meurs, Eliane F., Gatignol, Anne. Two Dimerization Domains in the Trans-activation Response RNA-binding Protein (TRBP) Individually Reverse the Protein Kinase R Inhibition of HIV-1 Long Terminal Repeat Expression. The Journal of biological chemistry, vol.276, no.36, 33899-33905.
Dar, Arvin C., Dever, Thomas E., Sicheri, Frank. Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR. Cell, vol.122, no.6, 887-900.
Darnell Jr., James E.. STATs and Gene Regulation. Science, vol.277, no.5332, 1630-1635.
Datta, B, Chakrabarti, D, Roy, A L, Gupta, N K. Roles of a 67-kDa polypeptide in reversal of protein synthesis inhibition in heme-deficient reticulocyte lysate.. Proceedings of the National Academy of Sciences of the United States of America, vol.85, no.10, 3324-3328.
Datta, B., Datta, R.. Induction of Apoptosis Due to Lowering the Level of Eukaryotic Initiation Factor 2-Associated Protein, p67, from Mammalian Cells by Antisense Approach. Experimental cell research, vol.246, no.2, 376-383.
Datta, Bansidhar, Datta, Rekha. Mutation at the acidic residue-rich domain of eukaryotic initiation factor 2 (eIF2α)-associated glycoprotein p67 increases the protection of eIF2α phosphorylation during heat shock. Archives of biochemistry and biophysics, vol.413, no.1, 116-122.
Datta, Bansidhar, Datta, Rekha, Ghosh, Arnab, Majumdar, Avijit. Eukaryotic initiation factor 2-associated glycoprotein, p67, shows differential effects on the activity of certain kinases during serum-starved conditions. Archives of biochemistry and biophysics, vol.427, no.1, 68-78.
Datta, B, Ray, M.K., Chakrabarti, D, Wylie, D.E., Gupta, N.K.. Glycosylation of eukaryotic peptide chain initiation factor 2 (eIF-2)-associated 67-kDa polypeptide (p67) and its possible role in the inhibition of eIF-2 kinase-catalyzed phosphorylation of the eIF-2 α-subunit. The Journal of biological chemistry, vol.264, no.34, 20620-20624.
Datta, Rekha, Tammali, Ravinder, Datta, Bansidhar. Negative regulation of the protection of eIF2α phosphorylation activity by a unique acidic domain present at the N-terminus of p67. Experimental cell research, vol.283, no.2, 237-246.
Davies, M V, Chang, H W, Jacobs, B L, Kaufman, R J. The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms. Journal of virology, vol.67, no.3, 1688-1692.
Davies, M V, Elroy-Stein, O, Jagus, R, Moss, B, Kaufman, R J. The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2. Journal of virology, vol.66, no.4, 1943-1950.
Davis, S, Watson, J C. In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.. Proceedings of the National Academy of Sciences of the United States of America, vol.93, no.1, 508-513.
Deb, Amitabha, Haque, S. Jaharul, Mogensen, Trine, Silverman, Robert H., Williams, Bryan R. G.. RNA-Dependent Protein Kinase PKR Is Required for Activation of NF-κB by IFN-γ in a STAT1-Independent Pathway. The journal of immunology : official journal of the American Association of Immunologists, vol.166, no.10, 6170-6180.
Deb, Amitabha, Zamanian‐Daryoush, Maryam, Xu, Zan, Kadereit, Suzanne, Williams, Bryan R.G.. Protein kinase PKR is required for platelet‐derived growth factor signaling of c‐fos gene expression via Erks and Stat3. The EMBO journal, vol.20, no.10, 2487-2496.
De Haro, César, Méndez, Raúl, Santoyo, Javier. The eIF‐2α kinases and the control of protein synthesis 1. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.10, no.12, 1378-1387.
Delhem, Nadvia, Sabile, Abdelmajid, Gajardo, Rodrigo, Podevin, Philippe, Abadie, Annie, Blaton, Maria Agnes, Kremsdorf, Dina, Beretta, Laura, Brechot, Christian. Activation of the interferon-inducible protein kinase PKR by Hepatocellular carcinoma derived-Hepatitis C virus core protein. Oncogene, vol.20, no.41, 5836-5845.
Der, S D, Lau, A S. Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.. Proceedings of the National Academy of Sciences of the United States of America, vol.92, no.19, 8841-8845.
Der, Sandy D., Yang, Yi-Li, Weissmann, Charles, Williams, Bryan R. G.. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America, vol.94, no.7, 3279-3283.
Dever, Thomas E.. Gene-Specific Regulation by General Translation Factors. Cell, vol.108, no.4, 545-556.
Dever, T.E., Feng, L., Wek, R.C., Cigan, A.M., Donahue, T.F., Hinnebusch, A.G.. Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell, vol.68, no.3, 585-596.
Dey, Madhusudan, Cao, Chune, Dar, Arvin C., Tamura, Tomohiko, Ozato, Keiko, Sicheri, Frank, Dever, Thomas E.. Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition. Cell, vol.122, no.6, 901-913.
Diaz-guerra, M., Kahn, J.S., Esteban, M.. A Mutation of the Nucleoside Triphosphate Phosphohydrolase I (NPH-I) Gene Confers Sensitivity of Vaccinia Virus to Interferon. Virology, vol.197, no.1, 485-491.
Diaz-Guerra, M., Rivas, C., Esteban, M.. Activation of the IFN-Inducible Enzyme RNase L Causes Apoptosis of Animal Cells. Virology, vol.236, no.2, 354-363.
Donzé, Olivier, Abbas‐Terki, Toufik, Picard, Didier. The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA‐dependent kinase PKR. The EMBO journal, vol.20, no.14, 3771-3780.
Donzé, Olivier, Deng, Jing, Curran, Joseph, Sladek, Robert, Picard, Didier, Sonenberg, Nahum. The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. The EMBO journal, vol.23, no.3, 564-571.
Donzé, O., Jagus, R., Koromilas, A. E., Hershey, J. W., Sonenberg, N.. Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.. The EMBO journal, vol.14, no.15, 3828-3834.
Dorin, Dominique, Bonnet, Marion C., Bannwarth, Sylvie, Gatignol, Anne, Meurs, Eliane F., Vaquero, Catherine. The TAR RNA-binding Protein, TRBP, Stimulates the Expression of TAR-containing RNAs in Vitro and in VivoIndependently of Its Ability to Inhibit the dsRNA-dependent Kinase PKR. The Journal of biological chemistry, vol.278, no.7, 4440-4448.
Dumbar, Tamba S., Gentry, Glenn A., Olson, Mark O. J.. Interaction of nucleolar phosphoprotein B23 with nucleic acids. Biochemistry, vol.28, no.24, 9495-9501.
Edery, I., Petryshyn, R., Sonenberg, N.. Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism. Cell, vol.56, no.2, 303-312.
Elia, Androulla, Vyas, Jashmin, Laing, Kenneth G., Clemens, Michael J.. Ribosomal protein L22 inhibits regulation of cellular activities by the Epstein-Barr virus small RNA EBER-1. European journal of biochemistry, vol.271, no.10, 1895-1905.
Endo-Munoz, Liliana, Warby, Tammra, Harrich, David, McMillan, Nigel AJ. Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription. Virology journal, vol.2, no.1, 17-17.
Enomoto, N, Sakuma, I, Asahina, Y, Kurosaki, M, Murakami, T, Yamamoto, C, Izumi, N, Marumo, F, Sato, C. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.. The Journal of clinical investigation, vol.96, no.1, 224-230.
Enomoto, Nobuyuki, Sakuma, Ikuo, Asahina, Yasuhiro, Kurosaki, Masayuki, Murakami, Takeshi, Yamamoto, Chikara, Ogura, Yuki, Izumi, Namiki, Marumo, Fumiaki, Sato, Chifumi. Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection. The New England journal of medicine, vol.334, no.2, 77-82.
Esteban, M., García, M. A., Domingo-Gil, E., Arroyo, J., Nombela, C., Rivas, C.. The latency protein LANA2 from Kaposi's sarcoma-associated herpesvirus inhibits apoptosis induced by dsRNA-activated protein kinase but not RNase L activation. The Journal of general virology, vol.84, no.6, 1463-1470.
Reference deleted.
Falcon, A. M., Fortes, P., Marion, R. M., Beloso, A., Ortin, J.. Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucleic acids research, vol.27, no.11, 2241-2247.
Falini, Brunangelo, Mecucci, Cristina, Tiacci, Enrico, Alcalay, Myriam, Rosati, Roberto, Pasqualucci, Laura, La Starza, Roberta, Diverio, Daniela, Colombo, Emanuela, Santucci, Antonella, Bigerna, Barbara, Pacini, Roberta, Pucciarini, Alessandra, Liso, Arcangelo, Vignetti, Marco, Fazi, Paola, Meani, Natalia, Pettirossi, Valentina, Saglio, Giuseppe, Mandelli, Franco, Lo-Coco, Francesco, Pelicci, Pier-Giuseppe, Martelli, Massimo F.. Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype. The New England journal of medicine, vol.352, no.3, 254-266.
Fickenscher, Helmut, Hör, Simon, Küpers, Heide, Knappe, Andrea, Wittmann, Sabine, Sticht, Heinrich. The interleukin-10 family of cytokines. Trends in immunology, vol.23, no.2, 89-96.
Flati, V., Haque, S. J., Williams, B. R.. Interferon-alpha-induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon-stimulated gene factor three.. The EMBO journal, vol.15, no.7, 1566-1571.
Friedman, R. M., Metz, D. H., Esteban, R. M., Tovell, D. R., Ball, L. A., Kerr, I. M.. Mechanism of Interferon Action: Inhibition of Viral Messenger Ribonucleic Acid Translation in L-Cell Extracts. Journal of virology, vol.10, no.6, 1184-1198.
Friedrich, Inbar, Ben-Bassat, Hannah, Levitzki, Alexander. Activation of dsRNA dependent protein kinase PKR in Karpas299 does not lead to cell death. Cancer biology & therapy, vol.4, no.7, 734-739.
Gaestel, Matthias. MAPKAP kinases ？? MKs ？? two's company, three's a crowd. Nature reviews. Molecular cell biology, vol.7, no.2, 120-130.
Galabru, J, Hovanessian, A. Autophosphorylation of the protein kinase dependent on double-stranded RNA.. The Journal of biological chemistry, vol.262, no.32, 15538-15544.
Gale Jr., M., Blakely, C. M., Darveau, A., Romano, P. R., Korth, M. J., Katze, M. G.. P52rIPK Regulates the Molecular Cochaperone P58IPK To Mediate Control of the RNA-Dependent Protein Kinase in Response to Cytoplasmic Stress. Biochemistry, vol.41, no.39, 11878-11887.
Gale Jr., Michael, Blakely, Collin M., Kwieciszewski, Bart, Tan, Seng-Lai, Dossett, Michelle, Tang, Norina M., Korth, Marcus J., Polyak, Stephen J., Gretch, David R., Katze, Michael G.. Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation. Molecular and cellular biology, vol.18, no.9, 5208-5218.
Gale Jr., Michael, Kwieciszewski, Bart, Dossett, Michelle, Nakao, Haruhisa, Katze, Michael G.. Antiapoptotic and Oncogenic Potentials of Hepatitis C Virus Are Linked to Interferon Resistance by Viral Repression of the PKR Protein Kinase. Journal of virology, vol.73, no.8, 6506-6516.
Gale Jr., Michael, Tan, Seng-Lai, Wambach, Marlene, Katze, Michael G.. Interaction of the Interferon-Induced PKR Protein Kinase with Inhibitory Proteins P58IPKand Vaccinia Virus K3L Is Mediated by Unique Domains: Implications for Kinase Regulation. Molecular and cellular biology, vol.16, no.8, 4172-4181.
Gale, Jr, Michael J, Korth, Marcus J, Katze, Michael G. Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance. Clinical and diagnostic virology, vol.10, no.2, 157-162.
Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein. Virology, vol.230, no.2, 217-227.
García, María A, Collado, Manuel, Muñoz-Fontela, César, Matheu, Ander, Marcos-Villar, Laura, Arroyo, Javier, Esteban, Mariano, Serrano, Manuel, Rivas, Carmen. Antiviral action of the tumor suppressor ARF. The EMBO journal, vol.25, no.18, 4284-4292.
García, Maria Angel, Guerra, Susana, Gil, Jesús, Jimenez, Victoria, Esteban, Mariano. Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L. Oncogene, vol.21, no.55, 8379-8387.
Gatignol, A, Buckler-White, A, Berkhout, B, Jeang, KT. Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. Science, vol.251, no.5001, 1597-1600.
Gatignol, A, Kumar, A, Rabson, A, Jeang, K T. Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNA.. Proceedings of the National Academy of Sciences of the United States of America, vol.86, no.20, 7828-7832.
Gerotto, M., Pero, F.D., Pontisso, P., Noventa, F., Gatta, A., Alberti, A.. Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon. Gastroenterology, vol.119, no.6, 1649-1655.
Ghosh, A K, Steele, R, Meyer, K, Ray, R, Ray, R B. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth.. The Journal of general virology, vol.80, no.5, 1179-1183.
Cell 1 S81 09 2002 Ghosh, S., and M. Karin. 2002. Missing pieces in the NF-kappaB puzzle. Cell 109(Suppl):S81-S96.
Ghosh, Sankar, May, Michael J., Kopp, Elizabeth B.. NF-kappaB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses. Annual review of immunology, vol.16, 225-260.
Gil, Jesús, Alcamí, José, Esteban, Mariano. Activation of NF-κB by the dsRNA-dependent protein kinase, PKR involves the IκB kinase complex. Oncogene, vol.19, no.11, 1369-1378.
Gil, Jesús, Alcamí, José, Esteban, Mariano. Induction of Apoptosis by Double-Stranded-RNA-Dependent Protein Kinase (PKR) Involves the α Subunit of Eukaryotic Translation Initiation Factor 2 and NF-κB. Molecular and cellular biology, vol.19, no.7, 4653-4663.
Gil, Jesús, Esteban, Mariano. Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): Mechanism of action. Apoptosis : an international journal on programmed cell death, vol.5, no.2, 107-114.
Gil, Jesús, Esteban, Mariano. The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-α receptors. Oncogene, vol.19, no.32, 3665-3674.
Gil, J., Esteban, M., Roth, D.. In Vivo Regulation of the dsRNA-Dependent Protein Kinase PKR by the Cellular Glycoprotein P67. Biochemistry, vol.39, no.51, 16016-16025.
Gil, Jesús, Garcı́a, Maria Angel, Esteban, Mariano. Caspase 9 activation by the dsRNA-dependent protein kinase, PKR: molecular mechanism and relevance. FEBS letters, vol.529, no.2, 249-255.
Gil, Jesús, García, Maria Angel, Gomez-Puertas, Paulino, Guerra, Susana, Rullas, Joaquín, Nakano, Hiroyasu, Alcamí, José, Esteban, Mariano. TRAF Family Proteins Link PKR with NF-κB Activation. Molecular and cellular biology, vol.24, no.10, 4502-4512.
Gil, Jesús, Rullas, Joaquín, Alcamí, José, Esteban, Mariano. MC159L protein from the poxvirus molluscum contagiosum virus inhibits NF-κB activation and apoptosis induced by PKR. The Journal of general virology, vol.82, no.12, 3027-3034.
Gil, Jesús, Rullas, Joaquín, García, María Angel, Alcamí, José, Esteban, Mariano. The catalytic activity of dsRNA-dependent protein kinase, PKR, is required for NF-κB activation. Oncogene, vol.20, no.3, 385-394.
Gil, Jesús, Esteban, Mariano. Vaccinia Virus Recombinants as a Model System to Analyze Interferon-Induced Pathways. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol.24, no.11, 637-646.
10.1016/S0168-8278(01)80579-1
Goh, K C, deVeer, M J, Williams, B R. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin.. The EMBO journal, vol.19, no.16, 4292-4297.
Gohda, Jin, Matsumura, Takayuki, Inoue, Jun-ichiro. Cutting Edge: TNFR-Associated Factor (TRAF) 6 Is Essential for MyD88-Dependent Pathway but Not Toll/IL-1 Receptor Domain-Containing Adaptor-Inducing IFN-β (TRIF)-Dependent Pathway in TLR Signaling. The journal of immunology : official journal of the American Association of Immunologists, vol.173, no.5, 2913-2917.
Gómez, Carmen E, Vandermeeren, Andrée Marie, García, María Angel, Domingo-Gil, Elena, Esteban, Mariano. Involvement of PKR and RNase L in translational control and induction of apoptosis after Hepatitis C polyprotein expression from a Vaccinia virus recombinant. Virology journal, vol.2, no.1, 81-81.
González-López, Claudia, Martínez-Costas, José, Esteban, Mariano, Benavente, Javier. Evidence that avian reovirus σA protein is an inhibitor of the double-stranded RNA-dependent protein kinase. The Journal of general virology, vol.84, no.6, 1629-1639.
Goodbourn, S., Didcock, L., Randall, R. E.. Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. The Journal of general virology, vol.81, no.10, 2341-2364.
Green, Douglas R., Reed, John C.. Mitochondria and Apoptosis. Science, vol.281, no.5381, 1309-1312.
Guerra, Susana, López-Fernández, Luis A., Conde, Raquel, Pascual-Montano, Alberto, Harshman, Keith, Esteban, Mariano. Microarray Analysis Reveals Characteristic Changes of Host Cell Gene Expression in Response to Attenuated Modified Vaccinia Virus Ankara Infection of Human HeLa Cells. Journal of virology, vol.78, no.11, 5820-5834.
Guerra, Susana, López-Fernández, Luis A., García, María Angel, Zaballos, Angel, Esteban, Mariano. Human Gene Profiling in Response to the Active Protein Kinase, Interferon-induced Serine/threonine Protein Kinase (PKR), in Infected Cells. The Journal of biological chemistry, vol.281, no.27, 18734-18745.
Gunnery, S, Green, S R, Mathews, M B. Tat-responsive region RNA of human immunodeficiency virus type 1 stimulates protein synthesis in vivo and in vitro: relationship between structure and function.. Proceedings of the National Academy of Sciences of the United States of America, vol.89, no.23, 11557-11561.
Gunnery, S, Rice, A P, Robertson, H D, Mathews, M B. Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase.. Proceedings of the National Academy of Sciences of the United States of America, vol.87, no.22, 8687-8691.
Haase, Astrid D, Jaskiewicz, Lukasz, Zhang, Haidi, Lainé, Sébastien, Sack, Ragna, Gatignol, Anne, Filipowicz, Witold. TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO reports, vol.6, no.10, 961-967.
Häcker, Hans, Redecke, Vanessa, Blagoev, Blagoy, Kratchmarova, Irina, Hsu, Li-Chung, Wang, Gang G., Kamps, Mark P., Raz, Eyal, Wagner, Hermann, Häcker, Georg, Mann, Matthias, Karin, Michael. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature, vol.439, no.7073, 204-207.
Hai, Tsonwin, Hartman, Matthew G. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene, vol.273, no.1, 1-11.
Gene Expr. 321 7 1999 Hai, T., C. D. Wolfgang, D. K. Marsee, A. E. Allen, and U. Sivaprasad. 1999. ATF3 and stress responses. Gene Expr.7:321-335.
Haines, G. K., Becker, S., Ghadge, G., Kies, M., Pelzer, H., Radosevich, J. A. Expression of the Double-Stranded RNA-Dependent Protein Kinase (p68) in Squamous Cell Carcinoma of the Head and Neck Region. Archives of otolaryngology--head & neck surgery, vol.119, no.10, 1142-1147.
Haines III, G. Kenneth, Panos, Ralph J., Bak, Philip M., Brown, Tim, Zielinski, Mike, Leyland, John, Radosevich, James A.. Interferon-Responsive Protein Kinase (p68) and Proliferating Cell Nuclear Antigen Are Inversely Distributed in Head and Neck Squamous Cell Carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, vol.19, no.1, 52-59.
Haines, G.K., Cajulis, R., Hayden, R., Duda, R., Talamonti, M., Radosevich, J.A.. Expression of the Double-Stranded RNA-Dependent Protein Kinase (p68) in Human Breast Tissues. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, vol.17, no.1, 5-12.
Haines, G. K., Ghadge, G., Thimmappaya, B., Radosevich, J. A.. Expression of the protein kinase p-68 recognized by the monoclonal antibody TJ4C4 in human lung neoplasms. Virchows Archiv B, Cell pathology including molecular pathology, vol.62, no.1, 151-158.
Haines, G.K., Ghadge, G.D., Combs, S.G., Leslie, W., Thimmappaya, B., Radosevich, J.A.. Immunohistochemical Detection of Double-Stranded-RNA- Dependent Protein Kinase (p68) with a Novel Monoclonal Antibody TJ4C4. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, vol.13, no.5, 324-329.
Harding, H.P., Novoa, I., Zhang, Y., Zeng, H., Wek, R., Schapira, M., Ron, D.. Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells. Molecular cell, vol.6, no.5, 1099-1108.
Hartman, Matthew G., Lu, Dan, Kim, Mi-Lyang, Kociba, Gary J., Shukri, Tala, Buteau, Jean, Wang, Xiaozhong, Frankel, Wendy L., Guttridge, Denis, Prentki, Marc, Grey, Shane T., Ron, David, Hai, Tsonwin. Role for Activating Transcription Factor 3 in Stress-Induced β-Cell Apoptosis. Molecular and cellular biology, vol.24, no.13, 5721-5732.
Hatada, Eriko, Saito, Sakura, Fukuda, Ryuji. Mutant Influenza Viruses with a Defective NS1 Protein Cannot Block the Activation of PKR in Infected Cells. Journal of virology, vol.73, no.3, 2425-2433.
Arch. Immunol. Ther. Exp. (Warsz) 95 48 2000 Haus, O. 2000. The genes of interferons and interferon-related factors: localization and relationships with chromosome aberrations in cancer. Arch. Immunol. Ther. Exp. (Warsz)48:95-100.
He, B, Chou, J, Brandimarti, R, Mohr, I, Gluzman, Y, Roizman, B. Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene. Journal of virology, vol.71, no.8, 6049-6054.
He, Bin, Gross, Martin, Roizman, Bernard. The γ134.5 Protein of Herpes Simplex Virus 1 Has the Structural and Functional Attributes of a Protein Phosphatase 1 Regulatory Subunit and Is Present in a High Molecular Weight Complex with the Enzyme in Infected Cells. The Journal of biological chemistry, vol.273, no.33, 20737-20743.
He, Bin, Gross, Martin, Roizman, Bernard. The γ 1 34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America, vol.94, no.3, 843-848.
Hershey, J W B. Translational Control in Mammalian Cells. Annual review of biochemistry, vol.60, 717-755.
Hii, Su Ing, Hardy, Lani, Crough, Tania, Payne, Elizabeth J., Grimmett, Karen, Gill, Devinder, McMillan, Nigel A.J.. Loss of PKR activity in chronic lymphocytic leukemia. International journal of cancer: Journal international du cancer, vol.109, no.3, 329-335.
Horng, Tiffany, Barton, Gregory M., Medzhitov, Ruslan. TIRAP: an adapter molecule in the Toll signaling pathway. Nature immunology, vol.2, no.9, 835-841.
HOVANESSIAN, ARA G.. The Double Stranded RNA-Activated Protein Kinase Induced by Interferon: dsRNA-PK. Journal of interferon research, vol.9, no.6, 641-647.
HOVANESSIAN, Ara G., GALABRU, Julien. The double‐stranded RNA‐dependent protein kinase is also activated by heparin. European journal of biochemistry, vol.167, no.3, 467-473.
HOVANESSIAN, Ara G., KERR, Ian M.. The (2′‐5′)Oligoadenylate (pppA2′‐5′A2′‐5′A) Synthetase and Protein Kinase(s) from Interferon‐Treated Cells. European journal of biochemistry, vol.93, no.3, 515-526.
Hsu, Li-Chung, Mo Park, Jin, Zhang, Kezhong, Luo, Jun-Li, Maeda, Shin, Kaufman, Randal J., Eckmann, Lars, Guiney, Donald G., Karin, Michael. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature, vol.428, no.6980, 341-345.
Icely, P.L., Gros, P., Bergeron, J.J., Devault, A., Afar, D.E., Bell, J.C.. TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. The Journal of biological chemistry, vol.266, no.24, 16073-16077.
Iordanov, M. S., Ryabinina, O. P., Schneider, P., Magun, B. E.. Two mechanisms of caspase 9 processing in double-stranded RNA- and virus-triggered apoptosis. Apoptosis : an international journal on programmed cell death, vol.10, no.1, 153-166.
Virus interference. I. The interferon. Proceedings of the Royal Society of London. Series B, Biological sciences, vol.147, no.927, 258-267.
Itahana, Koji, Bhat, Krishna P., Jin, Aiwen, Itahana, Yoko, Hawke, David, Kobayashi, Ryuji, Zhang, Yanping. Tumor Suppressor ARF Degrades B23, a Nucleolar Protein Involved in Ribosome Biogenesis and Cell Proliferation. Molecular cell, vol.12, no.5, 1151-1164.
Ito, T, Jagus, R, May, W S. Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase.. Proceedings of the National Academy of Sciences of the United States of America, vol.91, no.16, 7455-7459.
Ito, Takahiko, Yang, Mingli, May, W. Stratford. RAX, a Cellular Activator for Double-stranded RNA-dependent Protein Kinase during Stress Signaling. The Journal of biological chemistry, vol.274, no.22, 15427-15432.
Iwamura, Tomokatsu, Yoneyama, Mitsutoshi, Koizumi, Nobuo, Okabe, Yasutaka, Namiki, Hideo, Samuel, Charles E., Fujita, Takashi. PACT, a Double-Stranded RNA Binding Protein Acts as a Positive Regulator for Type I Interferon Gene Induced by Newcastle Disease Virus. Biochemical and biophysical research communications, vol.282, no.2, 515-523.
Iwamura, Tomokatsu, Yoneyama, Mitsutoshi, Yamaguchi, Kazumi, Suhara, Wakako, Mori, Wakana, Shiota, Kazutaka, Okabe, Yasutaka, Namiki, Hideo, Fujita, Takashi. Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways. Genes to cells : devoted to molecular & cellular mechanisms, vol.6, no.4, 375-388.
Curr. Top. Microbiol. Immunol. 185 233 1998 Jacobs, B. L., and J. O. Langland. 1998. Reovirus sigma 3 protein: dsRNA binding and inhibition of RNA-activated protein kinase. Curr. Top. Microbiol. Immunol.233:185-196.
Jacquemont, B, Roizman, B. RNA synthesis in cells infected with herpes simplex virus. X. Properties of viral symmetric transcripts and of double-stranded RNA prepared from them. Journal of virology, vol.15, no.4, 707-713.
Jagus, R., Gray, M.M.. Proteins that interact with PKR. Biochimie, vol.76, no.8, 779-791.
Jagus, Rosemary, Joshi, Bhavesh, Barber, Glen N. PKR, apoptosis and cancer. The international journal of biochemistry & cell biology, vol.31, no.1, 123-138.
ent of Virology, Universität Freiburg, Hermann-Herderstrasse 11, D-79104 Freiburg, Federal Republic of Germany, Division of Biochemistry, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom; Unité de Virologie et d'Immunologie Cellulaire, Institut Pasteur, 75724 Paris Cédex 15, France; Abteilung für Angewandte Molekularbiologie, Institut für Physiologische Chemie, Universität Mainz, Duesbergweg 6, D-55099 Mainz, Federal Republic of Germany; and Department of Virology, Universität Freiburg, Hermann-Herderstrasse 11, D-79104 Freiburg, Federal Republic of Germany, Division of Biochemistry, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom; Unité de Virologie et d'Immunologie Cellulaire, Institut Pasteur, 75724 Paris Cédex 15, France; Abteilung für Angewandte Molekularbiologie, Institut für Physiologische Chemie, Universität Mainz, Du. Nuclear Localization of the Interferon-Inducible Protein Kinase PKR in Human Cells and Transfected Mouse Cells. Experimental cell research, vol.218, no.1, 17-27.
Jiang, Hao-Yuan, Wek, Sheree A., McGrath, Barbara C., Lu, Dan, Hai, Tsonwin, Harding, Heather P., Wang, Xiaozhong, Ron, David, Cavener, Douglas R., Wek, Ronald C.. Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response. Molecular and cellular biology, vol.24, no.3, 1365-1377.
Jiang, Zhengfan, Zamanian-Daryoush, Maryam, Nie, Huiqing, Silva, Aristobolo M., Williams, Bryan R.G., Li, Xiaoxia. Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR. The Journal of biological chemistry, vol.278, no.19, 16713-16719.
Jindal, S, Young, R A. Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins. Journal of virology, vol.66, no.9, 5357-5362.
Jing, Xianghong, Cerveny, Melissa, Yang, Kui, He, Bin. Replication of Herpes Simplex Virus 1 Depends on the γ 1 34.5 Functions That Facilitate Virus Response to Interferon and Egress in the Different Stages of Productive Infection. Journal of virology, vol.78, no.14, 7653-7666.
Jones, K A, Peterlin, M B. Control of RNA Initiation and Elongation at the HIV-1 Promoter. Annual review of biochemistry, vol.63, 717-743.
Kadereit, Suzanne, Xu, Hui, Engeman, Tara M., Yang, Yi-Li, Fairchild, Robert L., Williams, Bryan R. G.. Negative Regulation of CD8+ T Cell Function by the IFN-Induced and Double-Stranded RNA-Activated Kinase PKR. The journal of immunology : official journal of the American Association of Immunologists, vol.165, no.12, 6896-6901.
Kadowaki, Norimitsu, Ho, Stephen, Antonenko, Svetlana, de Waal Malefyt, Rene, Kastelein, Robert A., Bazan, Fernando, Liu, Yong-Jun. Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens. The Journal of experimental medicine, vol.194, no.6, 863-870.
Kaempfer, Raymond. RNA sensors: novel regulators of gene expression. EMBO reports, vol.4, no.11, 1043-1047.
Kang, Dong-chul, Gopalkrishnan, Rahul V., Wu, Qingping, Jankowsky, Eckhard, Pyle, Anna Marie, Fisher, Paul B.. mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proceedings of the National Academy of Sciences of the United States of America, vol.99, no.2, 637-642.
Kasibhatla, Shailaja, Brunner, Thomas, Genestier, Laurent, Echeverri, Fernando, Mahboubi, Artin, Green, Douglas R. DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1. Molecular cell, vol.1, no.4, 543-551.
Katze, Michael G.. Interferon, PKR, Virology, and Genomics: What Is Past and What Is Next in the New Millennium?. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol.22, no.3, 283-286.
Katze, Michael G.. Regulation of the interferon-induced PKR: can viruses cope?. Trends in microbiology, vol.3, no.2, 75-78.
Kaufman, Randal J.. Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: A new role for an old actor. Proceedings of the National Academy of Sciences of the United States of America, vol.96, no.21, 11693-11695.
Kaufman, Randal J., Davies, Monique V., Pathak, Vinay K., Hershey, John W. B.. The Phosphorylation State of Eucaryotic Initiation Factor 2 Alters Translational Efficiency of Specific mRNAs. Molecular and cellular biology, vol.9, no.3, 946-958.
Kawagishi-Kobayashi, Makiko, Silverman, Joshua B., Ung, Tekly L., Dever, Thomas E.. Regulation of the Protein Kinase PKR by the Vaccinia Virus Pseudosubstrate Inhibitor K3L Is Dependent on Residues Conserved between the K3L Protein and the PKR Substrate eIF2α. Molecular and cellular biology, vol.17, no.7, 4146-4158.
Kawakubo, Ken, Kuhen, Kelli L., Vessey, Jill W., George, Cyril X., Samuel, Charles E.. Alternative Splice Variants of the Human PKR Protein Kinase Possessing Different 5′-Untranslated Regions: Expression in Untreated and Interferon-Treated Cells and Translational Activity. Virology, vol.264, no.1, 106-114.
Kawauchi, Junya, Zhang, Chun, Nobori, Kiyoshi, Hashimoto, Yoshinori, Adachi, Mimi T., Noda, Asao, Sunamori, Makoto, Kitajima, Shigetaka. Transcriptional Repressor Activating Transcription Factor 3 Protects Human Umbilical Vein Endothelial Cells from Tumor Necrosis Factor-α-induced Apoptosis through Down-regulation ofp53 Transcription. The Journal of biological chemistry, vol.277, no.41, 39025-39034.
Kazemi, Shirin, Papadopoulou, Stavroula, Li, Suiyang, Su, Qiaozhu, Wang, Shuo, Yoshimura, Akihiko, Matlashewski, Greg, Dever, Thomas E., Koromilas, Antonis E.. Control of α Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2α) Phosphorylation by the Human Papillomavirus Type 18 E6 Oncoprotein: Implications for eIF2α-Dependent Gene Expression and Cell Death. Molecular and cellular biology, vol.24, no.8, 3415-3429.
KERR, IAN M., BROWN, R. E., BALL, L. A.. Increased sensitivity of cell-free protein synthesis to double-stranded RNA after interferon treatment. Nature, vol.250, no.5461, 57-59.
Khoo, David, Perez, Cesar, Mohr, Ian. Characterization of RNA Determinants Recognized by the Arginine- and Proline-Rich Region of Us11, a Herpes Simplex Virus Type 1-Encoded Double-Stranded RNA Binding Protein That Prevents PKR Activation. Journal of virology, vol.76, no.23, 11971-11981.
Kibler, K V, Shors, T, Perkins, K B, Zeman, C C, Banaszak, M P, Biesterfeldt, J, Langland, J O, Jacobs, B L. Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells. Journal of virology, vol.71, no.3, 1992-2003.
Kim, Insil, Liu, Corey W., Puglisi, Joseph D.. Specific Recognition of HIV TAR RNA by the dsRNA Binding Domains (dsRBD1–dsRBD2) of PKR. Journal of molecular biology, vol.358, no.2, 430-442.
Kim, Steve H, Forman, Adam P, Mathews, Michael B, Gunnery, Shobha. Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR. Oncogene, vol.19, no.27, 3086-3094.
Kim, Steve H, Gunnery, Shobha, Choe, Jin K, Mathews, Michael B. Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR. Oncogene, vol.21, no.57, 8741-8748.
Kim, Yang-Gyun, Muralinath, Maneesha, Brandt, Teresa, Pearcy, Matthew, Hauns, Kevin, Lowenhaupt, Ky, Jacobs, Bertram L., Rich, Alexander. A role for Z-DNA binding in vaccinia virus pathogenesis. Proceedings of the National Academy of Sciences of the United States of America, vol.100, no.12, 6974-6979.
Oncogene 439 11 1995 Kirchhoff, S., A. E. Koromilas, F. Schaper, M. Grashoff, N. Sonenberg, and H. Hauser. 1995. IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR. Oncogene11:439-445.
Koromilas, AE, Roy, S, Barber, GN, Katze, MG, Sonenberg, N. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science, vol.257, no.5077, 1685-1689.
Cell Growth Differ. 201 10 1999 Kronfeld-Kinar, Y., S. Vilchik, T. Hyman, F. Leibkowicz, and S. Salzberg. 1999. Involvement of PKR in the regulation of myogenesis. Cell Growth Differ.10:201-212.
Structural Organization of the Human Gene (PKR) Encoding an Interferon-Inducible RNA-Dependent Protein Kinase (PKR) and Differences from Its Mouse Homolog. Genomics, vol.36, no.1, 197-201.
Kumar, A, Haque, J, Lacoste, J, Hiscott, J, Williams, B R. Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.. Proceedings of the National Academy of Sciences of the United States of America, vol.91, no.14, 6288-6292.
Kumar, A, Yang, Y L, Flati, V, Der, S, Kadereit, S, Deb, A, Haque, J, Reis, L, Weissmann, C, Williams, B R. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB.. The EMBO journal, vol.16, no.2, 406-416.
Kumar, Kotlo U., Srivastava, Sri P., Kaufman, Randal J.. Double-Stranded RNA-Activated Protein Kinase (PKR) Is Negatively Regulated by 60S Ribosomal Subunit Protein L18. Molecular and cellular biology, vol.19, no.2, 1116-1125.
Kuyama, Michiyo, Nakanishi, Gen, Arata, Jirô, Iwatsuki, Keiji, Fujimoto, Wataru. Expression of Double‐Stranded RNA‐Activated Protein Kinase in Keratinocytes and Keratinocytic Neoplasia. The Journal of dermatology, vol.30, no.8, 579-589.
Kwon, Hyuk-Chan, Moon, Chang Hoon, Kim, Sung-Hyun, Choi, Hong-Jo, Lee, Hyung-Sik, Roh, Mee Sook, Hwang, Tae-Ho, Kim, Jae-Seok, Kim, Hyo-Jin. Expression of Double-stranded RNA-activated Protein kinase (PKR) and its Prognostic Significance in Lymph Node Negative Rectal Cancer. Japanese journal of clinical oncology, vol.35, no.9, 545-550.
Kwon, Jin-Ah, Rich, Alexander. Biological function of the vaccinia virus Z-DNA-binding protein E3L: Gene transactivation and antiapoptotic activity in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America, vol.102, no.36, 12759-12764.
Kyriakis, John M., Avruch, Joseph. Protein kinase cascades activated by stress and inflammatory cytokines. BioEssays, vol.18, no.7, 567-577.
Laing, Kenneth G., Elia, Androulla, Jeffrey, Ian, Matys, Volker, Tilleray, Vivienne J., Souberbielle, Bernard, Clemens, Michael J.. In Vivo Effects of the Epstein–Barr Virus Small RNA EBER-1 on Protein Synthesis and Cell Growth Regulation. Virology, vol.297, no.2, 253-269.
Langland, Jeffrey O, Jacobs, Bertram L. Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. Virology, vol.324, no.2, 419-429.
Langland, Jeffrey O., Jacobs, Bertram L.. The Role of the PKR-Inhibitory Genes, E3L and K3L, in Determining Vaccinia Virus Host Range. Virology, vol.299, no.1, 133-141.
Laurent, A G, Krust, B, Galabru, J, Svab, J, Hovanessian, A G. Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.. Proceedings of the National Academy of Sciences of the United States of America, vol.82, no.13, 4341-4345.
Reference deleted.
Lee, Jee Hoon, Park, Eun Jung, Kim, Ohn Soon, Kim, Hee Young, Joe, Eun-Hye, Jou, Ilo. Double-stranded RNA–activated protein kinase is required for the LPS-induced activation of STAT1 inflammatory signaling in rat brain glial cells. GLIA, vol.50, no.1, 66-79.
LEE, SEAN BONG, BABLANIAN, ROSTOM, ESTEBAN1, MARIANO. Regulated Expression of the Interferon-Induced Protein Kinase p68 (PKR) by Vaccinia Virus Recombinants Inhibits the Replication of Vesicular Stomatitis Virus but Not That of Poliovirus. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol.16, no.12, 1073-1078.
Lee, S.B., Esteban, M.. The Interferon-induced Double-Stranded RNA-Activated Protein Kinase Induces Apoptosis. Virology, vol.199, no.2, 491-496.
Lee, S.B., Melkova, Z., Yan, W., Williams, B.R.G., Hovanessian, A.G., Esteban, M.. The Interferon-Induced Double-Stranded RNA-Activated Human p68 Protein Kinase Potently Inhibits Protein Synthesis in Cultured Cells. Virology, vol.192, no.1, 380-385.
Lee, S.B., Rodriguez, D., Rodriguez, J.R., Esteban, M.. The Apoptosis Pathway Triggered by the Interferon-Induced Protein Kinase PKR Requires the Third Basic Domain, Initiates Upstream of Bcl-2, and Involves ICE-like Proteases1. Virology, vol.231, no.1, 81-88.
Lee, Tae Gyu, Tang, Norina, Thompson, Samantha, Miller, James, Katze, Michael G.. The 58,000-Dalton Cellular Inhibitor of the Interferon-Induced Double-Stranded RNA-Activated Protein Kinase (PKR) Is a member of the Tetratricopeptide Repeat Family of Proteins. Molecular and cellular biology, vol.14, no.4, 2331-2342.
Lee, T.G., Tomita, J, Hovanessian, A.G., Katze, M.G.. Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase.. The Journal of biological chemistry, vol.267, no.20, 14238-14243.
Lee, T G, Tomita, J, Hovanessian, A G, Katze, M G. Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.. Proceedings of the National Academy of Sciences of the United States of America, vol.87, no.16, 6208-6212.
Lehner, Paul J, Cresswell, Peter. Processing and delivery of peptides presented by MHC class I molecules. Current opinion in immunology, vol.8, no.1, 59-67.
Leib, David A., Machalek, Michael A., Williams, Bryan R. G., Silverman, Robert H., Virgin, Herbert W.. Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene. Proceedings of the National Academy of Sciences of the United States of America, vol.97, no.11, 6097-6101.
Leitner, Wolfgang W., Hwang, Leroy N., deVeer, Michael J., Zhou, Aimin, Silverman, Robert H., Williams, Bryan R.G., Dubensky, Thomas W., Ying, Han, Restifo, Nicholas P.. Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways. Nature medicine, vol.9, no.1, 33-39.
Lengyel, P. Tumor-suppressor genes: news about the interferon connection.. Proceedings of the National Academy of Sciences of the United States of America, vol.90, no.13, 5893-5895.
Li, James C.B., Lee, Davy C.W., Cheung, Benny K.W., Lau, Allan S.Y.. Mechanisms for HIV Tat upregulation of IL-10 and other cytokine expression: Kinase signaling and PKR-mediated immune response. FEBS letters, vol.579, no.14, 3055-3062.
Li, Suiyang, Koromilas, Antonis E.. Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKR. The Journal of biological chemistry, vol.276, no.17, 13881-13890.
Li, Shoudong, Min, Ji-Young, Krug, Robert M., Sen, Ganes C.. Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology, vol.349, no.1, 13-21.
Li, Suiyang, Nagai, Kazushige, Koromilas, Antonis E.. A diminished activation capacity of the interferon-inducible protein kinase PKR in human T lymphocytes. European journal of biochemistry, vol.267, no.6, 1598-1606.
Li, Shoudong, Peters, Gregory A., Ding, Keyang, Zhang, Xiaolun, Qin, Jun, Sen, Ganes C.. Molecular basis for PKR activation by PACT or dsRNA. Proceedings of the National Academy of Sciences of the United States of America, vol.103, no.26, 10005-10010.
Liu, Yong, Wolff, Karen C., Jacobs, Bertram L., Samuel, Charles E.. Vaccinia Virus E3L Interferon Resistance Protein Inhibits the Interferon-Induced Adenosine Deaminase A-to-I Editing Activity. Virology, vol.289, no.2, 378-387.
Lu, Dan, Wolfgang, Curt D., Hai, Tsonwin. Activating Transcription Factor 3, a Stress-inducible Gene, Suppresses Ras-stimulated Tumorigenesis. The Journal of biological chemistry, vol.281, no.15, 10473-10481.
Lu, Phoebe D., Harding, Heather P., Ron, David. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. The Journal of cell biology, vol.167, no.1, 27-33.
Binding of the Influenza Virus NS1 Protein to Double-Stranded RNA Inhibits the Activation of the Protein Kinase That Phosphorylates the eIF-2 Translation Initiation Factor. Virology, vol.214, no.1, 222-228.
Lubyova, Barbora, Pitha, Paula M.. Characterization of a Novel Human Herpesvirus 8-Encoded Protein, vIRF-3, That Shows Homology to Viral and Cellular Interferon Regulatory Factors. Journal of virology, vol.74, no.17, 8194-8201.
MacLean, A. R., Ul-Fareed, M., Robertson, L., Harland, J., Brown, S. M.. Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence. The Journal of general virology, vol.72, no.3, 631-639.
Majumdar, Romit, Maitra, Umadas. Regulation of GTP hydrolysis prior to ribosomal AUG selection during eukaryotic translation initiation. The EMBO journal, vol.24, no.21, 3737-3746.
Malathi, Krishnamurthy, Paranjape, Jayashree M., Bulanova, Elena, Shim, Minsub, Guenther-Johnson, Jeanna M., Faber, Pieter W., Eling, Thomas E., Williams, Bryan R. G., Silverman, Robert H.. A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L. Proceedings of the National Academy of Sciences of the United States of America, vol.102, no.41, 14533-14538.
Manche, Lisa, Green, Simon R., Schmedt, Christian, Mathews, Michael B.. Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI. Molecular and cellular biology, vol.12, no.11, 5238-5248.
Maran, A, Maitra, RK, Kumar, A, Dong, B, Xiao, W, Li, G, Williams, BR, Torrence, PF, Silverman, RH. Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras. Science, vol.265, no.5173, 789-792.
Maran, A., Mathews, M.B.. Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA. Virology, vol.164, no.1, 106-113.
Markert, J M, Medlock, M D, Rabkin, S D, Gillespie, G Y, Todo, T, Hunter, W D, Palmer, C A, Feigenbaum, F, Tornatore, C, Tufaro, F, Martuza, R L. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene therapy, vol.7, no.10, 867-874.
Martínez-Costas, José, González-López, Claudia, Vakharia, Vikram N., Benavente, Javier. Possible Involvement of the Double-Stranded RNA-Binding Core Protein ςA in the Resistance of Avian Reovirus to Interferon. Journal of virology, vol.74, no.3, 1124-1131.
MCMILLAN, N.A.J., CHUN, R.F., SIDEROVSKI, D.P., GALABRU, J., TOONE, W., SAMUEL, C.E., MAK, T.W., HOVANESSIAN, A.G., JEANG, K.T., WILLIAMS, B.R.G.. HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR. Virology, vol.213, no.2, 413-424.
METZ, D. H., ESTEBAN, M.. Interferon inhibits Viral Protein Synthesis in L Cells infected with Vaccinia Virus. Nature, vol.238, no.5364, 385-388.
Meurs, E., Chong, K., Galabru, J., Thomas, N.S.B., Kerr, I.M., Williams, B.R.G., Hovanessian, A.G.. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell, vol.62, no.2, 379-390.
Meurs, E F, Galabru, J, Barber, G N, Katze, M G, Hovanessian, A G. Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.. Proceedings of the National Academy of Sciences of the United States of America, vol.90, no.1, 232-236.
Mhashilkar, Abner M, Stewart, Alexis L, Sieger, Kerry, Yang, Heng-Yin, Khimani, Anis H, Ito, Isao, Saito, Yuji, Hunt, Kelly K, Grimm, Elizabeth A, Roth, Jack A, Meyn, Raymond E, Ramesh, Rajagopal, Chada, Sunil. MDA-7 negatively regulates the β-catenin and PI3K signaling pathways in breast and lung tumor cells. Molecular therapy : the journal of the American Society of Gene Therapy, vol.8, no.2, 207-219.
Mohr, I., Gluzman, Y.. A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function.. The EMBO journal, vol.15, no.17, 4759-4766.
Morimoto, Hiroyuki, Ozaki, Akiko, Okamura, Hirohiko, Yoshida, Kaya, Kitamura, Seiichiro, Haneji, Tatsuji. Okadaic acid induces tyrosine phosphorylation of IκBα that mediated by PKR pathway in human osteoblastic MG63 cells. Molecular and cellular biochemistry, vol.276, no.1, 211-217.
Morris, SW, Kirstein, MN, Valentine, MB, Dittmer, KG, Shapiro, DN, Saltman, DL, Look, AT. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science, vol.263, no.5151, 1281-1284.
Mosser, Dick D., Caron, Antoine W., Bourget, Lucie, Meriin, Anatoli B., Sherman, Michael Y., Morimoto, Richard I., Massie, Bernard. The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis. Molecular and cellular biology, vol.20, no.19, 7146-7159.
Mulvey, Matthew, Poppers, Jeremy, Sternberg, David, Mohr, Ian. Regulation of eIF2α Phosphorylation by Different Functions That Act during Discrete Phases in the Herpes Simplex Virus Type 1 Life Cycle. Journal of virology, vol.77, no.20, 10917-10928.
Mundschau, L.J., Faller, D.V.. Endogenous inhibitors of the dsRNA-dependent eIF-2α protein kinase PKR in normal and ras-transformed cells. Biochimie, vol.76, no.8, 792-800.
Mundschau, Laura J., Faller, Douglas V.. Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR. The Journal of biological chemistry, vol.270, no.7, 3100-3106.
Muñoz-Fontela, C., Collado, M., Rodriguez, E., García, M.A., Alvarez-Barrientos, A., Arroyo, J., Nombela, C., Rivas, C.. Identification of a nuclear export signal in the KSHV latent protein LANA2 mediating its export from the nucleus. Experimental cell research, vol.311, no.1, 96-105.
Murad, Joana M., Tone, Luiz G., de Souza, Liliana R., De Lucca, Fernando L.. A point mutation in the RNA-binding domain I results in decrease of PKR activation in acute lymphoblastic leukemia. Blood cells, molecules & diseases, vol.34, no.1, 1-5.
Nanbo, Asuka, Inoue, Kaori, Adachi‐Takasawa, Kumi, Takada, Kenzo. Epstein–Barr virus RNA confers resistance to interferon‐α‐induced apoptosis in Burkitt’s lymphoma. The EMBO journal, vol.21, no.5, 954-965.
Nanduri, S, Carpick, B, Yang, Y, Williams, B R, Qin, J. 1H, 13C, 15N resonance assignment of the 20 kDa double stranded RNA binding domain of PKR.. Journal of biomolecular NMR, vol.12, no.2, 349-351.
Nanduri, Sambasivarao, Carpick, Bruce W., Yang, Yanwu, Williams, Bryan R.G., Qin, Jun. Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation. The EMBO journal, vol.17, no.18, 5458-5465.
Nawa, Tigre, Nawa, Makiko T, Adachi, Mimi T, Uchimura, Isao, Shimokawa, Reiko, Fujisawa, Kazuhiko, Tanaka, Akira, Numano, Fujio, Kitajima, Shigetaka. Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: colocalization and possible involvement in cell death of vascular endothelial cells. Atherosclerosis, vol.161, no.2, 281-291.
Noguchi, Tohru, Satoh, Shinya, Noshi, Takeshi, Hatada, Eriko, Fukuda, Ryuji, Kawai, Akihiko, Ikeda, Satoru, Hijikata, Makoto, Shimotohno, Kunitada. Effects of Mutation in Hepatitis C Virus Nonstructural Protein 5A on Interferon Resistance Mediated by Inhibition of PKR Kinase Activity in Mammalian Cells. Microbiology and immunology, vol.45, no.12, 829-840.
10.1002/(SICI)1096-9896(199601)178:1<48::AID-PATH432>3.0.CO;2-Y
Nussbaum, Jean M., Gunnery, Shobha, Mathews, Michael B.. The 3′-untranslated regions of cytoskeletal muscle mRNAs inhibit translation by activating the double-stranded RNA-dependent protein kinase PKR. Nucleic acids research, vol.30, no.5, 1205-1212.
Nussbaum, Jean M, Major, Marian, Gunnery, Shobha. Transcriptional upregulation of interferon-induced protein kinase, PKR, in breast cancer. Cancer letters, vol.196, no.2, 207-216.
Offermann, Margaret K., Zimring, James, Mellits, Kenneth H., Hagan, M. Kelly, Shaw, Reneé, Medford, Russell M., Mathews, Michael B., Goodbourn, Stephen, Jagus, Rosemary. Activation of the Double‐Stranded‐RNA‐Activated Protein Kinase and Induction of Vascular Cell Adhesion Molecule‐1 by Poly (I) · Poly (C) in Endothelial Cells. European journal of biochemistry, vol.232, no.1, 28-36.
Oganesyan, Gagik, Saha, Supriya K., Guo, Beichu, He, Jeannie Q., Shahangian, Arash, Zarnegar, Brian, Perry, Andrea, Cheng, Genhong. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature, vol.439, no.7073, 208-211.
Olson, Mark O. J., Wallace, Michael O., Herrera, Amy H., Marshall-Carlson, Linda, Hunt, Richard C.. Preribosomal ribonucleoprotein particles are a major component of a nucleolar matrix fraction. Biochemistry, vol.25, no.2, 484-491.
Ong, Chi L., Thorpe, Janine C., Gorry, Paul R., Bannwarth, Sylvie, Jaworowski, Anthony, Howard, Jane L., Chung, Sean, Campbell, Shahan, Christensen, Helen S., Clerzius, Guerline, Mouland, Andrew J., Gatignol, Anne, Purcell, Damian F. J.. Low TRBP Levels Support an Innate Human Immunodeficiency Virus Type 1 Resistance in Astrocytes by Enhancing the PKR Antiviral Response. Journal of virology, vol.79, no.20, 12763-12772.
Onuki, Reiko, Bando, Yoshio, Suyama, Eigo, Katayama, Taiichi, Kawasaki, Hiroaki, Baba, Tadashi, Tohyama, Masaya, Taira, Kazunari. An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. The EMBO journal, vol.23, no.4, 959-968.
Paez, E., Esteban, M.. Nature and mode of action of vaccinia virus products that block activation of the interferon-mediated ppp(A2'p)nA-synthetase. Virology, vol.134, no.1, 29-39.
Paez, E., Esteban, M.. Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system. Virology, vol.134, no.1, 12-28.
Pang, Qishen, Christianson, Tracy A., Keeble, Winifred, Koretsky, Tara, Bagby, Grover C.. The Anti-apoptotic Function of Hsp70 in the Interferon-inducible Double-stranded RNA-dependent Protein Kinase-mediated Death Signaling Pathway Requires the Fanconi Anemia Protein, FANCC. The Journal of biological chemistry, vol.277, no.51, 49638-49643.
Pang, Qishen, Christianson, Tracy A., Koretsky, Tara, Carlson, Hanqian, David, Larry, Keeble, Winifred, Faulkner, Gregory R., Speckhart, Ashley, Bagby, Grover C.. Nucleophosmin Interacts with and Inhibits the Catalytic Function of Eukaryotic Initiation Factor 2 Kinase PKR. The Journal of biological chemistry, vol.278, no.43, 41709-41717.
Park, H, Davies, M V, Langland, J O, Chang, H W, Nam, Y S, Tartaglia, J, Paoletti, E, Jacobs, B L, Kaufman, R J, Venkatesan, S. TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.. Proceedings of the National Academy of Sciences of the United States of America, vol.91, no.11, 4713-4717.
Pataer, Abujiang, Chada, Sunil, Hunt, Kelly K, Roth, Jack A, Swisher, Stephen G.. Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release. The Journal of thoracic and cardiovascular surgery, vol.125, no.6, 1328-1335.
Cancer Res. 2239 62 2002 Pataer, A., S. A. Vorburger, G. N. Barber, S. Chada, A. M. Mhashilkar, H. Zou-Yang, A. L. Stewart, S. Balachandran, J. A. Roth, K. K. Hunt, and S. G. Swisher. 2002. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res.62:2239-2243.
Pataer, Abujiang, Vorburger, Stephan A., Chada, Sunil, Balachandran, Siddharth, Barber, Glen N., Roth, Jack A., Hunt, Kelly K., Swisher, Stephen G.. Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR. Molecular therapy : the journal of the American Society of Gene Therapy, vol.11, no.5, 717-723.
Patel, Chandrashekhar V., Handy, Indhira, Goldsmith, Tiffany, Patel, Rekha C.. PACT, a Stress-modulated Cellular Activator of Interferon-induced Double-stranded RNA-activated Protein Kinase, PKR. The Journal of biological chemistry, vol.275, no.48, 37993-37998.
Patel, R C, Sen, G C. PACT, a protein activator of the interferon-induced protein kinase, PKR.. The EMBO journal, vol.17, no.15, 4379-4390.
Peel, Alyson L.. PKR Activation in Neurodegenerative Disease. Journal of neuropathology and experimental neurology, vol.63, no.2, 97-105.
Pestka, Sidney, Krause, Christopher D., Walter, Mark R.. Interferons, interferon-like cytokines, and their receptors. Immunological reviews, vol.202, no.1, 8-32.
Peters, Gregory A., Hartmann, Rune, Qin, Jun, Sen, Ganes C.. Modular Structure of PACT: Distinct Domains for Binding and Activating PKR. Molecular and cellular biology, vol.21, no.6, 1908-1920.
Peters, Gregory A., Khoo, David, Mohr, Ian, Sen, Ganes C.. Inhibition of PACT-Mediated Activation of PKR by the Herpes Simplex Virus Type 1 Us11 Protein. Journal of virology, vol.76, no.21, 11054-11064.
10.1007/978-3-642-78549-8_1
Reference deleted.
Pomerantz, Joel L, Baltimore, David. Two Pathways to NF-κB. Molecular cell, vol.10, no.4, 693-695.
Poppers, Jeremy, Mulvey, Matthew, Perez, Cesar, Khoo, David, Mohr, Ian. Identification of a Lytic-Cycle Epstein-Barr Virus Gene Product That Can Regulate PKR Activation. Journal of virology, vol.77, no.1, 228-236.
Prostko, C. Robert, Dholakia, Jaydev N., Brostrom, Margaret A., Brostrom, Charles O.. Activation of the Double-stranded RNA-regulated Protein Kinase by Depletion of Endoplasmic Reticular Calcium Stores. The Journal of biological chemistry, vol.270, no.11, 6211-6215.
Raingeaud, Joël, Whitmarsh, Alan J., Barrett, Tamera, Dérijard, Benoit, Davis, Roger J.. MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway. Molecular and cellular biology, vol.16, no.3, 1247-1255.
Ramana, Chilakamarti V., Grammatikakis, Nicholas, Chernov, Mikhail, Nguyen, Hannah, Chuan Goh, Kee, Williams, Bryan R.G., Stark, George R.. Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways. The EMBO journal, vol.19, no.2, 263-272.
Rampling, R, Cruickshank, G, Papanastassiou, V, Nicoll, J, Hadley, D, Brennan, D, Petty, R, MacLean, A, Harland, J, McKie, E, Mabbs, R, Brown, M. Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma. Gene therapy, vol.7, no.10, 859-866.
Raveh, Tal, Hovanessian, Ara G., Meurs, Eliane F., Sonenberg, Nahum, Kimchi, Adi. Double-stranded RNA-dependent Protein Kinase Mediates c-Myc Suppression Induced by Type I Interferons. The Journal of biological chemistry, vol.271, no.41, 25479-25484.
Rhoads, R.E.. Regulation of eukaryotic protein synthesis by initiation factors.. The Journal of biological chemistry, vol.268, no.5, 3017-3020.
Rivas, C., Gil, J., Melkova, Z., Esteban, M., Diaz-Guerra, M.. Vaccinia Virus E3L Protein Is an Inhibitor of the Interferon (IFN)-Induced 2-5A Synthetase Enzyme. Virology, vol.243, no.2, 406-414.
Rivas, Carmen, Thlick, Ai-En, Parravicini, Carlo, Moore, Patrick S., Chang, Yuan. Kaposi's Sarcoma-Associated Herpesvirus LANA2 Is a B-Cell-Specific Latent Viral Protein That Inhibits p53. Journal of virology, vol.75, no.1, 429-438.
ROBERTS, WALDEN K., HOVANESSIAN, ARA, BROWN, RONALD E., CLEMENS, MICHAEL J., KERR, IAN M.. Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis. Nature, vol.264, no.5585, 477-480.
Roff, Marilynn, Thompson, Jill, Rodriguez, Manuel S., Jacque, Jean-Marc, Baleux, Francoise, Arenzana-Seisdedos, Fernando, Hay, Ronald T.. Role of I Bα Ubiquitination in Signal-induced Activation of NF- B in Vivo. The Journal of biological chemistry, vol.271, no.13, 7844-7850.
Roh, Mee Sook, Kwak, Ju Young, Kim, Su Jin, Lee, Hyun Wook, Kwon, Hyuk Chan, Hwang, Tae Ho, Choi, Phil Jo, Hong, Young Seoub. Expression of double-stranded RNA-activated protein kinase in small-size peripheral adenocarcinoma of the lung. Pathology international, vol.55, no.11, 688-693.
Roller, R J, Roizman, B. The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits. Journal of virology, vol.66, no.6, 3624-3632.
Romano, Patrick R., Zhang, Fan, Tan, Seng-Lai, Garcia-Barrio, Minerva T., Katze, Michael G., Dever, Thomas E., Hinnebusch, Alan G.. Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR by Vaccinia Virus E3: Role of Complex Formation and the E3 N-Terminal Domain. Molecular and cellular biology, vol.18, no.12, 7304-7316.
Roy, S, Katze, MG, Parkin, NT, Edery, I, Hovanessian, AG, Sonenberg, N. Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product. Science, vol.247, no.4947, 1216-1219.
Ruvolo, Peter P., Gao, Fengqin, Blalock, William L., Deng, Xingming, May, W.Stratford. Ceramide Regulates Protein Synthesis by a Novel Mechanism Involving the Cellular PKR Activator RAX. The Journal of biological chemistry, vol.276, no.15, 11754-11758.
Salzberg, S., Vilchik, S., Cohen, S., Heller, A., Kronfeld-Kinar, Y.. Expression of a PKR Dominant-Negative Mutant in Myogenic Cells Interferes with the Myogenic Process. Experimental cell research, vol.254, no.1, 45-54.
Samuel, C.E.. Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology, vol.183, no.1, 1-11.
Samuel, C.E., Kuhen, K.L., George, C.X., Ortega, L.G., Rende-Fournier, R., Tanaka, H.. The PKR protein kinase -- an interferon-inducible regulator of cell growth and differentiation. International journal of hematology, vol.65, no.3, 227-237.
Sarkar, Devanand, Su, Zao-Zhong, Lebedeva, Irina V., Sauane, Moira, Gopalkrishnan, Rahul V., Valerie, Kristoffer, Dent, Paul, Fisher, Paul B.. mda- 7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proceedings of the National Academy of Sciences of the United States of America, vol.99, no.15, 10054-10059.
Sarrazin, Christoph, Bruckner, Markus, Herrmann, Eva, Rüster, Brigitte, Bruch, Katharina, Roth, W.Kurt, Zeuzem, Stefan. Quasispecies Heterogeneity of the Carboxy-Terminal Part of the E2 Gene Including the PePHD and Sensitivity of Hepatitis C Virus 1b Isolates to Antiviral Therapy. Virology, vol.289, no.1, 150-163.
Sarrazin, Christoph, Kornetzky, Ilka, Rüster, Brigitte, Lee, Jung‐Hun, Kronenberger, Bernd, Bruch, Katharina, Roth, W. Kurt, Zeuzem, Stefan. Mutations within the E2 and NS5A protein in patients infected with hepatitis C virus type 3a and correlation with treatment response. Hepatology : official journal of the American Association for the Study of Liver Diseases, vol.31, no.6, 1360-1370.
SAUNDERS, LAURA R., BARBER, GLEN N.. The dsRNA binding protein family: critical roles, diverse cellular functions. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol.17, no.9, 961-983.
Savkur, R S, Olson, M O. Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease.. Nucleic acids research, vol.26, no.19, 4508-4515.
Schiappa, Deborah A, Mittal, Chetna, Brown, Jennifer A, Mika, Brian P. Relationship of hepatitis C genotype 1 NS5A sequence mutations to early phase viral kinetics and interferon effectiveness.. The Journal of infectious diseases : official publication of the Infectious Diseases Society of America, vol.185, no.7, 868-877.
Schlee, Martin, Hornung, Veit, Hartmann, Gunther. siRNA and isRNA: two edges of one sword. Molecular therapy : the journal of the American Society of Gene Therapy, vol.14, no.4, 463-470.
Sedger, L, Ruby, J. Heat shock response to vaccinia virus infection. Journal of virology, vol.68, no.7, 4685-4689.
Sekellick, Margaret J., Carra, Scott A., Bowman, Amy, Hopkins, Deborah A., Marcus, Philip I.. Transient Resistance of Influenza Virus to Interferon Action Attributed to Random Multiple Packaging and Activity of NS Genes. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol.20, no.11, 963-970.
Sen, Adrish, Steele, Robert, Ghosh, Asish K., Basu, Arnab, Ray, Ranjit, Ray, Ratna B.. Inhibition of hepatitis C virus protein expression by RNA interference. Virus research : an international journal of molecular and cellular virology, vol.96, no.1, 27-35.
Sen, G.C., Lengyel, P. The interferon system. A bird's eye view of its biochemistry.. The Journal of biological chemistry, vol.267, no.8, 5017-5020.
Sen, G.C., Taira, H., Lengyel, P.. Interferon, double-stranded RNA, and protein phosphorylation. Characteristics of a double-stranded RNA-activated protein kinase system partially purified from interferon treated Ehrlich ascites tumor cells.. The Journal of biological chemistry, vol.253, no.17, 5915-5921.
SenGupta, D N, Berkhout, B, Gatignol, A, Zhou, A M, Silverman, R H. Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1.. Proceedings of the National Academy of Sciences of the United States of America, vol.87, no.19, 7492-7496.
Shang, Yongfeng, Baumrucker, Craig R., Green, Michael H.. c-Myc Is a Major Mediator of the Synergistic Growth Inhibitory Effects of Retinoic Acid and Interferon in Breast Cancer Cells. The Journal of biological chemistry, vol.273, no.46, 30608-30613.
Sharp, T.V., Moonan, F., Romashko, A., Joshi, B., Barber, G.N., Jagus, R.. The Vaccinia Virus E3L Gene Product Interacts with both the Regulatory and the Substrate Binding Regions of PKR: Implications for PKR Autoregulation. Virology, vol.250, no.2, 302-315.
Sharp, T V, Schwemmle, M, Jeffrey, I, Laing, K, Mellor, H, Proud, C G, Hilse, K, Clemens, M J. Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA.. Nucleic acids research, vol.21, no.19, 4483-4490.
Sharp, Tyson V., Witzel, J. Eric, Jagus, Rosemary. Homologous Regions of the α Subunit of Eukaryotic Translational Initiation Factor 2 (eIF2α) and the Vaccinia Virus K3L Gene Product Interact with the Same Domain within the dsRNA-Activated Protein Kinase (PKR). European journal of biochemistry, vol.250, no.1, 85-91.
Cancer Res. 4434 58 1998 Shimada, A., G. Shiota, H. Miyata, T. Kamahora, H. Kawasaki, K. Shiraki, S. Hino, and T. Terada. 1998. Aberrant expression of double-stranded RNA-dependent protein kinase in hepatocytes of chronic hepatitis and differentiated hepatocellular carcinoma. Cancer Res.58:4434-4438.
Shir, Alexei, Friedrich, Inbar, Levitzki, Alexander. Tumor specific activation of PKR as a non-toxic modality of cancer treatment. Seminars in cancer biology, vol.13, no.4, 309-314.
Shir, Alexei, Levitzki, Alexander. Inhibition of glioma growth by tumor-specific activation of double-stranded RNA–dependent protein kinase PKR. Nature biotechnology, vol.20, no.9, 895-900.
Complementation of Vaccinia Virus Deleted of the E3L Gene by Mutants of E3L. Virology, vol.239, no.2, 269-276.
Siffroi, Jean Pierre, Pawlak, André, Alfonsi, Marie Françoise, Troalen, Frédéric, Guellaen, Georges, Dadoune, Jean Pierre. Expression of the TAR RNA binding protein in human testis. Molecular human reproduction, vol.7, no.3, 219-225.
Sionov, Ronit Vogt, Haupt, Ygal. The cellular response to p53: the decision between life and death. Oncogene, vol.18, no.45, 6145-6157.
Sledz, Carol A., Holko, Michelle, de Veer, Michael J., Silverman, Robert H., Williams, Bryan R.G.. Activation of the interferon system by short-interfering RNAs. Nature cell biology, vol.5, no.9, 834-839.
Smith, Eric J., Marié, Isabelle, Prakash, Arun, Garcı́a-Sastre, Adolfo, Levy, David E.. IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein. The Journal of biological chemistry, vol.276, no.12, 8951-8957.
Squire, J., Meurs, E.F., Chong, K.L., McMillan, N.A.J., Hovanessian, A.G., Williams, B.R.G.. Localization of the Human Interferon-Induced, ds-RNA Activated p68 Kinase Gene (PRKR) to Chromosome 2p21-p22. Genomics, vol.16, no.3, 768-770.
Srivastava, Sri Prakash, Davies, Monique V., Kaufman, Randal J.. Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis. The Journal of biological chemistry, vol.270, no.28, 16619-16624.
Srivastava, Sri P., Kumar, Kotlo U., Kaufman, Randal J.. Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase. The Journal of biological chemistry, vol.273, no.4, 2416-2423.
Stark, George R., Kerr, Ian M., Williams, Bryan R. G., Silverman, Robert H., Schreiber, Robert D.. HOW CELLS RESPOND TO INTERFERONS. Annual review of biochemistry, vol.67, 227-264.
Stewart, Michael J, Blum, Mary Ann, Sherry, Barbara. PKR's protective role in viral myocarditis. Virology, vol.314, no.1, 92-100.
Stojdl, David F., Abraham, Ninan, Knowles, Shane, Marius, Ricardo, Brasey, Ann, Lichty, Brian D., Brown, Earl G., Sonenberg, Nahum, Bell, John C.. The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus. Journal of virology, vol.74, no.20, 9580-9585.
Strong, J E, Coffey, M C, Tang, D, Sabinin, P, Lee, P W. The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus.. The EMBO journal, vol.17, no.12, 3351-3362.
Su, Qiaozhu, Wang, Shuo, Baltzis, Dionissios, Qu, Li-Ke, Wong, Andrew Hoi-Tao, Koromilas, Antonis E.. Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2α RNA-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America, vol.103, no.1, 63-68.
Sudhakar, A., Ramachandran, A., Ghosh, S., Hasnain, S. E., Kaufman, R. J., Ramaiah, K. V. A.. Phosphorylation of Serine 51 in Initiation Factor 2&agr; (eIF2&agr;) Promotes Complex Formation between eIF2&agr;(P) and eIF2B and Causes Inhibition in the Guanine Nucleotide Exchange Activity of eIF2B. Biochemistry, vol.39, no.42, 12929-12938.
Sugimoto, Masataka, Kuo, Mei-Ling, Roussel, Martine F, Sherr, Charles J. Nucleolar Arf Tumor Suppressor Inhibits Ribosomal RNA Processing. Molecular cell, vol.11, no.2, 415-424.
Syed, Viqar, Mukherjee, Kasturi, Lyons-Weiler, James, Lau, Kin-Mang, Mashima, Tetsuo, Tsuruo, Takashi, Ho, Shuk-mei. Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. Oncogene, vol.24, no.10, 1774-1787.
Symons, Julian A., Alcamí, Antonio, Smith, Geoffrey L.. Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity. Cell, vol.81, no.4, 551-560.
Taddeo, Brunella, Luo, Ting Rong, Zhang, Weiran, Roizman, Bernard. Activation of NF-κB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis. Proceedings of the National Academy of Sciences of the United States of America, vol.100, no.21, 12408-12413.
Takeda, Kiyoshi, Kaisho, Tsuneyasu, Akira, Shizuo. TOLL-LIKE RECEPTORS. Annual review of immunology, vol.21, 335-376.
Takizawa, T, Ohashi, K, Nakanishi, Y. Possible involvement of double-stranded RNA-activated protein kinase in cell death by influenza virus infection. Journal of virology, vol.70, no.11, 8128-8132.
Talon, Julie, Horvath, Curt M., Polley, Rosalind, Basler, Christopher F., Muster, Thomas, Palese, Peter, García-Sastre, Adolfo. Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein. Journal of virology, vol.74, no.17, 7989-7996.
Tamura, Kiyoshi, Hua, Bayin, Adachi, Susumu, Guney, Isil, Kawauchi, Junya, Morioka, Masaki, Tamamori-Adachi, Mimi, Tanaka, Yujiro, Nakabeppu, Yusaku, Sunamori, Makoto, Sedivy, John M, Kitajima, Shigetaka. Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. The EMBO journal, vol.24, no.14, 2590-2601.
Tan, Shirlee, Sagara, Yutaka, Liu, Yuanbin, Maher, Pamela, Schubert, David. The Regulation of Reactive Oxygen Species Production during Programmed Cell Death. The Journal of cell biology, vol.141, no.6, 1423-1432.
TAN, SENG-LAI, KATZE, MICHAEL G.. Biochemical and Genetic Evidence for Complex Formation Between the Influenza A Virus NS1 Protein and the Interferon-induced PKR Protein Kinase. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol.18, no.9, 757-766.
Tan, Seng-Lai, Katze, Michael G.. How Hepatitis C Virus Counteracts the Interferon Response: The Jury Is Still out on NS5A. Virology, vol.284, no.1, 1-12.
Tanaka, H, Samuel, C E. Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.. Proceedings of the National Academy of Sciences of the United States of America, vol.91, no.17, 7995-7999.
Tang, Norina M., Korth, Marcus J., Gale Jr., Michael, Wambach, Marlene, Der, Sandy D., Bandyopadhyay, Sudip K., Williams, Bryan R. G., Katze, Michael G.. Inhibition of Double-Stranded RNA- and Tumor Necrosis Factor Alpha-Mediated Apoptosis by Tetratricopeptide Repeat Protein and Cochaperone P58IPK. Molecular and cellular biology, vol.19, no.7, 4757-4765.
Taniguchi, Tadatsugu, Takaoka, Akinori. The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Current opinion in immunology, vol.14, no.1, 111-116.
Taylor, Deborah R., Lee, Sean Bong, Romano, Patrick R., Marshak, Daniel R., Hinnebusch, Alan G., Esteban, Mariano, Mathews, Michael B.. Autophosphorylation Sites Participate in the Activation of the Double-Stranded-RNA-Activated Protein Kinase PKR. Molecular and cellular biology, vol.16, no.11, 6295-6302.
Taylor, Deborah R., Shi, Stephanie T., Romano, Patrick R., Barber, Glen N., Lai, Michael M. C.. Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein. Science, vol.285, no.5424, 107-110.
Taylor, Susan S., Haste, Nina M., Ghosh, Gourisankar. PKR and eIF2α: Integration of Kinase Dimerization, Activation, and Substrate Docking. Cell, vol.122, no.6, 823-825.
Terada, Tadashi, Maeta, Hiroyuki, Endo, Kanenori, Ohta, Tetsuo. Protein expression of double-stranded RNA-activated protein kinase in thyroid carcinomas: Correlations with histologic types, pathologic parameters, and Ki-67 labeling. Human pathology, vol.31, no.7, 817-821.
Terada, Tadashi, Ueyama, Junichi, Ukita, Yoko, Ohta, Tetsuo. Protein expression of double‐stranded RNA‐activated protein kinase (PKR) in intrahepatic bile ducts in normal adult livers, fetal livers, primary biliary cirrhosis, hepatolithiasis and intrahepatic cholangiocarcinoma. Liver, vol.20, no.6, 450-457.
Turk, Benjamin E, Griffith, Eric C, Wolf, Susan, Biemann, Klaus, Chang, Yie-Hwa, Liu, Jun O. Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells. Chemistry & biology, vol.6, no.11, 823-833.
Ung, Tekly L., Cao, Chune, Lu, Jianming, Ozato, Keiko, Dever, Thomas E.. Heterologous dimerization domains functionally substitute for the double‐stranded RNA binding domains of the kinase PKR. The EMBO journal, vol.20, no.14, 3728-3737.
Valyi-Nagy, T., Fareed, M. U., O'Keefe, J. S., Gesser, R. M., MacLean, A. R., Brown, S. M., Spivack, J. G., Fraser, N. W.. The herpes simplex virus type 1 strain 17+ 34.5 deletion mutant 1716 is avirulent in SCID mice. The Journal of general virology, vol.75, no.8, 2059-2063.
Reference deleted.
Reference deleted.
Ventoso, Iván, Sanz, Miguel Angel, Molina, Susana, Berlanga, Juan José, Carrasco, Luis, Esteban, Mariano. Translational resistance of late alphavirus mRNA to eIF2α phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR. Genes & development, vol.20, no.1, 87-100.
Verma, I M, Stevenson, J K, Schwarz, E M, Van Antwerp, D, Miyamoto, S. Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.. Genes & development, vol.9, no.22, 2723-2735.
Visvanathan, K. V., Goodbourn, S.. Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.. The EMBO journal, vol.8, no.4, 1129-1138.
von Holzen, Urs, Bocangel, Dora, Pataer, Abujiang, Vorburger, Stephan A., Liu, Yanna, Lu, Xialolin, Hunt, Kelly K., Swisher, Stephen G.. Role for the double-stranded RNA-activated protein kinase PKR in Ad-TNF-α gene therapy in esophageal cancer. Surgery, vol.138, no.2, 261-268.
Vorburger, Stephan A., Hetrakul, Nophadol, Xia, Weiya, Wilson-Heiner, Marcia, Mirza, Nadeem, Pollock, Raphael E., Feig, Barry, Swisher, Stephen G., Hunt, Kelly K.. Gene therapy withE2F-1up-regulates the protein kinase PKR and inhibits growth of leiomyosarcomain vivo. Molecular cancer therapeutics, vol.4, no.11, 1710-1716.
Vorburger, Stephan A, Pataer, Abujiang, Swisher, Stephen G, Hunt, Kelly K. Genetically Targeted Cancer Therapy : Tumor Destruction by PKR Activation. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice, vol.4, no.3, 189-198.
Vorburger, Stephan A, Pataer, Abujiang, Yoshida, Kazumi, Barber, Glen N, Xia, Weiya, Chiao, Paul, Ellis, Lee M, Hung, Mien-Chie, Swisher, Stephen G, Hunt, Kelly K. Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene, vol.21, no.41, 6278-6288.
Wada, Naoya, Matsumura, Miho, Ohba, Yoshiki, Kobayashi, Nobuyuki, Takizawa, Takenori, Nakanishi, Yoshinobu. Transcription Stimulation of the Fas-encoding Gene by Nuclear Factor for Interleukin-6 Expression upon Influenza Virus Infection. The Journal of biological chemistry, vol.270, no.30, 18007-18012.
Wang, Xiuyan, Li, Ming, Zheng, Hongyong, Muster, Thomas, Palese, Peter, Beg, Amer A., Garcı́a-Sastre, Adolfo. Influenza A Virus NS1 Protein Prevents Activation of NF-κB and Induction of Alpha/Beta Interferon. Journal of virology, vol.74, no.24, 11566-11573.
10.2174/157016205774370447
Watson, J.C., Chang, H.-W., Jacobs, B.L.. Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded rna-dependent protein kinase. Virology, vol.185, no.1, 206-216.
Wesche, H., Henzel, W.J., Shillinglaw, W., Li, S., Cao, Z.. MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex. Immunity, vol.7, no.6, 837-847.
Wilson, Joan E, Pestova, Tatyana V, Hellen, Christopher U.T, Sarnow, Peter. Initiation of Protein Synthesis from the A Site of the Ribosome. Cell, vol.102, no.4, 511-520.
Williams, Bryan RG. PKR; a sentinel kinase for cellular stress. Oncogene, vol.18, no.45, 6112-6120.
Williams, B. R. G.. Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation. Biochemical Society transactions, vol.25, no.2, 509-513.
Williams, Bryan R. G.. Signal Integration via PKR. Science's STKE signal transduction knowledge environment, vol.2001, no.89,
Willman, CL, Sever, CE, Pallavicini, MG, Harada, H, Tanaka, N, Slovak, ML, Yamamoto, H, Harada, K, Meeker, TC, List, AF, et, al.. Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science, vol.259, no.5097, 968-971.
Woldehawariat, Girma, Nekhai, Sergei, Petryshyn, Raymond, Petryshyn, Raymond. Differential phosphorylation of PKR associates with deregulation of eIF-2&agr; phosphorylation and altered growth characteristics in 3T3-F442A fibroblasts. Molecular and cellular biochemistry, vol.198, no.1, 7-17.
Wong, A H, Tam, N W, Yang, Y L, Cuddihy, A R, Li, S, Kirchhoff, S, Hauser, H, Decker, T, Koromilas, A E. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.. The EMBO journal, vol.16, no.6, 1291-1304.
Wu, Ming H., Yung, Benjamin Y.M.. UV Stimulation of Nucleophosmin/B23 Expression Is an Immediate-early Gene Response Induced by Damaged DNA. The Journal of biological chemistry, vol.277, no.50, 48234-48240.
Wu, S., Kumar, K. U., Kaufman, R. J.. Identification and Requirement of Three Ribosome Binding Domains in dsRNA-Dependent Protein Kinase (PKR). Biochemistry, vol.37, no.39, 13816-13826.
Wu, X, Levine, A J. p53 and E2F-1 cooperate to mediate apoptosis.. Proceedings of the National Academy of Sciences of the United States of America, vol.91, no.9, 3602-3606.
Yajima, Misako, Kanda, Teru, Takada, Kenzo. Critical Role of Epstein-Barr Virus (EBV)-Encoded RNA in Efficient EBV-Induced B-Lymphocyte Growth Transformation. Journal of virology, vol.79, no.7, 4298-4307.
Yaman, Ibrahim, Fernandez, James, Liu, Haiyan, Caprara, Mark, Komar, Anton A., Koromilas, Antonis E., Zhou, Lingyin, Snider, Martin D., Scheuner, Donalyn, Kaufman, Randal J., Hatzoglou, Maria. The Zipper Model of Translational Control : A Small Upstream ORF Is the Switch that Controls Structural Remodeling of an mRNA Leader. Cell, vol.113, no.4, 519-531.
Yamaoka, Shoji, Courtois, Gilles, Bessia, Christine, Whiteside, Simon T, Weil, Robert, Agou, Fabrice, Kirk, Heather E, Kay, Robert J, Israël, Alain. Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation. Cell, vol.93, no.7, 1231-1240.
Mol. Cancer Ther. 233 4 2005 10.1158/1535-7163.233.4.2 Yan, C., M. S. Jamaluddin, B. Aggarwal, J. Myers, and D. D. Boyd. 2005. Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol. Cancer Ther.4:233-241.
Yan, Chunhong, Lu, Dan, Hai, Tsonwin, Boyd, Douglas D. Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. The EMBO journal, vol.24, no.13, 2425-2435.
Yang, Y. L., Reis, L. F., Pavlovic, J., Aguzzi, A., Schäfer, R., Kumar, A., Williams, B. R., Aguet, M., Weissmann, C.. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.. The EMBO journal, vol.14, no.24, 6095-6106.
Yeung, Michael C., Chang, Danny L., Camantigue, Randell E., Lau, Allan S.. Inhibitory role of the host apoptogenic gene PKR in the establishment of persistent infection by encephalomyocarditis virus in U937 cells. Proceedings of the National Academy of Sciences of the United States of America, vol.96, no.21, 11860-11865.
Yeung, M C, Liu, J, Lau, A S. An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.. Proceedings of the National Academy of Sciences of the United States of America, vol.93, no.22, 12451-12455.
Yoneyama, Mitsutoshi, Kikuchi, Mika, Natsukawa, Takashi, Shinobu, Noriaki, Imaizumi, Tadaatsu, Miyagishi, Makoto, Taira, Kazunari, Akira, Shizuo, Fujita, Takashi. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nature immunology, vol.5, no.7, 730-737.
Double-Stranded RNA-Dependent Protein Kinase (PKR) Is Regulated by Reovirus Structural Proteins. Virology, vol.234, no.2, 364-371.
Yuwen, H., Cox, J.H., Yewdell, J.W., Bennink, J.R., Moss, B.. Nuclear Localization of a Double-Stranded RNA-Binding Protein Encoded by the Vaccinia Virus E3L Gene. Virology, vol.195, no.2, 732-744.
Zamanian-Daryoush, Maryam, Der, Sandy D, Williams, Bryan RG. Cell cycle regulation of the double stranded RNA activated protein kinase, PKR. Oncogene, vol.18, no.2, 315-326.
Zamanian-Daryoush, Maryam, Mogensen, Trine H., DiDonato, Joseph A., Williams, Bryan R. G.. NF-κB Activation by Double-Stranded-RNA-Activated Protein Kinase (PKR) Is Mediated through NF-κB-Inducing Kinase and IκB Kinase. Molecular and cellular biology, vol.20, no.4, 1278-1290.
Zhang, Chun, Kawauchi, Junya, Adachi, Mimi T., Hashimoto, Yoshinori, Oshiro, Satoru, Aso, Teijiro, Kitajima, Shigetaka. Activation of JNK and Transcriptional Repressor ATF3/LRF1 through the IRE1/TRAF2 Pathway Is Implicated in Human Vascular Endothelial Cell Death by Homocysteine. Biochemical and biophysical research communications, vol.289, no.3, 718-724.
Zhang, Fan, Romano, Patrick R., Nagamura-Inoue, Tokiko, Tian, Bin, Dever, Thomas E., Mathews, Michael B., Ozato, Keiko, Hinnebusch, Alan G.. Binding of Double-stranded RNA to Protein Kinase PKR Is Required for Dimerization and Promotes Critical Autophosphorylation Events in the Activation Loop. The Journal of biological chemistry, vol.276, no.27, 24946-24958.
ZHOU, AIMIN, PARANJAPE, JAYASHREE M., HASSEL, BRET A., NIE, HUIQIN, SHAH, STEVEN, GALINSKI, BEVERLY, SILVERMAN, ROBERT H.. Impact of RNase L Overexpression on Viral and Cellular Growth and Death. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol.18, no.11, 953-961.
Zhou, Y, Gobl, A, Wang, S, Jacobsen, M.B, Janson, E.T, Haines III, G.K, Radosevich, J.A, Oberg, K. Expression of p68 protein kinase and its prognostic significance during IFN-α therapy in patients with carcinoid tumours. European journal of cancer, vol.34, no.13, 2046-2052.
Zhu, Shuhao, Romano, Patrick R., Wek, Ronald C.. Ribosome Targeting of PKR Is Mediated by Two Double-stranded RNA-binding Domains and Facilitates in Vivo Phosphorylation of Eukaryotic Initiation Factor-2. The Journal of biological chemistry, vol.272, no.22, 14434-14441.
Zürcher, Thomas, Marión, Rosa María, Ortín, Juan. Protein Synthesis Shut-Off Induced by Influenza Virus Infection Is Independent of PKR Activity. Journal of virology, vol.74, no.18, 8781-8784.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.