[논문]A voxel-based mouse for internal dose calculations using Monte Carlo simulations (MCNP)

Bitar, A; Lisbona, A; Thedrez, P; Sai Maurel, C; Le Forestier, D; Barbet, J; Bardies, M

doi:10.1088/0031-9155/52/4/010

[해외논문] A voxel-based mouse for internal dose calculations using Monte Carlo simulations (MCNP)

Physics in medicine & biology, v.52 no.4, 2007년, pp.1013 - 1025

Bitar, A (INSERM, U601, Nantes, F-44093, France) , Lisbona, A (Medical Physics Department, CRLCC Rene Gauducheau, F-44805 Saint-Herblain, France) , Thedrez, P (INSERM, U601, Nantes, F-44093, France) , Sai Maurel, C (INSERM, U601, Nantes, F-44093, France) , Le Forestier, D (Universit？ de Nantes, Facult？ de m？decine, Nantes, F-44093, France) , Barbet, J (INSERM, U601, Nantes, F-44093, France) , Bardies, M (INSERM, U601, Nantes, F-44093, France)

Abstract ▼ AI-Helper

Murine models are useful for targeted radiotherapy pre-clinical experiments. These models can help to assess the potential interest of new radiopharmaceuticals. In this study, we developed a voxel-based mouse for dosimetric estimates. A female nude mouse (30 g) was frozen and cut into slices. High-resolution digital photographs were taken directly on the frozen block after each section. Images were segmented manually. Monoenergetic photon or electron sources were simulated using the MCNP4c2 Monte Carlo code for each source organ, in order to give tables of S-factors (in Gy Bq−1 s−1) for all target organs. Results obtained from monoenergetic particles were then used to generate S-factors for several radionuclides of potential interest in targeted radiotherapy. Thirteen source and 25 target regions were considered in this study. For each source region, 16 photon and 16 electron energies were simulated. Absorbed fractions, specific absorbed fractions and S-factors were calculated for 16 radionuclides of interest for targeted radiotherapy. The results obtained generally agree well with data published previously. For electron energies ranging from 0.1 to 2.5 MeV, the self-absorbed fraction varies from 0.98 to 0.376 for the liver, and from 0.89 to 0.04 for the thyroid. Electrons cannot be considered as ‘non-penetrating’ radiation for energies above 0.5 MeV for mouse organs. This observation can be generalized to radionuclides: for example, the beta self-absorbed fraction for the thyroid was 0.616 for I-131; absorbed fractions for Y-90 for left kidney-to-left kidney and for left kidney-to-spleen were 0.486 and 0.058, respectively. Our voxel-based mouse allowed us to generate a dosimetric database for use in preclinical targeted radiotherapy experiments.

참고문헌 (30)

1994 10.1088/0031-9155/39/6/004 39 961 0031-9155 Phys. Med. Biol. Bardiès M

상세보기
2000 Briesmeister J F
2006 10.1088/0031-9155/51/3/009 51 601 0031-9155 Phys. Med. Biol. Chiavassa S

상세보기
Flynn, AA, Green, AJ, Pedley, RB, Boxer, GM, Boden, R, Begent, RHJ. A Mouse Model for Calculating the Absorbed Beta-Particle Dose from 131I- and 90Y-Labeled Immunoconjugates, Including a Method for Dealing with Heterogeneity in Kidney and Tumor. Radiation research, vol.156, no.1, 28-35.

상세보기
Funk, Tobias, Sun, Mingshan, Hasegawa, Bruce H.. Radiation dose estimate in small animal SPECT and PET. Medical physics, vol.31, no.9, 2680-2686.

상세보기
Furhang, Eli E., Sgouros, George, Chui, Chen‐Shou. Radionuclide photon dose kernels for internal emitter dosimetry. Medical physics, vol.23, no.5, 759-764.

상세보기
2004 Hendricks J S
2004 45 1960 0161-5505 J. Nucl. Med. Hindorf C

상세보기
10.1002/1097-0142(19940201)73:3+ 3.0.CO;2-1

상세보기
1989 ICRU
1983 ICRP
2001 A Color Atlas of Sectional Anatomy of the Mouse Iwaki T
Johnson, Timothy K., McClure, David, McCourt, Steven. MABDOSE. I: Characterization of a general purpose dose estimation code. Medical physics, vol.26, no.7, 1389-1395.

상세보기
Kennel, Stephen J., Stabin, Michael, Yoriyaz, Helio, Brechbiel, Martin, Mirzadeh, Saed. Treatment of lung tumor colonies with ⁹⁰Y targeted to blood vessels: comparison with the α-particle emitter ²¹³Bi. Nuclear medicine and biology, vol.26, no.1, 149-157.

상세보기
2003 44 784 J. Nucl. Med. Kolbert K S

상세보기
2004 45 1260 0161-5505 J. Nucl. Med. Konijnenberg M W

상세보기
1991 MIRD Primer for Absorbed Dose Calculations rev edn Loevinger R
Miller, William H., Hartmann-Siantar, Christine, Fisher, Darrell, Descalle, Marie-Anne, Daly, Tom, Lehmann, Joerg, Lewis, Michael R., Hoffman, Timothy, Smith, Jeff, Situ, Peter D., Volkert, Wynn A.. Evaluation of Beta-Absorbed Fractions in a Mouse Model for ⁹⁰Y, ¹⁸⁸Re, ¹⁶⁶Ho, ¹⁴⁹Pm, ⁶⁴Cu, and ¹⁷⁷Lu Radionuclides. Cancer biotherapy & radiopharmaceuticals, vol.20, no.4, 436-449.

상세보기
2006 Rasband W S
Segars, William.P., Tsui, Benjamin M.W., Frey, Eric C., Johnson, G.Allan, Berr, Stuart S.. Development of a 4-D digital mouse phantom for molecular imaging research. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol.6, no.3, 149-159.

상세보기
Simpkin, Douglas J., Mackie, T. Rockwell. EGS4 Monte Carlo determination of the beta dose kernel in water. Medical physics, vol.17, no.2, 179-186.

상세보기
2005 46 2278 J. Nucl. Med. Situ P D
1975 11 ‘S’, Absorbed Dose per Unit Cumulated Activity for Selected Radionuclides and Organs MIRD Pamphlet Snyder W S
1996 37 538 0161-5505 J. Nucl. Med. Stabin M G
2006 47 655 0161-5505 J. Nucl. Med. Stabin M G

상세보기
Stabin, M. G., Yoriyaz, H.. PHOTON SPECIFIC ABSORBED FRACTIONS CALCULATED IN THE TRUNK OF AN ADULT MALE VOXEL-BASED PHANTOM :. Health physics : official journal of the Health Physics Society, vol.82, no.1, 21-44.

상세보기
Taschereau, Richard, Chow, Patrick L., Chatziioannou, Arion F.. Monte Carlo simulations of dose from microCT imaging procedures in a realistic mouse phantom. Medical physics, vol.33, no.1, 216-224.

상세보기
1998 Nonclinical Pharmacokinetic Studies Tse F L S
1986 10.1259/0007-1285-59-708-1209 59 1209 0007-1285 Br. J. Radiol. Woodard H Q

상세보기
1997 38 228P 0161-5505 J. Nucl. Med. Yoriyaz H

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[해외논문] A voxel-based mouse for internal dose calculations using Monte Carlo simulations (MCNP)

Abstract ▼ AI-Helper

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