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NTIS 바로가기Expert opinion on therapeutic targets, v.11 no.2, 2007년, pp.161 - 179
Holzgrabe, Ulrike , Kapková, Petra , Alptüzün, Vildan , Scheiber, Josef , Kugelmann, Eva
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Lleó, A., Greenberg, S.M., Growdon, J.H.. CURRENT PHARMACOTHERAPY FOR ALZHEIMER'S DISEASE. Annual review of medicine, vol.57, 513-533.
Trends Neurosci. SMALL 245 27 2004 10.1016/j.tins.2004.03.006
ALVAREZ A, INESTROSA NC: Acetylcholinesterase in Alzheimer’s disease: Its molecular interactions with the amyloid β peptide. In: Recent Trends in the Acetylcholinesterase System . Parveen M et al. (Eds), IOS Press, Amsterdam, The Netherlands (2005):11-22.
Rees, T, Hammond, P.I, Soreq, H, Younkin, S, Brimijoin, S. Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex. Neurobiology of aging, vol.24, no.6, 777-787.
Biochem. Pharmacol. BARTOLINI 407 65 2003 10.1016/S0006-2952(02)01514-9
J. Biol. Chem. BOURNE 2963 274 1999 10.1074/jbc.274.5.2963
Curr. Pharm. Des. JOHNSON 217 12 2006 10.2174/138161206775193127
Neurosci. Lett. STEFANOVA 159 338 2003 10.1016/S0304-3940(02)01384-8
Neuroreport VENNERI 83 13 2002 10.1097/00001756-200201210-00020
J. Neurol. Sci. LOJKOWSKA 119 216 2003 10.1016/S0022-510X(03)00229-6
Acta Psychiatr. Scand. MAIDMENT 403 111 2005 10.1111/j.1600-0447.2005.00516.x
J. Neurol. BOHNEN 242 253 2006 10.1007/s00415-005-0971-0
Poewe, Werner, Wolters, Erik, Emre, Murat, Onofrj, Marco, Hsu, Chuanchieh, Tekin, Sibel, Lane, Roger. Long‐term benefits of rivastigmine in dementia associated with Parkinson's disease: An active treatment extension study. Movement disorders : official journal of the Movement Disorder Society, vol.21, no.4, 456-461.
Int. J. Geriatr. Psychiatry VAN DER PUTT 755 21 2006 10.1002/gps.1557
Arch. Gerontol. Geriatr. RAMPELLO 1 39 2004 10.1016/j.archger.2003.11.003
J. Psychopharmacol. ALWAHHABI 214 19 2005 10.1177/0269881105049045
J. Neuropsychiatry Clin. Neurosci. SIMARD 409 16 2004 10.1176/jnp.16.4.409
CNS Drugs ERKINJUNTTI 35 12 1999 10.2165/00023210-199912010-00004
Moretti, Rita, Torre, Paola, Antonello, Rodolfo M., Cazzato, Giuseppe, Griggio, Stefania, Bava, Antonio. An open-label pilot study comparing rivastigmine and low-dose aspirin for the treatment of symptoms specific to patients with subcortical vascular dementia. Current therapeutic research, vol.63, no.7, 443-458.
Am. J. Alzheimers Dis. Demen. MORETTI 333 19 2004 10.1177/153331750401900607
Mov. Disord. FERNANDEZ 173 15 2000 10.1002/1531-8257(200001)15:1<173::AID-MDS1032>3.0.CO;2-T
Int. J. Clin. Psychopharmacol. PETRIKIS 49 19 2004 10.1097/00004850-200401000-00010
Proc. Natl. Acad. Sci. USA STERNFELD 8647 97 2000 10.1073/pnas.140004597
Curr. Protein Pept. Sci. HOLMQUIST 209 1 2000 10.2174/1389203003381405
Science SUSSMAN 872 253 1991 10.1126/science.1678899
Ann. Pharmacotherapy CRISMON 744 28 1994 10.1177/106002809402800612
J. Clin. Pharm. Ther. MISSON 251 22 1997 10.1046/j.1365-2710.1997.10275102.x
Drugs SCOTT 1095 60 2000 10.2165/00003495-200060050-00008
Br. J. Clin. Pharmacol. MCGLEENON 471 48 1999 10.1046/j.1365-2125.1999.00026.x
Mol. Brain Res. WANG 1 107 2002 10.1016/S0169-328X(02)00402-3
Zhao, Qin, Tang, Xi Can. Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. European journal of pharmacology, vol.455, no.2, 101-107.
Proc. Natl. Acad. Sci. USA HAREL 9031 90 1993 10.1073/pnas.90.19.9031
Biochem. Soc. Trans. SILMAN 745 22 1994 10.1042/bst0220745
Structure KRYGER 297 7 1999 10.1016/S0969-2126(99)80040-9
J. Med. Chem. RYDBERG 5491 49 2006 10.1021/jm060164b
Lancet DAVIS 625 345 1995 10.1016/S0140-6736(95)90526-X
Blackard Jr., William G., Sood, Gagan K., Crowe, D. Ralph, Fallon, Michael B.. Tacrine : A Cause of Fatal Hepatotoxicity?. Journal of clinical gastroenterology, vol.26, no.1, 57-59.
Muñoz-Torrero, D, Camps, P. Dimeric and hybrid anti-Alzheimer drug candidates.. Current medicinal chemistry, vol.13, no.4, 399-422.
Jpn. J. Pharmacol. SUGIMOTO 7 89 2002 10.1254/jjp.89.7
Br. J. Clin. Pharmacol. JACKSON 1 58 2004 10.1111/j.1365-2125.2004.01848.x
Br. J. Clin. Pharmacol. REYES 9 58 2004 10.1111/j.1365-2125.2004.01802.x
Dement. Geriatr. Cogn. Disord. LILIENFELD 19 11 2000 10.1159/000051228
Santos, Máriton D., Alkondon, Manickavasagom, Pereira, Edna F. R., Aracava, Yasco, Eisenberg, Howard M., Maelicke, Alfred, Albuquerque, Edson X.. The Nicotinic Allosteric Potentiating Ligand Galantamine Facilitates Synaptic Transmission in the Mammalian Central Nervous System. Molecular pharmacology, vol.61, no.5, 1222-1234.
Methods Find. Exp. Clin. Pharmacol. ALES 151 24 2002 10.1358/mf.2002.24.3.802300
J. Mol. Graphics Model PILGER 288 19 2001 10.1016/S1093-3263(00)00056-5
Arias, Esperanza, Alés, Eva, Gabilan, Nelson H., Cano-Abad, María F., Villarroya, Mercedes, García, Antonio G., López, Manuela G.. Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology, vol.46, no.1, 103-114.
Drugs Fut. TANG 647 24 1999 10.1358/dof.1999.024.06.545143
J. Biol. Chem. PANG 23646 271 1996 10.1074/jbc.271.39.23646
J. Am. Chem. Soc. WONG 363 125 2003 10.1021/ja021111w
Zangara, Andrea. The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease. Pharmacology, biochemistry, and behavior, vol.75, no.3, 675-686.
Drug. Fut. BRUFANI 379 22 1997
Clin. Ther. RONALD 634 20 1998 10.1016/S0149-2918(98)80127-6
Shaw, Karen T. Y., Utsuki, Tadanobu, Rogers, Jack, Yu, Qian-Sheng, Sambamurti, Kumar, Brossi, Arnold, Ge, Yuan-Wen, Lahiri, Debomoy K., Greig, Nigel H.. Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proceedings of the National Academy of Sciences of the United States of America, vol.98, no.13, 7605-7610.
Utsuki, Tada, Yu, Qian-sheng, Davidson, Diane, Chen, Demao, Holloway, Harold W., Brossi, Arnold, Sambamurti, Kumar, Lahiri, Debomoy K., Greig, Nigel H., Giordano, Tony. Identification of Novel Small Molecule Inhibitors of Amyloid Precursor Protein Synthesis as a Route to Lower Alzheimer's Disease Amyloid-β Peptide. The Journal of pharmacology and experimental therapeutics, vol.318, no.2, 855-862.
Martinez, Ana, Castro, Ana. Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer’s disease. Expert opinion on investigational drugs, vol.15, no.1, 1-12.
Prog. Brain Res. ENZ 431 98 1993 10.1016/S0079-6123(08)62429-2
Cutler, N. R., Polinsky, R. J., Srarnek, J. J., Enz, A., Jhee, S. S., Mancione, L., Hourani, J., Zolnouni, P.. Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer's disease. Acta neurologica Scandinavica, vol.97, no.4, 244-250.
Eur. Neurol. BALLARD 64 47 2002 10.1159/000047952
Neuroreport VENNERI 107 16 2005 10.1097/00001756-200502080-00006
Pharmacol. Res. GIACOBINI 433 50 2004 10.1016/j.phrs.2003.11.017
Greig, Nigel H., Lahiri, Debomoy K., Sambamurti, Kumar. Butyrylcholinesterase: An Important New Target in Alzheimer's Disease Therapy. International psychogeriatrics, vol.14, no.suppl1, 77-91.
Int. J. Clin. Pract. WILKINSON 441 56 2002 10.1111/j.1742-1241.2002.tb11294.x
Eur. J. Pharmacol. LISTON 9 486 2004 10.1016/j.ejphar.2003.11.080
Med. Chem. Rev. GREIG 3 15 1995
Carlier, P.R., Han, Y.F., Chow, E.S.H., Li, C.P.L., Wang, H., Xuan Lieu, T., Sum Wong, H., Pang, Y.P.. Evaluation of short-tether Bis-THA AChE inhibitors. A further test of the dual binding site hypothesis. Bioorganic & medicinal chemistry, vol.7, no.2, 351-357.
Neurosci. Lett. LIU 165 282 2000 10.1016/S0304-3940(00)00905-8
Neurosci. Lett. WU 95 288 2000 10.1016/S0304-3940(00)01198-8
J. Biol. Chem. LI 18179 280 2005 10.1074/jbc.M411085200
J. Med. Chem. CARLIER 4225 42 1999 10.1021/jm990224w
J. Med. Chem. RECANATINI 2007 43 2000 10.1021/jm990971t
J. Med. Chem. HU 2277 45 2002 10.1021/jm010308g
Gregor, V.E., Emmerling, M.R., Lee, C., Moore, C.J.. The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivaties. Bioorganic & medicinal chemistry letters, vol.2, no.8, 861-864.
Biopolymers WLODEK 109 38 1996 10.1002/(SICI)1097-0282(199601)38:1<109::AID-BIP9>3.0.CO;2-#
Dvir, H., Wong, D. M., Harel, M., Barril, X., Orozco, M., Luque, F. J., Munoz-Torrero, D., Camps, P., Rosenberry, T. L., Silman, I., Sussman, J. L.. 3D Structure of Torpedo californica Acetylcholinesterase Complexed with Huprine X at 2.1 Å Resolution: Kinetic and Molecular Dynamic Correlates,. Biochemistry, vol.41, no.9, 2970-2981.
Munoz-Ruiz, P., Rubio, L., Garcia-Palomero, E., Dorronsoro, I., del Monte-Millan, M., Valenzuela, R., Usan, P., de Austria, C., Bartolini, M., Andrisano, V., Bidon-Chanal, A., Orozco, M., Luque, F. J., Medina, M., Martinez, A.. Design, Synthesis, and Biological Evaluation of Dual Binding Site Acetylcholinesterase Inhibitors: New Disease-Modifying Agents for Alzheimer's Disease. Journal of medicinal chemistry, vol.48, no.23, 7223-7233.
Mini-Rev. Med.Chem. BARRIL 27 2 2002 10.2174/1389557023406494
J. Med. Chem. SAVINI 1 46 2003 10.1021/jm0255668
J. Med. Chem. CAMPIANI 1919 48 2005 10.1021/jm049510k
Bioorg. Med. Chem. Lett. SHAO 4639 14 2004 10.1016/j.bmcl.2004.07.005
Bioorg. Med. Chem. ALONSO 6588 13 2005 10.1016/j.bmc.2005.09.029
Rosini, M., Andrisano, V., Bartolini, M., Bolognesi, M. L., Hrelia, P., Minarini, A., Tarozzi, A., Melchiorre, C.. Rational Approach To Discover Multipotent Anti-Alzheimer Drugs. Journal of medicinal chemistry, vol.48, no.2, 360-363.
J. Med. Chem. RODRIGUEZ-FRANCO 459 49 2006 10.1021/jm050746d
Bolognesi, M. L., Andrisano, V., Bartolini, M., Banzi, R., Melchiorre, C.. Propidium-Based Polyamine Ligands as Potent Inhibitors of Acetylcholinesterase and Acetylcholinesterase-Induced Amyloid-&bgr; Aggregation. Journal of medicinal chemistry, vol.48, no.1, 24-27.
J. Med. Chem. ROSINI 1860 45 2002 10.1021/jm011067f
J. Med. Chem. BOLOGNESI 3286 45 2002 10.1021/jm020835f
J. Med. Chem. TUMIATTI 954 46 2003 10.1021/jm021055+
Proc. Natl. Acad. Sci. USA BOURNE 1449 101 2004 10.1073/pnas.0308206100
J. Am. Chem. Soc. KRASINSKI 6686 127 2005 10.1021/ja043031t
Synapse LIU 57 13 1993 10.1002/syn.890130108
J. Med. Chem. FENG 655 48 2005 10.1021/jm0496178
Bioorg. Med. Chem. Lett. CARLIER 2335 9 1999 10.1016/S0960-894X(99)00396-0
Camps, P., El Achab, R., Morral, J., Munoz-Torrero, D., Badia, A., Banos, J. E., Vivas, N. M., Barril, X., Orozco, M., Luque, F. J.. New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease. Journal of medicinal chemistry, vol.43, no.24, 4657-4666.
Neuropharmacology DEL MAR ALCALÁ 749 44 2003 10.1016/S0028-3908(03)00071-6
Canudas, Anna M, Pubill, David, Sureda, Francesc X, Verdaguer, Ester, Camps, Pelayo, Muñoz-Torrero, Diego, Jiménez, Andrés, Camins, Antoni, Pallàs, Mercè. Neuroprotective effects of (±)-huprine Y on in vitro and in vivo models of excitoxicity damage. Experimental neurology, vol.180, no.2, 123-130.
Camps, P., Formosa, X., Munoz-Torrero, D., Petrignet, J., Badia, A., Clos, M. V.. Synthesis and Pharmacological Evaluation of Huprine−Tacrine Heterodimers: Subnanomolar Dual Binding Site Acetylcholinesterase Inhibitors. Journal of medicinal chemistry, vol.48, no.6, 1701-1704.
Bioorg. Med. Chem. Lett. MARY 835 6 1998 10.1016/S0968-0896(98)00133-3
Bioorg. Med. Chem. Lett. GUILLOU 637 10 2000 10.1016/S0960-894X(00)00059-7
Proteins: Struct. Funct. Genet. BARTOLUCCI 182 42 2001 10.1002/1097-0134(20010201)42:2<182::AID-PROT50>3.0.CO;2-1
J. Pharm. Pharmacol. ALPTÜZÜN 1397 55 2003 10.1211/0022357021855
Bioorg. Med. Chem. KAPKOVÁ 472 14 2006 10.1016/j.bmc.2005.08.034
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