[논문]The cefoxitin disk test – what a clinical microbiologist needs to know

doi:10.1016/j.clinmicnews.2007.02.004

The cefoxitin disk test – what a clinical microbiologist needs to know

Clinical microbiology newsletter, v.29 no.5, 2007년, pp.33 - 40

Swenson, Jana M. (Anti-infectives Investigation Team, Epidemiology and Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia) , Skov, Robert (National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen, Denmark) , Patel, Jean B. (Anti-infectives Investigation Team, Epidemiology and Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia)

Abstract ▼ AI-Helper

Abstract Accurate prediction of mecA- mediated resistance in Staphylococcus spp. has been a challenge for the clinical microbiologist ever since the discovery of methicillin resistance. In 2004, a cefoxitin disk diffusion test was recommended by the Clinical and Laboratory Standards Institute (formerly NCCLS) for prediction of mecA- mediated resistance in both Staphylococcus aureus and coagulase-negative staphylococci because of its high sensitivity and specificity compared to PCR tests for mecA. It is also much easier to read that the oxacillin disk diffusion test, not requiring close scrutiny of the zone of inhibition or 24 h of incubation. The test is used as a surrogate for oxacillin testing. In other words, when cefoxitin is tested, the results are applied to oxacillin and oxacillin is reported. For resistant strains, the results are applied not only to oxacillin, but also to all other β-lactam agents, which must also be reported as resistant if they are reported. There has been some confusion among clinical microbiologists about when and how the test should be used. We answer some of the questions that have been raised about the test.

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The cefoxitin disk test – what a clinical microbiologist needs to know

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